{"id":"https://openalex.org/W2133388292","doi":"https://doi.org/10.1152/ajprenal.00126.2013","title":"Class I histone deacetylase activity is required for proliferation of renal epithelial cells","display_name":"Class I histone deacetylase activity is required for proliferation of renal epithelial cells","publication_year":2013,"publication_date":"2013-05-22","ids":{"openalex":"https://openalex.org/W2133388292","doi":"https://doi.org/10.1152/ajprenal.00126.2013","mag":"2133388292","pmid":"https://pubmed.ncbi.nlm.nih.gov/23698124","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3742866"},"language":"en","primary_location":{"id":"doi:10.1152/ajprenal.00126.2013","doi":"https://doi.org/10.1152/ajprenal.00126.2013","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.00126.2013","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3742866","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103044951","display_name":"Jinhua Tang","orcid":"https://orcid.org/0009-0000-7563-6175","observed_orcids":["https://orcid.org/0009-0000-7563-6175"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]},{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jinhua Tang","raw_affiliation_strings":["Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; and","Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; and","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]},{"raw_affiliation_string":"Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210128175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103105639","display_name":"Yanli Yan","orcid":"https://orcid.org/0000-0001-7252-280X","observed_orcids":["https://orcid.org/0000-0001-7252-280X","https://orcid.org/0000-0002-0232-8160"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]},{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yanli Yan","raw_affiliation_strings":["Department of Emergency Medicine and Critical Care, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;","Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine and Critical Care, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210128175"]},{"raw_affiliation_string":"Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; and","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085462251","display_name":"Ting Cun Zhao","orcid":"https://orcid.org/0000-0003-1622-2663","observed_orcids":["https://orcid.org/0000-0003-1622-2663","https://orcid.org/0000-0001-6376-0275"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ting C. Zhao","raw_affiliation_strings":["Department of Surgery, Roger William Medical Center, Boston University Medical School, Providence, Rhode Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Roger William Medical Center, Boston University Medical School, Providence, Rhode Island","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078149541","display_name":"George P Bayliss","orcid":"https://orcid.org/0000-0002-7508-9762","observed_orcids":["https://orcid.org/0000-0002-7508-9762"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Bayliss","raw_affiliation_strings":["Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; and","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100864137","display_name":"Haidong Yan","orcid":"https://orcid.org/0009-0003-3833-9034","observed_orcids":["https://orcid.org/0009-0003-3833-9034"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haidong Yan","raw_affiliation_strings":["Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210128175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048518436","display_name":"Shougang Zhuang","orcid":"https://orcid.org/0000-0001-9719-4187","observed_orcids":["https://orcid.org/0000-0001-9719-4187","https://orcid.org/0009-0003-7743-3971","https://orcid.org/0000-0001-5806-8209","https://orcid.org/0009-0001-1680-9272"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]},{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Shougang Zhuang","raw_affiliation_strings":["Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; and","Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island; and","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]},{"raw_affiliation_string":"Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210128175"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5048518436"],"corresponding_institution_ids":["https://openalex.org/I116953780","https://openalex.org/I27804330","https://openalex.org/I2800446032","https://openalex.org/I4210128175"],"apc_list":null,"apc_paid":null,"fwci":0.597,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.68457386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"305","issue":"3","first_page":"F244","last_page":"F254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.3122999966144562,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/class-i-histone-deacetylases","display_name":"class I histone deacetylases","score":0.9990000128746033},{"id":"https://openalex.org/keywords/proximal-tubular-epithelial-cells","display_name":"proximal tubular epithelial cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/kidney-regeneration","display_name":"kidney regeneration","score":0.9089999794960022},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hdac1","display_name":"HDAC1","score":0.800000011920929},{"id":"https://openalex.org/keywords/hdac3","display_name":"HDAC3","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hdac8","display_name":"HDAC8","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hdac2","display_name":"HDAC2","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.875},{"id":"https://openalex.org/keywords/entinostat","display_name":"entinostat","score":0.7870000004768372},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.6578301787376404},{"id":"https://openalex.org/C71723506","wikidata":"https://www.wikidata.org/wiki/Q18026859","display_name":"Histone deacetylase 2","level":5,"score":0.6147486567497253},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6029174327850342},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5818473100662231},{"id":"https://openalex.org/C85240754","wikidata":"https://www.wikidata.org/wiki/Q14914420","display_name":"HDAC1","level":5,"score":0.5580727458000183},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5530019998550415},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5488928556442261},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.531737744808197},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.5303251147270203},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.5268104076385498},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5060409903526306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46193137764930725},{"id":"https://openalex.org/C13721689","wikidata":"https://www.wikidata.org/wiki/Q18033475","display_name":"HDAC3","level":5,"score":0.4536738097667694},{"id":"https://openalex.org/C27253355","wikidata":"https://www.wikidata.org/wiki/Q18034954","display_name":"Histone