{"id":"https://openalex.org/W2133474937","doi":null,"title":"Roles of EGFR and KRAS Mutations in the Treatment Of Patients With Non-Small-Cell Lung Cancer.","display_name":"Roles of EGFR and KRAS Mutations in the Treatment Of Patients With Non-Small-Cell Lung Cancer.","publication_year":2011,"publication_date":"2011-05-01","ids":{"openalex":"https://openalex.org/W2133474937","mag":"2133474937","pmid":"https://pubmed.ncbi.nlm.nih.gov/21785539","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3138369"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3138369","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3138369","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"P T","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3138369","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090256464","display_name":"Corey Jay Langer","orcid":"https://orcid.org/0000-0002-8483-6811","observed_orcids":["https://orcid.org/0000-0002-8483-6811"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Corey J Langer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5090256464"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7217,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.93245048,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"36","issue":"5","first_page":"263","last_page":"79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.996999979019165},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8169999718666077},{"id":"https://openalex.org/keywords/anti-egfr-therapy","display_name":"anti-EGFR therapy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.9589999914169312},{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.9919999837875366},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.7490000128746033},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.7379999756813049},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8925900459289551},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.7965287566184998},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6897531151771545},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.6472501158714294},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6445044279098511},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6352496147155762},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5673074722290039},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.5409117937088013},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.494247704744339},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.45997169613838196},{"id":"https://openalex.org/C2777506169","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"EGFR inhibitors","level":4,"score":0.4316665530204773},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4130431115627289},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3826543092727661},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3800535798072815},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24564018845558167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20515695214271545},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1441211998462677},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0724467933177948}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3138369","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3138369","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"P T","raw_type":"Text"},{"id":"pmid:21785539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21785539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"P & T : a peer-reviewed journal for formulary management","raw_type":"Journal Article"},{"id":"mag:2133474937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21785539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3138369","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3138369","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"P T","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W17456534","https://openalex.org/W1819015028","https://openalex.org/W1879998198","https://openalex.org/W1971737397","https://openalex.org/W1979332174","https://openalex.org/W2005216767","https://openalex.org/W2007528734","https://openalex.org/W2015436643","https://openalex.org/W2023060964","https://openalex.org/W2029155774","https://openalex.org/W2029446677","https://openalex.org/W2031494655","https://openalex.org/W2034751446","https://openalex.org/W2040636001","https://openalex.org/W2041620914","https://openalex.org/W2043696829","https://openalex.org/W2055402151","https://openalex.org/W2058088773","https://openalex.org/W2070522526","https://openalex.org/W2087924132","https://openalex.org/W2091639070","https://openalex.org/W2092063599","https://openalex.org/W2093139349","https://openalex.org/W2095201384","https://openalex.org/W2095618958","https://openalex.org/W2096786080","https://openalex.org/W2099725888","https://openalex.org/W2100785570","https://openalex.org/W2101329867","https://openalex.org/W2104573387","https://openalex.org/W2104748005","https://openalex.org/W2105026490","https://openalex.org/W2105309532","https://openalex.org/W2107304950","https://openalex.org/W2112621029","https://openalex.org/W2120490763","https://openalex.org/W2120718661","https://openalex.org/W2122553809","https://openalex.org/W2127640925","https://openalex.org/W2129360604","https://openalex.org/W2130652363","https://openalex.org/W2132157071","https://openalex.org/W2134667653","https://openalex.org/W2135800465","https://openalex.org/W2138297714","https://openalex.org/W2139110945","https://openalex.org/W2139236349","https://openalex.org/W2139720565","https://openalex.org/W2139939379","https://openalex.org/W2144026118","https://openalex.org/W2144425748","https://openalex.org/W2145835533","https://openalex.org/W2153345506","https://openalex.org/W2161821474","https://openalex.org/W2164837623","https://openalex.org/W2166084034","https://openalex.org/W2168106545","https://openalex.org/W2228124235","https://openalex.org/W2249621005","https://openalex.org/W2277462269","https://openalex.org/W2299969119","https://openalex.org/W2303844774","https://openalex.org/W2311552347","https://openalex.org/W2320138981","https://openalex.org/W2395015236","https://openalex.org/W2566863750","https://openalex.org/W2589909402","https://openalex.org/W2591284091"],"related_works":["https://openalex.org/W2134370756","https://openalex.org/W2232515353","https://openalex.org/W2399272182","https://openalex.org/W2331413585","https://openalex.org/W2142850084","https://openalex.org/W2055030390","https://openalex.org/W2989076687","https://openalex.org/W2601016663","https://openalex.org/W2404558429","https://openalex.org/W2029446677"],"abstract_inverted_index":{"After":[0],"decades":[1],"of":[2,7,28,58,128,138],"empirical":[3],"treatment,":[4],"molecular":[5],"subtypes":[6],"non-small-cell":[8],"lung":[9],"cancer":[10],"(NSCLC)":[11],"are":[12,37,100],"now":[13],"emerging":[14],"that":[15],"may":[16],"enable":[17],"us":[18],"to":[19,79,96,103,136,148],"target":[20],"treatment":[21],"for":[22,43],"patients":[23,81,98],"and":[24,74,117,153],"increase":[25],"the":[26,31,52,59,126],"likelihood":[27],"response.":[29],"Of":[30],"biomarkers":[32],"under":[33],"evaluation,":[34],"gene":[35],"mutations":[36],"gaining":[38],"recognition":[39],"as":[40,131],"predictive":[41],"markers":[42],"anti-epidermal-growth":[44],"factor":[45],"receptor":[46],"(EGFR)":[47],"therapy.":[48,84],"To":[49],"date,":[50],"unlike":[51],"situation":[53],"in":[54,72],"colorectal":[55],"cancer,":[56],"mutation":[57,90,140],"v-Ki-Ras-2":[60],"Kirsten":[61],"rat":[62],"sarcoma":[63],"viral":[64],"oncogene":[65],"homolog":[66],"(KRAS)":[67],"has":[68],"an":[69],"inconclusive":[70],"role":[71],"NSCLC":[73,87],"should":[75],"not":[76],"be":[77],"used":[78],"exclude":[80],"from":[82,105,112],"anti-EGFR":[83],"For":[85],"first-line":[86,115],"therapy,":[88],"EGFR":[89,139],"status":[91],"constitutes":[92],"a":[93],"prudent":[94],"test":[95],"identify":[97],"who":[99],"most":[101],"likely":[102],"benefit":[104,149],"EGFR-tyrosine":[106],"kinase":[107],"inhibitor":[108],"therapy":[109],"rather":[110],"than":[111],"chemotherapy.":[113],"In":[114],"maintenance":[116],"relapsed":[118],"(second-line":[119],"or":[120],"third-line)":[121],"settings,":[122],"clinical":[123],"data":[124],"support":[125],"use":[127],"erlotinib":[129],"(Tarceva),":[130],"currently":[132],"indicated,":[133],"without":[134],"regard":[135],"evaluation":[137],"status.":[141],"All":[142],"patient":[143],"subsets":[144],"have":[145],"been":[146],"shown":[147],"with":[150],"prolonged":[151],"progression-free":[152],"overall":[154],"survival.":[155]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}