{"id":"https://openalex.org/W2132003502","doi":null,"title":"Suppression of polyclonal immunoglobulin production by M-proteins shows isotype specificity.","display_name":"Suppression of polyclonal immunoglobulin production by M-proteins shows isotype specificity.","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W2132003502","mag":"2132003502","pmid":"https://pubmed.ncbi.nlm.nih.gov/11508831"},"language":"en","primary_location":{"id":"pmid:11508831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11508831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical and laboratory science","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051182441","display_name":"Linghua Wang","orcid":"https://orcid.org/0000-0001-9380-0266","observed_orcids":["https://orcid.org/0000-0001-9380-0266","https://orcid.org/0000-0003-3117-1390"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Wang","raw_affiliation_strings":["Department of Pathology, University of Texas Houston Health Science Center, Houston 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Texas Houston Health Science Center, Houston 77030, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111826274","display_name":"Donn C. Young","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D C Young","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.16318661,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"31","issue":"3","first_page":"274","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoclonal-gammopathy","display_name":"monoclonal gammopathy","score":0.9150000214576721},{"id":"https://openalex.org/keywords/m-protein","display_name":"M protein","score":0.9240000247955322}],"concepts":[{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.9254399538040161},{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.8839009404182434},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6356293559074402},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.5834747552871704},{"id":"https://openalex.org/C2778808339","wikidata":"https://www.wikidata.org/wiki/Q2785444","display_name":"Immunofixation","level":5,"score":0.5526391863822937},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.5409319400787354},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5352455377578735},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5239244103431702},{"id":"https://openalex.org/C2776855637","wikidata":"https://www.wikidata.org/wiki/Q10633013","display_name":"Serum protein electrophoresis","level":5,"score":0.5093444585800171},{"id":"https://openalex.org/C2908711476","wikidata":"https://www.wikidata.org/wiki/Q6947334","display_name":"Paraproteins","level":5,"score":0.503668487071991},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4851173162460327},{"id":"https://openalex.org/C2776553844","wikidata":"https://www.wikidata.org/wiki/Q79451","display_name":"Immunoglobulin M","level":4,"score":0.45032799243927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4264594614505768},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4134003818035126},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3689251244068146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1706700325012207},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004586","descriptor_name":"Electrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010265","descriptor_name":"Paraproteinemias","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010265","descriptor_name":"Paraproteinemias","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010266","descriptor_name":"Paraproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:11508831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11508831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical and laboratory science","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.615.3057","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.615.3057","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.annclinlabsci.org/content/31/3/274.full.pdf","raw_type":"text"},{"id":"mag:2132003502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11508831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1533841403","https://openalex.org/W1535428241","https://openalex.org/W1550451690","https://openalex.org/W1580328156","https://openalex.org/W1610674244","https://openalex.org/W1968137715","https://openalex.org/W1989219157","https://openalex.org/W1992767609","https://openalex.org/W2043781062","https://openalex.org/W2107685164","https://openalex.org/W2123340007","https://openalex.org/W2136694032","https://openalex.org/W2396029499","https://openalex.org/W2468921979"],"related_works":["https://openalex.org/W1906639551","https://openalex.org/W2057411432","https://openalex.org/W2088371368","https://openalex.org/W1982424178","https://openalex.org/W1970992844","https://openalex.org/W4321440344","https://openalex.org/W71792400","https://openalex.org/W2395078282","https://openalex.org/W4236880236","https://openalex.org/W2323571498"],"abstract_inverted_index":{"Monoclonal":[0],"gammopathies":[1],"are":[2,7,28],"B":[3],"cell":[4],"neoplasms":[5],"that":[6,155,176],"characterized":[8],"by":[9],"the":[10,17,23,38,94,103,110,130,139,151,185],"presence":[11],"of":[12,33,40,74,146,170,188],"monoclonal":[13,53],"immunoglobulins":[14,56],"(M-proteins)":[15],"in":[16,31,43,57,102,184],"serum.":[18],"By":[19],"an":[20,177],"unknown":[21],"mechanism,":[22],"normal":[24,186],"polyclonal":[25,55,96,123,140,164],"immunoglobulin":[26,97,124,141],"levels":[27,125,166],"frequently":[29],"reduced":[30],"sera":[32],"these":[34,148],"patients.":[35],"To":[36],"assess":[37],"role":[39],"M-protein":[41,68,105],"isotype":[42],"this":[44],"effect,":[45],"we":[46,60],"used":[47,61],"serum":[48,62,189],"protein":[49],"electrophoresis":[50,64],"to":[51,65],"quantitate":[52],"and":[54,59,83],"patients":[58,76,85,131],"immunofixation":[63],"determine":[66],"their":[67],"isotype.":[69],"When":[70],"divided":[71],"into":[72],"populations":[73],"30":[75],"with":[77,86,116,129,132],"IgG":[78,104,117,156,165,190],"M-proteins":[79,90,118,157,169],"(mean":[80,91],"2.5":[81],"g/dl)":[82,108],"19":[84],"IgM":[87,136],"or":[88,135],"IgA":[89,134],"2.6":[92],"g/dl),":[93],"mean":[95],"level":[98],"was":[99],"significantly":[100,121],"lower":[101,122],"population":[106,112],"(0.4":[107],"than":[109,167],"IgM/IgA":[111],"(0.8":[113],"g/dl).":[114],"Patients":[115],"also":[119],"had":[120],"when":[126],"compared":[127],"separately":[128],"either":[133],"paraproteins.":[137],"Since":[138],"fraction":[142],"is":[143],"comprised":[144],"mostly":[145],"IgG,":[147],"results":[149],"give":[150],"first":[152],"direct":[153],"indication":[154],"have":[158],"a":[159],"greater":[160],"suppressive":[161],"effect":[162],"on":[163],"do":[168],"other":[171],"isotypes.":[172],"These":[173],"findings":[174],"suggest":[175],"isotype-specific":[178],"feedback":[179],"mechanism":[180],"could":[181],"be":[182],"involved":[183],"regulation":[187],"levels.":[191]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}