{"id":"https://openalex.org/W2133198677","doi":"https://doi.org/10.1634/theoncologist.2009-0117","title":"Combining Targeted Therapies: Practical Issues to Consider at the Bench and Bedside","display_name":"Combining Targeted Therapies: Practical Issues to Consider at the Bench and Bedside","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2133198677","doi":"https://doi.org/10.1634/theoncologist.2009-0117","mag":"2133198677","pmid":"https://pubmed.ncbi.nlm.nih.gov/20080862","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3227881"},"language":"en","primary_location":{"id":"doi:10.1634/theoncologist.2009-0117","doi":"https://doi.org/10.1634/theoncologist.2009-0117","is_oa":true,"landing_page_url":"https://doi.org/10.1634/theoncologist.2009-0117","pdf_url":"https://academic.oup.com/oncolo/article-pdf/15/1/37/41842838/oncolo_15_1_37.pdf","source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/oncolo/article-pdf/15/1/37/41842838/oncolo_15_1_37.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031165814","display_name":"Jordi Ahnert Rodon","orcid":"https://orcid.org/0000-0001-6467-3632","observed_orcids":["https://orcid.org/0000-0001-6467-3632","https://orcid.org/0000-0003-2234-5248"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4387155398","display_name":"Vall d'Hebron Institute of Oncology","ror":"https://ror.org/054xx3904","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4387153040","https://openalex.org/I4387155398"]}],"countries":["ES","US"],"is_corresponding":true,"raw_author_name":"Jordi Rodon","raw_affiliation_strings":["a Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA","b Medical Oncology Program, Vall d Hebron Institut de Oncologia, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"b Medical Oncology Program, Vall d Hebron Institut de Oncologia, Barcelona, Spain","institution_ids":["https://openalex.org/I4387155398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090108117","display_name":"Jos\u00e9 Manuel P\u00e9rez-Garc\u00eda","orcid":"https://orcid.org/0000-0003-4238-2046","observed_orcids":["https://orcid.org/0000-0003-4238-2046","https://orcid.org/0009-0004-2204-2014"]},"institutions":[{"id":"https://openalex.org/I4387155398","display_name":"Vall d'Hebron Institute of Oncology","ror":"https://ror.org/054xx3904","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4387153040","https://openalex.org/I4387155398"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Perez","raw_affiliation_strings":["b Medical Oncology Program, Vall d Hebron Institut de Oncologia, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b Medical Oncology Program, Vall d Hebron Institut de Oncologia, Barcelona, Spain","institution_ids":["https://openalex.org/I4387155398"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053481267","display_name":"Razelle Kurzrock","orcid":"https://orcid.org/0000-0003-4110-1214","observed_orcids":["https://orcid.org/0000-0003-4110-1214"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Razelle Kurzrock","raw_affiliation_strings":["a Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031165814"],"corresponding_institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4387155398"],"apc_list":{"value":3852,"currency":"USD","value_usd":3852},"apc_paid":null,"fwci":1.2274,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.75339897,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"37","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5443999767303467,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5443999767303467,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.10100000351667404,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.0989999994635582,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6759999990463257},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8759999871253967},{"id":"https://openalex.org/keywords/multikinase-inhibitor","display_name":"multikinase inhibitor","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tumor-resistance-mechanisms","display_name":"tumor resistance mechanisms","score":0.7540000081062317},{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.8309999704360962},{"id":"https://openalex.org/keywords/phase-i-trial-design","display_name":"phase I trial design","score":0.8259999752044678},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.5899999737739563},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.36500000953674316},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.609000027179718},{"id":"https://openalex.org/keywords/feedback-loops","display_name":"feedback