{"id":"https://openalex.org/W2133545486","doi":"https://doi.org/10.1128/jvi.06225-11","title":"Ligand-Bound Structures of the Dengue Virus Protease Reveal the Active Conformation","display_name":"Ligand-Bound Structures of the Dengue Virus Protease Reveal the Active Conformation","publication_year":2011,"publication_date":"2011-10-27","ids":{"openalex":"https://openalex.org/W2133545486","doi":"https://doi.org/10.1128/jvi.06225-11","mag":"2133545486","pmid":"https://pubmed.ncbi.nlm.nih.gov/22031935","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3255909"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.06225-11","doi":"https://doi.org/10.1128/jvi.06225-11","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.06225-11","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3255909/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028680656","display_name":"Christian G. Noble","orcid":"https://orcid.org/0009-0000-4004-1091","observed_orcids":["https://orcid.org/0009-0000-4004-1091"]},"institutions":[{"id":"https://openalex.org/I4210124465","display_name":"Novartis (Singapore)","ror":"https://ror.org/02v66pf20","country_code":"SG","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210124465"]},{"id":"https://openalex.org/I4405253178","display_name":"Novartis Institute For Tropical Diseases","ror":"https://ror.org/00cn3vx82","country_code":"SG","type":"facility","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210124465","https://openalex.org/I4405253178"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Christian G. Noble","raw_affiliation_strings":["Novartis Institute for Tropical Diseases, Chromos, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institute for Tropical Diseases, Chromos, Singapore","institution_ids":["https://openalex.org/I4210124465","https://openalex.org/I4405253178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020366410","display_name":"Cheah C. Seh","orcid":"https://orcid.org/0000-0003-3468-2348","observed_orcids":["https://orcid.org/0000-0003-3468-2348"]},"institutions":[{"id":"https://openalex.org/I4210124465","display_name":"Novartis (Singapore)","ror":"https://ror.org/02v66pf20","country_code":"SG","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210124465"]},{"id":"https://openalex.org/I4405253178","display_name":"Novartis Institute For Tropical Diseases","ror":"https://ror.org/00cn3vx82","country_code":"SG","type":"facility","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210124465","https://openalex.org/I4405253178"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Cheah Chen Seh","raw_affiliation_strings":["Novartis Institute for Tropical Diseases, Chromos, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institute for Tropical Diseases, Chromos, Singapore","institution_ids":["https://openalex.org/I4210124465","https://openalex.org/I4405253178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084790412","display_name":"Alexander Theodore Chao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124465","display_name":"Novartis (Singapore)","ror":"https://ror.org/02v66pf20","country_code":"SG","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210124465"]},{"id":"https://openalex.org/I4405253178","display_name":"Novartis Institute For Tropical Diseases","ror":"https://ror.org/00cn3vx82","country_code":"SG","type":"facility","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210124465","https://openalex.org/I4405253178"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Alexander T. Chao","raw_affiliation_strings":["Novartis Institute for Tropical Diseases, Chromos, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institute for Tropical Diseases, Chromos, Singapore","institution_ids":["https://openalex.org/I4210124465","https://openalex.org/I4405253178"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057764651","display_name":"Pei\u2010Yong Shi","orcid":"https://orcid.org/0000-0001-5553-1616","observed_orcids":["https://orcid.org/0000-0001-5553-1616"]},"institutions":[{"id":"https://openalex.org/I4210124465","display_name":"Novartis (Singapore)","ror":"https://ror.org/02v66pf20","country_code":"SG","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210124465"]},{"id":"https://openalex.org/I4405253178","display_name":"Novartis Institute For Tropical Diseases","ror":"https://ror.org/00cn3vx82","country_code":"SG","type":"facility","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210124465","https://openalex.org/I4405253178"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Pei