{"id":"https://openalex.org/W2132949320","doi":null,"title":"Gelstat Migraine (sublingually administered feverfew and ginger compound) for acute treatment of migraine when administered during the mild pain phase.","display_name":"Gelstat Migraine (sublingually administered feverfew and ginger compound) for acute treatment of migraine when administered during the mild pain phase.","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W2132949320","mag":"2132949320","pmid":"https://pubmed.ncbi.nlm.nih.gov/16127373"},"language":"en","primary_location":{"id":"pmid:16127373","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16127373","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical science monitor : international medical journal of experimental and clinical research","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084396069","display_name":"Roger K. Cady","orcid":"https://orcid.org/0000-0003-4081-8395","observed_orcids":["https://orcid.org/0000-0003-4081-8395"]},"institutions":[{"id":"https://openalex.org/I4210094741","display_name":"Clinvest (United States)","ror":"https://ror.org/00vxrsr56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094741"]},{"id":"https://openalex.org/I4210155452","display_name":"Headache Care Center","ror":"https://ror.org/055sg7x74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210155452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger K Cady","raw_affiliation_strings":["Clinvest, Inc., Springfield and Headache Care Center, Springfield, Missouri, USA. rcady@primarycarenet.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinvest, Inc., Springfield and Headache Care Center, Springfield, Missouri, USA. rcady@primarycarenet.org","institution_ids":["https://openalex.org/I4210094741","https://openalex.org/I4210155452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025785157","display_name":"Curtis P. Schreiber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Curtis P Schreiber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050930807","display_name":"M.E. Beach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary E Beach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029749816","display_name":"Carolyn C. Hart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carolyn C Hart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2832,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.79529841,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"9","first_page":"PI65","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/feverfew","display_name":"feverfew","score":0.7580000162124634},{"id":"https://openalex.org/keywords/ginger","display_name":"ginger","score":0.9919999837875366},{"id":"https://openalex.org/keywords/acute-migraine","display_name":"acute migraine","score":0.6299999952316284},{"id":"https://openalex.org/keywords/abortive-therapy","display_name":"abortive treatment","score":0.8600000143051147},{"id":"https://openalex.org/keywords/over-the-counter-analgesics","display_name":"over-the-counter analgesics","score":0.6850000023841858},{"id":"https://openalex.org/keywords/patient-satisfaction","display_name":"patient satisfaction","score":0.5509999990463257},{"id":"https://openalex.org/keywords/headache-recurrence","display_name":"headache recurrence","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.9709329605102539},{"id":"https://openalex.org/C2780966972","wikidata":"https://www.wikidata.org/wiki/Q86","display_name":"Headaches","level":2,"score":0.8590197563171387},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8409656882286072},{"id":"https://openalex.org/C2777350023","wikidata":"https://www.wikidata.org/wiki/Q1154226","display_name":"Aura","level":3,"score":0.7786194086074829},{"id":"https://openalex.org/C2778871607","wikidata":"https://www.wikidata.org/wiki/Q416978","display_name":"Sumatriptan","level":4,"score":0.7162389755249023},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5631396174430847},{"id":"https://openalex.org/C2780564907","wikidata":"https://www.wikidata.org/wiki/Q6844299","display_name":"Migraine treatment","level":3,"score":0.4566560983657837},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.44788050651550293},{"id":"https://openalex.org/C2777119127","wikidata":"https://www.wikidata.org/wiki/Q423866","display_name":"Triptans","level":3,"score":0.44650721549987793},{"id":"https://openalex.org/C2910587157","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Chronic