{"id":"https://openalex.org/W2133061035","doi":"https://doi.org/10.1002/pro.654","title":"Crystallographic study of red fluorescent protein eqFP578 and its far\u2010red variant Katushka reveals opposite pH\u2010induced isomerization of chromophore","display_name":"Crystallographic study of red fluorescent protein eqFP578 and its far\u2010red variant Katushka reveals opposite pH\u2010induced isomerization of chromophore","publication_year":2011,"publication_date":"2011-05-11","ids":{"openalex":"https://openalex.org/W2133061035","doi":"https://doi.org/10.1002/pro.654","mag":"2133061035","pmid":"https://pubmed.ncbi.nlm.nih.gov/21563226","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3149199"},"language":"en","primary_location":{"id":"doi:10.1002/pro.654","doi":"https://doi.org/10.1002/pro.654","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.654","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.654","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.654","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031117472","display_name":"Nadya V. Pletneva","orcid":"https://orcid.org/0000-0001-9681-4022","observed_orcids":["https://orcid.org/0000-0001-9681-4022"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nadya V. Pletneva","raw_affiliation_strings":["Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow 117997, Miklukho-Maklaya 16/10, Russia. pletnevs@mail.nih.gov","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow 117997, Miklukho-Maklaya 16/10, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow 117997, Miklukho-Maklaya 16/10, Russia. pletnevs@mail.nih.gov","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow 117997, Miklukho-Maklaya 16/10, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016035860","display_name":"Vladimir Z. Pletnev","orcid":"https://orcid.org/0000-0003-1453-6597","observed_orcids":["https://orcid.org/0000-0003-1453-6597"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I880747138","display_name":"Science Applications International Corporation (United States)","ror":"https://ror.org/00zv91802","country_code":"US","type":"company","lineage":["https://openalex.org/I880747138"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"Vladimir Z. Pletnev","raw_affiliation_strings":["Basic Research Program, SAIC-Frederick, Argonne, Illinois 60439","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow 117997, Miklukho-Maklaya 16/10, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Research Program, SAIC-Frederick, Argonne, Illinois 60439","institution_ids":["https://openalex.org/I880747138"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow 117997, Miklukho-Maklaya 16/10, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062147089","display_name":"Irina I. Shemiakina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina I. Shemiakina","raw_affiliation_strings":["Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow 117997, Miklukho-Maklaya 16/10, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow 117997, Miklukho-Maklaya 16/10, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060028352","display_name":"Dmitriy M. Chudakov","orcid":"https://orcid.org/0000-0003-0430-790X","observed_orcids":["https://orcid.org/0000-0003-0430-790X","https://orcid.org/0000-0003-2143-9824","https://orcid.org/0000-0001-6273-4008"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitriy M. Chudakov","raw_affiliation_strings":["Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow 117997, Miklukho-Maklaya 16/10, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow 117997, Miklukho-Maklaya 16/10, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033673155","display_name":"I. V. Artemyev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Igor Artemyev","raw_affiliation_strings":["Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow 117997, Miklukho-Maklaya 16/10, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow 117997, Miklukho-Maklaya 16/10, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027980832","display_name":"Alexander Wlodawer","orcid":"https://orcid.org/0000-0002-5510-9703","observed_orcids":["https://orcid.org/0000-0002-5510-9703"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Wlodawer","raw_affiliation_strings":["Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015434460","display_name":"Zbigniew Dauter","orcid":"https://orcid.org/0000-0002-8806-9066","observed_orcids":["https://orcid.org/0000-0002-8806-9066"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zbigniew Dauter","raw_affiliation_strings":["Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Argonne, Illinois 60439"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Argonne, Illinois 60439","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102831144","display_name":"Sergei