{"id":"https://openalex.org/W2133014144","doi":"https://doi.org/10.1093/bioinformatics/btm291","title":"Total ancestry measure: quantifying the similarity in tree-like classification, with genomic applications","display_name":"Total ancestry measure: quantifying the similarity in tree-like classification, with genomic applications","publication_year":2007,"publication_date":"2007-05-31","ids":{"openalex":"https://openalex.org/W2133014144","doi":"https://doi.org/10.1093/bioinformatics/btm291","mag":"2133014144","pmid":"https://pubmed.ncbi.nlm.nih.gov/17540677"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btm291","doi":"https://doi.org/10.1093/bioinformatics/btm291","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm291","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/16/2163/16858004/btm291.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","ccf-a","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/23/16/2163/16858004/btm291.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067174340","display_name":"Haiyuan Yu","orcid":"https://orcid.org/0000-0001-7597-6049","observed_orcids":["https://orcid.org/0000-0001-7597-6049"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210114115","display_name":"IBM Research - Thomas J. Watson Research Center","ror":"https://ror.org/0265w5591","country_code":"US","type":"facility","lineage":["https://openalex.org/I1341412227","https://openalex.org/I4210114115"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haiyuan Yu","raw_affiliation_strings":["1 Department of Molecular Biophysics & Biochemistry, 2Department of Computer Science, 3Program in Computational Biology and Bioinformatics, 266 Whitney Avenue, Yale University, PO Box 208114, New Haven, CT 06520, 4Department of Genetics, Harvard University, 5Department of Cancer Biology, Dana-Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115 and 6IBM Computational Biology Center, T.J. Watson Research Center, PO Box 704, Yorktown Heights, NY 10598"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Molecular Biophysics & Biochemistry, 2Department of Computer Science, 3Program in Computational Biology and Bioinformatics, 266 Whitney Avenue, Yale University, PO Box 208114, New Haven, CT 06520, 4Department of Genetics, Harvard University, 5Department of Cancer Biology, Dana-Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115 and 6IBM Computational Biology Center, T.J. Watson Research Center, PO Box 704, Yorktown Heights, NY 10598","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I32971472","https://openalex.org/I4210114115","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010827887","display_name":"Ronald Jansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210114115","display_name":"IBM Research - Thomas J. Watson Research Center","ror":"https://ror.org/0265w5591","country_code":"US","type":"facility","lineage":["https://openalex.org/I1341412227","https://openalex.org/I4210114115"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Jansen","raw_affiliation_strings":["1 Department of Molecular Biophysics & Biochemistry, 2Department of Computer Science, 3Program in Computational Biology and Bioinformatics, 266 Whitney Avenue, Yale University, PO Box 208114, New Haven, CT 06520, 4Department of Genetics, Harvard University, 5Department of Cancer Biology, Dana-Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115 and 6IBM Computational Biology Center, T.J. Watson Research Center, PO Box 704, Yorktown Heights, NY 10598"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Molecular Biophysics & Biochemistry, 2Department of Computer Science, 3Program in Computational Biology and Bioinformatics, 266 Whitney Avenue, Yale University, PO Box 208114, New Haven, CT 06520, 4Department of Genetics, Harvard University, 5Department of Cancer Biology, Dana-Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115 and 6IBM Computational Biology Center, T.J. Watson Research Center, PO Box 704, Yorktown Heights, NY 10598","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I32971472","https://openalex.org/I4210114115","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000065699","display_name":"Gustavo A. Stolovitzky","orcid":"https://orcid.org/0000-0002-9618-2819","observed_orcids":["https://orcid.org/0000-0002-9618-2819"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210114115","display_name":"IBM Research - Thomas J. Watson Research Center","ror":"https://ror.org/0265w5591","country_code":"US","type":"facility","lineage":["https://openalex.org/I1341412227","https://openalex.org/I4210114115"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gustavo Stolovitzky","raw_affiliation_strings":["1 Department of Molecular Biophysics & Biochemistry, 2Department of Computer Science, 3Program in Computational Biology and Bioinformatics, 266 Whitney Avenue, Yale University, PO Box 208114, New Haven, CT 06520, 4Department of Genetics, Harvard University, 5Department of Cancer Biology, Dana-Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115 and 6IBM Computational Biology Center, T.J. Watson Research Center, PO Box 704, Yorktown Heights, NY 10598"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Molecular Biophysics & Biochemistry, 2Department of Computer Science, 3Program in Computational