{"id":"https://openalex.org/W2132889005","doi":"https://doi.org/10.1128/iai.66.11.5406-5413.1998","title":"CD4+T-Lymphocyte and Immunoglobulin G2 Responses in Calves Immunized withAnaplasma marginaleOuter Membranes and Protected against Homologous Challenge","display_name":"CD4+T-Lymphocyte and Immunoglobulin G2 Responses in Calves Immunized withAnaplasma marginaleOuter Membranes and Protected against Homologous Challenge","publication_year":1998,"publication_date":"1998-11-01","ids":{"openalex":"https://openalex.org/W2132889005","doi":"https://doi.org/10.1128/iai.66.11.5406-5413.1998","mag":"2132889005","pmid":"https://pubmed.ncbi.nlm.nih.gov/9784551"},"language":"en","primary_location":{"id":"doi:10.1128/iai.66.11.5406-5413.1998","doi":"https://doi.org/10.1128/iai.66.11.5406-5413.1998","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.66.11.5406-5413.1998","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/108677","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021992592","display_name":"Wendy C. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy C. Brown","raw_affiliation_strings":["<!--label omitted: 1-->Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042763196","display_name":"Varda Shkap","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Varda Shkap","raw_affiliation_strings":["<!--label omitted: 2-->Department of Parasitology, Kimron Veterinary Institute, Bet-Dagan, Israel2","Department of Parasitology, Kimron Veterinary Institute, Bet-Dagan, Israel2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 2-->Department of Parasitology, Kimron Veterinary Institute, Bet-Dagan, Israel2","institution_ids":[]},{"raw_affiliation_string":"Department of Parasitology, Kimron Veterinary Institute, Bet-Dagan, Israel2","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102969456","display_name":"Daming Zhu","orcid":"https://orcid.org/0000-0001-7397-2685","observed_orcids":["https://orcid.org/0000-0001-7397-2685"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daming Zhu","raw_affiliation_strings":["<!--label omitted: 1-->Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109242959","display_name":"Travis C. McGuire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Travis C. McGuire","raw_affiliation_strings":["<!--label omitted: 1-->Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021827662","display_name":"Wenbin Tuo","orcid":"https://orcid.org/0000-0002-3764-8981","observed_orcids":["https://orcid.org/0000-0002-3764-8981"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenbin Tuo","raw_affiliation_strings":["<!--label omitted: 1-->Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112870388","display_name":"Terry F. McElwain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terry F. McElwain","raw_affiliation_strings":["<!--label omitted: 1-->Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085242160","display_name":"Guy H. Palmer","orcid":"https://orcid.org/0000-0001-5679-4709","observed_orcids":["https://orcid.org/0000-0001-5679-4709"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guy H. Palmer","raw_affiliation_strings":["<!--label omitted: 1-->Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164,1 and","institution_ids":["https://openalex.org/I72951846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.7876,"has_fulltext":false,"cited_by_count":143,"citation_normalized_percentile":{"value":0.97382199,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"66","issue":"11","first_page":"5406","last_page":"5413"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anaplasma-marginale","display_name":"Anaplasma marginale","score":1.0},{"id":"https://openalex.org/keywords/outer-membrane-proteins","display_name":"outer membrane proteins","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8029999732971191},{"id":"https://openalex.org/keywords/igg2-antibodies","display_name":"IgG2 antibodies","score":0.7099999785423279},{"id":"https://openalex.org/keywords/major-surface-protein","display_name":"major surface protein","score":0.7580000162124634},{"id":"https://openalex.org/keywords/merozoite-surface-protein-1","display_name":"merozoite surface protein 1","score":0.8690000176429749},{"id":"https://openalex.org/keywords/msp2","display_name":"msp2","score":1.0},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.7160000205039978},{"id":"https://openalex.org/keywords/protective-immunity","display_name":"protective immunity","score":0.5789999961853027},{"id":"https://openalex.org/keywords/calves","display_name":"calves","score":0.5740000009536743},{"id":"https://openalex.org/keywords/t-cell-epitopes","display_name":"T cell epitopes","score":0.7120000123977661},{"id":"https://openalex.org/keywords/anaplasma-ovis","display_name":"Anaplasma ovis","score":0.746999979019165},{"id":"https://openalex.org/keywords/heterologous-protection","display_name":"heterologous