{"id":"https://openalex.org/W2132154261","doi":"https://doi.org/10.1186/1479-5876-9-111","title":"Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneration","display_name":"Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneration","publication_year":2011,"publication_date":"2011-07-15","ids":{"openalex":"https://openalex.org/W2132154261","doi":"https://doi.org/10.1186/1479-5876-9-111","mag":"2132154261","pmid":"https://pubmed.ncbi.nlm.nih.gov/21762495","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3154861"},"language":"en","primary_location":{"id":"doi:10.1186/1479-5876-9-111","doi":"https://doi.org/10.1186/1479-5876-9-111","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1479-5876-9-111","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/1479-5876-9-111","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/1479-5876-9-111","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101820698","display_name":"Baoying Liu","orcid":"https://orcid.org/0000-0003-2389-5946","observed_orcids":["https://orcid.org/0000-0003-2389-5946"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baoying Liu","raw_affiliation_strings":["Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100461545","display_name":"Lai Wei","orcid":"https://orcid.org/0000-0002-3300-8506","observed_orcids":["https://orcid.org/0000-0002-3300-8506","https://orcid.org/0009-0000-6995-6498"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lai Wei","raw_affiliation_strings":["Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066334310","display_name":"CATHERINE B. MEYERLE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Meyerle","raw_affiliation_strings":["Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]},{"raw_affiliation_string":"Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072687034","display_name":"Jingsheng Tuo","orcid":"https://orcid.org/0000-0002-1372-7810","observed_orcids":["https://orcid.org/0000-0002-1372-7810"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingsheng Tuo","raw_affiliation_strings":["Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027427092","display_name":"Hatice Nida Sen","orcid":"https://orcid.org/0000-0002-5919-0377","observed_orcids":["https://orcid.org/0000-0002-5919-0377"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Nida Sen","raw_affiliation_strings":["Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100390288","display_name":"Zhiyu Li","orcid":"https://orcid.org/0000-0001-5837-0547","observed_orcids":["https://orcid.org/0000-0001-5837-0547","https://orcid.org/0000-0003-0546-3023","https://orcid.org/0009-0002-9797-097X","https://orcid.org/0009-0008-3196-7739"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiyu Li","raw_affiliation_strings":["Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052866855","display_name":"Sagarika Chakrabarty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sagarika Chakrabarty","raw_affiliation_strings":["Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088588454","display_name":"Elvira Agr\u00f3n","orcid":"https://orcid.org/0000-0002-2829-4042","observed_orcids":["https://orcid.org/0000-0002-2829-4042"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elvira Agron","raw_affiliation_strings":["Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055348574","display_name":"Chi\u2010Chao Chan","orcid":"https://orcid.org/0000-0001-9460-8049","observed_orcids":["https://orcid.org/0000-0001-9460-8049"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi-Chao Chan","raw_affiliation_strings":["Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102940439","display_name":"Michael L. Klein","orcid":"https://orcid.org/0000-0001-7312-9719","observed_orcids":["https://orcid.org/0000-0001-7312-9719"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L Klein","raw_affiliation_strings":["Macular Degeneration Center and Leonard Christensen Eye Pathology Laboratory, Casey Eye Institute, Oregon Health & Science University, Portland, OR, 97239, USA","Macular Degeneration Center and Leonard Christensen Eye Pathology Laboratory, Casey Eye Institute, Oregon Health & Science University, Portland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macular Degeneration Center and Leonard Christensen Eye Pathology Laboratory, Casey Eye Institute, Oregon Health & Science University, Portland, OR, 97239, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Macular Degeneration Center and Leonard Christensen Eye Pathology Laboratory, Casey Eye Institute, Oregon Health & Science University, Portland, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090802305","display_name":"Emily Y. Chew","orcid":"https://orcid.org/0000-0003-0999-9802","observed_orcids":["https://orcid.org/0000-0003-0999-9802"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Chew","raw_affiliation_strings":["Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010240899","display_name":"Frederick