{"id":"https://openalex.org/W2132492497","doi":"https://doi.org/10.1002/cne.903450302","title":"Cholinergic innervation in the human hippocampal formation including the entorhinal cortex","display_name":"Cholinergic innervation in the human hippocampal formation including the entorhinal cortex","publication_year":1994,"publication_date":"1994-07-15","ids":{"openalex":"https://openalex.org/W2132492497","doi":"https://doi.org/10.1002/cne.903450302","mag":"2132492497","pmid":"https://pubmed.ncbi.nlm.nih.gov/7929905"},"language":"en","primary_location":{"id":"doi:10.1002/cne.903450302","doi":"https://doi.org/10.1002/cne.903450302","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cne.903450302","pdf_url":null,"source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Comparative Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088038199","display_name":"Sonsoles De Lacalle","orcid":"https://orcid.org/0000-0001-9594-698X","observed_orcids":["https://orcid.org/0000-0001-9594-698X"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonsoles De Lacalle","raw_affiliation_strings":["Department of Neurology, Beth Israel Hospital, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Beth Israel Hospital, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chun Lim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chun Lim","raw_affiliation_strings":["Department of Neurology and Program in Neuroscience, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Program in Neuroscience, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063524610","display_name":"Teresa Sobreviela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Teresa Sobreviela","raw_affiliation_strings":["Department of Anatomy, University of Navarra, 31080 Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of Navarra, 31080 Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072527270","display_name":"Elliott Jay Mufson","orcid":"https://orcid.org/0000-0003-4438-7334","observed_orcids":["https://orcid.org/0000-0003-4438-7334"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elliott J. Mufson","raw_affiliation_strings":["Department of Neurological Sciences, Rush Presbyterian St. Luke's Medical Center, Chicago, Illinois 60612","Department of Neurological Sciences Rush Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush Presbyterian St. Luke's Medical Center, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Neurological Sciences Rush Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109249437","display_name":"Louis B. Hersh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis B. Hersh","raw_affiliation_strings":["Department of Biochemistry, University of Kentucky, Lexington, Kentucky 40536-0084","Department of Biochemistry, University of Kentucky, Lexington, Kentucky 40536\u20130084"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Kentucky, Lexington, Kentucky 40536-0084","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Biochemistry, University of Kentucky, Lexington, Kentucky 40536\u20130084","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027042734","display_name":"Clifford B. Saper","orcid":"https://orcid.org/0000-0002-5788-3014","observed_orcids":["https://orcid.org/0000-0002-5788-3014"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Clifford B. Saper","raw_affiliation_strings":["Department of Neurology and Program in Neuroscience, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02115","Department of Neurology, Beth Israel Hospital, 330 Brookline Avenue, Boston, MA 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Program in Neuroscience, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Neurology, Beth Israel Hospital, 330 Brookline Avenue, Boston, MA 02215","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5027042734"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":2.7284,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.91286348,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"345","issue":"3","first_page":"321","last_page":"344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.03189999982714653,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholinergic-innervation","display_name":"cholinergic innervation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"hippocampal formation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/entorhinal-cortex","display_name":"entorhinal cortex","score":0.9959999918937683},{"id":"https://openalex.org/keywords/choline-acetyltransferase","display_name":"choline acetyltransferase","score":0.8870000243186951},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/p75-nerve-growth-factor-receptor","display_name":"p75 nerve growth factor receptor","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cholinergic-fibers","display_name":"cholinergic