{"id":"https://openalex.org/W2132807431","doi":null,"title":"Induction of transplantable mouse renal cell cancers by streptozotocin: in vivo growth, metastases, and angiogenic phenotype.","display_name":"Induction of transplantable mouse renal cell cancers by streptozotocin: in vivo growth, metastases, and angiogenic phenotype.","publication_year":2001,"publication_date":"2001-08-15","ids":{"openalex":"https://openalex.org/W2132807431","mag":"2132807431","pmid":"https://pubmed.ncbi.nlm.nih.gov/11507080"},"language":"en","primary_location":{"id":"pmid:11507080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11507080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059532441","display_name":"M. Eilene Gruys","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M E Gruys","raw_affiliation_strings":["Laboratories of Experimental Immunology, Center for Cancer Research, IRSP, Frederick, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories of Experimental Immunology, Center for Cancer Research, IRSP, Frederick, Maryland, USA","institution_ids":["https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006381802","display_name":"Timothy Carrel Back","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T C Back","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039261944","display_name":"Jeffrey J. Subleski","orcid":"https://orcid.org/0000-0002-7442-1807","observed_orcids":["https://orcid.org/0000-0002-7442-1807"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Subleski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087954058","display_name":"Theresa A. Wiltrout","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T A Wiltrout","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064298275","display_name":"John K. Lee","orcid":"https://orcid.org/0000-0002-6570-2180","observed_orcids":["https://orcid.org/0000-0002-6570-2180"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J K Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101826881","display_name":"Laura S. Schmidt","orcid":"https://orcid.org/0000-0002-5050-5491","observed_orcids":["https://orcid.org/0000-0002-5050-5491"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Schmidt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109109881","display_name":"Mariko Watanabe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Watanabe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029286344","display_name":"Roscoe Stanyon","orcid":"https://orcid.org/0000-0002-7229-1092","observed_orcids":["https://orcid.org/0000-0002-7229-1092"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Stanyon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061909361","display_name":"Jerrold Michael Ward","orcid":"https://orcid.org/0000-0002-6350-8982","observed_orcids":["https://orcid.org/0000-0002-6350-8982"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Ward","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051746857","display_name":"Jon M. Wigginton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Wigginton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110913744","display_name":"Robert H. Wiltrout","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R H Wiltrout","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0476,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.77413741,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"61","issue":"16","first_page":"6255","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/streptozotocin","display_name":"streptozotocin","score":0.8790000081062317},{"id":"https://openalex.org/keywords/transplantable-tumor-model","display_name":"transplantable tumor model","score":0.7419999837875366},{"id":"https://openalex.org/keywords/orthotopic-tumor-implantation","display_name":"orthotopic tumor implantation","score":0.656000018119812},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/hypervascularity","display_name":"hypervascularity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/vhl-gene","display_name":"VHL gene","score":0.6489999890327454},{"id":"https://openalex.org/keywords/ras-genes","display_name":"ras gene","score":0.9390000104904175},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.641097903251648},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6377581357955933},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.5511019229888916},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5356895923614502},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5311877727508545},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5277517437934875},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4937628209590912},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.49052900075912476},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.4509281516075134},{"id":"https://openalex.org/C78795084","wikidata":"https://www.wikidata.org/wiki/Q5113900","display_name":"Chromophobe cell","level":4,"score":0.4292309880256653},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3134503960609436},{"id":"https://openalex.org/C2778560582","wikidata":"https://www.wikidata.org/wiki/Q18347894","display_name":"Clear