{"id":"https://openalex.org/W2132728360","doi":"https://doi.org/10.1111/j.1600-0773.1990.tb00818.x","title":"Effect of Chlordecone (Kepone\u00ae) on Calcium Transport Mechanisms in Rat Heart Sarcoplasmic Reticulum*","display_name":"Effect of Chlordecone (Kepone\u00ae) on Calcium Transport Mechanisms in Rat Heart Sarcoplasmic Reticulum*","publication_year":1990,"publication_date":"1990-09-01","ids":{"openalex":"https://openalex.org/W2132728360","doi":"https://doi.org/10.1111/j.1600-0773.1990.tb00818.x","mag":"2132728360","pmid":"https://pubmed.ncbi.nlm.nih.gov/1701552"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0773.1990.tb00818.x","doi":"https://doi.org/10.1111/j.1600-0773.1990.tb00818.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0773.1990.tb00818.x","pdf_url":null,"source":{"id":"https://openalex.org/S62051601","display_name":"Pharmacology & Toxicology","issn_l":"0901-9928","issn":["0901-9928","1600-0773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062746470","display_name":"Prasada Rao S. Kodavanti","orcid":"https://orcid.org/0000-0002-4593-4654","observed_orcids":["https://orcid.org/0000-0002-4593-4654"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prasada Rao S. Kodavanti","raw_affiliation_strings":["Department of Neurology, University of Mississippi Medical Center, Jackson 39216"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Mississippi Medical Center, Jackson 39216","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112187613","display_name":"Joseph A. Cameron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61937129","display_name":"Jackson State University","ror":"https://ror.org/01ecnnp60","country_code":"US","type":"education","lineage":["https://openalex.org/I4210141039","https://openalex.org/I61937129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. Cameron","raw_affiliation_strings":["Department of Biology, Jackson State University, Jackson, MS 39217, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Jackson State University, Jackson, MS 39217, U.S.A","institution_ids":["https://openalex.org/I61937129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006880829","display_name":"Prabhakara Rao Yallapragada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prabhakara R. Yallapragada","raw_affiliation_strings":["Department of Neurology, University of Mississippi Medical Center, Jackson, MS 39216"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Mississippi Medical Center, Jackson, MS 39216","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007350826","display_name":"Durisala Desaiah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Durisala Desaiah","raw_affiliation_strings":["Department of Neurology, University of Mississippi Medical Center, Jackson, MS 39216"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Mississippi Medical Center, Jackson, MS 39216","institution_ids":["https://openalex.org/I29606459"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007350826"],"corresponding_institution_ids":["https://openalex.org/I29606459"],"apc_list":null,"apc_paid":null,"fwci":0.7567,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.749981,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"67","issue":"3","first_page":"227","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.6327999830245972,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.6327999830245972,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.32179999351501465,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chlordecone","display_name":"chlordecone","score":0.996999979019165},{"id":"https://openalex.org/keywords/kepone","display_name":"kepone","score":0.8759999871253967},{"id":"https://openalex.org/keywords/organochlorine-insecticides","display_name":"organochlorine insecticides","score":0.7720000147819519},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-calcium-pump","display_name":"sarcoplasmic reticulum calcium pump","score":0.8790000081062317},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-ca2-atpase","display_name":"sarcoplasmic reticulum Ca2+-ATPase","score":0.9150000214576721},{"id":"https://openalex.org/keywords/calcium-uptake","display_name":"calcium uptake","score":0.5740000009536743},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.5619999766349792},{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":0.972000002861023},{"id":"https://openalex.org/keywords/cardiac-ventricle","display_name":"cardiac ventricle","score":0.4959999918937683},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.71909499168396},{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.6773641705513},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6696659326553345},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5976459383964539},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.5320742130279541},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.5203627943992615},{"id":"https://openalex.org/C935647","wikidata":"https://www.wikidata.org/wiki/Q17113155","display_name":"Calcium pump","level":4,"score":0.5065692663192749},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.49306580424308777},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48281392455101013},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4728394150733948},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.4149101972579956},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.39621302485466003},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30917972326278687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19184094667434692},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08572983741760254},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07675245404243469},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007631","descriptor_name":"Chlordecone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007631","descriptor_name":"Chlordecone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0773.1990.tb00818.x","doi":"https://doi.org/10.1111/j.1600-0773.1990.tb00818.