deacetylase 5","level":5,"score":0.42019107937812805},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3667299151420593},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.3426697254180908},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.23553484678268433},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.16041341423988342},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.08298790454864502},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07426491379737854},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056284","descriptor_name":"Histone Deacetylase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056284","descriptor_name":"Histone Deacetylase 1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajprenal.00126.2013","doi":"https://doi.org/10.1152/ajprenal.00126.2013","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.00126.2013","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3742866","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3742866","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Renal Physiol","raw_type":"Text"},{"id":"pmid:23698124","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23698124","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Renal physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3742866","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3742866","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Renal Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G488548388","display_name":null,"funder_award_id":"DK-085065","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6046128968","display_name":"Histone deacetylases as novel therapeutic targets for kidney fibrosis","funder_award_id":"R01DK085065","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W137932298","https://openalex.org/W1558256693","https://openalex.org/W1650742008","https://openalex.org/W1889152575","https://openalex.org/W1910848366","https://openalex.org/W1964321121","https://openalex.org/W1967300023","https://openalex.org/W1974024530","https://openalex.org/W1976987666","https://openalex.org/W1986829962","https://openalex.org/W1989227773","https://openalex.org/W1989945871","https://openalex.org/W1993577311","https://openalex.org/W1993624071","https://openalex.org/W1997671473","https://openalex.org/W2000424910","https://openalex.org/W2006751397","https://openalex.org/W2014763555","https://openalex.org/W2018091219","https://openalex.org/W2018272903","https://openalex.org/W2018303828","https://openalex.org/W2038320708","https://openalex.org/W2050931169","https://openalex.org/W2052167002","https://openalex.org/W2052467994","https://openalex.org/W2061446762","https://openalex.org/W2067179898","https://openalex.org/W2067376187","https://openalex.org/W2070221969","https://openalex.org/W2077166988","https://openalex.org/W2082354365","https://openalex.org/W2083275885","https://openalex.org/W2095751051","https://openalex.org/W2097084183","https://openalex.org/W2097097666","https://openalex.org/W2099013228","https://openalex.org/W2104008103","https://openalex.org/W2105526739","https://openalex.org/W2106252772","https://openalex.org/W2107398189","https://openalex.org/W2110959000","https://openalex.org/W2114338375","https://openalex.org/W2115744231","https://openalex.org/W2128542354","https://openalex.org/W2130638154","https://openalex.org/W2132090254","https://openalex.org/W2133802070","https://openalex.org/W2135892482","https://openalex.org/W2155508219","https://openalex.org/W2155631307","https://openalex.org/W2156200233","https://openalex.org/W2170411990","https://openalex.org/W2441829793"],"related_works":["https://openalex.org/W2333420997","https://openalex.org/W2061446762","https://openalex.org/W2918139154","https://openalex.org/W2077166988","https://openalex.org/W2951833461","https://openalex.org/W2470451315","https://openalex.org/W2160005456","https://openalex.org/W2018303828","https://openalex.org/W4396993595","https://openalex.org/W2170491804"],"abstract_inverted_index":{"The":[0,50],"process":[1],"of":[2,17,55,117,140,151,164,171,200,211,218,224],"renal":[3,13,18,219],"regeneration":[4],"after":[5],"acute":[6],"kidney":[7,44],"injury":[8],"is":[9,23],"thought":[10],"to":[11,73],"recapitulate":[12],"development,":[14],"and":[15,48,52,86,114,120,146,149,160,179,181,184,198,202],"proliferation":[16,197,217],"proximal":[19],"tubular":[20],"cells":[21,221],"(RPTCs)":[22],"a":[24,101,208],"critical":[25,209],"step":[26],"in":[27,60,91,135,215],"the":[28,225],"regenerative":[29],"response.":[30],"Recent":[31],"studies":[32],"indicate":[33],"that":[34],"class":[35,56,79,96,212],"I":[36,57,80,97,213],"histone":[37,108],"deacetylases":[38],"(HDACs)":[39],"are":[40,88],"required":[41,156],"for":[42,157],"embryonic":[43],"gene":[45],"expression,":[46],"growth,":[47],"differentiation.":[49],"role":[51,210],"underlying":[53],"mechanisms":[54],"HDAC":[58,81,98],"activation":[59,223],"RPTC":[61,112,158,196],"proliferation,":[62,113,159],"however,":[63],"remain":[64],"unclear.":[65],"In":[66],"this":[67,75,92],"study,":[68],"we":[69],"used":[70],"cultured":[71],"RPTCs":[72],"examine":[74],"issue":[76],"since":[77],"four":[78],"isoforms":[82],"(1,":[83],"2,":[84],"3,":[85,127,173],"8)":[87],"abundantly":[89],"expressed":[90],"cell":[93,122],"type.":[94],"Blocking":[95],"activity":[99],"with":[100,130,167],"highly":[102],"selective":[103],"inhibitor,":[104],"MS-275,":[105],"induced":[106],"global":[107],"H3":[109],"hyperacetylation,":[110],"reduced":[111,187],"diminished":[115],"expression":[116,178],"cyclin":[118],"D1":[119],"proliferating":[121],"nuclear":[123],"antigen.":[124],"Silencing":[125],"HDAC1,":[126,172],"or":[128,169,174],"8":[129,175],"small":[131],"interfering":[132],"RNA":[133],"resulted":[134],"similar":[136],"biological":[137],"effects.":[138],"Activation":[139],"epidermal":[141],"growth":[142],"factor":[143],"receptor":[144],"(EGFR)":[145],"signal":[147],"transducers":[148],"activators":[150],"transcription":[152],"3":[153,185],"(STAT3)":[154],"was":[155],"STAT3":[161,188],"functioned":[162],"downstream":[163],"EGFR.":[165],"Treatment":[166],"MS-275":[168],"knockdown":[170],"suppressed":[176],"EGFR":[177,201],"phosphorylation,":[180],"silencing":[182],"HDAC1":[183],"also":[186],"phosphorylation.":[189],"However,":[190],"HDAC2":[191],"downregulation":[192],"did":[193],"not":[194],"affect":[195],"phosphorylation":[199],"STAT3.":[203],"Collectively,":[204],"these":[205],"data":[206],"reveal":[207],"HDACs":[214],"mediating":[216],"epithelial":[220],"through":[222],"EGFR/STAT3":[226],"signaling":[227],"pathway.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}