{"id":"https://openalex.org/W2133169656","doi":"https://doi.org/10.1016/j.biopsych.2008.01.005","title":"Meta-Analysis of the Cognitive Effects of the Catechol-O-Methyltransferase Gene Val158/108Met Polymorphism","display_name":"Meta-Analysis of the Cognitive Effects of the Catechol-O-Methyltransferase Gene Val158/108Met Polymorphism","publication_year":2008,"publication_date":"2008-03-15","ids":{"openalex":"https://openalex.org/W2133169656","doi":"https://doi.org/10.1016/j.biopsych.2008.01.005","mag":"2133169656","pmid":"https://pubmed.ncbi.nlm.nih.gov/18339359"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopsych.2008.01.005","doi":"https://doi.org/10.1016/j.biopsych.2008.01.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2008.01.005","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008089065","display_name":"Jennifer H. Barnett","orcid":"https://orcid.org/0000-0002-4851-5949","observed_orcids":["https://orcid.org/0000-0002-4851-5949"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jennifer H. Barnett","raw_affiliation_strings":["Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059513479","display_name":"Linda Scoriels","orcid":"https://orcid.org/0000-0001-6767-0189","observed_orcids":["https://orcid.org/0000-0001-6767-0189","https://orcid.org/0000-0002-6241-1177"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Linda Scoriels","raw_affiliation_strings":["Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006758334","display_name":"Marcus Robert Munafo","orcid":"https://orcid.org/0000-0002-4049-993X","observed_orcids":["https://orcid.org/0000-0002-4049-993X","https://orcid.org/0000-0002-4793-6290"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Marcus R. Munaf\u00f2","raw_affiliation_strings":["Department of Experimental Psychology, University of Bristol, Bristol, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Psychology, University of Bristol, Bristol, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006758334"],"corresponding_institution_ids":["https://openalex.org/I36234482"],"apc_list":{"value":5489,"currency":"USD","value_usd":5489},"apc_paid":null,"fwci":3.3208,"has_fulltext":false,"cited_by_count":429,"citation_normalized_percentile":{"value":0.94352159,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"64","issue":"2","first_page":"137","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.14380000531673431,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.09109999984502792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/catechol-o-methyltransferase","display_name":"catechol-O-methyltransferase","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.7279999852180481},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.6460000276565552},{"id":"https://openalex.org/keywords/memory","display_name":"memory","score":0.984000027179718},{"id":"https://openalex.org/keywords/iq","display_name":"IQ","score":0.7870000004768372},{"id":"https://openalex.org/keywords/n-back-task","display_name":"n-back task","score":0.8090000152587891},{"id":"https://openalex.org/keywords/trail-making-test","display_name":"Trail Making Test","score":0.7649999856948853},{"id":"https://openalex.org/keywords/wisconsin-card-sorting-test","display_name":"Wisconsin Card Sorting Test","score":0.9890000224113464},{"id":"https://openalex.org/keywords/verbal-fluency","display_name":"verbal fluency","score":0.8519999980926514},{"id":"https://openalex.org/keywords/verbal-recall","display_name":"word recall","score":0.890999972820282},{"id":"https://openalex.org/keywords/publication-bias","display_name":"publication bias","score":0.8420000076293945},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.49300000071525574},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.6620000004768372},{"id":"https://openalex.org/keywords/endophenotypes","display_name":"endophenotypes","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C187869287","wikidata":"https://www.wikidata.org/wiki/Q2032061","display_name":"Endophenotype","level":3,"score":0.7534473538398743},{"id":"https://openalex.org/C97530452","wikidata":"https://www.wikidata.org/wiki/Q7920939","display_name":"Verbal fluency test","level":4,"score":0.6713548302650452},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6250624656677246},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6037141680717468},{"id":"https://openalex.org/C185361966","wikidata":"https://www.wikidata.org/wiki/Q94291140","display_name":"Catechol-O-methyl transferase","level":4,"score":0.5651121735572815},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5641995668411255},{"id":"https://openalex.org/C2778524067","wikidata":"https://www.wikidata.org/wiki/Q17142059","display_name":"rs4680","level":5,"score":0.4624486267566681},{"id":"https://openalex.org/C2780439572","wikidata":"https://www.wikidata.org/wiki/Q919364","display_name":"Publication bias","level":3,"score":0.44130992889404297},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.44120508432388306},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.4136312007904053},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.37407588958740234},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.31512147188186646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27296268939971924},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25572192668914795},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.24641114473342896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18308329582214355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1345154345035553},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12471038103103638},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002394","descriptor_name":"Catechol O-Methyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007360","descriptor_name":"Intelligence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011340","descriptor_name":"Problem Solving","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.biopsych.2008.01.005","doi":"https://doi.org/10.1016/j.biopsych.2008.01.