{"id":"https://openalex.org/W2133399397","doi":"https://doi.org/10.1084/jem.178.6.1903","title":"Human rheumatoid factor cross-idiotypes. IV. Studies on WA XId-positive IgM without rheumatoid factor activity provide evidence that the WA XId is not unique to rheumatoid factors and is distinct from the 17.109 and G6 XIds.","display_name":"Human rheumatoid factor cross-idiotypes. IV. Studies on WA XId-positive IgM without rheumatoid factor activity provide evidence that the WA XId is not unique to rheumatoid factors and is distinct from the 17.109 and G6 XIds.","publication_year":1993,"publication_date":"1993-12-01","ids":{"openalex":"https://openalex.org/W2133399397","doi":"https://doi.org/10.1084/jem.178.6.1903","mag":"2133399397","pmid":"https://pubmed.ncbi.nlm.nih.gov/8245772","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2191299"},"language":"en","primary_location":{"id":"doi:10.1084/jem.178.6.1903","doi":"https://doi.org/10.1084/jem.178.6.1903","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.178.6.1903","pdf_url":"https://rupress.org/jem/article-pdf/178/6/1903/1104416/1903.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jem/article-pdf/178/6/1903/1104416/1903.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006896919","display_name":"Glenn B. Knight","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289019353","display_name":"Lahey Hospital and Medical Center","ror":"https://ror.org/03mbq3y29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289019353"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G B Knight","raw_affiliation_strings":["Department of Laboratory Medicine, Lahey Clinic, Burlington, Massachusetts 01805"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Lahey Clinic, Burlington, Massachusetts 01805","institution_ids":["https://openalex.org/I1289019353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113577228","display_name":"Vincent Agnello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289019353","display_name":"Lahey Hospital and Medical Center","ror":"https://ror.org/03mbq3y29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289019353"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V Agnello","raw_affiliation_strings":["Department of Laboratory Medicine, Lahey Clinic, Burlington, Massachusetts 01805"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Lahey Clinic, Burlington, Massachusetts 01805","institution_ids":["https://openalex.org/I1289019353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035212092","display_name":"Vincent Robert Bonagura","orcid":"https://orcid.org/0000-0002-0681-2099","observed_orcids":["https://orcid.org/0000-0002-0681-2099"]},"institutions":[{"id":"https://openalex.org/I1289019353","display_name":"Lahey Hospital and Medical Center","ror":"https://ror.org/03mbq3y29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289019353"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V Bonagura","raw_affiliation_strings":["Department of Laboratory Medicine, Lahey Clinic, Burlington, Massachusetts 01805"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Lahey Clinic, Burlington, Massachusetts 01805","institution_ids":["https://openalex.org/I1289019353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081307422","display_name":"Joye Lynn Barnes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289019353","display_name":"Lahey Hospital and Medical Center","ror":"https://ror.org/03mbq3y29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289019353"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J L Barnes","raw_affiliation_strings":["Department of Laboratory Medicine, Lahey Clinic, Burlington, Massachusetts 01805"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Lahey Clinic, Burlington, Massachusetts 01805","institution_ids":["https://openalex.org/I1289019353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105939567","display_name":"David J. Panka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289019353","display_name":"Lahey Hospital and Medical Center","ror":"https://ror.org/03mbq3y29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289019353"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D J Panka","raw_affiliation_strings":["Department of Laboratory Medicine, Lahey Clinic, Burlington, Massachusetts 01805"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Lahey Clinic, Burlington, Massachusetts 