{"id":"https://openalex.org/W2132883871","doi":"https://doi.org/10.2337/db10-1220","title":"The RANKL/RANK/OPG Signaling Pathway Mediates Medial Arterial Calcification in Diabetic Charcot Neuroarthropathy","display_name":"The RANKL/RANK/OPG Signaling Pathway Mediates Medial Arterial Calcification in Diabetic Charcot Neuroarthropathy","publication_year":2011,"publication_date":"2011-06-10","ids":{"openalex":"https://openalex.org/W2132883871","doi":"https://doi.org/10.2337/db10-1220","mag":"2132883871","pmid":"https://pubmed.ncbi.nlm.nih.gov/21659498","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3142088"},"language":"en","primary_location":{"id":"doi:10.2337/db10-1220","doi":"https://doi.org/10.2337/db10-1220","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db10-1220","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.2337/db10-1220","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088896819","display_name":"Agbor Ndip","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801926401","display_name":"Manchester Royal Infirmary","ror":"https://ror.org/03kr30n36","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801926401","https://openalex.org/I4210092852"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Agbor Ndip","raw_affiliation_strings":["Cardiovascular Research Group, School of Biomedicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester, U.K","Department of Medicine and Diabetes, Manchester Royal Infirmary, Manchester, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Group, School of Biomedicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester, U.K","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Department of Medicine and Diabetes, Manchester Royal Infirmary, Manchester, U.K","institution_ids":["https://openalex.org/I2801926401"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alfred Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alfred Williams","raw_affiliation_strings":["Cardiovascular Research Group, School of Biomedicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Group, School of Biomedicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester, U.K","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034897442","display_name":"Edward Bernard Jude","orcid":"https://orcid.org/0000-0002-3186-4122","observed_orcids":["https://orcid.org/0000-0002-3186-4122","https://orcid.org/0000-0002-4096-3376"]},"institutions":[{"id":"https://openalex.org/I2802499524","display_name":"Tameside Hospital","ror":"https://ror.org/04d713p41","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802499524","https://openalex.org/I4210108530"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Edward B. Jude","raw_affiliation_strings":["Cardiovascular Research Group, School of Biomedicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester, U.K","Diabetes Centre, Tameside General Hospital, Ashton-Under-Lyne, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Group, School of Biomedicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester, U.K","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Diabetes Centre, Tameside General Hospital, Ashton-Under-Lyne, U.K","institution_ids":["https://openalex.org/I2802499524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019009827","display_name":"Ferdinand Serracino\u2010Inglott","orcid":"https://orcid.org/0000-0002-3188-7957","observed_orcids":["https://orcid.org/0000-0002-3188-7957"]},"institutions":[{"id":"https://openalex.org/I2801926401","display_name":"Manchester Royal Infirmary","ror":"https://ror.org/03kr30n36","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801926401","https://openalex.org/I4210092852"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ferdinand Serracino-Inglott","raw_affiliation_strings":["Department of Vascular Surgery, Manchester Royal Infirmary, Manchester, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, Manchester Royal Infirmary, Manchester, U.K","institution_ids":["https://openalex.org/I2801926401"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Steve Richardson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801926401","display_name":"Manchester Royal Infirmary","ror":"https://ror.org/03kr30n36","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801926401","https://openalex.org/I4210092852"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steve Richardson","raw_affiliation_strings":["Department of Vascular Surgery, Manchester Royal Infirmary, Manchester, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, Manchester Royal Infirmary, Manchester, U.K","institution_ids":["https://openalex.org/I2801926401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110285860","display_name":"John Vincent Smyth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801926401","display_name":"Manchester Royal Infirmary","ror":"https://ror.org/03kr30n36","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801926401","https://openalex.org/I4210092852"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J.V. Smyth","raw_affiliation_strings":["Department of Vascular Surgery, Manchester Royal Infirmary, Manchester, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, Manchester Royal