protection","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8138315677642822},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.594045877456665},{"id":"https://openalex.org/C2777511614","wikidata":"https://www.wikidata.org/wiki/Q5348631","display_name":"Anaplasmataceae","level":4,"score":0.5936242341995239},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5517477989196777},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5189918875694275},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5082242488861084},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4726359248161316},{"id":"https://openalex.org/C2777479583","wikidata":"https://www.wikidata.org/wiki/Q70288","display_name":"Anaplasma","level":3,"score":0.4649784564971924},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.46270349621772766},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.457304984331131},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4503362476825714},{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.4289228618144989},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.4257080554962158},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.386776328086853},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.327075719833374},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.10420840978622437},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07222196459770203},{"id":"https://openalex.org/C2779620486","wikidata":"https://www.wikidata.org/wiki/Q10304508","display_name":"Tick","level":2,"score":0.06235101819038391},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0590992271900177},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05497691035270691},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000709","descriptor_name":"Anaplasma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000709","descriptor_name":"Anaplasma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000709","descriptor_name":"Anaplasma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000709","descriptor_name":"Anaplasma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000712","descriptor_name":"Anaplasmosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000712","descriptor_name":"Anaplasmosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000712","descriptor_name":"Anaplasmosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000712","descriptor_name":"Anaplasmosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000712","descriptor_name":"Anaplasmosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000712","descriptor_name":"Anaplasmosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000712","descriptor_name":"Anaplasmosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000712","descriptor_name":"Anaplasmosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002418","descriptor_name":"Cattle Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002418","descriptor_name":"Cattle Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002418","descriptor_name":"Cattle Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002418","descriptor_name":"Cattle Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002418","descriptor_name":"Cattle Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D002418","descriptor_name":"Cattle Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D002418","descriptor_name":"Cattle Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D002418","descriptor_name":"Cattle Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/iai.66.11.5406-5413.1998","doi":"https://doi.org/10.1128/iai.66.11.5406-5413.1998","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.66.11.5406-5413.1998","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmid:9784551","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9784551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:165881","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC108677","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:108677","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/108677","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Infect Immun","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:108677","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/108677","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Infect Immun","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life on