{"id":"https://openalex.org/W2132425798","doi":"https://doi.org/10.1136/gutjnl-2011-301746","title":"Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes","display_name":"Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes","publication_year":2012,"publication_date":"2012-11-20","ids":{"openalex":"https://openalex.org/W2132425798","doi":"https://doi.org/10.1136/gutjnl-2011-301746","mag":"2132425798","pmid":"https://pubmed.ncbi.nlm.nih.gov/23172890"},"language":"en","primary_location":{"id":"doi:10.1136/gutjnl-2011-301746","doi":"https://doi.org/10.1136/gutjnl-2011-301746","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gutjnl-2011-301746","pdf_url":"https://gut.bmj.com/content/gutjnl/62/9/1328.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://gut.bmj.com/content/gutjnl/62/9/1328.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009167745","display_name":"Hirotoshi Ishiwatari","orcid":"https://orcid.org/0000-0002-6719-4466","observed_orcids":["https://orcid.org/0000-0002-6719-4466"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotoshi Ishiwatari","raw_affiliation_strings":["Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","Fourth Dept. of Internal Med., Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Fourth Dept. of Internal Med., Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021158752","display_name":"Yasushi Sato","orcid":"https://orcid.org/0000-0002-6776-4609","observed_orcids":["https://orcid.org/0000-0002-6776-4609","https://orcid.org/0000-0003-0446-8017"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Sato","raw_affiliation_strings":["Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","Sapporo Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Sapporo Medical University","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102823411","display_name":"Kazuyuki Murase","orcid":"https://orcid.org/0000-0003-2642-8665","observed_orcids":["https://orcid.org/0000-0003-2642-8665"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuyuki Murase","raw_affiliation_strings":["Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","Sapporo Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Sapporo Medical University","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Akihiro Yoneda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiro Yoneda","raw_affiliation_strings":["Department of Molecular Target Exploration, Sapporo Medical University,Sapporo, Japan","Sapporo Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Target Exploration, Sapporo Medical University,Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Sapporo Medical University","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110780560","display_name":"Ryosuke Fujita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryosuke Fujita","raw_affiliation_strings":["Department of Molecular Target Exploration, Sapporo Medical University,Sapporo, Japan","Sapporo Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Target Exploration, Sapporo Medical University,Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Sapporo Medical University","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019920385","display_name":"Hiroki Nishita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Nishita","raw_affiliation_strings":["Department of Molecular Target Exploration, Sapporo Medical University,Sapporo, Japan","Sapporo Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Target Exploration, Sapporo Medical University,Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Sapporo Medical University","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048166181","display_name":"Naoko Kubo Birukawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoko Kubo Birukawa","raw_affiliation_strings":["Department of Molecular Target Exploration, Sapporo Medical University,Sapporo, Japan","Sapporo Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Target Exploration, Sapporo Medical University,Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Sapporo Medical University","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058075352","display_name":"Tsuyoshi Hayashi","orcid":"https://orcid.org/0000-0001-7666-5795","observed_orcids":["https://orcid.org/0000-0001-7666-5795"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Hayashi","raw_affiliation_strings":["Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","Sapporo Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Sapporo Medical University","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022193625","display_name":"Tsutomu Sato","orcid":"https://orcid.org/0000-0002-8827-2582","observed_orcids":["https://orcid.org/0000-0002-8827-2582"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsutomu Sato","raw_affiliation_strings":["Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","Sapporo Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Sapporo Medical University","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101549457","display_name":"Koji Miyanishi","orcid":"https://orcid.org/0000-0002-6466-3458","observed_orcids":["https://orcid.org/0000-0002-6466-3458"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Miyanishi","raw_affiliation_strings":["Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","Sapporo Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Sapporo Medical University","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008694549","display_name":"Rishu Takimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rishu Takimoto","raw_affiliation_strings":["Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","Sapporo Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Sapporo Medical University","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074930047","display_name":"Masayoshi