loops","score":0.4970000088214874},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6627060770988464},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5631271600723267},{"id":"https://openalex.org/C3020000666","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Bench to bedside","level":2,"score":0.5252111554145813},{"id":"https://openalex.org/C68762167","wikidata":"https://www.wikidata.org/wiki/Q910164","display_name":"Cheminformatics","level":2,"score":0.5121514797210693},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.44840502738952637},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44360560178756714},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.41936787962913513},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.41253846883773804},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.39015787839889526},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33148103952407837},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.18742063641548157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12649676203727722},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003657","descriptor_name":"Decision Making","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017321","descriptor_name":"Clinical Trials, Phase I as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020714","descriptor_name":"Maximum Tolerated Dose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1634/theoncologist.2009-0117","doi":"https://doi.org/10.1634/theoncologist.2009-0117","is_oa":true,"landing_page_url":"https://doi.org/10.1634/theoncologist.2009-0117","pdf_url":"https://academic.oup.com/oncolo/article-pdf/15/1/37/41842838/oncolo_15_1_37.pdf","source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2339930","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3227881","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3227881","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3227881","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncologist","raw_type":"Text"},{"id":"pmid:20080862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20080862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The oncologist","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1634/theoncologist.2009-0117","doi":"https://doi.org/10.1634/theoncologist.2009-0117","is_oa":true,"landing_page_url":"https://doi.org/10.1634/theoncologist.2009-0117","pdf_url":"https://academic.oup.com/oncolo/article-pdf/15/1/37/41842838/oncolo_15_1_37.pdf","source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2133198677.pdf","grobid_xml":"https://content.openalex.org/works/W2133198677.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W1487355304","https://openalex.org/W1965887310","https://openalex.org/W1966803171","https://openalex.org/W1968137491","https://openalex.org/W1970476748","https://openalex.org/W1972852140","https://openalex.org/W1985638918","https://openalex.org/W1988104771","https://openalex.org/W1991384876","https://openalex.org/W1996234795","https://openalex.org/W1999065747","https://openalex.org/W2000980666","https://openalex.org/W2001999652","https://openalex.org/W2014557438","https://openalex.org/W2014599726","https://openalex.org/W2020372547","https://openalex.org/W2028704745","https://openalex.org/W2028959752","https://openalex.org/W2030205108","https://openalex.org/W2031585970","https://openalex.org/W2043714862","https://openalex.org/W2045156702","https://openalex.org/W2048440423","https://openalex.org/W2050846833","https://openalex.org/W2059890247","https://openalex.org/W2061708072","https://openalex.org/W2061827267","https://openalex.org/W2066865216","https://openalex.org/W2067653691","https://openalex.org/W2070705072","https://openalex.org/W2072174281","https://openalex.org/W2074703731","https://openalex.org/W2082833890","https://openalex.org/W2089288294","https://openalex.org/W2091582819","https://openalex.org/W2093613683","https://openalex.org/W2094882473","https://openalex.org/W2100403180","https://openalex.org/W2100808408","https://openalex.org/W2100924186","https://openalex.org/W2103445331","https://openalex.org/W2104540972","https://openalex.org/W2106656437","https://openalex.org/W2106789440","https://openalex.org/W2111065680","https://openalex.org/W2114260801","https://openalex.org/W2114622977","https://openalex.org/W2116566535","https://openalex.org/W2118371851","https://openalex.org/W2122088232","https://openalex.org/W2123532766","https://openalex.org/W2124886112","https://openalex.org/W2126042521","https://openalex.org/W2126783165","https://openalex.org/W2127933711","https://openalex.org/W2128373232","https://openalex.org/W2128905862","https://openalex.org/W2129172946","https://openalex.org/W2130982149","https://openalex.