Biology and Bioinformatics, 266 Whitney Avenue, Yale University, PO Box 208114, New Haven, CT 06520, 4Department of Genetics, Harvard University, 5Department of Cancer Biology, Dana-Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115 and 6IBM Computational Biology Center, T.J. Watson Research Center, PO Box 704, Yorktown Heights, NY 10598","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I32971472","https://openalex.org/I4210114115","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042321575","display_name":"Mark Gerstein","orcid":"https://orcid.org/0000-0002-9746-3719","observed_orcids":["https://orcid.org/0000-0002-9746-3719"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210114115","display_name":"IBM Research - Thomas J. Watson Research Center","ror":"https://ror.org/0265w5591","country_code":"US","type":"facility","lineage":["https://openalex.org/I1341412227","https://openalex.org/I4210114115"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark Gerstein","raw_affiliation_strings":["1 Department of Molecular Biophysics & Biochemistry, 2Department of Computer Science, 3Program in Computational Biology and Bioinformatics, 266 Whitney Avenue, Yale University, PO Box 208114, New Haven, CT 06520, 4Department of Genetics, Harvard University, 5Department of Cancer Biology, Dana-Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115 and 6IBM Computational Biology Center, T.J. Watson Research Center, PO Box 704, Yorktown Heights, NY 10598"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Molecular Biophysics & Biochemistry, 2Department of Computer Science, 3Program in Computational Biology and Bioinformatics, 266 Whitney Avenue, Yale University, PO Box 208114, New Haven, CT 06520, 4Department of Genetics, Harvard University, 5Department of Cancer Biology, Dana-Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115 and 6IBM Computational Biology Center, T.J. Watson Research Center, PO Box 704, Yorktown Heights, NY 10598","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I32971472","https://openalex.org/I4210114115","https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5042321575"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I32971472","https://openalex.org/I4210114115","https://openalex.org/I4210117453"],"apc_list":{"value":3989,"currency":"USD","value_usd":3989},"apc_paid":{"value":3989,"currency":"USD","value_usd":3989},"fwci":1.7207,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.83548728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"23","issue":"16","first_page":"2163","last_page":"2173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-ontology","display_name":"Gene Ontology","score":0.9660000205039978},{"id":"https://openalex.org/keywords/directed-acyclic-graphs","display_name":"directed acyclic graphs","score":0.9350000023841858},{"id":"https://openalex.org/keywords/functional-annotation","display_name":"functional annotation","score":0.5950000286102295},{"id":"https://openalex.org/keywords/power-law-distribution","display_name":"power-law distribution","score":0.8500000238418579},{"id":"https://openalex.org/keywords/shortest-path","display_name":"shortest path","score":0.39899998903274536},{"id":"https://openalex.org/keywords/lowest-common-ancestor","display_name":"lowest common ancestor","score":0.9670000076293945},{"id":"https://openalex.org/keywords/web-page-classification","display_name":"web page classification","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.651409387588501},{"id":"https://openalex.org/C2780009758","wikidata":"https://www.wikidata.org/wiki/Q6804172","display_name":"Measure (data warehouse)","level":2,"score":0.5390595197677612},{"id":"https://openalex.org/C74197172","wikidata":"https://www.wikidata.org/wiki/Q1195339","display_name":"Directed acyclic graph","level":2,"score":0.5369531512260437},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.503243625164032},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.48336929082870483},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.46670055389404297},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.4262838065624237},{"id":"https://openalex.org/C113174947","wikidata":"https://www.wikidata.org/wiki/Q2859736","display_name":"Tree (set theory)","level":2,"score":0.4186038374900818},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4158138632774353},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3637135624885559},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.25044578313827515},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.20984339714050293},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.14383429288864136},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.12189871072769165},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btm291","doi":"https://doi.org/10.1093/bioinformatics/btm291","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm291","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/16/2163/16858004/btm291.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","ccf-a","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17540677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17540677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btm291","doi":"https://doi.org/10.1093/bioinformatics/btm291","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm291","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/16/2163/16858004/btm291.