Yong Shi","raw_affiliation_strings":["Novartis Institute for Tropical Diseases, Chromos, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institute for Tropical Diseases, Chromos, Singapore","institution_ids":["https://openalex.org/I4210124465","https://openalex.org/I4405253178"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.7877,"has_fulltext":false,"cited_by_count":308,"citation_normalized_percentile":{"value":0.99224157,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"86","issue":"1","first_page":"438","last_page":"446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.7235999703407288,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.7235999703407288,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.2628999948501587,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/denv-3","display_name":"DENV-3","score":0.9100000262260437},{"id":"https://openalex.org/keywords/ns2b-ns3-protease","display_name":"NS2B-NS3 protease","score":0.8579999804496765},{"id":"https://openalex.org/keywords/closed-conformation","display_name":"closed conformation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/aprotinin","display_name":"aprotinin","score":0.7229999899864197},{"id":"https://openalex.org/keywords/peptide-substrate-binding","display_name":"peptide substrate binding","score":0.6029999852180481},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.7450000047683716},{"id":"https://openalex.org/keywords/antiviral-drug-targets","display_name":"antiviral drug targets","score":0.6000000238418579},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C132379496","wikidata":"https://www.wikidata.org/wiki/Q83141645","display_name":"NS3","level":4,"score":0.9066426753997803},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.7683677673339844},{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.7556376457214355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6806704998016357},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.6252182722091675},{"id":"https://openalex.org/C2780568436","wikidata":"https://www.wikidata.org/wiki/Q1165479","display_name":"Flavivirus","level":3,"score":0.5298866033554077},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.5121119022369385},{"id":"https://openalex.org/C83100098","wikidata":"https://www.wikidata.org/wiki/Q106297070","display_name":"NS2-3 protease","level":4,"score":0.5036775469779968},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.501572847366333},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.4814421534538269},{"id":"https://openalex.org/C82553315","wikidata":"https://www.wikidata.org/wiki/Q14905312","display_name":"MASP1","level":5,"score":0.46222129464149475},{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.429451584815979},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.4249866008758545},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38937103748321533},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.28682488203048706},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2450786530971527}],"mesh":[{"descriptor_ui":"D000085242","descriptor_name":"Viral Proteases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1128/jvi.06225-11","doi":"https://doi.org/10.1128/jvi.06225-11","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.06225-11","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmid:22031935","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22031935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3255909","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3255909/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.837.7030","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.837.7030","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jvi.asm.org/content/86/1/438.