Kobune","orcid":"https://orcid.org/0000-0003-3828-8444","observed_orcids":["https://orcid.org/0000-0003-3828-8444"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayoshi Kobune","raw_affiliation_strings":["Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","Sapporo Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Sapporo Medical University","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060679816","display_name":"Shigenori Ota","orcid":"https://orcid.org/0000-0003-3123-9172","observed_orcids":["https://orcid.org/0000-0003-3123-9172"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigenori Ota","raw_affiliation_strings":["First Department of Surgery, Sapporo Medical University, Sapporo, Japan","Sapporo Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Sapporo Medical University","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045415586","display_name":"Yasutoshi Kimura","orcid":"https://orcid.org/0000-0002-7790-9250","observed_orcids":["https://orcid.org/0000-0002-7790-9250"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasutoshi Kimura","raw_affiliation_strings":["First Department of Surgery, Sapporo Medical University, Sapporo, Japan","Sapporo Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Sapporo Medical University","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101847731","display_name":"Koichi Hirata","orcid":"https://orcid.org/0000-0002-6492-4734","observed_orcids":["https://orcid.org/0000-0002-6492-4734"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Hirata","raw_affiliation_strings":["First Department of Surgery, Sapporo Medical University, Sapporo, Japan","Sapporo Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Sapporo Medical University","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103049153","display_name":"Junji Kato","orcid":"https://orcid.org/0000-0002-7367-8344","observed_orcids":["https://orcid.org/0000-0002-7367-8344"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junji Kato","raw_affiliation_strings":["Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","Sapporo Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Sapporo Medical University","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112643596","display_name":"Yoshiro Niitsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshiro Niitsu","raw_affiliation_strings":["Department of Molecular Target Exploration, Sapporo Medical University,Sapporo, Japan","Sapporo Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Target Exploration, Sapporo Medical University,Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Sapporo Medical University","institution_ids":["https://openalex.org/I141882310"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112643596"],"corresponding_institution_ids":["https://openalex.org/I141882310"],"apc_list":null,"apc_paid":null,"fwci":5.3368,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.95691413,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"62","issue":"9","first_page":"1328","last_page":"1339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.7749000191688538,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.7749000191688538,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.21610000729560852,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-fibrosis","display_name":"pancreatic fibrosis","score":1.0},{"id":"https://openalex.org/keywords/chronic-pancreatitis","display_name":"chronic pancreatitis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/sirna-therapeutics","display_name":"siRNA therapeutics","score":0.6809999942779541},{"id":"https://openalex.org/keywords/gp46","display_name":"gp46","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pancreatic-stellate-cells","display_name":"pancreatic stellate cells","score":0.949999988079071},{"id":"https://openalex.org/keywords/dibutyltin-dichloride","display_name":"dibutyltin dichloride","score":0.9110000133514404},{"id":"https://openalex.org/keywords/caerulein","display_name":"caerulein","score":0.9470000267028809},{"id":"https://openalex.org/keywords/collagen-synthesis","display_name":"collagen synthesis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/liposomal-drug-delivery","display_name":"liposomal drug delivery","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.7809487581253052},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.6432493925094604},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6021556854248047},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.47507041692733765},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4565122127532959},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4097170829772949},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3686729073524475},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3461906909942627},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3398633599281311},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3068087100982666},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27386730909347534},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27005988359451294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26021867990493774}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002108","descriptor_name":"Ceruletide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005765","descriptor_name":"Gastrointestinal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009947","descriptor_name":"Organotin Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014801","descriptor_name":"Vitamin A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014815","descriptor_name":"Vitamins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D050500","descriptor_name":"Pancreatitis, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D050958","descriptor_name":"HSP47 Heat-Shock Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/gutjnl-2011-301746","doi":"https://doi.org/10.1136/gutjnl-2011-301746","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gutjnl-2011-301746","pdf_url":"https://gut.bmj.com/content/gutjnl/62/9/1328.