org/W2131351052","https://openalex.org/W2131413118","https://openalex.org/W2134748741","https://openalex.org/W2136791645","https://openalex.org/W2137600224","https://openalex.org/W2138977668","https://openalex.org/W2139225734","https://openalex.org/W2139819066","https://openalex.org/W2140512094","https://openalex.org/W2142046859","https://openalex.org/W2149344761","https://openalex.org/W2152829742","https://openalex.org/W2155384808","https://openalex.org/W2157769714","https://openalex.org/W2157983986","https://openalex.org/W2160565595","https://openalex.org/W2161422104","https://openalex.org/W2162423163","https://openalex.org/W2169083148","https://openalex.org/W2171313739","https://openalex.org/W2171608750","https://openalex.org/W2172265576","https://openalex.org/W2225644272","https://openalex.org/W2243408991","https://openalex.org/W2318605753","https://openalex.org/W2464502417","https://openalex.org/W2938564540","https://openalex.org/W3149591292","https://openalex.org/W3196281496","https://openalex.org/W4231550722","https://openalex.org/W4239102610","https://openalex.org/W4256007139","https://openalex.org/W4298017640","https://openalex.org/W6683300772"],"related_works":["https://openalex.org/W2416603274","https://openalex.org/W225326856","https://openalex.org/W2767168338","https://openalex.org/W2277678393","https://openalex.org/W7119506977","https://openalex.org/W2471562228","https://openalex.org/W2551588227","https://openalex.org/W2110646396","https://openalex.org/W2024317960","https://openalex.org/W4311247426"],"abstract_inverted_index":{"Numerous":[0],"practical":[1],"issues":[2,163,192],"must":[3,220],"be":[4,221],"considered":[5],"when":[6],"combining":[7,145],"targeted":[8],"therapies":[9,32],"in":[10,144,182],"early":[11],"clinical":[12,186,245],"drug":[13,209,211],"development.":[14],"These":[15],"include":[16,43],"tumor":[17],"resistance":[18],"mechanisms,":[19],"the":[20,28,44,65,90,111,114,119,178,205,242],"existence":[21],"of":[22,30,46,62,67,92,180,207,244],"multiple,":[23],"redundant":[24],"signaling":[25],"pathways,":[26,150],"and":[27,58,79,94,102,105,153,156,177,193,226,238,247],"failure":[29],"single-agent":[31],"to":[33,39,87,107,113,129,172,185,229],"achieve":[34],"cures.":[35],"The":[36],"strategies":[37,140],"adopted":[38],"examine":[40],"combinatorial":[41,77,253],"therapy":[42],"goal":[45],"hitting":[47],"more":[48],"than":[49],"one":[50],"target":[51,167],"by":[52,73],"specifically":[53],"inhibiting":[54,151],"signal":[55],"transduction":[56],"cascades":[57],"suppressing":[59],"specific":[60],"mechanisms":[61],"action":[63],"with":[64,175],"use":[66],"multitargeted":[68],"kinase":[69],"inhibitors":[70],"made":[71],"possible":[72],"high-throughput":[74],"screening":[75],"techniques,":[76],"chemistry,":[78],"chemoinformatics.":[80],"Two":[81],"complex":[82],"considerations":[83],"are:":[84,164],"which":[85,227],"agents":[86],"combine":[88,173],"given":[89],"heterogeneity":[91],"tumors":[93],"their":[95],"various":[96,196],"underlying":[97],"perturbations,":[98],"including":[99,147],"secondary":[100],"mutations":[101],"feedback":[103],"loops,":[104],"how":[106,171,224],"translate":[108],"findings":[109],"from":[110,118],"bench":[112],"bedside":[115],"or":[116,210],"directly":[117],"bedside.":[120],"Another":[121],"consideration":[122],"is:":[123],"When":[124],"is":[125,223],"there":[126],"enough":[127],"information":[128],"provide":[130],"a":[131,135,158,208],"rationale":[132],"for":[133,169,203,213],"instituting":[134],"phase":[136],"I":[137],"trial?":[138],"Various":[139],"have":[141],"been":[142],"used":[143],"molecules,":[146],"targeting":[148],"diverse":[149],"upstream":[152],"downstream":[154],"signals,":[155],"adopting":[157],"synthetic":[159],"lethality":[160],"paradigm.":[161],"Other":[162],"determining":[165,204],"appropriate":[166],"populations":[168],"treatment,":[170],"therapeutics":[174],"diagnostics,":[176],"frequency":[179],"targets":[181],"patients":[183],"referred":[184],"trials.":[187],"Here,":[188],"we":[189,194],"review":[190],"these":[191,250],"propose":[195],"novel":[197],"trial":[198],"designs":[199],"that":[200,219],"are":[201],"logical":[202],"efficacy":[206],"combination":[212],"personalized":[214],"treatment.":[215,254],"A":[216],"difficult":[217],"issue":[218],"answered":[222],"many":[225],"drugs":[228],"combine.":[230],"Recent":[231],"technologies,":[232],"such":[233],"as":[234],"multiplexed":[235],"assay":[236],"platforms":[237],"bioinformatics,":[239],"will":[240],"shape":[241],"future":[243],"trials":[246],"help":[248],"answer":[249],"questions":[251],"surrounding":[252]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
