{"id":"https://openalex.org/W2132211486","doi":"https://doi.org/10.1128/aac.01250-10","title":"Identification of Pyruvate Kinase in Methicillin-Resistant Staphylococcus aureus as a Novel Antimicrobial Drug Target","display_name":"Identification of Pyruvate Kinase in Methicillin-Resistant Staphylococcus aureus as a Novel Antimicrobial Drug Target","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W2132211486","doi":"https://doi.org/10.1128/aac.01250-10","mag":"2132211486","pmid":"https://pubmed.ncbi.nlm.nih.gov/21357306","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3088274"},"language":"en","primary_location":{"id":"doi:10.1128/aac.01250-10","doi":"https://doi.org/10.1128/aac.01250-10","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.01250-10","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3088274","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031757528","display_name":"Roya Zoraghi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Roya Zoraghi","raw_affiliation_strings":["Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","Department of Medicine, Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Department of Medicine, Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002218346","display_name":"Raymond H. See","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Raymond H. See","raw_affiliation_strings":["Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","the Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"the Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090325831","display_name":"Peter Axerio-Cilies","orcid":"https://orcid.org/0000-0003-4496-1172","observed_orcids":["https://orcid.org/0000-0003-4496-1172"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Peter Axerio-Cilies","raw_affiliation_strings":["Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033237174","display_name":"Nag S. Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802940977","display_name":"BC Centre for Disease Control","ror":"https://ror.org/05jyzx602","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1308729876","https://openalex.org/I156965999","https://openalex.org/I2802940977"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nag S. Kumar","raw_affiliation_strings":["British Columbia Center for Disease Control, Vancouver, British Columbia, Canada","5British Columbia Center for Disease Control, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Columbia Center for Disease Control, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I2802940977"]},{"raw_affiliation_string":"5British Columbia Center for Disease Control, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I2802940977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113838159","display_name":"Huansheng Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Huansheng Gong","raw_affiliation_strings":["Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anne Moreau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802940977","display_name":"BC Centre for Disease Control","ror":"https://ror.org/05jyzx602","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1308729876","https://openalex.org/I156965999","https://openalex.org/I2802940977"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Anne Moreau","raw_affiliation_strings":["British Columbia Center for Disease Control, Vancouver, British Columbia, Canada","5British Columbia Center for Disease Control, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Columbia Center for Disease Control, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I2802940977"]},{"raw_affiliation_string":"5British Columbia Center for Disease Control, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I2802940977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016605046","display_name":"Michael Hsing","orcid":"https://orcid.org/0000-0003-3437-7669","observed_orcids":["https://orcid.org/0000-0003-3437-7669"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael Hsing","raw_affiliation_strings":["Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada","Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","6Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"6Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101638317","display_name":"Sukhbir Kaur","orcid":"https://orcid.org/0000-0002-5234-533X","observed_orcids":["https://orcid.org/0000-0002-5234-533X"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sukhbir Kaur","raw_affiliation_strings":["Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087539897","display_name":"Richard D. Swayze","orcid":"https://orcid.org/0000-0003-0692-5648","observed_orcids":["https://orcid.org/0000-0003-0692-5648"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Richard D. Swayze","raw_affiliation_strings":["Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027732508","display_name":"L.J. Worrall","orcid":"https://orcid.org/0000-0003-4966-7175","observed_orcids":["https://orcid.org/0000-0003-4966-7175"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Liam Worrall","raw_affiliation_strings":["Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada","2Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"2Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008940512","display_name":"Emily Amandoron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Emily Amandoron","raw_affiliation_strings":["Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051882756","display_name":"Tian Lian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tian Lian","raw_affiliation_strings":["Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Linda Jackson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Linda Jackson","raw_affiliation_strings":["Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102320867","display_name":"Jihong Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jihong Jiang","raw_affiliation_strings":["Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005253195","display_name":"Lisa Thorson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lisa Thorson","raw_affiliation_strings":["Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada","2Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"2Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061403166","display_name":"Christophe Labri\u00e8re","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802940977","display_name":"BC Centre for Disease Control","ror":"https://ror.org/05jyzx602","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1308729876","https://openalex.org/I156965999","https://openalex.org/I2802940977"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christophe Labriere","raw_affiliation_strings":["British Columbia