{"id":"https://openalex.org/W2132274201","doi":"https://doi.org/10.1084/jem.188.3.539","title":"Transendothelial Migration of Megakaryocytes in Response to Stromal Cell-derived Factor 1 (SDF-1) Enhances Platelet Formation","display_name":"Transendothelial Migration of Megakaryocytes in Response to Stromal Cell-derived Factor 1 (SDF-1) Enhances Platelet Formation","publication_year":1998,"publication_date":"1998-08-03","ids":{"openalex":"https://openalex.org/W2132274201","doi":"https://doi.org/10.1084/jem.188.3.539","mag":"2132274201","pmid":"https://pubmed.ncbi.nlm.nih.gov/9687531","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2212480"},"language":"en","primary_location":{"id":"doi:10.1084/jem.188.3.539","doi":"https://doi.org/10.1084/jem.188.3.539","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.188.3.539","pdf_url":"https://rupress.org/jem/article-pdf/188/3/539/1116995/98-0363.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jem/article-pdf/188/3/539/1116995/98-0363.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025011287","display_name":"Tsuneyoshi Hamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Tsuneyoshi Hamada","raw_affiliation_strings":["From the *Division of Hematology-Oncology, Cornell University Medical College, New York 10021; the \u2021James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York 10021; the \u00a7Department of Immunology, Berlex Biosciences, Richmond, California 94804; the \u2016Department of Medicine II, University of T\u00fcbingen, T\u00fcbingen 72076, Germany; and the \u00b6Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","the Department of Immunology, Berlex Biosciences, Richmond, California 94804","the Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Division of Hematology-Oncology, Cornell University Medical College, New York 10021; the \u2021James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York 10021; the \u00a7Department of Immunology, Berlex Biosciences, Richmond, California 94804; the \u2016Department of Medicine II, University of T\u00fcbingen, T\u00fcbingen 72076, Germany; and the \u00b6Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295","https://openalex.org/I79576946","https://openalex.org/I8087733"]},{"raw_affiliation_string":"the Department of Immunology, Berlex Biosciences, Richmond, California 94804","institution_ids":[]},{"raw_affiliation_string":"the Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021533208","display_name":"Robert M\u00f6hle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Robert M\u00f6hle","raw_affiliation_strings":["From the *Division of Hematology-Oncology, Cornell University Medical College, New York 10021; the \u2021James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York 10021; the \u00a7Department of Immunology, Berlex Biosciences, Richmond, California 94804; the \u2016Department of Medicine II, University of T\u00fcbingen, T\u00fcbingen 72076, Germany; and the \u00b6Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","From the Division of Hematology-Oncology, Cornell University Medical College, New York 10021","the Department of Immunology, Berlex Biosciences, Richmond, California 94804","the Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Division of Hematology-Oncology, Cornell University Medical College, New York 10021; the \u2021James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York 10021; the \u00a7Department of Immunology, Berlex Biosciences, Richmond, California 94804; the \u2016Department of Medicine II, University of T\u00fcbingen, T\u00fcbingen 72076, Germany; and the \u00b6Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295","https://openalex.org/I79576946","https://openalex.org/I8087733"]},{"raw_affiliation_string":"From the Division of Hematology-Oncology, Cornell University Medical College, New York 10021","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"the Department of Immunology, Berlex Biosciences, Richmond, California 94804","institution_ids":[]},{"raw_affiliation_string":"the Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037794520","display_name":"Joseph Hesselgesser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Joseph Hesselgesser","raw_affiliation_strings":["From the *Division of Hematology-Oncology, Cornell University Medical College, New York 10021; the \u2021James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York 10021; the \u00a7Department of Immunology, Berlex Biosciences, Richmond, California 94804; the \u2016Department of Medicine II, University of T\u00fcbingen, T\u00fcbingen 72076, Germany; and the \u00b6Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","From the Division of