{"id":"https://openalex.org/W2133507679","doi":"https://doi.org/10.1164/rccm.201303-0505ed","title":"Recombinant Human Activated Protein C as a Therapy for Severe Sepsis: Lessons Learned?","display_name":"Recombinant Human Activated Protein C as a Therapy for Severe Sepsis: Lessons Learned?","publication_year":2013,"publication_date":"2013-05-01","ids":{"openalex":"https://openalex.org/W2133507679","doi":"https://doi.org/10.1164/rccm.201303-0505ed","mag":"2133507679","pmid":"https://pubmed.ncbi.nlm.nih.gov/23675711"},"language":"en","primary_location":{"id":"doi:10.1164/rccm.201303-0505ed","doi":"https://doi.org/10.1164/rccm.201303-0505ed","is_oa":false,"landing_page_url":"https://doi.org/10.1164/rccm.201303-0505ed","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025379878","display_name":"Steven M. Opal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2801290373","display_name":"Memorial Hospital of Rhode Island","ror":"https://ror.org/04c0a2j77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801290373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven M. Opal","raw_affiliation_strings":["Infectious Disease Division, The Alpert Medical School of Brown University, Providence, Rhode Island and Infectious Disease Division, Memorial Hospital of Rhode Island, Pawtucket, Rhode Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Division, The Alpert Medical School of Brown University, Providence, Rhode Island and Infectious Disease Division, Memorial Hospital of Rhode Island, Pawtucket, Rhode Island","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2801290373"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080897304","display_name":"Steven P. LaRosa","orcid":"https://orcid.org/0000-0002-0773-2816","observed_orcids":["https://orcid.org/0000-0002-0773-2816"]},"institutions":[{"id":"https://openalex.org/I4210152129","display_name":"Beverly Hospital","ror":"https://ror.org/04qhdw391","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210152129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven P. LaRosa","raw_affiliation_strings":["Infectious Disease, Beverly Hospital/Lahey Health, Beverly, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease, Beverly Hospital/Lahey Health, Beverly, Massachusetts","institution_ids":["https://openalex.org/I4210152129"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"187","issue":"10","first_page":"1041","last_page":"1043"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombinant-activated-protein-c","display_name":"recombinant activated protein C","score":0.9449999928474426},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/sepsis-treatment","display_name":"sepsis treatment","score":0.8930000066757202},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.39899998903274536},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8739383220672607},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.624854564666748},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5863021612167358},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5357055068016052},{"id":"https://openalex.org/C2994086866","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Severe sepsis","level":4,"score":0.4895366132259369},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3085608184337616},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.1597072184085846},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07743576169013977},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06330853700637817},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011486","descriptor_name":"Protein C","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1164/rccm.201303-0505ed","doi":"https://doi.org/10.1164/rccm.201303-0505ed","is_oa":false,"landing_page_url":"https://doi.org/10.1164/rccm.201303-0505ed","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:23675711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23675711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Editorial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1995727086","https://openalex.org/W2043932193","https://openalex.org/W2050569979","https://openalex.org/W2070946600","https://openalex.org/W2072954520","https://openalex.org/W2104825124","https://openalex.org/W2154611259","https://openalex.org/W2154949353","https://openalex.org/W2157199674","https://openalex.org/W2158623850","https://openalex.org/W2161771297","https://openalex.org/W2164334584","https://openalex.org/W2322121630","https://openalex.org/W3023757607"],"related_works":["https://openalex.org/W2281989109","https://openalex.org/W1917557897","https://openalex.org/W4254276327","https://openalex.org/W2416379532","https://openalex.org/W2063972595","https://openalex.org/W2413536800","https://openalex.org/W1987527052","https://openalex.org/W2611945296","https://openalex.org/W54985209","https://openalex.org/W1856983313"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}