{"id":"https://openalex.org/W2133388451","doi":null,"title":"Prognostic significance of urokinase-type plasminogen activator expression in squamous cell carcinomas of the esophagus.","display_name":"Prognostic significance of urokinase-type plasminogen activator expression in squamous cell carcinomas of the esophagus.","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W2133388451","mag":"2133388451","pmid":"https://pubmed.ncbi.nlm.nih.gov/9815623"},"language":"en","primary_location":{"id":"pmid:9815623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9815623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030814855","display_name":"Michael Torzewski","orcid":"https://orcid.org/0000-0002-2756-2201","observed_orcids":["https://orcid.org/0000-0002-2756-2201"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Torzewski","raw_affiliation_strings":["Departments of Pathology and Surgery, Heinrich Heine University, 40225 D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Surgery, Heinrich Heine University, 40225 D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026787816","display_name":"Mario Sarbia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Sarbia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113601354","display_name":"Patrick Robert Verreet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Verreet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078241279","display_name":"Philipp Dutkowski","orcid":"https://orcid.org/0000-0002-3016-604X","observed_orcids":["https://orcid.org/0000-0002-3016-604X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Dutkowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111716857","display_name":"Hansjoerg Heep","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Heep","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083085752","display_name":"Reinhart Willers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Willers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111866616","display_name":"Helmut Erich Gabbert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H E Gabbert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2494,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.85756312,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"3","issue":"12 Pt 1","first_page":"2263","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/esophageal-squamous-cell-carcinoma","display_name":"esophageal squamous cell carcinoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8190000057220459},{"id":"https://openalex.org/keywords/postoperative-survival","display_name":"postoperative survival","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tumor-cell-expression","display_name":"tumor cell expression","score":0.6010000109672546},{"id":"https://openalex.org/keywords/clinicopathological-features","display_name":"clinicopathological features","score":0.6079999804496765},{"id":"https://openalex.org/keywords/lymphatic-vessel-invasion","display_name":"lymphatic vessel invasion","score":0.753000020980835},{"id":"https://openalex.org/keywords/vascular-invasion","display_name":"vascular invasion","score":0.9440000057220459}],"concepts":[{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.7636064887046814},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6645462512969971},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.607460081577301},{"id":"https://openalex.org/C2776892390","wikidata":"https://www.wikidata.org/wiki/Q7119591","display_name":"Urokinase","level":2,"score":0.579962968826294},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.5046819448471069},{"id":"https://openalex.org/C2777819096","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophagus","level":2,"score":0.467602401971817},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.43053779006004333},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4219725728034973},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42132627964019775},{"id":"https://openalex.org/C2778740770","wikidata":"https://www.wikidata.org/wiki/Q6708283","display_name":"Lymphovascular