Hematology-Oncology, Cornell University Medical College, New York 10021","the Department of Immunology, Berlex Biosciences, Richmond, California 94804","the Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Division of Hematology-Oncology, Cornell University Medical College, New York 10021; the \u2021James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York 10021; the \u00a7Department of Immunology, Berlex Biosciences, Richmond, California 94804; the \u2016Department of Medicine II, University of T\u00fcbingen, T\u00fcbingen 72076, Germany; and the \u00b6Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295","https://openalex.org/I79576946","https://openalex.org/I8087733"]},{"raw_affiliation_string":"From the Division of Hematology-Oncology, Cornell University Medical College, New York 10021","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"the Department of Immunology, Berlex Biosciences, Richmond, California 94804","institution_ids":[]},{"raw_affiliation_string":"the Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074792801","display_name":"James A. Hoxie","orcid":"https://orcid.org/0000-0002-6257-4902","observed_orcids":["https://orcid.org/0000-0002-6257-4902"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"James Hoxie","raw_affiliation_strings":["From the *Division of Hematology-Oncology, Cornell University Medical College, New York 10021; the \u2021James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York 10021; the \u00a7Department of Immunology, Berlex Biosciences, Richmond, California 94804; the \u2016Department of Medicine II, University of T\u00fcbingen, T\u00fcbingen 72076, Germany; and the \u00b6Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","From the Division of Hematology-Oncology, Cornell University Medical College, New York 10021","the Department of Immunology, Berlex Biosciences, Richmond, California 94804","the Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Division of Hematology-Oncology, Cornell University Medical College, New York 10021; the \u2021James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York 10021; the \u00a7Department of Immunology, Berlex Biosciences, Richmond, California 94804; the \u2016Department of Medicine II, University of T\u00fcbingen, T\u00fcbingen 72076, Germany; and the \u00b6Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295","https://openalex.org/I79576946","https://openalex.org/I8087733"]},{"raw_affiliation_string":"From the Division of Hematology-Oncology, Cornell University Medical College, New York 10021","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"the Department of Immunology, Berlex Biosciences, Richmond, California 94804","institution_ids":[]},{"raw_affiliation_string":"the Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058411129","display_name":"Ralph L. Nachman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Ralph L. Nachman","raw_affiliation_strings":["From the *Division of Hematology-Oncology, Cornell University Medical College, New York 10021; the \u2021James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York 10021; the \u00a7Department of Immunology, Berlex Biosciences, Richmond, California 94804; the \u2016Department of Medicine II, University of T\u00fcbingen, T\u00fcbingen 72076, Germany; and the \u00b6Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","From the Division of Hematology-Oncology, Cornell University Medical College, New York 10021","the Department of Immunology, Berlex Biosciences, Richmond, California 94804","the Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Division of Hematology-Oncology, Cornell University Medical College, New York 10021; the \u2021James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York 10021; the \u00a7Department of Immunology, Berlex Biosciences, Richmond, California 94804; the \u2016Department of Medicine II, University of T\u00fcbingen, T\u00fcbingen 72076, Germany; and the \u00b6Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295","https://openalex.org/I79576946","https://openalex.org/I8087733"]},{"raw_affiliation_string":"From the Division of Hematology-Oncology, Cornell University Medical College, New York 10021","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"the Department of Immunology, Berlex Biosciences, Richmond, California 94804","institution_ids":[]},{"raw_affiliation_string":"the Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110863459","display_name":"Malcolm A.S. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Malcolm A.S. Moore","raw_affiliation_strings":["From the *Division of Hematology-Oncology, Cornell University Medical College, New York 10021; the \u2021James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York 10021; the \u00a7Department of Immunology, Berlex Biosciences, Richmond, California 94804; the \u2016Department of Medicine II, University of T\u00fcbingen, T\u00fcbingen 72076, Germany; and the \u00b6Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","From the Division of Hematology-Oncology, Cornell University Medical College, New York 10021","the Department of Immunology, Berlex Biosciences, Richmond, California 94804","the Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Division of Hematology-Oncology, Cornell University Medical College, New York 10021; the \u2021James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York 10021; the \u00a7Department of Immunology, Berlex Biosciences, Richmond, California 94804; the \u2016Department of Medicine II, University of T\u00fcbingen, T\u00fcbingen 72076, Germany; and the \u00b6Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295","https://openalex.org/I79576946","https://openalex.org/I8087733"]},{"raw_affiliation_string":"From the Division of Hematology-Oncology, Cornell University Medical College, New York 10021","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"the Department of Immunology, Berlex Biosciences, Richmond, California 94804","institution_ids":[]},{"raw_affiliation_string":"the Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090799132","display_name":"Shahin Rafii","orcid":"https://orcid.org/0000-0001-5605-1067","observed_orcids":["https://orcid.org/0000-0001-5605-1067"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Shahin Rafii","raw_affiliation_strings":["From the *Division of Hematology-Oncology, Cornell University Medical College, New York 10021; the \u2021James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York 10021; the \u00a7Department of Immunology, Berlex Biosciences, Richmond, California 94804; the \u2016Department of Medicine II, University of T\u00fcbingen, T\u00fcbingen 72076, Germany; and the \u00b6Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","From the Division of Hematology-Oncology, Cornell University Medical College, New York 10021","the Department of Immunology, Berlex Biosciences, Richmond, California 94804","the Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Division of Hematology-Oncology, Cornell University Medical College, New York 10021; the \u2021James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York 10021; the \u00a7Department of Immunology, Berlex Biosciences, Richmond, California 94804; the \u2016Department of Medicine II, University of T\u00fcbingen, T\u00fcbingen 72076, Germany; and the \u00b6Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295","https://openalex.org/I79576946","https://openalex.org/I8087733"]},{"raw_affiliation_string":"From the Division of Hematology-Oncology, Cornell University Medical College, New York 10021","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"the Department of Immunology, Berlex Biosciences, Richmond, California 94804","institution_ids":[]},{"raw_affiliation_string":"the Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5090799132"],"corresponding_institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295","https://openalex.org/I79576946","https://openalex.org/I8087733"],"apc_list":null,"apc_paid":null,"fwci":9.1708,"has_fulltext":true,"cited_by_count":243,"citation_normalized_percentile":{"value":0.98710115,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"188","issue":"3","first_page":"539","last_page":"548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/megakaryocytes","display_name":"megakaryocytes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/platelet-formation","display_name":"platelet formation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cxcl12","display_name":"CXCL12","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.9520000219345093},{"id":"https://openalex.org/keywords/transendothelial-migration","display_name":"transendothelial migration","score":0.871999979019165},{"id":"https://openalex.org/keywords/bone-marrow-endothelial-cells","display_name":"bone marrow endothelial cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.7319999933242798},{"id":"https://openalex.org/keywords/e-selectin","display_name":"E-selectin","score":0.7279999852180481},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.8109999895095825},{"id":"https://openalex.org/keywords/thrombopoietin","display_name":"thrombopoietin","score":0.8180000185966492},{"id":"https://openalex.org/keywords/p-selectin","display_name":"P-selectin","score":0.7680000066757202},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7829999923706055},{"id":"https://openalex.org/keywords/platelet-biogenesis","display_name":"platelet