{"id":"https://openalex.org/W2132741464","doi":"https://doi.org/10.1055/s-2007-965164","title":"CART-Peptide Immunoreactivity in Enteric Nerves in Patients with Hirschsprung's Disease","display_name":"CART-Peptide Immunoreactivity in Enteric Nerves in Patients with Hirschsprung's Disease","publication_year":2007,"publication_date":"2007-06-01","ids":{"openalex":"https://openalex.org/W2132741464","doi":"https://doi.org/10.1055/s-2007-965164","mag":"2132741464","pmid":"https://pubmed.ncbi.nlm.nih.gov/17638157"},"language":"en","primary_location":{"id":"doi:10.1055/s-2007-965164","doi":"https://doi.org/10.1055/s-2007-965164","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-965164","pdf_url":null,"source":{"id":"https://openalex.org/S42576627","display_name":"European Journal of Pediatric Surgery","issn_l":"0174-3082","issn":["0174-3082","0939-7248","1439-359X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pediatric Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102728749","display_name":"Anna Gunnarsd\u00f3ttir","orcid":"https://orcid.org/0009-0004-1145-6668","observed_orcids":["https://orcid.org/0009-0004-1145-6668"]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A. Gunnarsd\u00f3ttir","raw_affiliation_strings":["Department of Pediatric Surgery, Lund University Hospital, Lund, Sweden. Anna.Gunnarsdottir@med.lu.se","Department of Pediatric Surgery, Lund University Hospital, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Lund University Hospital, Lund, Sweden. Anna.Gunnarsdottir@med.lu.se","institution_ids":["https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Department of Pediatric Surgery, Lund University Hospital, Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068418631","display_name":"Nils Wierup","orcid":"https://orcid.org/0000-0001-6824-4093","observed_orcids":["https://orcid.org/0000-0001-6824-4093"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"N. Wierup","raw_affiliation_strings":["Department of Experimental Medical Science, Lund University, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medical Science, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059674225","display_name":"Lars Larsson","orcid":"https://orcid.org/0000-0003-3722-035X","observed_orcids":["https://orcid.org/0000-0003-3722-035X"]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"L. Larsson","raw_affiliation_strings":["Department of Pediatric Surgery, Lund University Hospital, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Lund University Hospital, Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104070676","display_name":"Michael J. Kuhar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4392738091","display_name":"Emory National Primate Research Center","ror":"https://ror.org/038kr2d80","country_code":"US","type":"facility","lineage":["https://openalex.org/I150468666","https://openalex.org/I4392738091"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Kuhar","raw_affiliation_strings":["Yerkes National Primate Research Center of Emory University, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yerkes National Primate Research Center of Emory University, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4392738091"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021879068","display_name":"Eva Ekblad","orcid":"https://orcid.org/0000-0003-3733-2941","observed_orcids":["https://orcid.org/0000-0003-3733-2941"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"E. Ekblad","raw_affiliation_strings":["Department of Experimental Medical Science, Lund University, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medical Science, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7521,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.84891961,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"17","issue":"3","first_page":"184","last_page":"189"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cocaine-and-amphetamine-regulated-transcript","display_name":"cocaine- and