V. Pletnev","orcid":"https://orcid.org/0000-0002-2502-4637","observed_orcids":["https://orcid.org/0000-0002-2502-4637"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I880747138","display_name":"Science Applications International Corporation (United States)","ror":"https://ror.org/00zv91802","country_code":"US","type":"company","lineage":["https://openalex.org/I880747138"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sergei Pletnev","raw_affiliation_strings":["Basic Research Program, SAIC-Frederick, Argonne, Illinois 60439","Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Argonne, Illinois 60439"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Research Program, SAIC-Frederick, Argonne, Illinois 60439","institution_ids":["https://openalex.org/I880747138"]},{"raw_affiliation_string":"Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Argonne, Illinois 60439","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5102831144"],"corresponding_institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I880747138"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":1.0531,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.75589837,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"20","issue":"7","first_page":"1265","last_page":"1274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.05000000074505806,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/red-fluorescent-protein","display_name":"red fluorescent protein","score":0.9079999923706055},{"id":"https://openalex.org/keywords/far-red-fluorescent-proteins","display_name":"far-red fluorescent proteins","score":0.7570000290870667},{"id":"https://openalex.org/keywords/chromophore-isomerization","display_name":"chromophore isomerization","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ph-dependent-fluorescence","display_name":"pH-dependent fluorescence","score":0.6940000057220459},{"id":"https://openalex.org/keywords/trans-cis-isomerization","display_name":"trans-cis isomerization","score":0.9300000071525574},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.6660000085830688},{"id":"https://openalex.org/keywords/entacmaea-quadricolor","display_name":"Entacmaea quadricolor","score":0.9610000252723694},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.48399999737739563},{"id":"https://openalex.org/keywords/fluorescence-quenching","display_name":"fluorescence quenching","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C192468462","wikidata":"https://www.wikidata.org/wiki/Q533543","display_name":"Chromophore","level":2,"score":0.9057013392448425},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.8714377880096436},{"id":"https://openalex.org/C126661725","wikidata":"https://www.wikidata.org/wiki/Q903420","display_name":"Isomerization","level":3,"score":0.7347201108932495},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6698675751686096},{"id":"https://openalex.org/C6929264","wikidata":"https://www.wikidata.org/wiki/Q5434480","display_name":"Far-red","level":3,"score":0.5003082752227783},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.44592276215553284},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.41977477073669434},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.3831166923046112},{"id":"https://openalex.org/C2986477067","wikidata":"https://www.wikidata.org/wiki/Q1210055","display_name":"Red light","level":2,"score":0.13578182458877563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10917973518371582},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08009997010231018},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097573","descriptor_name":"Red Fluorescent Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007536","descriptor_name":"Isomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012615","descriptor_name":"Sea Anemones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012615","descriptor_name":"Sea Anemones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/pro.654","doi":"https://doi.org/10.1002/pro.654","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.654","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.654","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3149199","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3149199","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Sci","raw_type":"Text"},{"id":"pmid:21563226","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21563226","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein science : a publication of the