L. Ferris","orcid":"https://orcid.org/0000-0002-4933-0639","observed_orcids":["https://orcid.org/0000-0002-4933-0639"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick Ferris","raw_affiliation_strings":["Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016920591","display_name":"Robert Burton Nussenblatt","orcid":"https://orcid.org/0000-0001-6469-1080","observed_orcids":["https://orcid.org/0000-0001-6469-1080"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert B Nussenblatt","raw_affiliation_strings":["Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016920591"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":6.9723,"has_fulltext":true,"cited_by_count":167,"citation_normalized_percentile":{"value":0.97836026,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"9","issue":"1","first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.5127000212669373,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.5127000212669373,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.40549999475479126,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.04690000042319298,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9950000047683716},{"id":"https://openalex.org/keywords/il-22","display_name":"IL-22","score":0.9409999847412109},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":1.0},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/complement-factor-h","display_name":"complement factor H","score":0.7940000295639038},{"id":"https://openalex.org/keywords/b7","display_name":"B7","score":0.5720000267028809},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8960000276565552},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/t-cell-apoptosis","display_name":"T cell apoptosis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/exudative-amd","display_name":"exudative AMD","score":0.7310000061988831},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.5615304112434387},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5453743934631348},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.5285640954971313},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5192294716835022},{"id":"https://openalex.org/C179369057","wikidata":"https://www.wikidata.org/wiki/Q20970075","display_name":"Complement factor I","level":4,"score":0.4824522137641907},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47499123215675354},{"id":"https://openalex.org/C14356644","wikidata":"https://www.wikidata.org/wiki/Q14911975","display_name":"Factor H","level":4,"score":0.43515971302986145},{"id":"https://openalex.org/C182629451","wikidata":"https://www.wikidata.org/wiki/Q18251054","display_name":"Complement factor B","level":4,"score":0.41013896465301514},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.340972363948822},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.24413329362869263},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09338441491127014},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097043","descriptor_name":"Interleukin-22","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015936","descriptor_name":"Complement C5a","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1479-5876-9-111","doi":"https://doi.org/10.1186/1479-5876-9-111","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1479-5876-9-111","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/1479-5876-9-111","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2161173","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3154861","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3154861","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3154861","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Transl Med","raw_type":"Text"},{"id":"pmid:21762495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21762495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.289.1768","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.289.1768","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/96/20/J_Transl_Med_2011_Jul_15_9_111.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:2a9c74bff31743b7acca073cbe144dd4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2a9c74bff31743b7acca073cbe144dd4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Translational Medicine, Vol 9, Iss 1, p 111 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1479-5876-9-111","doi":"https://doi.org/10.1186/1479-5876-9-111","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1479-5876-9-111","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/1479-5876-9-111","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2132154261.pdf","grobid_xml":"https://content.openalex.org/works/W2132154261.