amphetamine-regulated transcript","score":0.800000011920929},{"id":"https://openalex.org/keywords/cart","display_name":"CART","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hirschsprung-disease","display_name":"Hirschsprung disease","score":0.9710000157356262},{"id":"https://openalex.org/keywords/enteric-nervous-system","display_name":"enteric nervous system","score":0.9300000071525574},{"id":"https://openalex.org/keywords/myenteric-neurons","display_name":"myenteric neurons","score":0.9309999942779541},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.8920000195503235},{"id":"https://openalex.org/keywords/vasoactive-intestinal-peptide","display_name":"vasoactive intestinal peptide","score":0.9729999899864197},{"id":"https://openalex.org/keywords/neurotransmitter-co-localization","display_name":"neurotransmitter co-localization","score":0.8939999938011169},{"id":"https://openalex.org/keywords/intestinal-innervation","display_name":"intestinal innervation","score":0.5690000057220459},{"id":"https://openalex.org/keywords/neurotrophic-peptides","display_name":"neurotrophic peptides","score":0.5699999928474426},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"neuromodulation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/feeding-behavior","display_name":"feeding behavior","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C2777275308","wikidata":"https://www.wikidata.org/wiki/Q234668","display_name":"Cart","level":2,"score":0.9129144549369812},{"id":"https://openalex.org/C2780278141","wikidata":"https://www.wikidata.org/wiki/Q24776026","display_name":"Cocaine and amphetamine regulated transcript","level":4,"score":0.8257721662521362},{"id":"https://openalex.org/C8330315","wikidata":"https://www.wikidata.org/wiki/Q414964","display_name":"Vasoactive intestinal peptide","level":4,"score":0.8202147483825684},{"id":"https://openalex.org/C2777439022","wikidata":"https://www.wikidata.org/wiki/Q586582","display_name":"Enteric nervous system","level":2,"score":0.765068531036377},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.6049551367759705},{"id":"https://openalex.org/C2779089422","wikidata":"https://www.wikidata.org/wiki/Q1343645","display_name":"Hirschsprung's disease","level":3,"score":0.5955690145492554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5568881630897522},{"id":"https://openalex.org/C2776907353","wikidata":"https://www.wikidata.org/wiki/Q1890233","display_name":"Myenteric plexus","level":3,"score":0.4956153631210327},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.45563286542892456},{"id":"https://openalex.org/C2776280935","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Large intestine","level":2,"score":0.4538794755935669},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.4431285262107849},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4167957305908203},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.41039279103279114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36710408329963684},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.27597498893737793},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09877705574035645},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.053297340869903564},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000098882","descriptor_name":"Cocaine- and Amphetamine-Regulated Transcript Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000888","descriptor_name":"Antibodies, Anti-Idiotypic","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006627","descriptor_name":"Hirschsprung Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006627","descriptor_name":"Hirschsprung Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014660","descriptor_name":"Vasoactive Intestinal Peptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017615","descriptor_name":"Enteric Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1055/s-2007-965164","doi":"https://doi.org/10.1055/s-2007-965164","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-965164","pdf_url":null,"source":{"id":"https://openalex.org/S42576627","display_name":"European Journal of Pediatric Surgery","issn_l":"0174-3082","issn":["0174-3082","0939-7248","1439-359X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pediatric Surgery","raw_type":"journal-article"},{"id":"pmid:17638157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17638157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie","raw_type":"Journal Article"},{"id":"pmh:oai:lup.lub.lu.se:e3591811-0735-486e-b68e-c7dd61d6278f","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/688101","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1439-359X","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2091850453","https://openalex.org/W2322513295","https://openalex.org/W2168773316","https://openalex.org/W2055493327","https://openalex.org/W2061089414","https://openalex.org/W2141189426","https://openalex.org/W2044533939","https://openalex.org/W2410615484","https://openalex.org/W2324020217","https://openalex.org/W2027606590"],"abstract_inverted_index":{"Aims:":[0],"Cocaine-":[1],"and":[2,11,28,66,103,124,139,150,209,219,226],"amphetamine-regulated":[3],"transcript":[4],"(CART)-peptide":[5],"is":[6,20,29,163],"found":[7,113,156,195],"in":[8,13,23,37,52,93,101,114,125,157,172,184,196,828,840,895],"the":[9,14,24,48,53,67,97,120,158,164,168,173,177,197,203,216],"brain":[10],"participates":[12],"control":[15],"of":[16,42,50,99,133,135,170,205,215],"feeding":[17],"behavior.":[18],"It":[19],"also":[21],"expressed":[22],"peripheral":[25],"nervous":[26],"system":[27],"suggested":[30],"to":[31,46,95],"have":[32],"neuromodulatory":[33],"and/or":[34],"neurotrophic":[35],"effects":[36],"rat":[38],"intestine.":[39,160,175,199],"The":[40],"aims":[41],"this":[43],"study":[44],"were":[45,83,155,194],"investigate":[47],"presence":[49,98,169],"CART-peptide":[51,100,111,171,406],"normal":[54],"ganglionic":[55,109,178],"as":[56,58],"well":[57],"aganglionic":[59,159,198],"intestine":[60,179],"from":[61,77],"patients":[62,79,235,306,318],"with":[63,71,80,137,202,207],"Hirschsprung's":[64,81],"disease":[65,82],"peptide's":[68],"possible":[69,271],"coexistence":[70,204],"other":[72],"neurotransmitters.":[73],"Methods:":[74],"Intestinal":[75],"specimens":[76],"nine":[78],"examined":[84],"using":[85],"immunohistochemistry.":[86],"A":[87,130],"double":[88,333],"immunostaining":[89],"technique":[90,331],"was":[91,112,141,181],"used":[92],"order":[94],"elucidate":[96],"NOS":[102,138,208,373,444,464,591,920],"VIP-containing":[104],"enteric":[105],"neurons.":[106],"Results:":[107],"In":[108,176,846],"intestine,":[110],"numerous":[115],"nerve":[116,127,148,152,192],"fibers,":[117],"predominantly":[118],"within":[119],"smooth":[121],"muscle":[122],"layers":[123],"myenteric":[126,185],"cell":[128,153],"bodies.":[129],"high":[131],"degree":[132],"co-localization":[134],"CART":[136,146,180,206,222,371,384,414,429,442,453,457,539,586,602,627,660,682,696,700,853,868,936],"VIP":[140,375,629,684,707,942],"seen.":[142],"Only":[143],"very":[144,189],"few":[145,190],"immunoreactive":[147],"fibers":[149,193],"no":[151],"bodies":[154],"Conclusions:":[161],"This":[162],"first":[165],"report":[166],"on":[167],"human":[174],"detected":[182],"mainly":[183],"neurons,":[186],"while":[187],"only":[188],"CART\u2010IR":[191],"This,":[200],"together":[201],"VIP,":[210,446,922],"indicates":[211],"an":[212,733],"intrinsic":[213],"origin":[214],"CART-containing":[217],"neurons":[218],"suggests":[220],"that":[221],"may":[223],"influence":[224],"NO":[225,940],"VIP-induced":[227],"effects.":[228],"CART-Peptide":[229,827,893],"immuno-r\u00e9activit\u00e9":[230],"dans":[231,249,263,294,302,350,356,362,393,407,418,433],"l'innervation":[232],"ent\