{"id":"https://openalex.org/W2132467376","doi":"https://doi.org/10.1128/mcb.20.16.5828-5839.2000","title":"TEL, a Putative Tumor Suppressor, Modulates Cell Growth and Cell Morphology of Ras-Transformed Cells While Repressing the Transcription of stromelysin-1","display_name":"TEL, a Putative Tumor Suppressor, Modulates Cell Growth and Cell Morphology of Ras-Transformed Cells While Repressing the Transcription of stromelysin-1","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W2132467376","doi":"https://doi.org/10.1128/mcb.20.16.5828-5839.2000","mag":"2132467376","pmid":"https://pubmed.ncbi.nlm.nih.gov/10913166","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/86060"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.20.16.5828-5839.2000","doi":"https://doi.org/10.1128/mcb.20.16.5828-5839.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.20.16.5828-5839.2000","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/86060","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059238726","display_name":"Randy Fenrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randy Fenrick","raw_affiliation_strings":["Departments of Biochemistry","Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine","2 Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]},{"raw_affiliation_string":"2 Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee37232","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116493613","display_name":"Lilin Wang","orcid":"https://orcid.org/0009-0000-5411-0545","observed_orcids":["https://orcid.org/0009-0000-5411-0545"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lilin Wang","raw_affiliation_strings":["Departments of Biochemistry","Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine","2 Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]},{"raw_affiliation_string":"2 Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee37232","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063577496","display_name":"John Nip","orcid":"https://orcid.org/0009-0005-7781-4736","observed_orcids":["https://orcid.org/0009-0005-7781-4736"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Nip","raw_affiliation_strings":["Departments of Biochemistry","Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine","2 Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]},{"raw_affiliation_string":"2 Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee37232","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113793371","display_name":"Joseph M. Amann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph M. Amann","raw_affiliation_strings":["Departments of Biochemistry","Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine","2 Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]},{"raw_affiliation_string":"2 Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee37232","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061415711","display_name":"Robert J. Rooney","orcid":"https://orcid.org/0000-0002-0002-8770","observed_orcids":["https://orcid.org/0000-0002-0002-8770"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Rooney","raw_affiliation_strings":["Department of Genetics, Duke University Medical School","Department of Genetics, Duke University Medical School, Durham, North Carolina 27715-3054"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Duke University Medical School","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Genetics, Duke University Medical School, Durham, North Carolina 27715-3054","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019272496","display_name":"Jennifer Walker\u2010Daniels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Walker-Daniels","raw_affiliation_strings":["Department of Basic Medical Sciences, Purdue University","Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences, Purdue University","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054373028","display_name":"Howard C. Crawford","orcid":"https://orcid.org/0000-0001-9360-3019","observed_orcids":["https://orcid.org/0000-0001-9360-3019"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard C. Crawford","raw_affiliation_strings":["Cell Biology","Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine","5 Cell Biology","Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]},{"raw_affiliation_string":"5 Cell Biology","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049756813","display_name":"Diana L. Hulboy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana L. Hulboy","raw_affiliation_strings":["Cell Biology","Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine","5 Cell Biology","Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]},{"raw_affiliation_string":"5 Cell Biology","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011112601","display_name":"Michael S. Kinch","orcid":"https://orcid.org/0000-0003-3939-3756","observed_orcids":["https://orcid.org/0000-0003-3939-3756"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S. Kinch","raw_affiliation_strings":["Department of Basic Medical Sciences, Purdue University","Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences, Purdue University","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080017108","display_name":"Lynn McCormick Matrisian","orcid":"https://orcid.org/0000-0002-5631-2826","observed_orcids":["https://orcid.org/0000-0002-5631-2826"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn M. Matrisian","raw_affiliation_strings":["Cell Biology","Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine","5 Cell