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0773.1990.tb00818.x","pdf_url":null,"source":{"id":"https://openalex.org/S62051601","display_name":"Pharmacology & Toxicology","issn_l":"0901-9928","issn":["0901-9928","1600-0773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & Toxicology","raw_type":"journal-article"},{"id":"pmid:1701552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1701552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & toxicology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7547231838","display_name":"MINORITY INSTITUTIONAL RESEARCH TRAINING PROGRAM","funder_award_id":"T32HL007635","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W51702200","https://openalex.org/W123307320","https://openalex.org/W165415374","https://openalex.org/W1484714673","https://openalex.org/W1494422769","https://openalex.org/W1500339793","https://openalex.org/W1520266592","https://openalex.org/W1530579275","https://openalex.org/W1539133138","https://openalex.org/W1549216145","https://openalex.org/W1558794683","https://openalex.org/W1560203482","https://openalex.org/W1567439646","https://openalex.org/W1593848800","https://openalex.org/W1604513294","https://openalex.org/W1968709125","https://openalex.org/W1981236562","https://openalex.org/W1991141881","https://openalex.org/W1999184836","https://openalex.org/W2003946902","https://openalex.org/W2020708214","https://openalex.org/W2021697019","https://openalex.org/W2023229013","https://openalex.org/W2025858757","https://openalex.org/W2030197700","https://openalex.org/W2032829150","https://openalex.org/W2033468971","https://openalex.org/W2034511449","https://openalex.org/W2035182168","https://openalex.org/W2044390013","https://openalex.org/W2078754490","https://openalex.org/W2088658487","https://openalex.org/W2089166356","https://openalex.org/W2093476998","https://openalex.org/W2106653715","https://openalex.org/W2109366031","https://openalex.org/W2124664502","https://openalex.org/W2130533639","https://openalex.org/W2137412766","https://openalex.org/W2162025110","https://openalex.org/W2167973356","https://openalex.org/W2171392062","https://openalex.org/W2332498135","https://openalex.org/W2414667432"],"related_works":["https://openalex.org/W1998357118","https://openalex.org/W2414667432","https://openalex.org/W2026512472","https://openalex.org/W2137412766","https://openalex.org/W2291945262","https://openalex.org/W2092183696","https://openalex.org/W1984743670","https://openalex.org/W1997734459","https://openalex.org/W2015849994","https://openalex.org/W1995280708"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"from":[2,79,287,297],"our":[3],"laboratory":[4],"have":[5,56],"indicated":[6,307],"that":[7,23,341],"chlordecone":[8],"(Kepone\u00ae,":[9],"CD),":[10],"an":[11,36,137],"organochlorine":[12],"insecticide,":[13],"inhibited":[14,127,148,174],"cardiac":[15,28,51,61,196,268,363],"sodium":[16],"pump":[17,34,64],"activity":[18,115],"and":[19,42,73,90,108,118,143,160,187,193,320],"catecholamine":[20],"uptake":[21],"suggesting":[22],"CD":[24,48,58,124,176,205,330,342],"may":[25,344],"interfere":[26],"with":[27,50,136,155,182,204,248,261,280],"function.":[29],"Sarcoplasmic":[30],"reticulum":[31],"(SR)":[32],"calcium":[33,63,348],"has":[35],"important":[37],"role":[38],"in":[39,71,74,125,131,167,177,201,228,249,258,300,309,326,331,336,361],"myocardial":[40],"contraction":[41],"relaxation,":[43],"besides":[44],"Na+":[45,52],"transport.":[46],"Since":[47],"interferes":[49],"ion":[53],"translocases,":[54],"we":[55],"studied":[57],"effects":[59],"on":[60],"SR":[62,76,87,130,144,197,226,269,347],"activity.":[65],"Experiments":[66],"were":[67,100,172,198],"carried":[68],"out":[69],"both":[70,157],"vitro":[72,126,229,250,332],"vivo.":[75,337],"was":[77,103,146,240,255],"isolated":[78],"heart":[80],"ventricles":[81],"of":[82,140,185,236,266,273,303,354,357],"male":[83],"Sprague\u2010Dawley":[84],"rats.":[85,215],"Cardiac":[86],"Ca2+\u2010ATPase,":[88],"45Ca\u2010uptake":[89,128,145,194],"cAMP":[91,216,304],"as":[92,94,217,219,333,335],"well":[93,218,334],"calmodulin":[95],"(CaM)":[96],"dependent":[97,134,180],"protein":[98],"phosphorylation":[99,353],"measured.":[101],"Ca2+\u2010ATPase":[102,192],"differentiated":[104],"into":[105],"low":[106,161],"affinity":[107,110,159,162],"high":[109,158],"forms":[111],"by":[112,129,175,195,329,351],"measuring":[113],"the":[114,223,234,267,271,301],"using":[116,292],"50":[117,207],"0.7":[119,186],"\u03bcM":[120,142,151,189],"free":[121],"Ca2+":[122,168],"respectively.":[123,190],"a":[132,178,355],"concentration":[133,179,244],"manner":[135,181],"IC50":[138,183],"value":[139],"7":[141,310],"totally":[147],"at":[149,274],"20\u201330":[150],"CD.":[152,262],"In":[153,233,246],"agreement":[154,247],"this,":[156],"Ca2+\u2010ATPases,":[163],"which":[164],"are":[165],"involved":[166],"transport":[169,349],"across":[170],"membranes,":[171],"also":[173],"values":[184],"3.2":[188],"Both":[191],"significantly":[199,221,256],"lower":[200,322],"rats":[202,259],"treated":[203,260],"(25,":[206],"or":[208,305],"75":[209],"mg/kg)":[210],"when":[211],"compared":[212],"to":[213,225,230,253,283,289,316],"control":[214],"CaM":[220,306],"elevated":[222],"32P\u2010binding":[224,239],"proteins":[227,254,358],"about":[231,317],"70\u201380%.":[232],"presence":[235,272,302],"CD,":[237],"this":[238],"reduced,":[241],"however,":[242],"not":[243],"dependent.":[245],"studies,":[251],"32P\u2010bound":[252],"lowered":[257],"SDS\u2010polyacrylamide":[263],"gel":[264],"electrophoresis":[265],"revealed":[270],"least":[275],"30":[276],"comassie":[277],"blue\u2010stainable":[278],"bands":[279,314],"mobilities":[281],"corresponding":[282,315],"molecular":[284,323],"weights":[285,324],"ranging":[286],"9":[288],"120":[290],"kDa":[291,319],"15%":[293],"acrylamide":[294],"gels.":[295],"Autoradiographs":[296],"samples":[298],"incubated":[299],"32P\u2010incorporation":[308],"bands.":[311],"Of":[312],"these,":[313],"24":[318],"adjacent":[321],"decreased":[325],"their":[327],"intensity":[328],"These":[338],"results":[339],"indicate":[340],"treatment":[343],"be":[345],"reducing":[346],"mechanisms":[350],"altering":[352],"number":[356],"including":[359],"phospholamban":[360],"rat":[362],"SR.":[364]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}