u00e9rique":[233],"des":[234,305,450,843,898],"avec":[236,307,319,372,438,443],"maladie":[237,309,321],"de":[238,281,285,292,310,316,322,332,341,351,370,381,402,405,426,441,463,466,477,481,526,530,537,546,550,565,567,580,584,624,626,655,658,669,681,691,706],"Hirschsprung":[239,323,482,551,718,781,800],"Buts:":[240],"Coca\u00efne":[241],"et":[242,252,268,361,374,386,445,454,465],"amph\u00e9tamine":[243],"transcrites":[244],"peptides":[245],"(CART)":[246,492,725],"est":[247,260,270,288,348,398,415],"trouv\u00e9":[248,349],"le":[250,264],"cerveau":[251],"participe":[253],"au":[254],"contr\u00f4le":[255],"du":[256],"comportement":[257],"alimentaire.":[258],"Il":[259],"aussi":[261,299],"exprim\u00e9":[262],"syst\u00e8me":[265],"nerveux":[266],"p\u00e9riph\u00e9rique":[267],"il":[269],"qu'il":[272],"ait":[273,458],"un":[274,621],"r\u00f4le":[275],"neuro-modulateur":[276],"et/ou":[277],"neuro-trophique":[278],"pour":[279,337],"l'intestin":[280,303,345,394,408,434],"rat.":[282],"Le":[283],"but":[284],"cette":[286],"\u00e9tude":[287],"d'appr\u00e9cier":[289],"la":[290,295,339,399,403,439,501,535,582,648,656,679],"pr\u00e9sence":[291,340,404],"CART-peptides":[293],"cellule":[296,388],"ganglionnaire":[297],"normale,":[298],"bien":[300],"que":[301,423,456,517,651,694,699],"aganglionnaire":[304],"une":[308,320,328],"Hirschsprung.":[311,570],"M\u00e9thodes:":[312],"Des":[313],"fragments":[314],"intestinaux":[315],"9":[317,563,796],"\u00e9taient":[324],"examin\u00e9s":[325],"en":[326,472,495,500,509,523,540,587,603,613,661,673],"utilisant":[327],"immuno-histochimie.":[329],"Une":[330,367],"coloration":[334],"\u00e9tait":[335],"utilis\u00e9e":[336],"appr\u00e9cier":[338],"CART-peptide.":[342],"R\u00e9sultats:":[343],"Dans":[344,410],"ganglionnaire,":[346],"CART6-peptide":[347],"nombreuses":[352],"fibres":[353,382,427],"nerveux,":[354],"pr\u00e9dominant":[355],"les":[357,363,411,419,460],"plans":[358],"musculaires":[359],"lisses":[360],"cellules":[364,412],"nerveuses":[365,383,428],"myent\u00e9riques.":[366],"importante":[368],"colocalisation":[369],"sont":[376,391,431],"vues.":[377],"Seulement":[378],"tr\u00e8s":[379,424],"peu":[380,425],"immuno-r\u00e9actives":[385],"aucune":[387],"nerveuse":[389],"ne":[390],"retrouv\u00e9es":[392,432],"aganglionnaire.":[395,435],"Conclusion:":[396],"Ceci":[397],"premi\u00e8re":[400],"publication":[401],"humain.":[409],"ganglionnaires,":[413],"d\u00e9tect\u00e9e":[416],"principalement":[417],"neurones":[420,451],"myent\u00e9riques":[421],"alors":[422],"positives":[430],"Ceci,":[436],"associ\u00e9":[437],"co-existence":[440],"indique":[447],"l'origine":[448],"intrins\u00e8que":[449],"contenant":[452],"sugg\u00e8re":[455],"influenc\u00e9":[459],"effets":[461],"induits":[462],"VIP.":[467,593],"Inmunorreactividad":[468],"a":[469,678],"p\u00e9ptido":[470,485,538,585,601,659],"cart":[471],"el":[473,496,510,524,541,578,596,633,674,688],"sistema":[474,511],"nervioso":[475,512],"ent\u00e9rico":[476],"pacientes":[478,547,568],"con":[479,548,556,569,577,628,683],"enfermedad":[480,549],"Objetivos:":[483],"El":[484],"transcripto":[486],"regulado":[487],"por":[488],"cocaina":[489],"y":[490,498,514,544,552,592,612,630,640,668,685,697,708],"anfetamina":[491],"se":[493,507,515,599,652],"encuentra":[494],"cerebro":[497],"participa":[499],"regulaci\u00f3n":[502],"del":[503,616,665],"comportamiento":[504],"alimentario.":[505],"Tambi\u00e9n":[506],"expresa":[508],"perif\u00e9rico":[513],"sugiere":[516,698],"tiene":[518],"efectos":[519,704],"neuromodulatorios":[520],"y/o":[521],"neurotr\u00f3ficos":[522],"intestino":[525,542,566,597,634],"rata.":[527],"Los":[528],"objetivos":[529],"este":[531],"estudio":[532],"fueron":[533],"investigar":[534],"presencia":[536,583,657],"gangli\u00f3nico":[543,598,667],"agangli\u00f3nico":[545,635],"su":[553,670],"posible":[554],"coexistencia":[555,680],"otros":[557],"neurotransmisores.":[558],"M\u00e9todos:":[559],"Se