01805","institution_ids":["https://openalex.org/I1289019353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071393303","display_name":"Q X Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289019353","display_name":"Lahey Hospital and Medical Center","ror":"https://ror.org/03mbq3y29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289019353"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Q X Zhang","raw_affiliation_strings":["Department of Laboratory Medicine, Lahey Clinic, Burlington, Massachusetts 01805"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Lahey Clinic, Burlington, Massachusetts 01805","institution_ids":["https://openalex.org/I1289019353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1289019353"],"apc_list":null,"apc_paid":null,"fwci":2.0537,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.85956581,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"178","issue":"6","first_page":"1903","last_page":"1911"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.05959999933838844,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-factor","display_name":"rheumatoid factor","score":0.9610000252723694},{"id":"https://openalex.org/keywords/igm","display_name":"IgM","score":0.7480000257492065},{"id":"https://openalex.org/keywords/natural-antibodies","display_name":"natural antibodies","score":0.6010000109672546},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.781000018119812},{"id":"https://openalex.org/keywords/type-ii-mixed-cryoglobulinemia","display_name":"type II mixed cryoglobulinemia","score":0.9459999799728394},{"id":"https://openalex.org/keywords/antigen-specificity","display_name":"antigen specificity","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C90059517","wikidata":"https://www.wikidata.org/wiki/Q423572","display_name":"Bruton's tyrosine kinase","level":4,"score":0.8174364566802979},{"id":"https://openalex.org/C74505204","wikidata":"https://www.wikidata.org/wiki/Q1047644","display_name":"Idiotype","level":4,"score":0.7319849729537964},{"id":"https://openalex.org/C2776232647","wikidata":"https://www.wikidata.org/wiki/Q702883","display_name":"Rheumatoid factor","level":3,"score":0.6562278866767883},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6104047298431396},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5605131983757019},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.526242196559906},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.4979090690612793},{"id":"https://openalex.org/C2910082366","wikidata":"https://www.wikidata.org/wiki/Q1047644","display_name":"Immunoglobulin Idiotypes","level":5,"score":0.4287341237068176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3623621463775635},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35857588052749634},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23315274715423584},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.19407513737678528},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10403817892074585},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005803","descriptor_name":"Genes, Immunoglobulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007130","descriptor_name":"Immunoglobulin Idiotypes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012217","descriptor_name":"Rheumatoid Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1084/jem.178.6.1903","doi":"https://doi.org/10.1084/jem.178.6.1903","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.178.6.1903","pdf_url":"https://rupress.org/jem/article-pdf/178/6/1903/1104416/1903.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2191299","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2191299","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:8245772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8245772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1084/jem.178.6.1903","doi":"https://doi.org/10.1084/jem.178.6.1903","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.178.6.1903","pdf_url":"https://rupress.org/jem/article-pdf/178/6/1903/1104416/1903.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1814784085","display_name":"HUMAN IMMUNE COMPLEX DISEASES","funder_award_id":"5r01ar035487-08","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3865804128","display_name":null,"funder_award_id":"AR35487","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2133399397.pdf","grobid_xml":"https://content.openalex.org/works/W2133399397.