land","score":0.6399999856948853}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W158818930","https://openalex.org/W1441301749","https://openalex.org/W1521733510","https://openalex.org/W1584246476","https://openalex.org/W1796563856","https://openalex.org/W1858013354","https://openalex.org/W1900861595","https://openalex.org/W1930609608","https://openalex.org/W1933011804","https://openalex.org/W1933109781","https://openalex.org/W1946946176","https://openalex.org/W1956211298","https://openalex.org/W1963174328","https://openalex.org/W1966349222","https://openalex.org/W1967919909","https://openalex.org/W1981024135","https://openalex.org/W1989269469","https://openalex.org/W1989714491","https://openalex.org/W2004740651","https://openalex.org/W2006593970","https://openalex.org/W2007419713","https://openalex.org/W2027232001","https://openalex.org/W2029741653","https://openalex.org/W2031397333","https://openalex.org/W2036188790","https://openalex.org/W2053594261","https://openalex.org/W2055898584","https://openalex.org/W2078751953","https://openalex.org/W2099184115","https://openalex.org/W2102550638","https://openalex.org/W2104439753","https://openalex.org/W2111408714","https://openalex.org/W2112349953","https://openalex.org/W2112651984","https://openalex.org/W2121451593","https://openalex.org/W2124239727","https://openalex.org/W2133427302","https://openalex.org/W2143035914","https://openalex.org/W2146524182","https://openalex.org/W2154944913","https://openalex.org/W2157471263","https://openalex.org/W2158239197","https://openalex.org/W2165379126","https://openalex.org/W2167091003","https://openalex.org/W2170417972","https://openalex.org/W2171127795","https://openalex.org/W2172187342","https://openalex.org/W2359471484","https://openalex.org/W2410778716","https://openalex.org/W2412195326","https://openalex.org/W2418189535","https://openalex.org/W4407201740","https://openalex.org/W4407201875","https://openalex.org/W4407201993","https://openalex.org/W4409121912","https://openalex.org/W4409137559","https://openalex.org/W6628381385"],"related_works":["https://openalex.org/W1979646873","https://openalex.org/W1580725294","https://openalex.org/W4205744899","https://openalex.org/W2805855572","https://openalex.org/W1678074929","https://openalex.org/W3042876338","https://openalex.org/W3121344402","https://openalex.org/W2890254735","https://openalex.org/W4362704550","https://openalex.org/W4386056950"],"abstract_inverted_index":{"Protective":[0],"immunity":[1],"against":[2,19,89,212,232],"the":[3,34,56,75,82,118,171,189,218,250,256],"ehrlichial":[4],"pathogen":[5],"Anaplasma":[6,182],"marginale":[7,107,148,179,234],"has":[8],"been":[9],"hypothesized":[10],"to":[11,68,103,126,138,146,208,268],"require":[12],"induction":[13,41],"of":[14,27,42,55,59,120,153,162,255],"immunoglobulin":[15],"G2":[16],"(IgG2)":[17],"antibody":[18,271],"outer":[20,53,111,185,230],"membrane":[21,186],"protein":[22,278],"epitopes":[23,259],"and":[24,31,78,109,113,131,149,181,202,236,263,272],"coordinated":[25],"activation":[26],"macrophages":[28],"for":[29,136,217,252],"phagocytosis":[30],"killing.":[32],"In":[33],"present":[35],"study,":[36],"cell-mediated":[37],"immune":[38,244],"responses,":[39],"including":[40],"IgG":[43],"isotype":[44],"switching,":[45],"were":[46,65,86,124,205],"characterized":[47],"in":[48,101,144,192,225],"calves":[49,64,79,194],"immunized":[50,228],"with":[51,74,229],"purified":[52,110],"membranes":[54,231],"Florida":[57,76,173],"strain":[58],"A.":[60,106,147,178,233],"marginale.":[61],"Importantly,":[62],"these":[63],"subsequently":[66],"shown":[67,125,207],"be":[69,127],"protected":[70,88,193],"upon":[71],"experimental":[72],"challenge":[73,235],"strain,":[77,174],"which":[80,204],"developed":[81],"highest":[83],"IgG2":[84],"titers":[85,152],"completely":[87],"infection.":[90,213],"Peripheral":[91],"blood":[92],"mononuclear":[93],"cells":[94,123],"(PBMC)":[95],"obtained":[96],"after":[97],"immunization":[98],"proliferated":[99,142],"strongly":[100],"response":[102,145,159],"both":[104],"whole":[105],"homogenates":[108],"membranes,":[112],"this":[114],"responsiveness":[115],"persisted":[116],"until":[117],"time":[119],"challenge.":[121],"Responding":[122],"CD4(+)":[128,132],"T":[129,245],"cells,":[130],"T-cell":[133,158,223,258,274],"lines":[134],"cultured":[135],"2":[137],"4":[139],"weeks":[140],"also":[141],"specifically":[143],"produced":[150],"high":[151],"gamma":[154],"interferon.":[155],"The":[156,184],"helper":[157,222,257],"included":[160,195],"recognition":[161],"conserved":[163],"epitopes,":[164],"as":[165],"PBMC":[166,190],"proliferation":[167],"was":[168],"stimulated":[169],"by":[170,243,277],"homologous":[172],"four":[175],"genetically":[176],"distinct":[177],"strains,":[180],"ovis.":[183],"proteins":[187,198],"stimulating":[188],"responses":[191,224,275],"major":[196],"surface":[197],"(MSPs)":[199],"MSP-1,":[200,261],"MSP-2,":[201,262],"MSP-3,":[203],"previously":[206],"induce":[209],"partial":[210],"protection":[211],"These":[214,247],"studies":[215],"demonstrate,":[216],"first":[219],"time,":[220],"potent":[221],"cattle":[226],"protectively":[227],"identify":[237],"three":[238],"MSPs":[239],"that":[240,265],"are":[241,266],"recognized":[242],"cells.":[246],"experiments":[248],"provide":[249],"basis":[251],"subsequent":[253],"identification":[254],"on":[260],"MSP-3":[264],"needed":[267],"evoke":[269],"anamnestic":[270],"effector":[273],"elicited":[276],"or":[279],"nucleic":[280],"acid":[281],"immunization.":[282]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}