{"id":"https://openalex.org/W2133258673","doi":"https://doi.org/10.1111/j.1365-2141.1980.tb07187.x","title":"Coagulation Factors in the Human Fetus of about 20 Weeks of Gestational Age","display_name":"Coagulation Factors in the Human Fetus of about 20 Weeks of Gestational Age","publication_year":1980,"publication_date":"1980-08-01","ids":{"openalex":"https://openalex.org/W2133258673","doi":"https://doi.org/10.1111/j.1365-2141.1980.tb07187.x","mag":"2133258673","pmid":"https://pubmed.ncbi.nlm.nih.gov/7426442"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2141.1980.tb07187.x","doi":"https://doi.org/10.1111/j.1365-2141.1980.tb07187.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.1980.tb07187.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000205932","display_name":"J. P. Terwiel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Jack Ph. Terwiel","raw_affiliation_strings":["Haemostasis and Thrombosis Research Unit, Department of Medicine, Leiden University Hospital, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haemostasis and Thrombosis Research Unit, Department of Medicine, Leiden University Hospital, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112806274","display_name":"Jan J. Veltkamp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan J. Veltkamp","raw_affiliation_strings":["Haemostasis and Thrombosis Research Unit, Department of Medicine, Leiden University Hospital, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haemostasis and Thrombosis Research Unit, Department of Medicine, Leiden University Hospital, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109330820","display_name":"Rogier M. Bertina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rogier M. Bertina","raw_affiliation_strings":["Haemostasis and Thrombosis Research Unit, Department of Medicine, Leiden University Hospital, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haemostasis and Thrombosis Research Unit, Department of Medicine, Leiden University Hospital, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113760146","display_name":"Hein P. Muller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hein P. Muller","raw_affiliation_strings":["Haemostasis and Thrombosis Research Unit, Department of Medicine, Leiden University Hospital, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haemostasis and Thrombosis Research Unit, Department of Medicine, Leiden University Hospital, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000205932"],"corresponding_institution_ids":["https://openalex.org/I2800006345"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":0.3422,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.6162951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"45","issue":"4","first_page":"641","last_page":"650"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/second-trimester-fetus","display_name":"second trimester fetus","score":0.7699999809265137},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.7760000228881836},{"id":"https://openalex.org/keywords/prothrombin","display_name":"prothrombin","score":0.996999979019165},{"id":"https://openalex.org/keywords/factor-v","display_name":"factor V","score":0.8999999761581421},{"id":"https://openalex.org/keywords/factor-vii","display_name":"factor VII","score":0.9940000176429749},{"id":"https://openalex.org/keywords/factor-viii-coagulant-activity","display_name":"factor VIII coagulant activity","score":0.9430000185966492},{"id":"https://openalex.org/keywords/factor-viii-related-antigen","display_name":"factor VIII-related antigen","score":0.9819999933242798},{"id":"https://openalex.org/keywords/factor-ix","display_name":"factor IX","score":0.9559999704360962},{"id":"https://openalex.org/keywords/factor-x","display_name":"factor X","score":0.9850000143051147},{"id":"https://openalex.org/keywords/antithrombin-iii","display_name":"antithrombin III","score":1.0},{"id":"https://openalex.org/keywords/hemophilia-b","display_name":"hemophilia B","score":0.925000011920929},{"id":"https://openalex.org/keywords/reference-values","display_name":"reference values","score":0.8460000157356262},{"id":"https://openalex.org/keywords/sample-quality-control","display_name":"sample quality control","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C2781221834","wikidata":"https://www.wikidata.org/wiki/Q425360","display_name":"Factor IX","level":2,"score":0.6882466077804565},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.6302750110626221},{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.5720105767250061},{"id":"https://openalex.org/C2778385053","wikidata":"https://www.wikidata.org/wiki/Q134003","display_name":"Haemophilia","level":2,"score":0.5707507729530334},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.5698052048683167},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5601292848587036},{"id":"https://openalex.org/C2780930249","wikidata":"https://www.wikidata.org/wiki/Q412850","display_name":"Factor