invasion","level":4,"score":0.42018017172813416},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3533440828323364},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.23760029673576355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20725655555725098}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9815623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9815623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2133388451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9815623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W23122061","https://openalex.org/W45293395","https://openalex.org/W71834433","https://openalex.org/W363641452","https://openalex.org/W1487780734","https://openalex.org/W1528993577","https://openalex.org/W1557557336","https://openalex.org/W1571398079","https://openalex.org/W1589444833","https://openalex.org/W1607286821","https://openalex.org/W1607740737","https://openalex.org/W1724539534","https://openalex.org/W1732043081","https://openalex.org/W1853643611","https://openalex.org/W1965678716","https://openalex.org/W1968081073","https://openalex.org/W1968887212","https://openalex.org/W1971906639","https://openalex.org/W2003641450","https://openalex.org/W2011936885","https://openalex.org/W2025763214","https://openalex.org/W2026151657","https://openalex.org/W2027402611","https://openalex.org/W2040675957","https://openalex.org/W2041504187","https://openalex.org/W2045704580","https://openalex.org/W2047619166","https://openalex.org/W2047861295","https://openalex.org/W2049753109","https://openalex.org/W2049877768","https://openalex.org/W2052593722","https://openalex.org/W2060138882","https://openalex.org/W2068627578","https://openalex.org/W2096428903","https://openalex.org/W2102256014","https://openalex.org/W2116980099","https://openalex.org/W2119837316","https://openalex.org/W2123574059","https://openalex.org/W2134475414","https://openalex.org/W2150897185","https://openalex.org/W2402817188","https://openalex.org/W2407533327","https://openalex.org/W2417303506","https://openalex.org/W2418982819"],"related_works":["https://openalex.org/W2137675651","https://openalex.org/W2113574906","https://openalex.org/W2362674349","https://openalex.org/W2902146977","https://openalex.org/W2368361789","https://openalex.org/W2428399434","https://openalex.org/W2918950867","https://openalex.org/W2076870078","https://openalex.org/W1995841674","https://openalex.org/W2029074223"],"abstract_inverted_index":{"In":[0,192],"the":[1,16,39,49,69,130,160,184,194,231],"present":[2],"study,":[3],"urokinase-type":[4],"plasminogen":[5],"activator":[6],"(uPA)":[7],"expression":[8,135,235],"in":[9,80,92,104,117,183,203],"150":[10,40],"potentially":[11],"curatively":[12],"resected":[13],"SCCs":[14],"of":[15,23,38,46,82,94,106,119,133,186,196,233],"esophagus":[17],"was":[18,236],"analyzed":[19],"immunohistochemically":[20],"by":[21,225],"means":[22],"a":[24,56,64,77,89,101,114,211],"murine":[25],"monoclonal":[26],"antibody":[27],"(American":[28],"Diagnostica,":[29],"Greenwich,":[30],"CT)":[31],"and":[32,60,110,136,156,169],"correlated":[33],"with":[34,206,216],"survival.":[35],"Altogether,":[36],"122":[37,50],"tumors":[41,75,171,209],"(81.3%)":[42],"expressed":[43],"different":[44,131,180],"levels":[45],"uPA.":[47],"Among":[48,68],"uPA-positive":[51,70,168,187,208,218],"tumors,":[52,71],"104":[53],"(85.2%)":[54],"showed":[55,63,76,88,100,113],"weak":[57],"staining":[58,66,198],"intensity,":[59],"18":[61],"(14.8%)":[62],"strong":[65],"intensity.":[67],"29":[72],"(23.":[73],"8%)":[74],"uPA":[78,90,102,115,134,197,234],"immunoreactivity":[79,91,103,116],"6-25%":[81],"all":[83,95,107,120],"tumor":[84,96,108,121,146,188],"cells,":[85,97,109],"30":[86],"(24.6%)":[87],"26-50%":[93],"41":[98],"(33.6%)":[99],"51-75%":[105],"22":[111],"(18.0%)":[112],"76-100%":[118],"cells.":[122],"No":[123],"significant":[124,165,200],"correlation":[125],"could":[126,172],"be":[127,173],"shown":[128,224],"between":[129,167],"patterns":[132],"various":[137],"clinicopathological":[138],"parameters,":[139],"such":[140],"as":[141,223],"pT":[142],"category,":[143,145],"pN":[144],"size,":[147],"histological":[148],"grade,":[149],"blood":[150],"vessel":[151,154],"invasion,":[152,155],"lymphatic":[153],"inflammatory":[157],"response.":[158],"Concerning":[159],"overall":[161],"postoperative":[162],"survival,":[163],"no":[164],"differences":[166],"uPA-negative":[170,220],"verified.":[174],"This":[175],"also":[176],"held":[177],"true":[178],"when":[179],"cut":[181],"points":[182],"percentage":[185],"cells":[189],"were":[190],"used.":[191],"contrast,":[193],"intensity":[195,232],"provided":[199],"prognostic":[201,239],"information":[202],"that":[204],"patients":[205,215],"strongly":[207],"had":[210],"poorer":[212],"outcome":[213],"than":[214],"weakly":[217],"or":[219],"tumors.":[221],"Moreover,":[222],"stepwise":[226],"multivariate":[227],"Cox":[228],"regression":[229],"analysis,":[230],"an":[237],"independent":[238],"factor.":[240]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