fibers","score":0.7210000157356262},{"id":"https://openalex.org/keywords/ca3","display_name":"CA3","score":0.47099998593330383},{"id":"https://openalex.org/keywords/ca4","display_name":"CA4","score":0.9860000014305115},{"id":"https://openalex.org/keywords/subiculum","display_name":"subiculum","score":0.8029999732971191},{"id":"https://openalex.org/keywords/age-related-changes","display_name":"age-related changes","score":0.6620000004768372},{"id":"https://openalex.org/keywords/memory","display_name":"memory","score":0.4000000059604645},{"id":"https://openalex.org/keywords/human-brain","display_name":"human brain","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.8728814721107483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8643724322319031},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8521219491958618},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.7831210494041443},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7639628648757935},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5291894674301147},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.43872013688087463}],"mesh":[{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002795","descriptor_name":"Choline O-Acetyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002795","descriptor_name":"Choline O-Acetyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002795","descriptor_name":"Choline O-Acetyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010275","descriptor_name":"Parasympathetic Nervous System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010275","descriptor_name":"Parasympathetic Nervous System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010275","descriptor_name":"Parasympathetic Nervous System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010275","descriptor_name":"Parasympathetic Nervous System","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010275","descriptor_name":"Parasympathetic Nervous System","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010275","descriptor_name":"Parasympathetic Nervous System","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010275","descriptor_name":"Parasympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010275","descriptor_name":"Parasympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010275","descriptor_name":"Parasympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cne.903450302","doi":"https://doi.org/10.1002/cne.903450302","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cne.903450302","pdf_url":null,"source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Comparative Neurology","raw_type":"journal-article"},{"id":"pmid:7929905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7929905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of comparative neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1828916731","display_name":null,"funder_award_id":"AG 10161","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2673326244","display_name":"CENTRAL CARDIAC SYSTEMS","funder_award_id":"5r01ns022835-11","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G481380072","display_name":null,"funder_award_id":"AG09466","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5029820101","display_name":"Rush Alzheimer's Disease Core Center","funder_award_id":"5p30ag010161-30","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G566893082","display_name":null,"funder_award_id":"NS-22835","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7478080448","display_name":"Anatomic, Physiologic, and Cognitive Pathology of AD","funder_award_id":"5p01ag009466-18","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308102","display_name":"Illinois Department of Public Health","ror":"https://ror.org/027bk5v43"},{"id":"https://openalex.org/F4320322649","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W73659385","https://openalex.org/W579167334","https://openalex.org/W589396136","https://openalex.org/W984801916","https://openalex.org/W1505548944","https://openalex.org/W1582697909","https://openalex.org/W1969045806","https://openalex.org/W1970182701","https://openalex.org/W1971847164","https://openalex.org/W1972197544","https://openalex.org/W1973531344","https://openalex.org/W1975440411","https://openalex.org/W1975542537","https://openalex.org/W1979686107","https://openalex.org/W1980798945","https://openalex.org/W1981922585","https://openalex.org/W1984469633","https://openalex.org/W1985651343","https://openalex.org/W1986199494","https://openalex.org/W1988006955","https://openalex.org/W1988795019","https://openalex.org/W1990081297","https://openalex.org/W1994067502","https://openalex.org/W1994224094","https://openalex.org/W1996638302","https://openalex.org/W1998354033","https://openalex.org/W2000338975","https://openalex.org/W2001392782","https://openalex.org/W2004017074","https://openalex.org/W2007688707","https://openalex.org/W2008858187","https://openalex.org/W2009078449","https://openalex.org/W2009817649","https://openalex.org/W2010052734","https://openalex.org/W2010909249","https://openalex.org/W2011512156","https://openalex.org/W2012582173","https://openalex.org/W2012916210","https://openalex