Migraine","level":3,"score":0.43582063913345337},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28174981474876404},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.18013426661491394},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.08671504259109497},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000286","descriptor_name":"Administration, Sublingual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004366","descriptor_name":"Nonprescription Drugs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020903","descriptor_name":"Tanacetum parthenium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020939","descriptor_name":"Zingiber officinale","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16127373","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16127373","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical science monitor : international medical journal of experimental and clinical research","raw_type":"Clinical Trial"},{"id":"mag:2132949320","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16127373","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1965609186","https://openalex.org/W1984607232","https://openalex.org/W1987570957","https://openalex.org/W1990698167","https://openalex.org/W2018863103","https://openalex.org/W2022575186","https://openalex.org/W2056317944"],"related_works":["https://openalex.org/W1600827843","https://openalex.org/W2803362113","https://openalex.org/W7161498089","https://openalex.org/W2053879260","https://openalex.org/W2139670360","https://openalex.org/W1919323753","https://openalex.org/W2142401871","https://openalex.org/W2005128914","https://openalex.org/W7100428842","https://openalex.org/W2028844220"],"abstract_inverted_index":{"BACKGROUND:":[0],"Treatment":[1],"of":[2,14,41,52,66,82,126,148,165,193,212],"migraine":[3,83,136,143,246],"headaches":[4,139],"is":[5,237],"often":[6],"delayed":[7],"due":[8],"to":[9,48,116,131,134,230],"assessing":[10],"the":[11,37,50,61,146,156,174,251],"potential":[12],"severity":[13],"an":[15,53,149],"evolving":[16],"headache":[17,39,101,152,192,253],"or":[18,89,98,118,225],"anticipating":[19],"unwanted":[20],"consequences":[21],"from":[22,137],"prescription":[23,32],"medication.":[24,233],"Studies":[25],"have":[26],"demonstrated":[27],"improved":[28],"pain-free":[29,187],"response":[30],"when":[31,58,247],"treatments":[33],"are":[34],"taken":[35,59],"during":[36,250],"mild":[38,63,113,157,179,195,252],"phase":[40,65,159],"a":[42,79,163,191,199,240],"migraine.":[43,67],"This":[44],"study":[45,71],"was":[46,153,228],"designed":[47],"evaluate":[49],"efficacy":[51],"OTC":[54],"product,":[55],"GelStat":[56,161,223,235],"Migraine,":[57,162],"in":[60,122,145,155],"early,":[62],"pain":[64,158],"MATERIAL/METHODS:":[68],"An":[69],"open-label":[70],"enrolling":[72],"30":[73],"subjects,":[74],"male":[75],"and":[76,96,114,140,167,208,220],"female,":[77],"with":[78,88,160,188,216],"one-year":[80],"history":[81],"meeting":[84],"IHS":[85],"diagnostic":[86],"criteria":[87],"without":[90],"aura,":[91],"2-8":[92],"migraines":[93,108],"per":[94,103],"month":[95],"<":[97],"=":[99],"15":[100],"days":[102],"month.":[104],"Inclusion":[105],"required":[106],"having":[107],"that":[109],"consistently":[110],"started":[111],"at":[112,123,178],"worsened":[115],"moderate":[117],"severe,":[119],"if":[120],"untreated,":[121],"least":[124],"75%":[125],"attacks.":[127],"Subjects":[128],"also":[129],"had":[130],"be":[132],"able":[133],"distinguish":[135],"non-migraine":[138],"reliably":[141],"identify":[142],"early":[144,249],"course":[147],"attack.":[150],"One":[151],"treated":[154],"combination":[164],"feverfew":[166],"ginger.":[168],"RESULTS:":[169],"29":[170],"evaluable":[171],"subjects":[172,213],"completed":[173],"study,":[175],"all":[176],"treating":[177],"pain.":[180],"Two":[181],"hours":[182],"after":[183],"treatment,":[184],"48%":[185],"were":[186,206,214],"34%":[189],"reporting":[190],"only":[194],"severity.":[196],"29%":[197],"reported":[198],"recurrence":[200],"within":[201],"24":[202],"hours.":[203],"Side":[204],"effects":[205],"minimal":[207],"not":[209],"serious.":[210],"59%":[211],"satisfied":[215],"Gelstat":[217],"Migraine":[218,224,236],"therapy":[219],"41%":[221],"preferred":[222],"felt":[226],"it":[227],"equal":[229],"their":[231],"pre-study":[232],"CONCLUSIONS:":[234],"effective":[238],"as":[239],"first":[241],"line":[242],"abortive":[243],"treatment":[244],"for":[245],"initiated":[248],"phase.":[254]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}