Biology","Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]},{"raw_affiliation_string":"5 Cell Biology","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068430189","display_name":"Scott W. Hiebert","orcid":"https://orcid.org/0000-0001-5621-1454","observed_orcids":["https://orcid.org/0000-0001-5621-1454"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott W. Hiebert","raw_affiliation_strings":["Departments of Biochemistry","Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine","2 Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]},{"raw_affiliation_string":"2 Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee37232","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5068430189"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"],"apc_list":null,"apc_paid":null,"fwci":3.8754,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.94278863,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"20","issue":"16","first_page":"5828","last_page":"5839"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.1648000031709671,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.053300000727176666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tel","display_name":"TEL","score":0.8960000276565552},{"id":"https://openalex.org/keywords/ets-transcription-factors","display_name":"ETS transcription factors","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/stromelysin-1","display_name":"stromelysin-1","score":0.9300000071525574},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9580000042915344},{"id":"https://openalex.org/keywords/ras-transformation","display_name":"Ras transformation","score":0.703000009059906},{"id":"https://openalex.org/keywords/cell-aggregation","display_name":"cell aggregation","score":0.6349999904632568},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.6029999852180481},{"id":"https://openalex.org/keywords/smrt-corepressor","display_name":"SMRT corepressor","score":0.8289999961853027},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.9279999732971191},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.5379999876022339},{"id":"https://openalex.org/keywords/acute-leukemia","display_name":"acute leukemia","score":0.5669999718666077},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.8880000114440918},{"id":"https://openalex.org/keywords/batimastat","display_name":"batimastat","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8230206966400146},{"id":"https://openalex.org/C146777309","wikidata":"https://www.wikidata.org/wiki/Q1132599","display_name":"Corepressor","level":5,"score":0.7125856876373291},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5674729347229004},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.47899124026298523},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.4613708257675171},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.44177085161209106},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4408493638038635},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4386731684207916},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.43320131301879883},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4197382926940918},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3214881122112274},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30244600772857666},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28021860122680664},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2204645276069641},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097764","descriptor_name":"ETS Translocation Variant 6 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019278","descriptor_name":"Matrix Metalloproteinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050783","descriptor_name":"Proto-Oncogene Proteins c-ets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/mcb.20.16.5828-5839.2000","doi":"https://doi.org/10.1128/mcb.20.16.5828-5839.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.20.16.5828-5839.2000","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:86060","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/86060","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:10913166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10913166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.327.8002","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.8002","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mcb.asm.org/content/20/16/5828.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:86060","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/86060","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1580450130","display_name":null,"funder_award_id":"R0146843","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G505683346","display_name":"Role of TEL and the t(12;21) in B cell ALL","funder_award_id":"R01CA077274","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6726797912","display_name":"POSTGRADUATE TRAINING PROGRAM IN HEMATOLOGY","funder_award_id":"T32DK007186","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6849296902","display_name":"Role of AML1-ETO in Acute Leukemia","funder_award_id":"R01CA064140","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7033216786","display_name":"SYSTEMATIC STUDY OF BORON RICH ANTIBODY CONJUGATES","funder_award_id":"R01CA068465","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7300173694","display_name":null,"funder_award_id":"R01 DK20593","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000880732","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA068485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000900818","display_name":"Vanderbilt