{"id":"https://openalex.org/W2133108447","doi":"https://doi.org/10.1111/j.1471-4159.1991.tb08204.x","title":"Elevation of Taurine in Hippocampal Extracellular Fluid and Cerebrospinal Fluid of Acutely Hypoosmotic Rats: Contribution by Influx from Blood?","display_name":"Elevation of Taurine in Hippocampal Extracellular Fluid and Cerebrospinal Fluid of Acutely Hypoosmotic Rats: Contribution by Influx from Blood?","publication_year":1991,"publication_date":"1991-02-01","ids":{"openalex":"https://openalex.org/W2133108447","doi":"https://doi.org/10.1111/j.1471-4159.1991.tb08204.x","mag":"2133108447","pmid":"https://pubmed.ncbi.nlm.nih.gov/1899110"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.1991.tb08204.x","doi":"https://doi.org/10.1111/j.1471-4159.1991.tb08204.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1991.tb08204.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113689490","display_name":"Anders Lehmann","orcid":"https://orcid.org/0000-0002-6800-0205","observed_orcids":["https://orcid.org/0000-0002-6800-0205"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Anders Lehmann","raw_affiliation_strings":["Institute of Neurobiology, University of G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology, University of G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018648261","display_name":"C. Carlstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Christian Carlstr\u00f6m","raw_affiliation_strings":["Department of Neurology, University of Go\u0308teborg, Go\u0308teborg, Sweden","Department of Neurology, University of G\u00f6teborg, G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Go\u0308teborg, Go\u0308teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"Department of Neurology, University of G\u00f6teborg, G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066413716","display_name":"Erlend Arnulf Nagelhus","orcid":"https://orcid.org/0000-0002-8090-4362","observed_orcids":["https://orcid.org/0000-0002-8090-4362"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Erlend A. Nagelhus","raw_affiliation_strings":["Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087096006","display_name":"Ole Petter Ottersen","orcid":"https://orcid.org/0000-0003-1048-219X","observed_orcids":["https://orcid.org/0000-0003-1048-219X"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ole Petter Ottersen","raw_affiliation_strings":["Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113689490"],"corresponding_institution_ids":["https://openalex.org/I881427289"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":1.2884,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.79761905,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"56","issue":"2","first_page":"690","last_page":"697"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/water-intoxication","display_name":"water intoxication","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.906000018119812},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8920000195503235},{"id":"https://openalex.org/keywords/blood-cerebrospinal-fluid-barrier","display_name":"blood-CSF barrier","score":0.8930000066757202},{"id":"https://openalex.org/keywords/monoethanolamine","display_name":"monoethanolamine","score":0.609000027179718},{"id":"https://openalex.org/keywords/phosphoethanolamine","display_name":"phosphoethanolamine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/amino-acids","display_name":"amino acids","score":0.656000018119812},{"id":"https://openalex.org/keywords/extracellular-fluid","display_name":"extracellular fluid","score":0.6110000014305115},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.5329999923706055},{"id":"https://openalex.org/keywords/osmolality","display_name":"osmolality","score":0.6890000104904175},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C2779701627","wikidata":"https://www.wikidata.org/wiki/Q207051","display_name":"Taurine","level":3,"score":0.9209064245223999},{"id":"https://openalex.org/C2113261","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Extracellular fluid","level":3,"score":0.738029956817627},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7302263975143433},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7097249627113342},{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.7041424512863159},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6983429193496704},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.6179583072662354},{"id":"https://openalex.org/C2780762869","wikidata":"https://www.wikidata.org/wiki/Q7201783","display_name":"Plasma osmolality","level":3,"score":0.5916499495506287},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5605907440185547},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5316023826599121},{"id":"https://openalex.org/C2776575606","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Blood plasma","level":2,"score":0.49540865421295166},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3957892060279846},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23176059126853943},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1718670129776001},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13689187169075012},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.13634562492370605}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001769","descriptor_name":"Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002555","descriptor_name":"Cerebrospinal Fluid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004983","descriptor_name":"Ethanolamines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004983","descriptor_name":"Ethanolamines","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013654","descriptor_name":"Taurine","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D013654","descriptor_name":"Taurine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014869","descriptor_name":"Water Intoxication","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019856","descriptor_name":"Ethanolamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1471-4159.1991.tb08204.x","doi":"https://doi.org/10.1111/j.1471-4159.1991.tb08204.