biogenesis","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7419114112854004},{"id":"https://openalex.org/C2779705218","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocyte","level":4,"score":0.6716405153274536},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6093981862068176},{"id":"https://openalex.org/C2777863708","wikidata":"https://www.wikidata.org/wiki/Q424519","display_name":"Thrombopoietin","level":4,"score":0.538769006729126},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5163666009902954},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.49847412109375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49819278717041016},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4721667468547821},{"id":"https://openalex.org/C2776610909","wikidata":"https://www.wikidata.org/wiki/Q408598","display_name":"Stromal cell-derived factor 1","level":5,"score":0.4649003744125366},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.40507131814956665},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.38950231671333313},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38586586713790894},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2624807357788086},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.18957486748695374},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.1833954155445099},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11441376805305481},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.08456617593765259}],"mesh":[{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011123","descriptor_name":"Polyploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019743","descriptor_name":"Chemokines, CXC","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D054377","descriptor_name":"Chemokine CXCL12","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1084/jem.188.3.539","doi":"https://doi.org/10.1084/jem.188.3.539","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.188.3.539","pdf_url":"https://rupress.org/jem/article-pdf/188/3/539/1116995/98-0363.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2212480","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2212480","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:9687531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9687531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.282.7787","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.282.7787","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/af/cc/J_Exp_Med_1998_Aug_3_188(3)_539-548.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.327.7921","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.7921","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jem.rupress.org/content/188/3/539.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1084/jem.188.3.539","doi":"https://doi.org/10.1084/jem.188.3.539","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.188.3.539","pdf_url":"https://rupress.org/jem/article-pdf/188/3/539/1116995/98-0363.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2258671323","display_name":null,"funder_award_id":"R01-HL-58707-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4092088800","display_name":"CHEMOKINE RECEPTORS AND ITP AND HIV THROMBOCYTOPE","funder_award_id":"R01HL061849","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G546047228","display_name":null,"funder_award_id":"CA08748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5578670107","display_name":"ENDOTHELIUM REGULATION OF STEM CELL HOMING/PROLIFERATION","funder_award_id":"R01HL058707","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5909834123","display_name":null,"funder_award_id":"R01-HL-61849-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332415","display_name":"College of Veterinary Medicine, Cornell University","ror":"https://ror.org/05bnh6r87"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2132274201.pdf","grobid_xml":"https://content.openalex.org/works/W2132274201.