{"id":"https://openalex.org/W2132222089","doi":null,"title":"Activation of respiratory complex II by interferon-gamma and its inhibition by pyrimidine derivatives.","display_name":"Activation of respiratory complex II by interferon-gamma and its inhibition by pyrimidine derivatives.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2132222089","mag":"2132222089","pmid":"https://pubmed.ncbi.nlm.nih.gov/25638378"},"language":"en","primary_location":{"id":"pmid:25638378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25638378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042613113","display_name":"Zde\u0148ek Z\u00eddek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Zden\u011bk Z\u00eddek","raw_affiliation_strings":["Czech Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Czech Academy of Sciences","institution_ids":["https://openalex.org/I202391551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016928342","display_name":"Petr Jansa","orcid":"https://orcid.org/0000-0002-7001-1966","observed_orcids":["https://orcid.org/0000-0002-7001-1966"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Petr Jansa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5006054842","display_name":"Eva Kmon\u00ed\u010dkov\u00e1","orcid":"https://orcid.org/0000-0002-0940-4605","observed_orcids":["https://orcid.org/0000-0002-0940-4605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva Kmon\u00ed\u010dkov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1374,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.45897418,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"35 Suppl 2","issue":null,"first_page":"141","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.3208000063896179,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.3208000063896179,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.10409999638795853,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.06379999965429306,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/respiratory-complex-ii","display_name":"respiratory complex II","score":0.9150000214576721},{"id":"https://openalex.org/keywords/succinate-dehydrogenase","display_name":"succinate dehydrogenase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pyrimidine-derivatives","display_name":"pyrimidine derivatives","score":0.8050000071525574},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7059999704360962},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8479999899864197},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8539999723434448},{"id":"https://openalex.org/keywords/formazan-formation","display_name":"formazan formation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/immunostimulation","display_name":"immunostimulation","score":0.5789999961853027},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C2776892249","wikidata":"https://www.wikidata.org/wiki/Q2324668","display_name":"Formazan","level":2,"score":0.9822449684143066},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5375202894210815},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5194770693778992},{"id":"https://openalex.org/C2776390042","wikidata":"https://www.wikidata.org/wiki/Q415248","display_name":"Tetrazolium chloride","level":3,"score":0.5124374032020569},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5051794648170471},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4977686405181885},{"id":"https://openalex.org/C2781330172","wikidata":"https://www.wikidata.org/wiki/Q412837","display_name":"Succinate dehydrogenase","level":3,"score":0.4731781780719757},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.46375635266304016},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.46358323097229004},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.4315839409828186},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.40241849422454834},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3619966506958008},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31057798862457275},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.27805572748184204},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2663373351097107},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2369251251220703},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10999295115470886},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005562","descriptor_name":"Formazans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010537","descriptor_name":"Peritoneum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042963","descriptor_name":"Electron Transport Complex