Infirmary, Manchester, U.K","institution_ids":["https://openalex.org/I2801926401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033575514","display_name":"Andrew J.M. Boulton","orcid":"https://orcid.org/0000-0001-7856-1201","observed_orcids":["https://orcid.org/0000-0001-7856-1201"]},"institutions":[{"id":"https://openalex.org/I2801926401","display_name":"Manchester Royal Infirmary","ror":"https://ror.org/03kr30n36","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801926401","https://openalex.org/I4210092852"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew J.M. Boulton","raw_affiliation_strings":["Cardiovascular Research Group, School of Biomedicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester, U.K","Department of Medicine and Diabetes, Manchester Royal Infirmary, Manchester, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Group, School of Biomedicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester, U.K","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Department of Medicine and Diabetes, Manchester Royal Infirmary, Manchester, U.K","institution_ids":["https://openalex.org/I2801926401"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103203688","display_name":"M. Yvonne Alexander","orcid":"https://orcid.org/0000-0001-7151-8649","observed_orcids":["https://orcid.org/0000-0001-7151-8649"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. Yvonne Alexander","raw_affiliation_strings":["Cardiovascular Research Group, School of Biomedicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Group, School of Biomedicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester, U.K","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088896819"],"corresponding_institution_ids":["https://openalex.org/I2801926401","https://openalex.org/I28407311"],"apc_list":null,"apc_paid":null,"fwci":3.632,"has_fulltext":false,"cited_by_count":128,"citation_normalized_percentile":{"value":0.94263415,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"60","issue":"8","first_page":"2187","last_page":"2196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.7314000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.7314000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.02319999970495701,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medial-arterial-calcification","display_name":"medial arterial calcification","score":0.9150000214576721},{"id":"https://openalex.org/keywords/vascular-calcification","display_name":"vascular calcification","score":0.8989999890327454},{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":0.9229999780654907},{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":0.7239999771118164},{"id":"https://openalex.org/keywords/nuclear-factor-kappab","display_name":"nuclear factor-kappaB","score":0.7250000238418579},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8429999947547913},{"id":"https://openalex.org/keywords/tibial-artery","display_name":"tibial artery","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.581713855266571},{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.549017071723938},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46139904856681824},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4546038508415222},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.43853533267974854},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4304554760456085},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40523380041122437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26413384079933167},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15319040417671204},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.14391449093818665},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002607","descriptor_name":"Charcot-Marie-Tooth Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D053244","descriptor_name":"Osteoprotegerin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053245","descriptor_name":"RANK Ligand","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053246","descriptor_name":"Receptor Activator of Nuclear Factor-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.2337/db10-1220","doi":"https://doi.org/10.2337/db10-1220","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db10-1220","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3142088","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3142088","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Text"},{"id":"pmid:21659498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21659498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/10903abd-60a4-4650-aea7-f4ca1c241226","doi":null,"is_oa":false,"landing_page_url":"http://diabetes.diabetesjournals.org/content/60/8/2187.full.pdf+html","pdf_url":"http://diabetes.diabetesjournals.org/content/60/8/2187.full.pdf+html","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ndip, A, Williams, A, Jude, E B, Serracino-Inglott, F, Richardson, S, Smyth, J V, Boulton, A J M & Alexander, M Y 2011, 'The RANKL/RANK/OPG signaling pathway mediates medial arterial calcification in diabetic charcot neuroarthropathy', Diabetes, vol. 60, no. 8, pp. 