{"id":"https://openalex.org/W2133018215","doi":"https://doi.org/10.1093/infdis/175.3.707","title":"Early Detection of Perinatal Human Immunodeficiency Virus (HIV) Type 1 Infection Using HIV RNA Amplification and Detection","display_name":"Early Detection of Perinatal Human Immunodeficiency Virus (HIV) Type 1 Infection Using HIV RNA Amplification and Detection","publication_year":1997,"publication_date":"1997-03-01","ids":{"openalex":"https://openalex.org/W2133018215","doi":"https://doi.org/10.1093/infdis/175.3.707","mag":"2133018215","pmid":"https://pubmed.ncbi.nlm.nih.gov/9041350"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/175.3.707","doi":"https://doi.org/10.1093/infdis/175.3.707","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/175.3.707","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071656227","display_name":"Richard W. Steketee","orcid":"https://orcid.org/0000-0002-1831-3799","observed_orcids":["https://orcid.org/0000-0002-1831-3799"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. W. Steketee","raw_affiliation_strings":["Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058881734","display_name":"Elaine J. Abrams","orcid":"https://orcid.org/0000-0001-7938-8981","observed_orcids":["https://orcid.org/0000-0001-7938-8981"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. J. Abrams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078501452","display_name":"Donald M. Thea","orcid":"https://orcid.org/0000-0002-6933-1030","observed_orcids":["https://orcid.org/0000-0002-6933-1030"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. M. Thea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103671540","display_name":"Teresa M. Brown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. M. Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054035354","display_name":"Genevi\u00e8ve Lambert","orcid":"https://orcid.org/0000-0002-4982-6917","observed_orcids":["https://orcid.org/0000-0002-4982-6917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Lambert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084243063","display_name":"Sherry L. Orloff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Orloff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108449495","display_name":"Jeremy Weedon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Weedon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011409058","display_name":"Marukh Bamji","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Bamji","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086305989","display_name":"Ellie E. Schoenbaum","orcid":"https://orcid.org/0000-0002-0878-284X","observed_orcids":["https://orcid.org/0000-0002-0878-284X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. E. Schoenbaum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036960487","display_name":"Jennifer Rapier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Rapier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M. L. Kalish","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. L. Kalish","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"the New York City Perinatal HIV Transmission Collaborative Study","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"the New York City Perinatal HIV Transmission Collaborative Study","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":2.9641,"has_fulltext":false,"cited_by_count":112,"citation_normalized_percentile":{"value":0.925858,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"175","issue":"3","first_page":"707","last_page":"711"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8036999702453613,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8036999702453613,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.1873999983072281,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perinatal-hiv-infection","display_name":"perinatal HIV infection","score":0.777999997138977},{"id":"https://openalex.org/keywords/hiv-type-1","display_name":"HIV type 1","score":0.9399999976158142},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/plasma-hiv-rna","display_name":"plasma HIV RNA","score":0.8650000095367432},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.515999972820282},{"id":"https://openalex.org/keywords/viral-load-quantification","display_name":"viral load quantification","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6885543465614319},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6704097986221313},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.6163851022720337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5801385641098022},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5527151226997375},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.4780055582523346},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4549517035484314},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.42814141511917114},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35914134979248047},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13183173537254333},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06085577607154846}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007232","descriptor_name":"Infant, Newborn, Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009519","descriptor_name":"New York City","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010500","descriptor_name":"Perinatology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011251","descriptor_name":"Pregnancy Complications, Infectious","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000151","qualifier_name":"congenital","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/infdis/175.3.707","doi":"https://doi.org/10.1093/infdis/175.3.707","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/175.3.707","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:9041350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9041350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1482807358","https://openalex.org/W1966624986","https://openalex.org/W1980712544","https://openalex.org/W1990689151","https://openalex.org/W2018731691","https://openalex.org/W2021430036","https://openalex.org/W2032178560","https://openalex.org/W2067044614","https://openalex.org/W2076353967","https://openalex.org/W2153736652","https://openalex.org/W2614421670","https://openalex.org/W4240734597"],"related_works":["https://openalex.org/W1749438933","https://openalex.org/W2055163038","https://openalex.org/W1982074302","https://openalex.org/W2058943518","https://openalex.org/W51530005","https://openalex.org/W28139777","https://openalex.org/W53834226","https://openalex.org/W7096596789","https://openalex.org/W146369880","https://openalex.org/W184433278"],"abstract_inverted_index":{"Early":[0],"diagnosis":[1],"of":[2,57,101],"perinatally":[3,58],"transmitted":[4],"human":[5],"immunodeficiency":[6],"virus":[7],"type":[8],"1":[9],"(HIV)":[10],"infection":[11],"can":[12],"guide":[13],"early":[14,55],"interventions.":[15],"HIV":[16,38,47,82,121,131,140,147,156],"coculture":[17],"and":[18,30,73,84,90,130,152],"DNA":[19,157],"polymerase":[20],"chain":[21],"reaction":[22],"(DNA-PCR)":[23],"detect":[24],"few":[25],"HIV-infected":[26,71,125],"infants":[27,72,79,98,138],"at":[28,65],"birth":[29],"90%-100%":[31],"by":[32,120],"age":[33,102,113],"3":[34],"months.":[35],"Because":[36],"extracellular":[37],"RNA":[39,48,83,122,148],"may":[40],"appear":[41],"soon":[42],"after":[43,112],"infection,":[44],"a":[45],"plasma":[46,146],"assay":[49],"was":[50,149],"compared":[51],"with":[52],"DNA-PCR":[53,85],"for":[54],"detection":[56],"infected":[59],"infants.":[60],"Blood-draw":[61],"specimens":[62,75,95,110,127,134],"(108)":[63],"obtained":[64,111],"the":[66],"same":[67],"time":[68],"from":[69,76,96,135],"49":[70],"10":[74],"8":[77,136],"uninfected":[78,137],"were":[80,88,118,128,139],"tested.":[81],"positivity":[86],"rates":[87],"56%":[89],"33%,":[91],"respectively,":[92],"in":[93,158],"36":[94,97],"<28":[99],"days":[100],"(binomial":[103],"test,":[104],"P":[105],"=":[106],".001).":[107],"Among":[108],"81":[109],"14":[114],"days,":[115],"79":[116],"(98%)":[117],"positive":[119],"testing.":[123],"No":[124],"infant":[126],"DNA-PCR-positive":[129],"RNA-negative.":[132,141],"All":[133],"These":[142],"results":[143],"suggest":[144],"that":[145],"detectable":[150],"earlier":[151],"more":[153],"reliably":[154],"than":[155],"perinatal":[159],"infection.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}