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1991.tb08204.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:1899110","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1899110","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W306410456","https://openalex.org/W1767505574","https://openalex.org/W1981133890","https://openalex.org/W1989067222","https://openalex.org/W1992830977","https://openalex.org/W2002983094","https://openalex.org/W2005543067","https://openalex.org/W2007126242","https://openalex.org/W2009243881","https://openalex.org/W2016621631","https://openalex.org/W2029162666","https://openalex.org/W2034953568","https://openalex.org/W2035353648","https://openalex.org/W2043243802","https://openalex.org/W2046917847","https://openalex.org/W2062179045","https://openalex.org/W2062238583","https://openalex.org/W2067825154","https://openalex.org/W2081766114","https://openalex.org/W2082968739","https://openalex.org/W2085719787","https://openalex.org/W2086519216","https://openalex.org/W2096402263","https://openalex.org/W2106774052","https://openalex.org/W2141395313","https://openalex.org/W2151607303","https://openalex.org/W2153823370","https://openalex.org/W2264566749","https://openalex.org/W2289000567","https://openalex.org/W2332463655","https://openalex.org/W2473203863","https://openalex.org/W2491701652","https://openalex.org/W2617126731","https://openalex.org/W2764635197","https://openalex.org/W4249117658"],"related_works":["https://openalex.org/W2005543067","https://openalex.org/W1981226125","https://openalex.org/W1994756495","https://openalex.org/W1621301631","https://openalex.org/W2061049373","https://openalex.org/W189929774","https://openalex.org/W2069497814","https://openalex.org/W2085719787","https://openalex.org/W2141395313","https://openalex.org/W2074644543"],"abstract_inverted_index":{"Abstract:":[0],"Previous":[1],"work":[2],"has":[3],"demonstrated":[4],"that":[5,281,295,319],"there":[6,296],"is":[7,297,321],"a":[8,187,298,341],"selective":[9],"increase":[10,206],"in":[11,14,52,192,207,219,236,260,264,307,314,323,329,336],"extracellular":[12,115,305,334],"taurine":[13,32,191,209,259,302,320,335],"the":[15,24,40,93,96,108,119,163,177,205,227,245,308,331,337],"brain":[16,338],"during":[17],"acute":[18,111,282],"water":[19,122,142,311],"intoxication.":[20,312],"One":[21],"aim":[22],"of":[23,42,56,65,87,95,110,121,165,176,190,204,217,226,254,258,300,310,316,333],"present":[25],"study":[26,92],"was":[27,89,104,132,168,184,268,272,276],"to":[28,34,91,106,149,222,325],"investigate":[29],"whether":[30],"plasma":[31,53,77,112,208,224,283,301],"contributes":[33],"this":[35,38],"increase.":[36],"To":[37],"end,":[39],"concentrations":[41,253],"taurine,":[43],"other":[44],"amino":[45,116,130,228],"acids,":[46],"and":[47,54,72,78,128,136,170,197,232,238,274],"ethanolamine":[48],"(EA)":[49],"were":[50,81,138],"measured":[51],"CSF":[55,79,85,166,237,252],"urethane\u2010anesthetized":[57],"rats":[58],"injected":[59],"with":[60],"150":[61],"ml/kg":[62],"body":[63],"weight":[64],"distilled":[66],"water.":[67],"Blood":[68,134],"pressure,":[69],"blood":[70,146,213,218],"gases,":[71],"pH,":[73],"as":[74,76,248,347,349],"well":[75,348],"osmolality,":[80],"also":[82],"measured.":[83],"The":[84,173,256,278],"level":[86,257],"albumin":[88],"quantitated":[90],"function":[94],"blood\u2010CSF":[97,246],"barrier.":[98],"In":[99],"separate":[100],"experiments,":[101],"hippocampal":[102,125,239,261],"microdialysis":[103],"performed":[105],"determine":[107],"effects":[109],"hypoosmolality":[113,242,284],"on":[114,124],"acids.":[117],"Finally,":[118],"effect":[120],"injection":[123,183],"specific":[126],"gravity":[127],"tissue":[129,262],"acids":[131],"assessed.":[133],"gases":[135],"pH":[137],"essentially":[139],"unchanged":[140],"after":[141],"administration.":[143],"Mean":[144],"arterial":[145],"pressure":[147],"increased":[148,179,199,234],"peak":[150],"levels":[151,225],"approximately":[152],"50":[153],"mm":[154],"Hg":[155],"above":[156],"control.":[157],"Plasma":[158,241],"osmolality":[159,167],"decreased":[160],"rapidly,":[161],"whereas":[162,194,270],"depression":[164],"slower":[169],"less":[171],"pronounced.":[172],"average":[174],"volume":[175],"hippocampus":[178],"by":[180,186,250,343,350],"8%.":[181],"Water":[182],"accompanied":[185],"25\u2010fold":[188],"elevation":[189],"plasma,":[193],"phosphoethanolamine":[195],"(PEA)":[196],"EA":[198,233,271,290],"moderately.":[200],"A":[201],"small":[202],"fraction":[203],"might":[210],"derive":[211],"from":[212],"cells":[214],"because":[215],"dilution":[216],"vitro":[220],"led":[221],"doubled":[223],"acid.":[229],"Taurine,":[230],"PEA,":[231],"consistently":[235],"microdialysates.":[240],"transiently":[243],"opened":[244],"barrier":[247],"reflected":[249],"augmented":[251],"albumin.":[255],"(expressed":[263],"\u03bcmol/g":[265],"wet":[266],"weight)":[267],"unaffected":[269],"elevated,":[273],"PEA":[275,286],"depressed.":[277],"findings":[279],"suggest":[280],"promotes":[285],"dephosphorylation":[287],"and/or":[288,345],"inhibits":[289],"phosphorylation.":[291],"Furthermore,":[292],"they":[293],"indicate":[294],"leakage":[299],"into":[303],"cerebral":[304],"fluids":[306],"course":[309],"However,":[313],"view":[315],"earlier":[317],"observations":[318],"released":[322],"response":[324],"neural":[326],"cell":[327],"swelling":[328],"vitro,":[330],"augmentation":[332],"probably":[339],"reflects":[340],"contribution":[342],"neurons":[344],"astrocytes":[346],"blood.":[351]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}