{"id":"https://openalex.org/W2132654064","doi":"https://doi.org/10.1038/oby.2005.138","title":"Troglitazone\u2010Induced Changes in Adiponectin Do Not Affect Endothelial Function in Diabetes","display_name":"Troglitazone\u2010Induced Changes in Adiponectin Do Not Affect Endothelial Function in Diabetes","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W2132654064","doi":"https://doi.org/10.1038/oby.2005.138","mag":"2132654064","pmid":"https://pubmed.ncbi.nlm.nih.gov/16076985"},"language":"en","primary_location":{"id":"doi:10.1038/oby.2005.138","doi":"https://doi.org/10.1038/oby.2005.138","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oby.2005.138","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2005.138","source":{"id":"https://openalex.org/S68541908","display_name":"Obesity Research","issn_l":"1071-7323","issn":["1071-7323","1550-8528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2005.138","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040827726","display_name":"Jon A. Buras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon Buras","raw_affiliation_strings":["Microcirculation Laboratory, Palmer 317, West Campus, Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microcirculation Laboratory, Palmer 317, West Campus, Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040701391","display_name":"Wende R. Reenstra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wende R. Reenstra","raw_affiliation_strings":["Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066959834","display_name":"Daniel Orlow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Orlow","raw_affiliation_strings":["Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069336249","display_name":"Edward S. Horton","orcid":"https://orcid.org/0000-0002-5670-3157","observed_orcids":["https://orcid.org/0000-0002-5670-3157"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward S. Horton","raw_affiliation_strings":["Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048728346","display_name":"Aristidis Veves","orcid":"https://orcid.org/0000-0002-3901-4405","observed_orcids":["https://orcid.org/0000-0002-3901-4405"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aristidis Veves","raw_affiliation_strings":["Microcirculation Laboratory, Beth Israel Deaconess Medical Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microcirculation Laboratory, Beth Israel Deaconess Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048728346"],"corresponding_institution_ids":["https://openalex.org/I1316535847"],"apc_list":null,"apc_paid":null,"fwci":1.4336,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.82840565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"13","issue":"7","first_page":"1167","last_page":"1174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.6913999915122986,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.6913999915122986,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.218299999833107,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/troglitazone","display_name":"troglitazone","score":0.9620000123977661},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.9959999918937683},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8849999904632568},{"id":"https://openalex.org/keywords/endothelium-dependent-vasodilation","display_name":"endothelium-dependent vasodilation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/flow-mediated-dilation","display_name":"flow-mediated dilation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/nitroglycerin-induced-dilation","display_name":"nitroglycerin-induced dilation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/receptor-for-advanced-glycation-end-products","display_name":"receptor for advanced glycation end products","score":0.8690000176429749},{"id":"https://openalex.org/keywords/skin-microcirculation","display_name":"skin microcirculation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/vascular-reactivity","display_name":"vascular reactivity","score":0.6919999718666077},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.6029999852180481},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8220000267028809},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2778150266","wikidata":"https://www.wikidata.org/wiki/Q7844989","display_name":"Troglitazone","level":4,"score":0.8558138608932495},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.8069093227386475},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7748116254806519},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7173758745193481},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7013490200042725},{"id":"https://openalex.org/C2777604165","wikidata":"https://www.wikidata.org/wiki/Q503643","display_name":"Brachial artery","level":3,"score":0.6528805494308472},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.600272536277771},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5928765535354614},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.5563835501670837},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.44618740677833557},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.38290777802467346},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2611001431941986},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.21335089206695557},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.21173930168151855},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0722309947013855}],"mesh":[{"descriptor_ui":"D000077288","descriptor_name":"Troglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001916","descriptor_name":"Brachial