2187-2196. https://doi.org/10.2337/db10-1220","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2337/db10-1220","doi":"https://doi.org/10.2337/db10-1220","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db10-1220","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315071","display_name":"NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320065","display_name":"Diabetes UK","ror":"https://ror.org/050rgn017"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1898125913","https://openalex.org/W1972724626","https://openalex.org/W1973293048","https://openalex.org/W1979026008","https://openalex.org/W1979093563","https://openalex.org/W1991873795","https://openalex.org/W1996372998","https://openalex.org/W1998779317","https://openalex.org/W2007792295","https://openalex.org/W2007883596","https://openalex.org/W2012380963","https://openalex.org/W2026567789","https://openalex.org/W2034940209","https://openalex.org/W2038204617","https://openalex.org/W2044391450","https://openalex.org/W2061372600","https://openalex.org/W2069024129","https://openalex.org/W2076904776","https://openalex.org/W2088103742","https://openalex.org/W2096993036","https://openalex.org/W2101964371","https://openalex.org/W2103502313","https://openalex.org/W2106478562","https://openalex.org/W2115853702","https://openalex.org/W2117524665","https://openalex.org/W2118417281","https://openalex.org/W2120166750","https://openalex.org/W2122367477","https://openalex.org/W2140192254","https://openalex.org/W2141515762","https://openalex.org/W2142676544","https://openalex.org/W2146240002","https://openalex.org/W2148414912","https://openalex.org/W2151799721","https://openalex.org/W2158203405","https://openalex.org/W2159259228","https://openalex.org/W2162662163","https://openalex.org/W2169779161"],"related_works":["https://openalex.org/W7099226259","https://openalex.org/W2043878832","https://openalex.org/W1979093563","https://openalex.org/W6977761462","https://openalex.org/W1972724626","https://openalex.org/W2952752548","https://openalex.org/W2921632205","https://openalex.org/W2086431093","https://openalex.org/W2087439404","https://openalex.org/W105341245"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,217],"receptor":[2,201],"activator":[3],"of":[4,51,76,133,142,207,212,230],"nuclear":[5,228,231],"factor-\u03baB":[6],"(RANK),":[7],"RANK":[8],"ligand":[9],"(RANKL),":[10],"and":[11,66,80,93,107,131,145,162,179,209,223,253],"osteoprotegerin":[12],"(OPG)":[13],"signaling":[14,246],"pathway":[15,264],"(RANKL/RANK/OPG":[16],"signaling)":[17],"is":[18,247],"implicated":[19],"in":[20,38,53,55,82,124,136,154,169,249,257],"the":[21,30,49,199],"osteolysis":[22],"associated":[23],"with":[24,32,40,57,87,91,104,156,159,185,188,197,227,251],"diabetic":[25,160,189],"Charcot":[26],"neuroarthropathy":[27],"(CN);":[28],"however,":[29],"links":[31],"medial":[33],"arterial":[34,121],"calcification":[35],"(MAC)":[36],"seen":[37],"people":[39],"CN":[41,157,170,224,252],"are":[42],"unclear.":[43],"This":[44,260],"study":[45,261],"aimed":[46],"to":[47,72],"investigate":[48],"role":[50,256],"RANKL/OPG":[52],"MAC":[54],"patients":[56,86,90,161,250],"CN.":[58],"RESEARCH":[59],"DESIGN":[60],"AND":[61],"METHODS:":[62],"Enzyme-linked":[63],"immunosorbent":[64],"assay":[65],"Bio-plex":[67],"multiarray":[68],"technology":[69],"were":[70,101,117,152],"used":[71],"quantify":[73],"a":[74,213,233,255,266],"range":[75],"cytokines,":[77],"including":[78],"RANKL":[79,109,134,222],"OPG":[81],"sera":[83],"from":[84,120],"10":[85],"diabetes,":[88],"12":[89],"CN,":[92],"5":[94],"healthy":[95,163],"volunteers.":[96],"Human":[97,111,166],"tibial":[98],"artery":[99],"segments":[100,122],"immunohistochemically":[102],"stained":[103],"Alizarin":[105],"red":[106,182],"human":[108],"antibody.":[110],"vascular":[112,258],"smooth":[113],"muscle":[114],"cells":[115,186],"(VSMCs)":[116],"also":[118],"explanted":[119],"for":[123,202,269],"vitro":[125],"studies.":[126],"RESULTS:":[127],"We":[128],"demonstrate":[129],"colocalization":[130],"upregulation":[132],"expression":[135],"areas":[137],"displaying":[138],"MAC.":[139],"Systemic":[140],"levels":[141],"RANKL,":[143,203],"OPG,":[144,198],"inflammatory":[146],"cytokines":[147],"(interleukin-8,":[148],"granulocyte":[149],"colony-stimulating":[150],"factor)":[151],"elevated":[153],"those":[155],"compared":[158,184],"control":[164,191],"subjects.":[165],"VSMCs":[167,208],"cultured":[168],"serum":[171,192,225],"showed":[172],"accelerated":[173,218],"osteoblastic":[174],"differentiation":[175,206],"(alkaline":[176],"phosphatase":[177],"activity)":[178],"mineralization":[180,219],"(alizarin":[181],"staining)":[183],"treated":[187],"or":[190],"(P":[193],"<":[194],"0.05).":[195],"Coincubation":[196],"decoy":[200],"attenuated":[204],"osteogenic":[205],"was":[210],"independent":[211],"high":[214],"calcium-phosphate":[215],"milieu.":[216],"induced":[220],"by":[221,236],"correlated":[226],"translocation":[229],"factor-\u03baB,":[232],"process":[234],"abrogated":[235],"OPG.":[237],"CONCLUSIONS:":[238],"Our":[239],"data":[240],"provide":[241],"direct":[242],"evidence":[243],"that":[244],"RANKL/RANK/OPG":[245],"modulated":[248],"plays":[254],"calcification.":[259],"highlights":[262],"this":[263],"as":[265],"potential":[267],"target":[268],"intervention.":[270]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
