{"id":"https://openalex.org/W2133309096","doi":null,"title":"[Tinidazole: a classical anaerobical drug with multiple potential uses nowadays].","display_name":"[Tinidazole: a classical anaerobical drug with multiple potential uses nowadays].","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W2133309096","mag":"2133309096","pmid":"https://pubmed.ncbi.nlm.nih.gov/19544102"},"language":"es","primary_location":{"id":"pmid:19544102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19544102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104036016","display_name":"Juan Jos\u00e9 Granizo Mart\u00ednez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Granizo","raw_affiliation_strings":["Grana Datos, SL, 28223 Pozuelo de Alarc\u00f3n, Madrid. jjgranizo@granadatos.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grana Datos, SL, 28223 Pozuelo de Alarc\u00f3n, Madrid. jjgranizo@granadatos.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038390626","display_name":"P\u00eda Rodicio M","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M P\u00eda Rodicio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010873562","display_name":"Francisco Javier Manso Matienzo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F J Manso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077448608","display_name":"Mar\u00eda-Jos\u00e9 Gim\u00e9nez","orcid":"https://orcid.org/0000-0003-0830-4095","observed_orcids":["https://orcid.org/0000-0003-0830-4095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ma Jos\u00e9 Gim\u00e9nez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9331,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.73707499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"22","issue":"2","first_page":"106","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.5151000022888184,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.5151000022888184,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.13269999623298645,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.07339999824762344,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tinidazole","display_name":"tinidazole","score":1.0},{"id":"https://openalex.org/keywords/5-nitroimidazoles","display_name":"5-nitroimidazoles","score":0.9259999990463257},{"id":"https://openalex.org/keywords/anaerobic-infections","display_name":"anaerobic infections","score":0.8980000019073486},{"id":"https://openalex.org/keywords/anaerobic-protozoa","display_name":"anaerobic protozoa","score":0.8629999756813049},{"id":"https://openalex.org/keywords/trichomonas-vaginalis","display_name":"Trichomonas vaginalis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/entamoeba-histolytica","display_name":"Entamoeba histolytica","score":0.9039999842643738},{"id":"https://openalex.org/keywords/giardia-duodenalis","display_name":"Giardia lamblia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/bacterial-vaginosis","display_name":"bacterial vaginosis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/malaria","display_name":"malaria","score":0.5669999718666077},{"id":"https://openalex.org/keywords/dental-infection","display_name":"odontogenic infection","score":0.9459999799728394},{"id":"https://openalex.org/keywords/perioperative-antibiotic-prophylaxis","display_name":"perioperative antibiotic prophylaxis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/helicobacter-pylori-eradication","display_name":"Helicobacter pylori eradication","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8080000281333923},{"id":"https://openalex.org/keywords/metronidazole-comparison","display_name":"metronidazole comparison","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7879109382629395},{"id":"https://openalex.org/C2780626423","wikidata":"https://www.wikidata.org/wiki/Q155630","display_name":"Giardia lamblia","level":2,"score":0.6098051071166992},{"id":"https://openalex.org/C2780626017","wikidata":"https://www.wikidata.org/wiki/Q1321320","display_name":"Tinidazole","level":4,"score":0.5532431602478027},{"id":"https://openalex.org/C2776867272","wikidata":"https://www.wikidata.org/wiki/Q131027","display_name":"Entamoeba histolytica","level":2,"score":0.46902528405189514},{"id":"https://openalex.org/C2777396551","wikidata":"https://www.wikidata.org/wiki/Q169569","display_name":"Metronidazole","level":3,"score":0.4659823775291443},{"id":"https://openalex.org/C2779952448","wikidata":"https://www.wikidata.org/wiki/Q804521","display_name":"Bacterial vaginosis","level":2,"score":0.4143761992454529},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3355868458747864},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3086422383785248},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.16364672780036926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13862088322639465},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.112092524766922},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000693","descriptor_name":"Anaerobiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001421","descriptor_name":"Bacteria, Anaerobic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004749","descriptor_name":"Entamoebiasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005873","descriptor_name":"Giardiasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D014011","descriptor_name":"Tinidazole","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014011","descriptor_name":"Tinidazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014011","descriptor_name":"Tinidazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014011","descriptor_name":"Tinidazole","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014245","descriptor_name":"Trichomonas Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016585","descriptor_name":"Vaginosis, Bacterial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019072","descriptor_name":"Antibiotic Prophylaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056890","descriptor_name":"Eukaryota","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D056890","descriptor_name":"Eukaryota","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:19544102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19544102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","raw_type":"English Abstract"},{"id":"pmh:oai:abacus.universidadeuropea.es:11268/5565","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11268/5565","pdf_url":null,"source":{"id":"https://openalex.org/S4306400164","display_name":"ABACUS. Repositorio de Producci\u00f3n Cient\u00edfica (Universidad Europea)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210101845","host_organization_name":"Universidad Europea","host_organization_lineage":["https://openalex.org/I4210101845"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"mag:2133309096","doi":null,"is_oa":false,"landing_page_url":"http://seq.es/seq/0214-3429/22/2/revisionrodicio.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S976986303","display_name":"Revista espa\u00f1ola de quimioterapia. Suplemento","issn_l":"1130-331X","issn":["1130-331X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista espa\u00f1ola de quimioterapia. Suplemento","raw_type":null},{"id":"mag:2411865506","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19544102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W23818722","https://openalex.org/W40690974","https://openalex.org/W65043556","https://openalex.org/W110423698","https://openalex.org/W203197993","https://openalex.org/W282694839","https://openalex.org/W288052097","https://openalex.org/W334216023","https://openalex.org/W1276936844","https://openalex.org/W1900222236","https://openalex.org/W1978117246","https://openalex.org/W1981475310","https://openalex.org/W1982867878","https://openalex.org/W1991050218","https://openalex.org/W1994555035","https://openalex.org/W2000500375","https://openalex.org/W2007109238","https://openalex.org/W2012171112","https://openalex.org/W2015567379","https://openalex.org/W2016120110","https://openalex.org/W2020271088","https://openalex.org/W2021303229","https://openalex.org/W2036259942","https://openalex.org/W2036821005","https://openalex.org/W2043686966","https://openalex.org/W2052338131","https://openalex.org/W2052888691","https://openalex.org/W2055489819","https://openalex.org/W2058827357","https://openalex.org/W2060290730","https://openalex.org/W2061072662","https://openalex.org/W2061938579","https://openalex.org/W2067989704","https://openalex.org/W2069252754","https://openalex.org/W2073203046","https://openalex.org/W2082984819","https://openalex.org/W2086272030","https://openalex.org/W2098316223","https://openalex.org/W2100194553","https://openalex.org/W2102530596","https://openalex.org/W2106705567","https://openalex.org/W2109981777","https://openalex.org/W2126661068","https://openalex.org/W2137664399","https://openalex.org/W2140018140","https://openalex.org/W2145845923","https://openalex.org/W2158287049","https://openalex.org/W2160557825","https://openalex.org/W2161624184","https://openalex.org/W2163507075","https://openalex.org/W2166059779","https://openalex.org/W2168531255","https://openalex.org/W2183622001","https://openalex.org/W2274818464","https://openalex.org/W2313535803","https://openalex.org/W2327550909","https://openalex.org/W2499576167"],"related_works":["https://openalex.org/W2052888691","https://openalex.org/W23818722","https://openalex.org/W190958387","https://openalex.org/W1986892214","https://openalex.org/W2395734781","https://openalex.org/W1981475310","https://openalex.org/W2433078667","https://openalex.org/W2326016309","https://openalex.org/W2416383900","https://openalex.org/W2756782046"],"abstract_inverted_index":{"Tinidazole":[0,16,49,90],"is":[1,17,50],"a":[2,8,46],"5-nitroimidazole":[3],"active":[4],"in":[5,38,55],"vitro":[6,39],"against":[7,21],"wide":[9],"variety":[10],"of":[11,58,104],"anaerobic":[12,22,73],"bacteria":[13],"and":[14,35,65,67,84,86,97,112],"protozoa.":[15],"an":[18],"effective":[19,52],"treatment":[20,57,103],"microorganisms":[23],"based":[24],"on":[25],"its":[26,36],"pharmacokinetic":[27],"characteristics":[28],"(C(max)":[29],"51":[30],"microg/ml,":[31],"t(1/2)":[32],"12.5":[33],"h)":[34],"excellent":[37],"activity.":[40],"Its":[41],"long":[42],"half-life":[43],"allows":[44],"once":[45],"day":[47],"regimens.":[48],"as":[51,53],"metronidazole":[54],"the":[56,95,102],"infections":[59,75,105],"caused":[60,106],"by":[61,94,107],"T.":[62],"vaginalis,":[63,109],"giardiasis":[64],"amebiasis":[66],"bacterial":[68,74],"vaginosis,":[69],"malaria,":[70],"odontogenic":[71],"infections,":[72],"(pelvic":[76],"inflammatory":[77],"disease,":[78],"diabetic":[79],"foot),":[80],"surgical":[81],"prophylaxis":[82],"(abdominal":[83],"hysterectomy)":[85],"Helicobacter":[87],"pylori":[88],"eradication.":[89],"was":[91],"recently":[92],"approved":[93],"Food":[96],"Drug":[98],"Administration":[99],"(FDA)":[100],"for":[101],"Trichomonas":[108],"Entamoeba":[110],"histolytica":[111],"Giardia":[113],"lamblia.":[114]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}