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2008.01.005","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},{"id":"pmid:18339359","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18339359","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/1b800299-b4e7-4050-b4e0-3efed3f66a29","doi":null,"is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/1b800299-b4e7-4050-b4e0-3efed3f66a29","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Barnett, JH, Scoriels, L & Munafo, MR 2008, 'Meta-analysis of the cognitive effects of the catechol O-methyl transferase gene Vall08/158Met polymorphism', Biological Psychiatry, vol. 64, pp. 137 - 144. https://doi.org/10.1016/j.biopsych.2008.01.005","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W1644098900","https://openalex.org/W1965764907","https://openalex.org/W1968924958","https://openalex.org/W1970871071","https://openalex.org/W1972516480","https://openalex.org/W1973620160","https://openalex.org/W1974725748","https://openalex.org/W1980506405","https://openalex.org/W1984198463","https://openalex.org/W1984232480","https://openalex.org/W1986059489","https://openalex.org/W1991176673","https://openalex.org/W1991787755","https://openalex.org/W1992149782","https://openalex.org/W1995778321","https://openalex.org/W1997343027","https://openalex.org/W2007532520","https://openalex.org/W2011244958","https://openalex.org/W2011987261","https://openalex.org/W2018384285","https://openalex.org/W2028671802","https://openalex.org/W2031020345","https://openalex.org/W2032866243","https://openalex.org/W2035836238","https://openalex.org/W2036585736","https://openalex.org/W2038853017","https://openalex.org/W2039148287","https://openalex.org/W2040105622","https://openalex.org/W2041366518","https://openalex.org/W2044546476","https://openalex.org/W2047784996","https://openalex.org/W2048648661","https://openalex.org/W2054217820","https://openalex.org/W2054856852","https://openalex.org/W2054861645","https://openalex.org/W2057646888","https://openalex.org/W2062756480","https://openalex.org/W2063815735","https://openalex.org/W2069923399","https://openalex.org/W2070391744","https://openalex.org/W2071090720","https://openalex.org/W2072542232","https://openalex.org/W2074325113","https://openalex.org/W2077439273","https://openalex.org/W2080549218","https://openalex.org/W2080710624","https://openalex.org/W2082117755","https://openalex.org/W2083980029","https://openalex.org/W2093290270","https://openalex.org/W2101964018","https://openalex.org/W2104090580","https://openalex.org/W2104363283","https://openalex.org/W2105837661","https://openalex.org/W2106188731","https://openalex.org/W2106631668","https://openalex.org/W2109887282","https://openalex.org/W2112187750","https://openalex.org/W2112339576","https://openalex.org/W2113121748","https://openalex.org/W2115948763","https://openalex.org/W2116151911","https://openalex.org/W2118310978","https://openalex.org/W2123636362","https://openalex.org/W2124524555","https://openalex.org/W2128393709","https://openalex.org/W2128463395","https://openalex.org/W2129024304","https://openalex.org/W2131510354","https://openalex.org/W2132377514","https://openalex.org/W2137623293","https://openalex.org/W2138962612","https://openalex.org/W2140142910","https://openalex.org/W2141186163","https://openalex.org/W2141883431","https://openalex.org/W2143014346","https://openalex.org/W2146473511","https://openalex.org/W2146561516","https://openalex.org/W2146738944","https://openalex.org/W2147221474","https://openalex.org/W2148772507","https://openalex.org/W2157823046","https://openalex.org/W2162054698","https://openalex.org/W2163280381","https://openalex.org/W2164534384","https://openalex.org/W2167107218","https://openalex.org/W2168354735","https://openalex.org/W2170022218","https://openalex.org/W2171423623","https://openalex.org/W2318367847","https://openalex.org/W4251942102"],"related_works":["https://openalex.org/W4250190495","https://openalex.org/W2070262323","https://openalex.org/W3003370335","https://openalex.org/W2095635471","https://openalex.org/W2104363283","https://openalex.org/W2762068325","https://openalex.org/W2053586506","https://openalex.org/W2376418359","https://openalex.org/W2069254801","https://openalex.org/W2166947930"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":51},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":30},{"year":2014,"cited_by_count":33},{"year":2013,"cited_by_count":35},{"year":2012,"cited_by_count":47}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}