{"id":"https://openalex.org/W2132990151","doi":"https://doi.org/10.1158/0008-5472.can-05-4430","title":"Identification of Domains of BRCA1 Critical for the Ubiquitin-Dependent Inhibition of Centrosome Function","display_name":"Identification of Domains of BRCA1 Critical for the Ubiquitin-Dependent Inhibition of Centrosome Function","publication_year":2006,"publication_date":"2006-04-15","ids":{"openalex":"https://openalex.org/W2132990151","doi":"https://doi.org/10.1158/0008-5472.can-05-4430","mag":"2132990151","pmid":"https://pubmed.ncbi.nlm.nih.gov/16618730"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-05-4430","doi":"https://doi.org/10.1158/0008-5472.can-05-4430","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-05-4430","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039638734","display_name":"Satish Sankaran","orcid":"https://orcid.org/0009-0004-1456-8614","observed_orcids":["https://orcid.org/0009-0004-1456-8614"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satish Sankaran","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts","Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071126761","display_name":"Lea M. Starita","orcid":"https://orcid.org/0000-0003-2870-5099","observed_orcids":["https://orcid.org/0000-0003-2870-5099"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lea M. Starita","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080071603","display_name":"Amanda M. Simons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda M. Simons","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023251641","display_name":"Jeffrey D. Parvin","orcid":"https://orcid.org/0000-0001-5616-1928","observed_orcids":["https://orcid.org/0000-0001-5616-1928"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey D. Parvin","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6369,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.81731533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"66","issue":"8","first_page":"4100","last_page":"4107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":1.0},{"id":"https://openalex.org/keywords/bard1","display_name":"BARD1","score":1.0},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9419999718666077},{"id":"https://openalex.org/keywords/centrosome-function","display_name":"centrosome function","score":0.9340000152587891},{"id":"https://openalex.org/keywords/centrosome-number","display_name":"centrosome number","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.7950000166893005},{"id":"https://openalex.org/keywords/microtubule-nucleation","display_name":"microtubule nucleation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7829999923706055},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.890999972820282},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.7149999737739563},{"id":"https://openalex.org/keywords/hs578t-cells","display_name":"Hs578T cells","score":0.7239999771118164},{"id":"https://openalex.org/keywords/centrosome-localization","display_name":"centrosome localization","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C10447061","wikidata":"https://www.wikidata.org/wiki/Q190769","display_name":"Centrosome","level":4,"score":0.9732279181480408},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.7354934215545654},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.695667028427124},{"id":"https://openalex.org/C44064316","wikidata":"https://www.wikidata.org/wiki/Q5063037","display_name":"Centrosome cycle","level":5,"score":0.6706525087356567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5876762270927429},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.5509384274482727},{"id":"https://openalex.org/C146276462","wikidata":"https://www.wikidata.org/wiki/Q21131841","display_name":"PLK1","level":4,"score":0.45006856322288513},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32602348923683167},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2920644283294678},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2242085039615631},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20591771602630615},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10435691475868225}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018385","descriptor_name":"Centrosome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018385","descriptor_name":"Centrosome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019313","descriptor_name":"BRCA1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019313","descriptor_name":"BRCA1 Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.can-05-4430","doi":"https://doi.org/10.1158/0008-5472.can-05-4430","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-05-4430","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:16618730","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16618730","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.framingham.edu:bio_facpub-1032","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/66/8/4100.full.pdf+html","pdf_url":"http://cancerres.aacrjournals.org/content/66/8/4100.full.pdf+html","source":{"id":"https://openalex.org/S4377196932","display_name":"Framingham State University Digital Repository (Framingham State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47834966","host_organization_name":"Framingham State University","host_organization_lineage":["https://openalex.org/I47834966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology Department Faculty Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4133271150","display_name":"BRCA1 Function","funder_award_id":"R01CA090281","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W149621205","https://openalex.org/W935855719","https://openalex.org/W1768635289","https://openalex.org/W1967149801","https://openalex.org/W1969807455","https://openalex.org/W1977035912","https://openalex.org/W1977981331","https://openalex.org/W1981864085","https://openalex.org/W1984366469","https://openalex.org/W1986627314","https://openalex.org/W1987605482","https://openalex.org/W1994300590","https://openalex.org/W1999002383","https://openalex.org/W2003719123","https://openalex.org/W2020382936","https://openalex.org/W2021171182","https://openalex.org/W2025829112","https://openalex.org/W2036067070","https://openalex.org/W2036200482","https://openalex.org/W2038260399","https://openalex.org/W2041515353","https://openalex.org/W2044713924","https://openalex.org/W2044733046","https://openalex.org/W2045748439","https://openalex.org/W2047368106","https://openalex.org/W2053003311","https://openalex.org/W2061356413","https://openalex.org/W2063674018","https://openalex.org/W2068121956","https://openalex.org/W2068638854","https://openalex.org/W2088179903","https://openalex.org/W2105395542","https://openalex.org/W2130367127","https://openalex.org/W2147100149","https://openalex.org/W2155547021","https://openalex.org/W2156667778","https://openalex.org/W2164680318","https://openalex.org/W2164890615","https://openalex.org/W2171233133","https://openalex.org/W4233868004"],"related_works":["https://openalex.org/W2065423432","https://openalex.org/W1994015040","https://openalex.org/W2164680318","https://openalex.org/W2164890615","https://openalex.org/W1989119894","https://openalex.org/W2013908628","https://openalex.org/W3044556158","https://openalex.org/W38449617","https://openalex.org/W2064899027","https://openalex.org/W2077858453"],"abstract_inverted_index":{"The":[0],"breast":[1,76,166,178],"and":[2,47,72,86,119,132,159],"ovarian":[3],"cancer":[4,77],"specific":[5],"tumor":[6],"suppressor":[7],"BRCA1,":[8],"bound":[9],"to":[10,51,153,169],"BARD1,":[11],"has":[12],"multiple":[13],"functions":[14,152],"aimed":[15],"at":[16,137],"maintaining":[17],"genomic":[18],"stability":[19],"in":[20,74,98,156,163,176],"the":[21,28,53,57,64,84,123,138,141,147,164],"cell.":[22],"We":[23,144],"have":[24],"shown":[25],"earlier":[26],"that":[27,63,82,146],"BRCA1/BARD1":[29],"E3":[30,149],"ubiquitin":[31,150],"ligase":[32,151],"activity":[33,66],"regulates":[34,69],"centrosome-dependent":[35],"microtubule":[36],"nucleation.":[37],"In":[38,56],"this":[39],"study,":[40,59],"we":[41,61,80],"tested":[42],"which":[43],"domains":[44],"of":[45,67,89,95,116,161],"BRCA1":[46,68,90,162],"BARD1":[48,111,134],"were":[49],"required":[50,92,113],"control":[52],"centrosome":[54,70,96,108,117,139],"function.":[55],"present":[58],"(a)":[60],"confirmed":[62],"ubiquitination":[65],"number":[71],"function":[73,97,118],"Hs578T":[75],"cells;":[78],"(b)":[79],"observed":[81,175],"both":[83],"amino":[85,126],"carboxyl":[87],"termini":[88],"are":[91,128],"for":[93,107,114,130],"regulation":[94,115],"vitro;":[99],"(c)":[100],"an":[101],"internal":[102],"domain":[103],"(770-1,290)":[104],"is":[105,112,135],"dispensable":[106],"regulation;":[109],"(d)":[110],"protein":[120],"sequences":[121],"within":[122],"terminal":[124],"485":[125],"acids":[127],"necessary":[129],"activity;":[131],"(e)":[133],"localized":[136],"throughout":[140],"cell":[142,167],"cycle.":[143],"conclude":[145],"BRCA1-dependent":[148],"restrain":[154],"centrosomes":[155],"mammary":[157],"cells,":[158],"loss":[160],"precancerous":[165],"leads":[168],"centrosomal":[170],"hypertrophy,":[171],"a":[172],"phenotype":[173],"commonly":[174],"incipient":[177],"cancer.":[179]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