Protein Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/pro.654","doi":"https://doi.org/10.1002/pro.654","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.654","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.654","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1756342139","display_name":null,"funder_award_id":"W-31-109-Eng38","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G18202666","display_name":null,"funder_award_id":"W-31-109-ENG-38","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G2123841078","display_name":null,"funder_award_id":"W - 31 - 109 - Eng - 38","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3112995819","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G3503792436","display_name":null,"funder_award_id":"#HHSN261200800001E","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G386607036","display_name":null,"funder_award_id":"HHSN261200800001E)","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4585269469","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G572720644","display_name":null,"funder_award_id":"W-31-109-ENG-38","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337480","display_name":"Basic Energy Sciences","ror":"https://ror.org/05mg91w61"},{"id":"https://openalex.org/F4320338284","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2133061035.pdf","grobid_xml":"https://content.openalex.org/works/W2133061035.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W1522693579","https://openalex.org/W1539796472","https://openalex.org/W1595801582","https://openalex.org/W1626513324","https://openalex.org/W1983206917","https://openalex.org/W1992875306","https://openalex.org/W2001641653","https://openalex.org/W2006310856","https://openalex.org/W2024526152","https://openalex.org/W2038840577","https://openalex.org/W2047303494","https://openalex.org/W2047887335","https://openalex.org/W2051628563","https://openalex.org/W2052512546","https://openalex.org/W2057397408","https://openalex.org/W2058211348","https://openalex.org/W2078339242","https://openalex.org/W2080548445","https://openalex.org/W2081912151","https://openalex.org/W2089343984","https://openalex.org/W2090212447","https://openalex.org/W2091522551","https://openalex.org/W2092987196","https://openalex.org/W2096287802","https://openalex.org/W2097493124","https://openalex.org/W2098103683","https://openalex.org/W2105332737","https://openalex.org/W2112947216","https://openalex.org/W2126629698","https://openalex.org/W2127130852","https://openalex.org/W2128583282","https://openalex.org/W2144081223","https://openalex.org/W2150153332","https://openalex.org/W2150534859","https://openalex.org/W2153924661","https://openalex.org/W2161996750","https://openalex.org/W2170682202"],"related_works":["https://openalex.org/W2150534859","https://openalex.org/W7095994807","https://openalex.org/W2112947216","https://openalex.org/W1995119184","https://openalex.org/W2189419468","https://openalex.org/W1999059411","https://openalex.org/W2055022737","https://openalex.org/W2079448804","https://openalex.org/W2146236564","https://openalex.org/W2024806163"],"abstract_inverted_index":{"The":[0,45,85,142],"wild":[1],"type":[2],"red":[3],"fluorescent":[4,24,130],"protein":[5,57],"eqFP578":[6],"(from":[7],"sea":[8],"anemone":[9],"Entacmaea":[10],"quadricolor,":[11],"\u03bb(ex)":[12],"=":[13,17,28,32],"552":[14],"nm,":[15,30],"\u03bb(em)":[16,31],"578":[18],"nm)":[19,34],"and":[20,59,80,95,107,115,118,128,137],"its":[21],"bright":[22],"far-red":[23,155],"variant":[25],"Katushka":[26,60,96,138,162],"(\u03bb(ex)":[27],"588":[29],"635":[33],"are":[35],"characterized":[36],"by":[37,103],"the":[38,56,65,104,125,133,153,158],"pronounced":[39],"pH":[40,75,92],"dependence":[41],"of":[42,48,83,88,132,157,161,166],"their":[43],"fluorescence.":[44,84],"crystal":[46],"structures":[47],"eqFP578f":[49,94,136],"(eqFP578":[50],"with":[51],"two":[52,74],"point":[53],"mutations":[54],"improving":[55],"folding)":[58],"have":[61,120],"been":[62,98,121,146],"determined":[63],"at":[64,73,139],"resolution":[66],"ranging":[67],"from":[68],"1.15":[69],"to":[70,78,100,123,164],"1.85":[71],"\u00c5":[72],"values,":[76],"corresponding":[77],"low":[79],"high":[81],"level":[82],"observed":[86,154],"extinguishing":[87],"fluorescence":[89],"upon":[90],"reducing":[91],"in":[93,135],"has":[97,145],"shown":[99,122],"be":[101],"accompanied":[102],"opposite":[105],"trans-cis":[106],"cis-trans":[108],"chromophore":[109],"isomerization,":[110],"respectively.":[111],"Asn143,":[112],"Ser158,":[113],"His197":[114],"Ser143,":[116],"Leu174,":[117],"Arg197":[119],"stabilize":[124],"respective":[126],"trans":[127],"cis":[129,143],"states":[131],"chromophores":[134],"higher":[140],"pH.":[141],"state":[144],"suggested":[147],"as":[148],"being":[149],"primarily":[150],"responsible":[151],"for":[152],"shift":[156],"emission":[159],"maximum":[160],"relative":[163],"that":[165],"eqFP578f.":[167]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}