Artery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002839","descriptor_name":"Chromans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002839","descriptor_name":"Chromans","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/oby.2005.138","doi":"https://doi.org/10.1038/oby.2005.138","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oby.2005.138","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2005.138","source":{"id":"https://openalex.org/S68541908","display_name":"Obesity Research","issn_l":"1071-7323","issn":["1071-7323","1550-8528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity Research","raw_type":"journal-article"},{"id":"pmid:16076985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16076985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity research","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1038/oby.2005.138","doi":"https://doi.org/10.1038/oby.2005.138","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oby.2005.138","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2005.138","source":{"id":"https://openalex.org/S68541908","display_name":"Obesity Research","issn_l":"1071-7323","issn":["1071-7323","1550-8528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1521345354","display_name":null,"funder_award_id":"RR 01032","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2872377240","display_name":"General Clinical Research Center","funder_award_id":"M01RR001032","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2132654064.pdf","grobid_xml":"https://content.openalex.org/works/W2132654064.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1587875569","https://openalex.org/W1968580611","https://openalex.org/W1977188464","https://openalex.org/W1981261500","https://openalex.org/W1983128420","https://openalex.org/W1998393556","https://openalex.org/W2001727439","https://openalex.org/W2014877159","https://openalex.org/W2030652589","https://openalex.org/W2049965571","https://openalex.org/W2055378578","https://openalex.org/W2065697164","https://openalex.org/W2096478205","https://openalex.org/W2106697731","https://openalex.org/W2110871895","https://openalex.org/W2120590109","https://openalex.org/W2120977310","https://openalex.org/W2125344994","https://openalex.org/W2131379009","https://openalex.org/W2131541226","https://openalex.org/W2133545915","https://openalex.org/W2135298791","https://openalex.org/W2138599787","https://openalex.org/W2141608973","https://openalex.org/W2144046733","https://openalex.org/W2144725045","https://openalex.org/W2146753738","https://openalex.org/W2157441872","https://openalex.org/W2159316372","https://openalex.org/W2165391345","https://openalex.org/W2320006945"],"related_works":["https://openalex.org/W2141608973","https://openalex.org/W2080167189","https://openalex.org/W2159316372","https://openalex.org/W2083020826","https://openalex.org/W1994269792","https://openalex.org/W1975282928","https://openalex.org/W2166538701","https://openalex.org/W2165391345","https://openalex.org/W175196014","https://openalex.org/W2147836930"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Adiponectin":[1],"has":[2],"been":[3],"proposed":[4],"to":[5,8,54,74],"be":[6],"related":[7],"endothelial":[9,116,220],"function.":[10,221],"We":[11],"have":[12],"examined":[13],"the":[14,17,56,65,76,80,93,102,124,127,138,148,151,155,208,231],"relationship":[15],"between":[16,147],"increase":[18,91,194],"in":[19,31,43,79,87,92,101,123,133,150,157,195,207,230],"adiponectin":[20,94,152,196,213],"levels":[21,153,197],"that":[22,212],"is":[23,201,214,234],"associated":[24,203],"with":[25,204],"troglitazone":[26,145,199,238],"treatment":[27,85,146,200],"and":[28,60,154,183],"endothelium-dependent":[29,103,209],"vasodilation":[30],"type":[32],"2":[33],"diabetic":[34],"patients.":[35],"RESEARCH":[36],"METHODS":[37],"AND":[38],"PROCEDURES:":[39],"Seventy-two":[40],"patients":[41],"participated":[42],"this":[44],"randomized,":[45],"placebo-controlled,":[46],"double-blinded":[47],"study.":[48],"High-resolution":[49],"ultrasound":[50],"images":[51],"were":[52,99,121,142],"used":[53],"measure":[55,75],"flow-mediated":[57],"dilation":[58,62],"(endothelium-dependent)":[59],"nitroglycerin-induced":[61],"(endothelium-independent)":[63],"of":[64,108,115,126,219],"brachial":[66],"artery.":[67],"Laser":[68],"Doppler":[69],"perfusion":[70],"imaging":[71],"was":[72],"employed":[73],"vascular":[77,109],"reactivity":[78],"forearm":[81],"skin.":[82],"RESULTS:":[83],"Troglitazone":[84],"resulted":[86],"an":[88,205],"average":[89],"75%":[90],"levels,":[95],"but":[96],"no":[97,119],"changes":[98,120,149,156],"observed":[100,122,143],"vasodilation,":[104,210],"any":[105,112],"other":[106,113],"measurement":[107],"reactivity,":[110],"or":[111],"markers":[114],"activation.":[117],"Also,":[118],"expression":[125,229],"receptor":[128,224],"for":[129,225],"advanced":[130,226],"glycation":[131,227],"end-products":[132,228],"skin":[134,232],"biopsies":[135],"taken":[136],"from":[137],"forearm.":[139],"Significant":[140],"correlations":[141],"during":[144],"fasting":[158],"plasma":[159],"glucose":[160],"(r":[161,169,177,186],"=":[162,170,178,187],"-0.29,":[163],"p":[164,172,180,189],"<":[165,173,181,190],"0.05),":[166,174,182],"hemoglobin":[167],"A(1c)":[168],"-0.30,":[171],"total":[175],"cholesterol":[176],"0.25,":[179],"low-density":[184],"lipoprotein-cholesterol":[185],"0.34,":[188],"0.01).":[191],"DISCUSSION:":[192],"The":[193],"after":[198],"not":[202,215,235],"improvement":[206],"indicating":[211],"a":[216],"major":[217],"determinant":[218],"In":[222],"addition,":[223],"microcirculation":[233],"affected":[236],"by":[237],"treatment.":[239]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}