cell","level":3,"score":0.2616884112358093},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2541709542274475},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.14728501439094543},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.10030665993690491},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:11507080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11507080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:flore.unifi.it:2158/256584","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/256584","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2132807431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11507080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W36141288","https://openalex.org/W1498677439","https://openalex.org/W1501631015","https://openalex.org/W1521747187","https://openalex.org/W1897772287","https://openalex.org/W1963586465","https://openalex.org/W1972464496","https://openalex.org/W1985804036","https://openalex.org/W2005634564","https://openalex.org/W2010003229","https://openalex.org/W2010160635","https://openalex.org/W2010357177","https://openalex.org/W2010925210","https://openalex.org/W2016685687","https://openalex.org/W2019573100","https://openalex.org/W2026318599","https://openalex.org/W2071631954","https://openalex.org/W2075733574","https://openalex.org/W2077517865","https://openalex.org/W2080304059","https://openalex.org/W2090211266","https://openalex.org/W2091136802","https://openalex.org/W2092411424","https://openalex.org/W2101456601","https://openalex.org/W2104350756","https://openalex.org/W2104947013","https://openalex.org/W2123914905","https://openalex.org/W2128237718","https://openalex.org/W2138088551","https://openalex.org/W2144680000","https://openalex.org/W2278535663","https://openalex.org/W2314844425","https://openalex.org/W2319914165","https://openalex.org/W2409575470","https://openalex.org/W2422052250","https://openalex.org/W2461889278","https://openalex.org/W2467402094","https://openalex.org/W2768600953"],"related_works":["https://openalex.org/W7117484714","https://openalex.org/W2128237718","https://openalex.org/W2148808305","https://openalex.org/W2323504810","https://openalex.org/W2156079608","https://openalex.org/W7097877068","https://openalex.org/W2090546045","https://openalex.org/W2061326027","https://openalex.org/W1993658761","https://openalex.org/W2081308848"],"abstract_inverted_index":{"Interleukin-2-based":[0],"regimens":[1],"of":[2,13,41,45,74,83,88,110,147,172,180,187,197,207,228,235,248,269],"biological":[3],"therapy":[4],"have":[5,49],"shown":[6],"some":[7],"clinical":[8],"promise":[9],"for":[10,22,204,255,266],"the":[11,19,106,148,157,169,178,195,205,226,233,244,267],"treatment":[12],"kidney":[14,46,65,77,199,252],"cancer":[15],"in":[16,26,67,79,141,155,239],"humans,":[17],"although":[18,162],"mechanisms":[20,35],"responsible":[21],"tumor":[23,118],"regression":[24],"occurring":[25],"these":[27,34,111,188,262],"patients":[28],"remain":[29],"unclear.":[30],"Preclinical":[31],"insight":[32],"into":[33],"is":[36,215],"limited":[37],"by":[38,85,217],"a":[39,173,202],"paucity":[40],"orthotopic":[42,236],"animal":[43],"models":[44,265],"cancer.":[47],"We":[48],"used":[50],"streptozotocin,":[51],"an":[52],"antibiotic":[53],"and":[54,108,120,128,165,183,210,220,223,258,277],"diabetogenic":[55],"nitrosamine":[56],"compound":[57],"derived":[58],"from":[59,105,177],"Streptomyces":[60],"achromogenes":[61],"to":[62,81,92,125,138,194,243],"induce":[63],"new":[64,270],"tumors":[66,78,189,263],"BALB/c":[68],"mice.":[69],"Single":[70],"or":[71,151,159],"multiple":[72],"doses":[73],"streptozotocin":[75],"induced":[76],"up":[80,91],"25%":[82],"mice":[84],"50-90":[86],"weeks":[87],"age,":[89],"with":[90,225],"18%":[93],"characterized":[94],"as":[95],"renal":[96],"cell":[97],"carcinomas":[98],"(RCCs).":[99],"Several":[100],"transplantable":[101,250],"lines":[102,112],"were":[103,122],"obtained":[104],"RCCs,":[107,127],"one":[109],"was":[113],"subsequently":[114],"cloned.":[115],"The":[116],"initial":[117],"isolates":[119,150],"sublines":[121,152],"histologically":[123],"reconfirmed":[124],"be":[126],"all":[129],"grew":[130],"progressively":[131],"but":[132],"slowly":[133],"(mean":[134],"survival":[135],"times,":[136],"57":[137],">100":[139],"days)":[140],"vivo":[142,240],"after":[143],"intrarenal":[144],"implant.":[145],"None":[146],"primary":[149],"revealed":[153,168,190],"mutations":[154],"either":[156],"VHL":[158],"Ras":[160],"genes,":[161],"karyotype":[163],"analysis":[164,222],"chromosome":[166,175],"painting":[167],"consistent":[170],"presence":[171],"submetacentric":[174],"resulting":[176],"fusion":[179],"chromosomes":[181],"16":[182],"19.":[184],"Biological":[185],"characterization":[186],"several":[191,229],"features":[192,234],"analogous":[193],"growth":[196,241,246],"human":[198],"cancers,":[200],"including":[201],"propensity":[203,254],"formation":[206],"lung":[208,256],"metastases":[209],"high":[211],"vascularity.":[212],"This":[213],"hypervascularity":[214,259],"evident":[216],"both":[218],"gross":[219],"microscopic":[221],"correlates":[224],"expression":[227],"proangiogenic":[230],"genes.":[231],"Overall,":[232],"transplantability,":[237],"slower":[238],"(relative":[242],"rapid":[245],"rates":[247],"other":[249],"mouse":[251],"tumors),":[253],"metastases,":[257],"may":[260],"make":[261],"valuable":[264],"study":[268],"therapeutic":[271],"strategies":[272],"based":[273],"on":[274],"antineovascular":[275],"agents":[276],"antitumor":[278],"cytokines.":[279]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}