II","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:25638378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25638378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},{"id":"pmh:oai:asep.lib.cas.cz:CavUnEpca/0437836","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11104/0241357","pdf_url":null,"source":{"id":"https://openalex.org/S7407055266","display_name":"ASEP","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2132222089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25638378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W54593518","https://openalex.org/W199620319","https://openalex.org/W1566271574","https://openalex.org/W1593116706","https://openalex.org/W1944330918","https://openalex.org/W1967939624","https://openalex.org/W1974825648","https://openalex.org/W1979551064","https://openalex.org/W1987944461","https://openalex.org/W1991845993","https://openalex.org/W2003832593","https://openalex.org/W2016369333","https://openalex.org/W2027966949","https://openalex.org/W2029275361","https://openalex.org/W2038655329","https://openalex.org/W2039502840","https://openalex.org/W2042503285","https://openalex.org/W2045210787","https://openalex.org/W2076778029","https://openalex.org/W2085420225","https://openalex.org/W2091609427","https://openalex.org/W2114918609","https://openalex.org/W2131322950","https://openalex.org/W2135061219","https://openalex.org/W2144052431","https://openalex.org/W2144266362","https://openalex.org/W2159712011","https://openalex.org/W2169615089","https://openalex.org/W2186449950","https://openalex.org/W2239571459","https://openalex.org/W2301087700","https://openalex.org/W2339811142"],"related_works":["https://openalex.org/W2344904906","https://openalex.org/W2094233979","https://openalex.org/W7096688140","https://openalex.org/W2319259005","https://openalex.org/W2054363862","https://openalex.org/W1941459098","https://openalex.org/W4319433483","https://openalex.org/W2067027864","https://openalex.org/W7098106655","https://openalex.org/W2091609427"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Formation":[1],"of":[2,9,11,17,19,34,40,55,67,71,85,114,121,124,160,173,192,231,234,240,243],"formazan":[3,62,89,115,162,201,208,217],"is":[4,14],"a":[5,15,224],"commonly":[6],"used":[7],"measure":[8],"cytotoxicity":[10],"compounds.":[12],"It":[13,211],"product":[16],"reduction":[18,36],"tetrazolium":[20],"salts":[21],"such":[22],"as":[23],"4-[3-":[24],"(4-iodophenyl)-2-":[25],"(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene":[26],"disulfonate":[27],"(WST-1)":[28],"and":[29,48,76,79,94,129,141],"2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium":[30],"chloride.":[31],"The":[32,53,171,219],"extent":[33],"substrates":[35],"reflects":[37],"the":[38,65,119,127,189,199,206,215,228,238],"activity":[39,172],"enzymes":[41],"succinate":[42],"dehydrogenase":[43,50],"(SDH;":[44],"respiratory":[45],"complex":[46],"II)":[47],"lactate":[49],"(LDH),":[51],"respectively.":[52],"aim":[54],"present":[56],"study":[57],"was":[58,135,178],"a)":[59],"to":[60,81],"investigate":[61],"formation":[63],"under":[64,237],"conditions":[66,239],"in":[68,110,180],"vitro":[69],"stimulation":[70,242],"cells":[72,93],"with":[73,88,153,185],"interferon-\u03b3":[74],"(IFN-\u03b3)":[75],"lipopolysaccharide":[77],"(LPS),":[78],"b)":[80],"analyse":[82],"possible":[83],"interference":[84],"pyrimidine":[86],"analogues":[87],"production.":[90,202],"METHODS:":[91],"Peritoneal":[92],"splenocytes":[95],"were":[96,102,116,150],"obtained":[97],"from":[98],"C57BL/6":[99],"mice.":[100],"They":[101],"cultured":[103],"at":[104,118],"37":[105],"degrees":[106],"C,":[107],"5%":[108],"CO2":[109],"humidified":[111],"incubator.":[112],"Levels":[113],"determined":[117],"interval":[120],"24":[122,146],"h":[123,147],"culture":[125],"using":[126],"WST-1":[128],"LDH":[130,174],"assays.":[131],"Nitric":[132],"oxide":[133],"(NO)":[134],"activated":[136],"by":[137,143,163,166,168,209],"IFN-\u03b3":[138,157,204],"plus":[139],"LPS":[140,177],"assayed":[142],"Griess":[144],"reagent":[145],"afterwards.":[148],"Pyrimidines":[149],"applied":[151],"concomitantly":[152],"immunostimulatory":[154],"agents.":[155],"RESULTS:":[156],"enhanced":[158],"concentration":[159],"SDH-produced":[161,193,207],"macrophages":[164],"(not":[165],"splenocytes)":[167],"approximately":[169],"50%.":[170],"remained":[175],"unaffected.":[176],"ineffective":[179],"both":[181],"cases.":[182],"While":[183],"pyrimidines":[184],"NO-inhibitory":[186],"properties":[187,233],"suppressed":[188],"IFN-\u03b3-enhanced":[190],"levels":[191],"formazan,":[194],"they":[195],"did":[196],"not":[197,213],"change":[198,214],"LDH-dependent":[200,216],"CONCLUSION:":[203],"augments":[205],"macrophages.":[210],"does":[212],"formation.":[218],"enhancing":[220],"effect":[221],"may":[222],"have":[223],"significant":[225],"impact":[226],"upon":[227],"appropriate":[229],"interpretation":[230],"cytotoxic":[232],"drugs":[235],"investigated":[236],"immune":[241],"cells.":[244]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