Center for Disease Control, Vancouver, British Columbia, Canada","5British Columbia Center for Disease Control, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Columbia Center for Disease Control, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I2802940977"]},{"raw_affiliation_string":"5British Columbia Center for Disease Control, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I2802940977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044695259","display_name":"Leonard J. Foster","orcid":"https://orcid.org/0000-0001-8551-4817","observed_orcids":["https://orcid.org/0000-0001-8551-4817"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Leonard Foster","raw_affiliation_strings":["Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada","Bioinformatics Graduate Program, University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Bioinformatics Graduate Program, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047587564","display_name":"Robert C. Brunham","orcid":"https://orcid.org/0000-0002-2853-3402","observed_orcids":["https://orcid.org/0000-0002-2853-3402"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Robert C. Brunham","raw_affiliation_strings":["Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","the Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"the Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069711282","display_name":"W. Robert McMaster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"William R. McMaster","raw_affiliation_strings":["Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030919684","display_name":"B. Brett Finlay","orcid":"https://orcid.org/0000-0001-5303-6128","observed_orcids":["https://orcid.org/0000-0001-5303-6128"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"B. Brett Finlay","raw_affiliation_strings":["Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada","Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022292484","display_name":"Natalie C. J. Strynadka","orcid":"https://orcid.org/0000-0002-4058-9425","observed_orcids":["https://orcid.org/0000-0002-4058-9425"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Natalie C. Strynadka","raw_affiliation_strings":["Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada","2Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"2Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070580886","display_name":"Artem R Cherkasov","orcid":"https://orcid.org/0000-0002-1599-1439","observed_orcids":["https://orcid.org/0000-0002-1599-1439"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Artem Cherkasov","raw_affiliation_strings":["Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada","Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","6Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"1Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"6Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063566841","display_name":"Robert Norman Young","orcid":"https://orcid.org/0000-0002-8235-6080","observed_orcids":["https://orcid.org/0000-0002-8235-6080"]},"institutions":[{"id":"https://openalex.org/I2802940977","display_name":"BC Centre for Disease Control","ror":"https://ror.org/05jyzx602","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1308729876","https://openalex.org/I156965999","https://openalex.org/I2802940977"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Robert N. Young","raw_affiliation_strings":["British Columbia Center for Disease Control, Vancouver, British Columbia, Canada","5British Columbia Center for Disease Control, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Columbia Center for Disease Control, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I2802940977"]},{"raw_affiliation_string":"5British Columbia Center for Disease Control, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I2802940977"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039788418","display_name":"Neil E. Reiner","orcid":"https://orcid.org/0000-0003-2946-9999","observed_orcids":["https://orcid.org/0000-0003-2946-9999"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Neil E. Reiner","raw_affiliation_strings":["Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (Division of Infectious Diseases), University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9703,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.93712892,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"55","issue":"5","first_page":"2042","last_page":"2053"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.04989999905228615,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyruvate-kinase","display_name":"pyruvate kinase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.996999979019165},{"id":"https://openalex.org/keywords/multidrug-resistant-staphylococcus-aureus","display_name":"multidrug-resistant Staphylococcus aureus","score":0.9380000233650208},{"id":"https://openalex.org/keywords/antimicrobial-targets","display_name":"antimicrobial drug targets","score":0.7599999904632568},{"id":"https://openalex.org/keywords/network-science","display_name":"network science","score":0.7179999947547913},{"id":"https://openalex.org/keywords/acylhydrazones","display_name":"acylhydrazones","score":0.7799999713897705},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.5879999995231628},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.8610000014305115},{"id":"https://openalex.org/keywords/enterococcus","display_name":"Enterococcus","score":0.8500000238418579},{"id":"https://openalex.org/keywords/streptococcus","display_name":"Streptococcus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-resistance-emergence","display_name":"drug resistance emergence","score":0.4429999887943268},{"id":"https://openalex.org/keywords/anti-infective-drug-development","display_name":"anti-infective drug development","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2777052132","wikidata":"https://www.wikidata.org/wiki/Q595158","display_name":"Methicillin-resistant Staphylococcus aureus","level":4,"score":0.758740246295929},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.7173284888267517},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6431793570518494},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5933430790901184},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4414829909801483},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4413842558860779},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.43918800354003906},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.43628403544425964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39742010831832886},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3959260582923889},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.33531683683395386},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31947293877601624},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011770","descriptor_name":"Pyruvate Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011770","descriptor_name":"Pyruvate Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011770","descriptor_name":"Pyruvate Kinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.01250-10","doi":"https://doi.org/10.1128/aac.01250-10","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.01250-10","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3088274","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3088274","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:21357306","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21357306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.992.2128","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.992.2128","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://aac.asm.org/content/55/5/2042.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3088274","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3088274","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309627","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17"},{"id":"https://openalex.org/F4320310787","display_name":"Genome Canada","ror":"https://ror.org/029s29983"},{"id":"https://openalex.org/F4320319973","display_name":"Genome British Columbia","ror":"https://ror.org/03gne5057"},{"id":"https://openalex.org/F4320334362","display_name":"Department of Systems Biology, Harvard Medical School","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W50583176","https://openalex.org/W133864078","https://openalex.org/W611976593","https://openalex.org/W1581962345","https://openalex.org/W1971269833","https://openalex.org/W1974299093","https://openalex.org/W1975720177","https://openalex.org/W1983327843","https://openalex.org/W1992587080","https://openalex.org/W1993141922","https://openalex.org/W1995444593","https://openalex.org/W2002380590","https://openalex.org/W2003166050","https://openalex.org/W2009239267","https://openalex.org/W2013937471","https://openalex.org/W2015086187","https://openalex.org/W2015207840","https://openalex.org/W2016251356","https://openalex.org/W2029158589","https://openalex.org/W2043125514","https://openalex.org/W2043208192","https://openalex.org/W2043632241","https://openalex.org/W2046325580","https://openalex.org/W2047501670","https://openalex.org/W2054083400","https://openalex.org/W2054274394","https://openalex.org/W2055043387","https://openalex.org/W2063941771","https://openalex.org/W2066969376","https://openalex.org/W2079762396","https://openalex.org/W2081717635","https://openalex.org/W2082410084","https://openalex.org/W2082684495","https://openalex.org/W2091014677","https://openalex.org/W2103188790","https://openalex.org/W2115883942","https://openalex.org/W2128482141","https://openalex.org/W2132911648","https://openalex.org/W2138241173","https://openalex.org/W2156345326","https://openalex.org/W2158584099","https://openalex.org/W2158656283","https://openalex.org/W2176516200","https://openalex.org/W2336167279"],"related_works":["https://openalex.org/W1970171613","https://openalex.org/W2520893324","https://openalex.org/W2073120190","https://openalex.org/W2065187784","https://openalex.org/W4289711242","https://openalex.org/W3137619748","https://openalex.org/W2000052188","https://openalex.org/W2116247393","https://openalex.org/W7098604439","https://openalex.org/W2185730798"],"abstract_inverted_index":{"Novel":[0],"classes":[1],"of":[2,10,22,58,69,98,133,214,232,250],"antimicrobials":[3],"are":[4],"needed":[5],"to":[6,135,144,177,207,221],"address":[7],"the":[8,20,23,47,66,70,111,212],"challenge":[9],"multidrug-resistant":[11,152],"bacteria":[12],"such":[13],"as":[14,31,88,217,258],"methicillin-resistant":[15],"Staphylococcus":[16],"aureus":[17,128,154],"(MRSA).":[18],"Using":[19],"architecture":[21],"MRSA":[24,48,91,122,150],"interactome,":[25],"we":[26],"identified":[27,82,114],"pyruvate":[28],"kinase":[29],"(PK)":[30],"a":[32,41,89,218,230,240],"potential":[33],"novel":[34,139,223,251],"drug":[35,225,262],"target":[36],"based":[37,234],"upon":[38,235],"it":[39],"being":[40],"highly":[42],"connected,":[43],"essential":[44],"hub":[45],"in":[46,60,130,190,199,237],"interactome.":[49],"Structural":[50],"modeling,":[51],"including":[52,148,168],"X-ray":[53],"crystallography,":[54],"revealed":[55],"discrete":[56],"features":[57],"PK":[59,92,106,123,172,236],"MRSA,":[61,238],"which":[62],"appeared":[63],"suitable":[64],"for":[65,239,260],"selective":[67,248],"targeting":[68],"bacterial":[71,197,252],"enzyme.":[72],"In":[73,184],"silico":[74],"library":[75],"screening":[76],"combined":[77],"with":[78,101,187],"functional":[79],"enzymatic":[80,124],"assays":[81],"an":[83],"acyl":[84],"hydrazone-based":[85],"compound":[86],"(IS-130)":[87],"potent":[90],"inhibitor":[93],"(50%":[94],"inhibitory":[95],"concentration":[96],"[IC50]":[97],"0.1":[99],"\u03bcM)":[100],">1,000-fold":[102],"selectivity":[103],"over":[104],"human":[105,255],"isoforms.":[107],"Medicinal":[108],"chemistry":[109],"around":[110],"IS-130":[112],"scaffold":[113],"analogs":[115],"that":[116,202],"more":[117],"potently":[118],"and":[119,126,151,170,181,246],"selectively":[120],"inhibited":[121],"activity":[125],"S.":[127,153],"growth":[129],"vitro":[131],"(MIC":[132],"1":[134],"5":[136],"\u03bcg/ml).":[137],"These":[138,157,209],"anti-PK":[140],"compounds":[141,158,174],"were":[142,175,182,192],"found":[143,176],"possess":[145],"antistaphylococcal":[146],"activity,":[147],"both":[149],"(MDRSA)":[155],"strains.":[156],"also":[159,228],"exhibited":[160],"exceptional":[161],"antibacterial":[162,224],"activities":[163],"against":[164],"other":[165],"Gram-positive":[166],"genera,":[167],"enterococci":[169],"streptococci.":[171],"lead":[173],"be":[178,205],"noncompetitive":[179],"inhibitors":[180,249],"bactericidal.":[183],"addition,":[185],"mutants":[186],"significant":[188],"increases":[189],"MICs":[191],"not":[193],"isolated":[194],"after":[195],"25":[196],"passages":[198],"culture,":[200],"indicating":[201],"resistance":[203],"may":[204],"slow":[206],"emerge.":[208],"findings":[210],"validate":[211],"principles":[213],"network":[215],"science":[216],"powerful":[219],"approach":[220],"identify":[222],"targets.":[226],"They":[227],"provide":[229],"proof":[231],"principle,":[233],"research":[241],"platform":[242],"aimed":[243],"at":[244],"discovering":[245],"optimizing":[247],"targets":[253],"where":[254],"orthologs":[256],"exist,":[257],"leads":[259],"anti-infective":[261],"development.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}