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","ccf-a","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2030706691","display_name":null,"funder_award_id":"P50HG02357-01","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G2240706864","display_name":"Analysis of Human Genome Using Integrated Technologies","funder_award_id":"P50HG002357","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2133014144.pdf","grobid_xml":"https://content.openalex.org/works/W2133014144.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W938539187","https://openalex.org/W1527927437","https://openalex.org/W1566845903","https://openalex.org/W1647729745","https://openalex.org/W1655990431","https://openalex.org/W1958717431","https://openalex.org/W1971155547","https://openalex.org/W1987678450","https://openalex.org/W1988496202","https://openalex.org/W1989034333","https://openalex.org/W1990061958","https://openalex.org/W2010352922","https://openalex.org/W2016168355","https://openalex.org/W2030532947","https://openalex.org/W2046640957","https://openalex.org/W2072832822","https://openalex.org/W2099189600","https://openalex.org/W2102794349","https://openalex.org/W2103150692","https://openalex.org/W2103453943","https://openalex.org/W2109047523","https://openalex.org/W2117805756","https://openalex.org/W2123324624","https://openalex.org/W2126602684","https://openalex.org/W2127536416","https://openalex.org/W2128329041","https://openalex.org/W2137917513","https://openalex.org/W2140672160","https://openalex.org/W2149310258","https://openalex.org/W2150926065","https://openalex.org/W2154933629","https://openalex.org/W2166525781","https://openalex.org/W2171936986","https://openalex.org/W3151628504","https://openalex.org/W4248500926"],"related_works":["https://openalex.org/W7098985622","https://openalex.org/W2065982833","https://openalex.org/W7095103400","https://openalex.org/W2076735582","https://openalex.org/W7101150006","https://openalex.org/W2106419549","https://openalex.org/W2085032889","https://openalex.org/W7096561796","https://openalex.org/W1495712943","https://openalex.org/W2008830098"],"abstract_inverted_index":{"MOTIVATION:":[0],"Many":[1],"classifications":[2],"of":[3,38,43,47,111,120,131,158,162,220],"protein":[4],"function":[5],"such":[6,144],"as":[7],"Gene":[8],"Ontology":[9],"(GO)":[10],"are":[11,24,32,61,232,244],"organized":[12],"in":[13,63,66,125,222],"directed":[14],"acyclic":[15],"graph":[16],"(DAG)":[17],"structures.":[18],"In":[19],"these":[20],"classifications,":[21],"the":[22,28,41,70,75,99,109,117,128,135,138,155,159,212],"proteins":[23,52],"terminal":[25],"leaf":[26,112],"nodes;":[27],"categories":[29],"'above'":[30],"them":[31],"functional":[33,164,173,214,224],"annotations":[34],"at":[35,246],"various":[36],"levels":[37],"specialization":[39],"and":[40,74,77,187,191,211,216,230],"computation":[42],"a":[44,87,145,150,181,201],"numerical":[45],"measure":[46,104,146,208],"relatedness":[48,94],"between":[49],"two":[50,218],"arbitrary":[51],"is":[53,105,147],"an":[54],"important":[55,62],"proteomics":[56],"problem.":[57],"Moreover,":[58],"analogous":[59],"problems":[60],"other":[64,171],"contexts":[65],"large-scale":[67],"information":[68],"organization--e.g.":[69],"Wikipedia":[71],"online":[72],"encyclopedia":[73],"Yahoo":[76],"DMOZ":[78],"web":[79],"page":[80],"classification":[81],"schemes.":[82],"RESULTS:":[83],"Here":[84],"we":[85,97,199],"develop":[86],"simple":[88],"probabilistic":[89],"approach":[90],"for":[91,137,154,204,209],"computing":[92],"this":[93],"quantity,":[95],"which":[96],"call":[98],"total":[100,129,140,206],"ancestry":[101,207],"method.":[102],"Our":[103],"based":[106],"on":[107],"counting":[108],"number":[110,130],"nodes":[113,124],"that":[114],"share":[115],"exactly":[116],"same":[118,139],"set":[119],"'higher":[121],"up'":[122],"category":[123],"comparison":[126],"to":[127,195],"classified":[132],"pairs":[133],"(i.e.":[134],"chance":[136],"ancestry).":[141],"We":[142,166],"show":[143],"associated":[148],"with":[149,170],"power-law":[151],"distribution,":[152],"allowing":[153],"quick":[156],"assessment":[157],"statistical":[160],"significance":[161],"shared":[163,186],"annotations.":[165],"formally":[167],"compare":[168],"it":[169,221],"quantitative":[172],"similarity":[174],"measures":[175],"(such":[176],"as,":[177],"shortest":[178],"path":[179],"within":[180],"DAG,":[182],"lowest":[183],"common":[184],"ancestor":[185],"Azuaje's":[188],"information-theoretic":[189],"similarity)":[190],"provide":[192,200],"concrete":[193],"metrics":[194],"assess":[196],"differences.":[197],"Finally,":[198],"practical":[202],"implementation":[203],"our":[205,235],"GO":[210],"MIPS":[213],"catalog":[215],"give":[217],"applications":[219],"specific":[223],"genomics":[225],"contexts.":[226],"AVAILABILITY:":[227],"The":[228],"implementations":[229],"results":[231],"available":[233,245],"through":[234],"supplementary":[236],"website":[237],"at:":[238],"http://gersteinlab.org/proj/funcsim.":[239],"SUPPLEMENTARY":[240],"INFORMATION:":[241],"Supplementary":[242],"data":[243],"Bioinformatics":[247],"online.":[248]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}