":[560,571,619],"examinaron":[561],"inmunohistoqu\u00edmicamente":[562],"espec\u00edmenes":[564],"us\u00f3":[572],"una":[573],"t\u00e9cnica":[574],"inmunohistoqu\u00edmica":[575],"doble":[576],"fin":[579],"elucidar":[581],"neuronas":[588,615,663,693],"positivas":[589],"para":[590],"Resultados:":[594],"En":[595,632],"hall\u00f3":[600],"numerosas":[604],"fibras":[605,639],"nerviosas":[606],"predominantemente":[607],"enntre":[608],"las":[609,614,662,692],"capas":[610],"musculares":[611],"plexo":[617],"mient\u00e9rico.":[618],"observ\u00f3":[620],"alto":[622],"grado":[623],"colocalizaci\u00f3n":[625],"NOS.":[631,709],"hubo":[636],"muy":[637],"pocas":[638],"casi":[641],"ninguna":[642],"c\u00e9lula":[643],"positivas.":[644],"Conclusiones:":[645],"Esta":[646],"es":[647,747],"primera":[649],"vez":[650],"presenta":[653],"evidencia":[654],"mient\u00e9ricas":[664],"colon":[666],"escasa":[671],"positividad":[672],"agangli\u00f3nico.":[675],"Esto,":[676],"junto":[677],"NOS,":[686],"indica":[687],"origen":[689],"intr\u00ednseco":[690],"contienen":[695],"podr\u00eda":[701],"influenciar":[702],"los":[703],"dependientes":[705],"CART-Peptid-Immunreaktion":[710],"im":[711,727,740,752,769,774,885,903],"enteralen":[712],"Nervensystem":[713,742],"von":[714,767,777,795,814,852,883,919,939],"Patienten":[715,778,797],"mit":[716,779,788,798,915],"Morbus":[717,780,799],"Zielsetzung:":[719],"Kokain-":[720],"und":[721,746,783,816,839,854,871,921,932,941],"Amphetamin-":[722],"regulierte":[723],"Transkriptpeptide":[724],"sind":[726,732],"Gehirn":[728],"nachgewiesen":[729],"worden.":[730],"Sie":[731],"der":[734,736,877,928],"Kontrolle":[735],"Ern\u00e4hrungsmodulation":[737],"beteiligt.":[738],"Auch":[739],"peripheren":[741],"werden":[743],"sie":[744,751],"freigesetzt,":[745],"wird":[748],"vermutet,":[749],"dass":[750,935],"Rattendarm":[753],"eine":[754,806,850],"neuromodulatorische-":[755],"und/oder":[756],"neurotrophe":[757],"Wirkung":[758,938],"haben.":[759],"Ziel":[760],"dieser":[761],"Studie":[762],"war":[763],"es,":[764],"die":[765,811,881,892,937],"Anwesenheit":[766,813,882],"CART-Peptiden":[768,815,884],"ganglion\u00e4ren,":[770],"normalen":[771],"wie":[772],"auch":[773],"aganglion\u00e4ren":[775,861,904],"Darm":[776,825,862,890,905],"nachzuweisen":[782],"dar\u00fcber":[784],"hinaus":[785],"ihre":[786],"Koexistenz":[787],"anderen":[789],"Neurotransmittern":[790],"zu":[791],"\u00fcberpr\u00fcfen.":[792],"Methodik:":[793],"Proben":[794],"wurden":[801,891],"immunhistochemisch":[802],"untersucht.":[803],"Dabei":[804],"wurde":[805,849],"doppelte":[807],"F\u00e4rbetechnik":[808],"angewandt,":[809],"um":[810],"gleichzeitige":[812],"NOS-":[817,855],"sowie":[818,856],"VIP-haltigen":[819,857],"Neuronen":[820,858,897],"nachzuweisen.":[821],"Ergebnisse:":[822],"Im":[823,860,888],"ganglion\u00e4ren":[824,889],"waren":[826],"zahlreichen":[829],"neuronalen":[830],"Fasern":[831,870,909],"nachweisbar,":[832],"vor":[833],"allem":[834],"zwischen":[835],"den":[836,841,896],"glatten":[837],"Muskelschichten":[838],"Zellk\u00f6rpern":[842],"Plexus":[844,899],"myentericus.":[845],"hohem":[847],"Ma\u00dfe":[848],"Ko-Konzentration":[851],"beobachtet.":[859],"hingegen,":[863],"fanden":[864],"sich":[865],"nur":[866,906],"wenige":[867,907],"immunoreaktive":[869],"keine":[872],"Nervenzellen.":[873],"Schlussfolgerungen:":[874],"Dies":[875],"ist":[876],"erste":[878],"Bericht":[879],"\u00fcber":[880],"menschlichen":[886],"Darm.":[887],"vorwiegend":[894],"myentericus":[900],"beobachtet,":[901],"w\u00e4hrend":[902],"CART-IR-positive":[908],"gefunden":[910],"wurden.":[911],"Diese":[912],"Befunde,":[913],"gemeinsam":[914],"dem":[916],"gleichzeitigen":[917],"Vorkommen":[918],"weisen":[923],"auf":[924],"einen":[925],"intrinsischen":[926],"Ursprung":[927],"CART-haltigen":[929],"Neurone":[930],"hin":[931],"lassen":[933],"vermuten,":[934],"beeinflusst.":[943]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