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1481978003","https://openalex.org/W1530509485","https://openalex.org/W1974663077","https://openalex.org/W1977327764","https://openalex.org/W1977422420","https://openalex.org/W1977681642","https://openalex.org/W1982443452","https://openalex.org/W1982926364","https://openalex.org/W1989747234","https://openalex.org/W1990057691","https://openalex.org/W1994797655","https://openalex.org/W1997288094","https://openalex.org/W2012077729","https://openalex.org/W2012680181","https://openalex.org/W2021272086","https://openalex.org/W2027707278","https://openalex.org/W2028283509","https://openalex.org/W2039627373","https://openalex.org/W2044063309","https://openalex.org/W2064170412","https://openalex.org/W2067092037","https://openalex.org/W2067913923","https://openalex.org/W2069288346","https://openalex.org/W2075634939","https://openalex.org/W2085321949","https://openalex.org/W2102384125","https://openalex.org/W2105479207","https://openalex.org/W2108768628","https://openalex.org/W2109470430","https://openalex.org/W2113776905","https://openalex.org/W2113784410","https://openalex.org/W2117957387","https://openalex.org/W2121855384","https://openalex.org/W2125236492","https://openalex.org/W2129218540","https://openalex.org/W2130550928","https://openalex.org/W2131058743","https://openalex.org/W2136501493","https://openalex.org/W2151566115","https://openalex.org/W2156451877","https://openalex.org/W2157514220","https://openalex.org/W2306107073","https://openalex.org/W2335110838","https://openalex.org/W3145351529"],"related_works":["https://openalex.org/W7095142597","https://openalex.org/W1202398710","https://openalex.org/W2073924928","https://openalex.org/W2535897801","https://openalex.org/W2785786028","https://openalex.org/W1024661353","https://openalex.org/W2322911088","https://openalex.org/W1999710592","https://openalex.org/W1175803354","https://openalex.org/W4388501219"],"abstract_inverted_index":{"BACKGROUND:":[0],"Age":[1],"related":[2],"macular":[3],"degeneration":[4],"(AMD)":[5],"is":[6,75,180],"the":[7,47,68,100,135,157,238,246,250,268],"leading":[8],"cause":[9],"of":[10,50,55,70,102,105,132,209,245,263],"irreversible":[11],"blindness":[12],"in":[13,29,67,88,211,219,226,257,267],"elderly":[14],"populations":[15],"worldwide.":[16],"Inflammation,":[17],"among":[18],"many":[19],"factors,":[20],"has":[21],"been":[22,65],"suggested":[23],"to":[24,76,122,231,249,272,279],"play":[25],"an":[26],"important":[27],"role":[28,208],"AMD":[30,41,71,106,227,258,273],"pathogenesis.":[31],"Recent":[32],"studies":[33],"have":[34,64,191],"demonstrated":[35],"a":[36,109,143,207,276],"strong":[37],"genetic":[38],"association":[39],"between":[40],"and":[42,85,116,137,140,170,185,214,221,254,265],"complement":[43,51,56,60],"factor":[44,49],"H":[45],"(CFH),":[46],"down-regulatory":[48],"activation.":[52],"Elevated":[53],"levels":[54,223,256],"activating":[57],"molecules":[58],"including":[59],"component":[61],"5a":[62],"(C5a)":[63],"found":[66,193,225],"serum":[69,252],"patients.":[72,259],"Our":[73,235],"aim":[74],"study":[77],"whether":[78],"C5a":[79,166,195,210,241],"can":[80],"impact":[81],"human":[82,174,198],"T":[83,176],"cells":[84,95,127,133,200],"its":[86],"implication":[87],"AMD.":[89,281],"METHODS:":[90],"Human":[91],"peripheral":[92],"blood":[93,101],"mononuclear":[94],"(PBMCs)":[96],"were":[97,120,128],"isolated":[98],"from":[99,188,201],"exudative":[103],"form":[104],"patients":[107,228],"using":[108,156],"Ficoll":[110],"gradient":[111],"centrifugation":[112],"protocol.":[113],"Intracellular":[114],"staining":[115,131],"enzyme-linked":[117],"immunosorbent":[118],"assays":[119],"used":[121],"measure":[123],"protein":[124],"expression.":[125],"Apoptotic":[126],"detected":[129],"by":[130,142,152,173],"with":[134,206],"annexin-V":[136],"TUNEL":[138],"technology":[139],"analyzed":[141,151],"FACS":[144],"Caliber":[145],"flow":[146],"cytometer.":[147],"SNP":[148],"genotyping":[149,154],"was":[150,224],"TaqMan":[153],"assay":[155],"Real-time":[158],"PCR":[159],"system":[160],"7500.":[161],"RESULTS:":[162],"We":[163,190],"show":[164],"that":[165,194,240,270],"promotes":[167],"interleukin":[168],"(IL)-22":[169],"IL-17":[171,215,222,255,266],"expression":[172,187],"CD4+":[175,199],"cells.":[177],"This":[178],"effect":[179],"dependent":[181],"on":[182],"B7,":[183],"IL-1\u03b2":[184],"IL-6":[186],"monocytes.":[189],"also":[192],"could":[196],"protect":[197],"undergoing":[202],"apoptosis.":[203],"Importantly,":[204],"consistent":[205],"promoting":[212],"IL-22":[213,220,253,264],"expression,":[216],"significant":[217],"elevation":[218],"as":[229],"compared":[230],"non-AMD":[232],"controls.":[233],"CONCLUSIONS:":[234],"results":[236],"support":[237],"notion":[239],"may":[242,274],"be":[243],"one":[244],"factors":[247],"contributing":[248],"elevated":[251],"The":[260],"possible":[261],"involvement":[262],"inflammation":[269],"contributes":[271],"herald":[275],"new":[277],"approach":[278],"treat":[280]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