VII","level":3,"score":0.5548801422119141},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5044435262680054},{"id":"https://openalex.org/C2777232031","wikidata":"https://www.wikidata.org/wiki/Q2092064","display_name":"Haemophilia A","level":3,"score":0.4667506515979767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4586934447288513},{"id":"https://openalex.org/C2909974469","wikidata":"https://www.wikidata.org/wiki/Q2044524","display_name":"PROTHROMBIN COMPLEX","level":3,"score":0.45435085892677307},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.4304337501525879},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4158782362937927},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33246490359306335},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3236047029495239},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.24260881543159485},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1827910840511322},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.0961700975894928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06482860445976257},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001779","descriptor_name":"Blood Coagulation Factors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007123","descriptor_name":"Immunoelectrophoresis, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2141.1980.tb07187.x","doi":"https://doi.org/10.1111/j.1365-2141.1980.tb07187.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.1980.tb07187.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:7426442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7426442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W155613015","https://openalex.org/W1963689383","https://openalex.org/W1977384202","https://openalex.org/W1991687544","https://openalex.org/W2006538897","https://openalex.org/W2007432030","https://openalex.org/W2022627976","https://openalex.org/W2040885089","https://openalex.org/W2058127602","https://openalex.org/W2061361584","https://openalex.org/W2082190021","https://openalex.org/W2085295659","https://openalex.org/W2096426797","https://openalex.org/W2101997948","https://openalex.org/W2253814406","https://openalex.org/W2331408984","https://openalex.org/W2335948723","https://openalex.org/W2402558899","https://openalex.org/W2416642005","https://openalex.org/W2418723059","https://openalex.org/W2427445096","https://openalex.org/W2436279660","https://openalex.org/W2441722355","https://openalex.org/W2473262318","https://openalex.org/W4251824554","https://openalex.org/W4251846356"],"related_works":["https://openalex.org/W2006538897","https://openalex.org/W2366480160","https://openalex.org/W2065976200","https://openalex.org/W2945067503","https://openalex.org/W2032038757","https://openalex.org/W2945807647","https://openalex.org/W2378925558","https://openalex.org/W2001088058","https://openalex.org/W2400334327","https://openalex.org/W2335948723"],"abstract_inverted_index":{"In":[0],"plasma":[1],"samples":[2,117],"of":[3,6,10,98,116,129,132],"11":[4],"fetuses":[5],"about":[7],"20":[8],"weeks":[9],"gestational":[11],"age":[12,126],"the":[13,93,114,125,133],"following":[14],"coagulation":[15],"factors":[16],"have":[17],"been":[18],"determined":[19],"(mean":[20],"values":[21,123],"found":[22],"are":[23],"given":[24],"in":[25],"parentheses):":[26],"fibrinogen":[27],"(0.30":[28],"U/ml),":[29,32,36,40,48,55,63,69,79],"prothrombin":[30],"(+/-0.17":[31],"factor":[33,37,41,49,57,64,70,80],"V":[34],"(0.28":[35],"VII":[38],"(0.21":[39],"VIII":[42],"coagulant":[43,56,66],"activity":[44,67],"(factor":[45,52,60],"VIII:C)":[46],"(0.12":[47],"VIII-related":[50,58],"antigen":[51,59,72],"VIIIR:Ag)":[53],"(1.04":[54],"VII:CAg)":[61],"(0.19":[62],"IX":[65,71],"(0.05":[68],"(less":[73],"than":[74],"or":[75],"equal":[76],"to":[77,120,138],"0.03":[78],"X":[81],"(0,19":[82],"U/ml)":[83],"and":[84],"antithrombin":[85],"III":[86],"(AT-III)":[87],"(0.23":[88],"U/ml).":[89],"Our":[90],"data":[91],"support":[92],"evidence":[94],"that":[95],"prenatal":[96],"diagnosis":[97],"haemophilia":[99,110],"A":[100],"is":[101,107,112,118,135],"at":[102],"present":[103],"possible;":[104],"less":[105],"optimism":[106],"warranted":[108],"where":[109],"B":[111],"concerned.":[113],"number":[115],"sufficient":[119],"establish":[121],"normal":[122],"for":[124],"group.":[127],"Means":[128],"quality":[130],"control":[131],"sample-which":[134],"often":[136],"difficult":[137],"obtain-are":[139],"disscussed.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}