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.862.4458","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.862.4458","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jvi.asm.org/content/86/1/438.full.pdf?cited-by%3Dyes%26legid%3Djvi","raw_type":"text"},{"id":"pmh:oai:dora:psi_12055","doi":null,"is_oa":false,"landing_page_url":"https://www.dora.lib4ri.ch/psi/item/psi:12055","pdf_url":null,"source":{"id":"https://openalex.org/S4306402574","display_name":"DORA PSI (Paul Scherrer Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802229908","host_organization_name":"Paul Scherrer Institute","host_organization_lineage":["https://openalex.org/I2802229908"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virology","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3255909","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3255909/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1570836961","https://openalex.org/W1901804918","https://openalex.org/W1964571618","https://openalex.org/W1968353490","https://openalex.org/W1992285108","https://openalex.org/W1992411226","https://openalex.org/W1995667567","https://openalex.org/W1998178858","https://openalex.org/W1998660158","https://openalex.org/W2002185589","https://openalex.org/W2007198823","https://openalex.org/W2020460356","https://openalex.org/W2028064829","https://openalex.org/W2042479028","https://openalex.org/W2045367676","https://openalex.org/W2056057014","https://openalex.org/W2060217906","https://openalex.org/W2080900122","https://openalex.org/W2088389272","https://openalex.org/W2095368791","https://openalex.org/W2098687402","https://openalex.org/W2101706577","https://openalex.org/W2104412204","https://openalex.org/W2107739206","https://openalex.org/W2108921801","https://openalex.org/W2118150903","https://openalex.org/W2122994276","https://openalex.org/W2125808943","https://openalex.org/W2138830943","https://openalex.org/W2144081223","https://openalex.org/W2144171867","https://openalex.org/W2145704611","https://openalex.org/W2147949826","https://openalex.org/W2151802394","https://openalex.org/W2156549482","https://openalex.org/W2159211495"],"related_works":["https://openalex.org/W1996956356","https://openalex.org/W2125808943","https://openalex.org/W2101706577","https://openalex.org/W2608365258","https://openalex.org/W2507849094","https://openalex.org/W1968207680","https://openalex.org/W3201845440","https://openalex.org/W2155681277","https://openalex.org/W2028064829","https://openalex.org/W1971432065"],"abstract_inverted_index":{"Dengue":[0],"is":[1,8,186,220],"a":[2,9,26,56,93,183],"mosquito-borne":[3],"viral":[4],"hemorrhagic":[5],"disease":[6],"that":[7,108,185],"major":[10],"threat":[11],"to":[12,30,45,96,134],"human":[13],"health":[14],"in":[15,78,92,153,162,198,216],"tropical":[16],"and":[17,168,192,204],"subtropical":[18],"regions.":[19],"Here":[20],"we":[21],"report":[22],"crystal":[23],"structures":[24,50,126],"of":[25,61,68,84,99,137,177,225,228],"peptide":[27],"covalently":[28],"bound":[29,44],"dengue":[31],"virus":[32,102],"serotype":[33],"3":[34],"(DENV-3)":[35],"protease":[36,73,90,125,202],"as":[37,39,117,157,159],"well":[38,158],"the":[40,46,53,62,66,69,71,75,80,88,97,112,128,132,138,145,154,160,166,172,178,199,217,223],"serine-protease":[41],"inhibitor":[42],"aprotinin":[43],"same":[47],"enzyme.":[48],"These":[49],"reveal,":[51],"for":[52,120,149,208,222],"first":[54],"time,":[55],"catalytically":[57],"active,":[58],"closed":[59,76,113],"conformation":[60,77,114],"DENV":[63,169,229],"protease.":[64,104,230],"In":[65],"presence":[67],"peptide,":[70],"DENV-3":[72,124,179],"forms":[74],"which":[79],"hydrophilic":[81],"\u03b2-hairpin":[82],"region":[83],"NS2B":[85,191],"wraps":[86],"around":[87],"NS3":[89],"core,":[91],"manner":[94],"analogous":[95],"structure":[98,203],"West":[100],"Nile":[101],"(WNV)":[103],"Our":[105],"results":[106],"confirm":[107],"flavivirus":[109],"proteases":[110,170],"form":[111],"during":[115],"proteolysis,":[116],"previously":[118],"proposed":[119],"WNV.":[121],"The":[122,140,212],"current":[123,218],"reveal":[127],"detailed":[129],"interactions":[130],"at":[131,171],"P4'":[133],"P3":[135],"sites":[136],"substrate.":[139],"new":[141],"structural":[142,213],"information":[143,214],"explains":[144],"sequence":[146],"preference,":[147],"particularly":[148],"long":[150],"basic":[151],"residues":[152,189],"nonprime":[155],"side,":[156],"difference":[161],"substrate":[163],"specificity":[164],"between":[165],"WNV":[167,200],"prime":[173],"side.":[174],"Structural":[175],"analysis":[176],"protease-peptide":[180],"complex":[181],"revealed":[182],"pocket":[184,195],"formed":[187],"by":[188],"from":[190],"NS3;":[193],"this":[194],"also":[196],"exists":[197],"NS2B/NS3":[201],"could":[205],"be":[206],"targeted":[207],"potential":[209],"antivirus":[210],"development.":[211],"presented":[215],"study":[219],"invaluable":[221],"design":[224],"specific":[226],"inhibitors":[227]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":25},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}