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1484092314","https://openalex.org/W1509307817","https://openalex.org/W1529904888","https://openalex.org/W1556273434","https://openalex.org/W1564579597","https://openalex.org/W1695644463","https://openalex.org/W1900560511","https://openalex.org/W1972884489","https://openalex.org/W1976411430","https://openalex.org/W1984214755","https://openalex.org/W1989395145","https://openalex.org/W1994590517","https://openalex.org/W2022007343","https://openalex.org/W2024166002","https://openalex.org/W2030459950","https://openalex.org/W2031824271","https://openalex.org/W2034505316","https://openalex.org/W2055340854","https://openalex.org/W2060435981","https://openalex.org/W2080824017","https://openalex.org/W2082695351","https://openalex.org/W2093611967","https://openalex.org/W2099642213","https://openalex.org/W2135387211","https://openalex.org/W2139767135","https://openalex.org/W2148603125","https://openalex.org/W2153019342","https://openalex.org/W2324507396","https://openalex.org/W2409419033","https://openalex.org/W2469761206","https://openalex.org/W2472587801","https://openalex.org/W4237042838","https://openalex.org/W4248541645"],"related_works":["https://openalex.org/W7100598579","https://openalex.org/W1989395145","https://openalex.org/W2057295805","https://openalex.org/W2153019342","https://openalex.org/W2154357670","https://openalex.org/W52446276","https://openalex.org/W1965727412","https://openalex.org/W2469761206","https://openalex.org/W2151441602","https://openalex.org/W2221931871"],"abstract_inverted_index":{"The":[0,61,189],"WA":[1,42,76,84,105,119,175,193,204,231,261],"cross-idiotype":[2],"(XId)":[3],"is":[4,15,53,206,227,251],"the":[5,20,27,41,56,70,83,94,118,172,184,192,196,203,260],"major":[6],"XId":[7,120,194,205],"among":[8],"human":[9],"monoclonal":[10],"rheumatoid":[11,154],"factors":[12],"(mRF)":[13],"and":[14,26,52,58,121,151,156,165,186,217,247],"almost":[16],"always":[17],"associated":[18,209],"with":[19,48,103,153,210,220],"light":[21],"(L)":[22],"chain":[23,30,64],"XId,":[24,31,43],"17.109,":[25],"heavy":[28],"(H)":[29],"G6.":[32],"A":[33],"cell":[34,142],"line,":[35],"35G6,":[36],"was":[37,169],"cloned":[38],"that":[39,113,123,171,202,229,248],"bears":[40],"but":[44],"shows":[45],"no":[46],"reactivity":[47,200,250],"immunoglobulin":[49],"G":[50],"(IgG)":[51],"negative":[54,182],"for":[55,183],"17.109":[57,185],"G6":[59,187],"XIds.":[60,188],"35G6":[62,95,134],"L":[63,78],"appears":[65],"to":[66,82,117,126,133,243],"be":[67,115,224],"derived":[68],"from":[69,148],"same":[71],"VKIII-JKI":[72],"genes":[73,91],"as":[74,240],"most":[75],"mRFs":[77,85],"chains.":[79],"In":[80],"contrast":[81],"H":[86],"chains":[87],"in":[88,139,166,178,195],"which":[89],"VH1":[90],"are":[92],"used,":[93],"IgM":[96],"expresses":[97],"a":[98,237,244,252],"VH3":[99],"gene.":[100],"Sequence":[101],"comparisons":[102],"other":[104,214],"XId-positive":[106,176,232,262],"mRF":[107],"suggested":[108],"several":[109],"common":[110],"structural":[111],"features":[112],"may":[114,124,223,235],"related":[116],"differences":[122],"relate":[125],"lack":[127],"of":[128,144,174,191,198,254,259],"IgG":[129,199,249],"reactivity.":[130],"Cells":[131],"similar":[132],"have":[135],"previously":[136],"been":[137],"described":[138],"pokeweed":[140],"mitogen-stimulated":[141],"lines":[143],"peripheral":[145],"blood":[146],"lymphocytes":[147],"normal":[149],"individuals":[150],"patients":[152],"arthritis":[155],"type":[157],"II":[158],"mixed":[159],"cryoglobulinemia.":[160],"These":[161],"observations":[162],"were":[163,181],"confirmed,":[164],"addition,":[167],"it":[168],"shown":[170],"majority":[173],"cells":[177],"these":[179,230],"cultures":[180],"presence":[190],"absence":[197],"suggests":[201],"more":[207],"directly":[208],"an":[211],"antigen":[212],"specificity":[213],"than":[215],"IgG,":[216],"its":[218],"association":[219],"RF":[221],"activity":[222],"incidental.":[225],"It":[226],"postulated":[228],"RF-negative":[233,263],"antibodies":[234,242],"serve":[236],"physiologic":[238],"role":[239],"natural":[241],"pervasive":[245],"pathogen,":[246],"consequence":[253],"somatic":[255],"diversification":[256],"accompanying":[257],"proliferation":[258],"cell.":[264]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