Diabetes Research Center","funder_award_id":"P30DK020593","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320313998","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W1740534","https://openalex.org/W32506313","https://openalex.org/W61983648","https://openalex.org/W73018995","https://openalex.org/W127490758","https://openalex.org/W143872128","https://openalex.org/W146464735","https://openalex.org/W174289115","https://openalex.org/W229766018","https://openalex.org/W343881469","https://openalex.org/W948947165","https://openalex.org/W1487448001","https://openalex.org/W1498241445","https://openalex.org/W1525502277","https://openalex.org/W1526184968","https://openalex.org/W1607890390","https://openalex.org/W1719918577","https://openalex.org/W1825865469","https://openalex.org/W1959720425","https://openalex.org/W1969191130","https://openalex.org/W1970193090","https://openalex.org/W1976831807","https://openalex.org/W1980295525","https://openalex.org/W1980745837","https://openalex.org/W1983615642","https://openalex.org/W1987483436","https://openalex.org/W1998859037","https://openalex.org/W2002377159","https://openalex.org/W2008018118","https://openalex.org/W2015532531","https://openalex.org/W2015809080","https://openalex.org/W2016790281","https://openalex.org/W2018075615","https://openalex.org/W2023256994","https://openalex.org/W2036180570","https://openalex.org/W2038430021","https://openalex.org/W2043930487","https://openalex.org/W2045758962","https://openalex.org/W2046753134","https://openalex.org/W2048656467","https://openalex.org/W2053449922","https://openalex.org/W2060092781","https://openalex.org/W2061385217","https://openalex.org/W2062273992","https://openalex.org/W2067658771","https://openalex.org/W2068266757","https://openalex.org/W2073423744","https://openalex.org/W2077216446","https://openalex.org/W2084324934","https://openalex.org/W2087545262","https://openalex.org/W2091548699","https://openalex.org/W2096353669","https://openalex.org/W2096996870","https://openalex.org/W2100491851","https://openalex.org/W2102359581","https://openalex.org/W2103468507","https://openalex.org/W2104485296","https://openalex.org/W2104692426","https://openalex.org/W2105533439","https://openalex.org/W2108360007","https://openalex.org/W2125668148","https://openalex.org/W2131627815","https://openalex.org/W2138292652","https://openalex.org/W2142962849","https://openalex.org/W2145693049","https://openalex.org/W2158242249","https://openalex.org/W2159444937","https://openalex.org/W2160680028","https://openalex.org/W2163638464","https://openalex.org/W2165863699","https://openalex.org/W2167956058","https://openalex.org/W2168918180","https://openalex.org/W2172160601","https://openalex.org/W2272088676","https://openalex.org/W2276279453","https://openalex.org/W2303212700","https://openalex.org/W2344496868","https://openalex.org/W2416487144","https://openalex.org/W2444390998","https://openalex.org/W2466216758","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7097174535","https://openalex.org/W2331928000","https://openalex.org/W1522557296","https://openalex.org/W1981581392","https://openalex.org/W2077564543","https://openalex.org/W2014812129","https://openalex.org/W2167466932","https://openalex.org/W264072843","https://openalex.org/W2152816370","https://openalex.org/W2055298771"],"abstract_inverted_index":{"TEL":[0,22,35,49,71,97,123,168,172,188],"is":[1,23,114],"a":[2,115,126,144,159,191],"member":[3],"of":[4,8,31,48,81,122,154,176,199],"the":[5,14,34,79,88,101,106,130,135,151,174],"ETS":[6,136],"family":[7],"transcription":[9],"factors":[10],"that":[11,46,87,112,124,165,187],"interacts":[12],"with":[13],"mSin3":[15],"and":[16,29,61,70,104,181],"SMRT":[17],"corepressors":[18],"to":[19,77,139,150,164],"regulate":[20],"transcription.":[21],"biallelically":[24],"disrupted":[25],"in":[26,40,50,58,62,100,108,179,182,194],"acute":[27],"leukemia,":[28],"loss":[30],"heterozygosity":[32],"at":[33],"locus":[36],"has":[37],"been":[38],"observed":[39],"various":[41],"cancers.":[42],"Here":[43],"we":[44,85],"show":[45],"expression":[47],"Ras-transformed":[51,177],"NIH":[52],"3T3":[53],"cells":[54,66,178],"inhibits":[55],"cell":[56,160],"growth":[57],"soft":[59],"agar":[60],"normal":[63],"cultures.":[64],"Unexpectedly,":[65],"expressing":[67],"both":[68],"Ras":[69],"grew":[72],"as":[73,190],"aggregates.":[74],"To":[75],"begin":[76],"explain":[78],"morphology":[80],"Ras-plus":[82],"TEL-expressing":[83],"cells,":[84,156],"demonstrated":[86],"endogenous":[89],"matrix":[90,145],"metalloproteinase":[91,146],"stromelysin-1":[92,102],"was":[93,148],"repressed":[94,105],"by":[95,167,196],"TEL.":[96],"bound":[98],"sequences":[99],"promoter":[103,107],"transient-expression":[109],"assays,":[110],"suggesting":[111],"it":[113,157],"direct":[116],"target":[117],"for":[118,129],"TEL-mediated":[119],"regulation.":[120],"Mutants":[121],"removed":[125],"binding":[127],"site":[128],"mSin3A":[131],"corepressor":[132],"but":[133],"retained":[134],"domain":[137],"failed":[138],"repress":[140],"stromelysin-1.":[141,200],"When":[142],"BB-94,":[143],"inhibitor,":[147],"added":[149],"culture":[152],"medium":[153],"Ras-expressing":[155],"caused":[158,166],"aggregation":[161],"phenotype":[162],"similar":[163],"expression.":[169],"In":[170],"addition,":[171],"inhibited":[173],"invasiveness":[175],"vitro":[180],"vivo.":[183],"Our":[184],"results":[185],"suggest":[186],"acts":[189],"tumor":[192],"suppressor,":[193],"part,":[195],"transcriptional":[197],"repression":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