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W62323174","https://openalex.org/W116948353","https://openalex.org/W174869347","https://openalex.org/W227781810","https://openalex.org/W257391547","https://openalex.org/W331740097","https://openalex.org/W1591912379","https://openalex.org/W1600542667","https://openalex.org/W1742452979","https://openalex.org/W1747721019","https://openalex.org/W1864286509","https://openalex.org/W1963984954","https://openalex.org/W1965779501","https://openalex.org/W1971987125","https://openalex.org/W1983466424","https://openalex.org/W1987686674","https://openalex.org/W1996183705","https://openalex.org/W1998505827","https://openalex.org/W2019985934","https://openalex.org/W2023957032","https://openalex.org/W2038818733","https://openalex.org/W2041111200","https://openalex.org/W2051321857","https://openalex.org/W2057640796","https://openalex.org/W2075416959","https://openalex.org/W2081714880","https://openalex.org/W2081769332","https://openalex.org/W2087343656","https://openalex.org/W2093758335","https://openalex.org/W2115048327","https://openalex.org/W2145139769","https://openalex.org/W2145699974","https://openalex.org/W2151876628","https://openalex.org/W2169584423","https://openalex.org/W2171248814","https://openalex.org/W2228774622","https://openalex.org/W2235292514","https://openalex.org/W2235333994","https://openalex.org/W2249450151","https://openalex.org/W2276322160","https://openalex.org/W2334395893","https://openalex.org/W2344941588","https://openalex.org/W2408812404","https://openalex.org/W2410154533","https://openalex.org/W2414670958","https://openalex.org/W4285719527","https://openalex.org/W6691557428"],"related_works":["https://openalex.org/W2118020691","https://openalex.org/W2978876155","https://openalex.org/W2413714818","https://openalex.org/W2942721694","https://openalex.org/W28083597","https://openalex.org/W2403058886","https://openalex.org/W7098047216","https://openalex.org/W1510842546","https://openalex.org/W1539398892","https://openalex.org/W2077129452"],"abstract_inverted_index":{"Although":[0],"thrombopoietin":[1],"has":[2],"been":[3],"shown":[4,26],"to":[5,107,149,182,186,252,268],"promote":[6],"megakaryocyte":[7],"(MK)":[8],"proliferation":[9],"and":[10,15,37,128,216,246,313],"maturation,":[11],"the":[12,41,66,77,85,124,136,158,176,187,193,210,232,241,258,263,271,282,305],"exact":[13],"mechanism":[14],"site":[16],"of":[17,56,94,154,160,165,178,195,203,212,219,224,257,273,284,301,311],"platelet":[18,285,314],"formation":[19],"are":[20],"not":[21,99],"well":[22,278],"defined.":[23],"Studies":[24],"have":[25,59],"that":[27,52,61,79,133,200,260,290],"MKs":[28,64,148,161,179,196,204,221,276,280,312],"may":[29,53,89,303],"transmigrate":[30],"through":[31,151,262],"bone":[32],"marrow":[33],"endothelial":[34],"cells":[35,259],"(BMEC),":[36],"release":[38],"platelets":[39,229],"within":[40],"sinusoidal":[42],"space":[43],"or":[44,102],"lung":[45],"capillaries.":[46],"In":[47],"search":[48],"for":[49,87,143,162,209,297,309],"chemotactic":[50,295],"factor(s)":[51],"mediate":[54,108],"transmigration":[55,310],"MKs,":[57],"we":[58,75],"discovered":[60],"mature":[62,95,298],"polyploid":[63,225,275],"express":[65],"G":[67,137],"protein-coupled":[68,138],"chemokine":[69],"receptor":[70,139],"CXCR4":[71,140,302],"(Fusin,":[72],"LESTR).":[73],"Therefore,":[74],"explored":[76],"possibility":[78],"stromal":[80],"cell-derived":[81],"factor":[82,296],"1":[83],"(SDF-1),":[84],"ligand":[86],"CXCR4,":[88],"also":[90,146,235],"induce":[91],"transendothelial":[92],"migration":[93,110,177,194,211],"MKs.":[96,213,226,299],"SDF-1,":[97],"but":[98],"other":[100],"CXC":[101],"CC":[103],"chemokines,":[104],"was":[105,121,141],"able":[106],"MK":[109,116],"(ED50":[111],"=":[112],"125":[113],"pmol/liter).":[114],"The":[115],"chemotaxis":[117],"induced":[118,147],"by":[119,123,129,156,197],"SDF-1":[120,145,269,291],"inhibited":[122],"CXCR4-specific":[125],"mAb":[126,185],"(12G5)":[127],"pertussis":[130],"toxin,":[131],"demonstrating":[132],"signaling":[134],"via":[135],"necessary":[142],"migration.":[144],"migrate":[150],"confluent":[152],"monolayers":[153,265],"BMEC":[155,166,206,264],"increasing":[157],"affinity":[159],"BMEC.":[163],"Activation":[164],"with":[167,205],"interleukin":[168],"1beta":[169],"resulted":[170],"in":[171,175,180,231,240,250,266,281],"a":[172,293],"threefold":[173],"increase":[174],"response":[181,251,267],"SDF-1.":[183],"Neutralizing":[184],"endothelial-specific":[188],"adhesion":[189],"molecule":[190],"E-selectin":[191],"blocked":[192],"50%,":[198],"suggesting":[199],"cellular":[201,307],"interaction":[202],"is":[207,292],"critical":[208,306],"Light":[214],"microscopy":[215,256],"ploidy":[217],"determination":[218],"transmigrated":[220,261],"demonstrated":[222,270],"predominance":[223],"Virtually":[227],"all":[228],"generated":[230],"lower":[233,242],"chamber":[234,243],"expressed":[236,247],"CXCR4.":[237],"Platelets":[238],"formed":[239],"were":[244],"functional":[245],"P-selectin":[248],"(CD62P)":[249],"thrombin":[253],"stimulation.":[254],"Electron":[255],"presence":[272],"intact":[274],"as":[277,279],"process":[283],"formation.":[286,315],"These":[287],"results":[288],"suggest":[289],"potent":[294],"Expression":[300],"be":[304],"signal":[308]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