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},{"id":"pmid:23172890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23172890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:gutjnl:62/9/1328","doi":null,"is_oa":false,"landing_page_url":"http://gut.bmj.com/cgi/content/short/62/9/1328","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1136/gutjnl-2011-301746","doi":"https://doi.org/10.1136/gutjnl-2011-301746","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gutjnl-2011-301746","pdf_url":"https://gut.bmj.com/content/gutjnl/62/9/1328.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1428385589","display_name":"A novel ultrasound imaging for pancreatic cancer using tumor directed-contrast media","funder_award_id":"24659372","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7002286483","display_name":"Developing a novel vaccine therapy targeting cancer stem cells","funder_award_id":"24659592","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8770263815","display_name":"Analysis of relation between oxidative DNA repair genes,MUTYH and hepatocarcinogenesis","funder_award_id":"24590985","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2132425798.pdf","grobid_xml":"https://content.openalex.org/works/W2132425798.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1603230122","https://openalex.org/W1964936245","https://openalex.org/W1967336838","https://openalex.org/W1985457298","https://openalex.org/W1989732890","https://openalex.org/W1997064567","https://openalex.org/W2006014859","https://openalex.org/W2022289649","https://openalex.org/W2027140244","https://openalex.org/W2027328967","https://openalex.org/W2027550738","https://openalex.org/W2034597539","https://openalex.org/W2060941921","https://openalex.org/W2063396563","https://openalex.org/W2067167056","https://openalex.org/W2075708296","https://openalex.org/W2088492852","https://openalex.org/W2089724195","https://openalex.org/W2099069267","https://openalex.org/W2108076095","https://openalex.org/W2111870502","https://openalex.org/W2127409621","https://openalex.org/W2131623689","https://openalex.org/W2148929898","https://openalex.org/W2239460943","https://openalex.org/W2326650248"],"related_works":["https://openalex.org/W2164830233","https://openalex.org/W2027963200","https://openalex.org/W2127409621","https://openalex.org/W2005270215","https://openalex.org/W1984849230","https://openalex.org/W4238989642","https://openalex.org/W7135171063","https://openalex.org/W3009834370","https://openalex.org/W4311764024","https://openalex.org/W120413193"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"OBJECTIVE:":[2],"Fibrosis":[3],"associated":[4],"with":[5,75],"chronic":[6],"pancreatitis":[7],"is":[8],"an":[9],"irreversible":[10],"lesion":[11],"that":[12,32],"can":[13],"disrupt":[14],"pancreatic":[15,58,80,140,222,247],"exocrine":[16],"and":[17,65,133,144,152,174,181,209,224,231],"endocrine":[18],"function.":[19],"Currently,":[20],"there":[21],"are":[22],"no":[23],"approved":[24],"treatments":[25,220],"for":[26,57,245],"this":[27],"disease.":[28],"We":[29],"previously":[30],"showed":[31],"siRNA":[33],"against":[34],"collagen-specific":[35],"chaperone":[36],"protein":[37,167],"gp46,":[38],"encapsulated":[39],"in":[40,47,67,113,125,142,171,199,202,229],"vitamin":[41],"A-coupled":[42],"liposomes":[43],"(VA-lip-siRNAgp46),":[44],"resolved":[45,221],"fibrosis":[46,59],"a":[48],"model":[49],"of":[50,72,94,102,121,137,161,179,183,191,195,241],"liver":[51],"cirrhosis.":[52],"This":[53],"treatment":[54],"was":[55,84,96,107,115,128,147,205],"investigated":[56],"induced":[60],"by":[61,78,86,98,105,109,117,149,169,187,207],"dibutyltin":[62],"dichloride":[63],"(DBTC)":[64],"cerulein":[66],"rats.":[68,233],"METHODS:":[69],"Specific":[70,119,193],"uptake":[71,160],"VA-lip-siRNAgp46,":[73],"conjugated":[74],"6'-carboxyfluorescein":[76],"(FAM)":[77],"activated":[79,88],"stellate":[81],"cells":[82],"(aPSCs),":[83],"analysed":[85],"fluorescence":[87,208],"cell":[89],"sorting":[90],"(FACS).":[91],"Intracellular":[92],"distribution":[93],"VA-lip-siRNAgp46-FAM":[95,162],"examined":[97],"fluorescent":[99],"microscopy.":[100],"Suppression":[101],"gp46":[103,180],"expression":[104],"VA-lip-siRNAgp46":[106,122,196,219],"assessed":[108],"immunoblotting.":[110],"Collagen":[111],"synthesis":[112],"aPSCs":[114,124,170,188,198],"assayed":[116],"dye-binding.":[118],"delivery":[120,194],"to":[123,197],"DBTC":[126,203],"rats":[127,146,204],"verified":[129,177],"following":[130],"intravenous":[131],"VA-lip-siRNA-FAM":[132],"(3)H-VA-lip-siRNAgp46.":[134],"The":[135],"effect":[136],"VA-lip-siRNA":[138],"on":[139],"histology":[141],"DBTC-":[143,230],"cerulein-treated":[145,232],"determined":[148],"Azan-Mallory":[150],"staining":[151],"hydroxyproline":[153,227],"content.":[154],"RESULTS:":[155],"FACS":[156],"analysis":[157],"revealed":[158],"specific":[159],"through":[163],"the":[164,214,238,242],"retinol":[165],"binding":[166],"receptor":[168],"vitro.":[172],"Immunoblotting":[173],"collagen":[175,184],"assay":[176],"knockdown":[178],"suppression":[182],"secretion,":[185],"respectively,":[186],"after":[189,213],"transduction":[190],"VA-lip-siRNAgp46.":[192],"fibrotic":[200],"areas":[201],"confirmed":[206],"radioactivity":[210],"24":[211],"h":[212],"final":[215],"injection.":[216],"10":[217],"systemic":[218],"fibrosis,":[223],"suppressed":[225],"tissue":[226],"levels":[228],"CONCLUSION:":[234],"These":[235],"data":[236],"suggest":[237],"therapeutic":[239],"potential":[240],"present":[243],"approach":[244],"reversing":[246],"fibrosis.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}