.org/W2013409336","https://openalex.org/W2013854477","https://openalex.org/W2014266632","https://openalex.org/W2014630817","https://openalex.org/W2016372270","https://openalex.org/W2018434736","https://openalex.org/W2019703859","https://openalex.org/W2020474246","https://openalex.org/W2022191515","https://openalex.org/W2022297475","https://openalex.org/W2022982192","https://openalex.org/W2027009747","https://openalex.org/W2032687881","https://openalex.org/W2037338304","https://openalex.org/W2042661837","https://openalex.org/W2045032692","https://openalex.org/W2046096408","https://openalex.org/W2046855681","https://openalex.org/W2048751568","https://openalex.org/W2049111961","https://openalex.org/W2049127196","https://openalex.org/W2050024957","https://openalex.org/W2050164747","https://openalex.org/W2051775726","https://openalex.org/W2056177071","https://openalex.org/W2058179780","https://openalex.org/W2063009152","https://openalex.org/W2063348782","https://openalex.org/W2066191175","https://openalex.org/W2066287283","https://openalex.org/W2066506889","https://openalex.org/W2068118637","https://openalex.org/W2070455103","https://openalex.org/W2071190410","https://openalex.org/W2071751312","https://openalex.org/W2072538942","https://openalex.org/W2072717295","https://openalex.org/W2076151759","https://openalex.org/W2078329898","https://openalex.org/W2082501635","https://openalex.org/W2082769538","https://openalex.org/W2090233462","https://openalex.org/W2090863983","https://openalex.org/W2094273672","https://openalex.org/W2098777341","https://openalex.org/W2111493525","https://openalex.org/W2114129147","https://openalex.org/W2121543539","https://openalex.org/W2133320138","https://openalex.org/W2134677460","https://openalex.org/W2171030414","https://openalex.org/W2580821419","https://openalex.org/W2581066588","https://openalex.org/W2761787180","https://openalex.org/W3162876745","https://openalex.org/W4232914543","https://openalex.org/W4321061845"],"related_works":["https://openalex.org/W1976076281","https://openalex.org/W4323032452","https://openalex.org/W2385459031","https://openalex.org/W2090370544","https://openalex.org/W2071334059","https://openalex.org/W2018947767","https://openalex.org/W2376447893","https://openalex.org/W2791418051","https://openalex.org/W2074206307","https://openalex.org/W2004473215"],"abstract_inverted_index":{"The":[0,61,133],"cholinergic":[1,31],"innervation":[2,32,168,209],"of":[3,33,40,63,79,88,178,194,213,220,227],"the":[4,30,34,53,71,77,86,108,115,120,126,156,160,163,176,192,211,225,228],"hippocampal":[5,36],"formation":[6,37],"is":[7],"thought":[8],"to":[9,107,148],"play":[10],"an":[11,188],"important":[12],"role":[13],"in":[14,20,26,74,114,139,155,180,191,224],"memory":[15],"processes,":[16],"but":[17],"its":[18],"organization":[19],"humans":[21],"has":[22],"not":[23],"been":[24],"described":[25],"detail.":[27],"We":[28],"studied":[29],"human":[35],"by":[38],"means":[39],"immunohistochemistry":[41],"with":[42,99],"polyclonal":[43],"antisera":[44],"directed":[45],"against":[46],"acetylcholinesterase":[47],"(AChE),":[48],"choline":[49],"acetyltransferase":[50],"(ChAT),":[51],"and":[52,101,123,129,141,150,165,196,199,210],"low-affinity":[54],"(p75)":[55],"nerve":[56],"growth":[57],"factor":[58],"receptor":[59],"(NGFR).":[60],"density":[62,135,193],"ChAT-like":[64],"immunoreactive":[65],"(ChAT-li)":[66],"fibers":[67,100,113,198],"differed":[68],"substantially":[69,152],"among":[70],"various":[72],"regions,":[73],"general":[75],"paralleling":[76],"pattern":[78],"AChE-li":[80,89,197],"staining.":[81],"One":[82],"notable":[83],"exception":[84],"was":[85,96,136,151,184],"presence":[87,212],"cell":[90],"bodies.":[91],"In":[92,159],"contrast,":[93],"ChAT":[94],"immunoreactivity":[95],"associated":[97],"only":[98],"terminals.":[102,200],"NGFR-li":[103,166,208,215],"staining":[104],"corresponded":[105],"closely":[106],"ChAT-li":[109,112],"fiber":[110,167],"pattern.":[111],"CA":[116],"fields":[117],"diffusely":[118],"filled":[119],"stratum":[121,127],"pyramidale":[122],"extended":[124],"into":[125],"oriens":[128],"radiatum":[130],"as":[131],"well.":[132],"highest":[134],"consistently":[137],"observed":[138],"CA4":[140,147],"CA3":[142],"subfields.":[143],"Staining":[144],"decreased":[145],"from":[146],"CA1":[149],"less":[153],"dense":[154],"subicular":[157],"complex.":[158],"entorhinal":[161],"cortex,":[162],"ChAT-":[164,195],"displayed":[169],"a":[170,185,205,221],"laminar":[171],"pattern,":[172],"most":[173],"intense":[174],"over":[175],"nests":[177],"cells":[179],"layer":[181],"II.":[182],"There":[183],"trend":[186],"towards":[187],"age-related":[189],"reduction":[190],"Nonetheless,":[201],"we":[202],"also":[203],"found":[204],"surprisingly":[206],"conserved":[207],"occasional":[214],"pyramidal":[216],"cells,":[217],"providing":[218],"evidence":[219],"plastic":[222],"response":[223],"brains":[226],"elderly":[229],"patients.":[230]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}