{"id":"https://openalex.org/W2131991790","doi":"https://doi.org/10.4049/jimmunol.170.1.373","title":"High Affinity Xenoreactive TCR:MHC Interaction Recruits CD8 in Absence of Binding to MHC","display_name":"High Affinity Xenoreactive TCR:MHC Interaction Recruits CD8 in Absence of Binding to MHC","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2131991790","doi":"https://doi.org/10.4049/jimmunol.170.1.373","mag":"2131991790","pmid":"https://pubmed.ncbi.nlm.nih.gov/12496422"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.170.1.373","doi":"https://doi.org/10.4049/jimmunol.170.1.373","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.170.1.373","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030765388","display_name":"Jennifer Buslepp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Buslepp","raw_affiliation_strings":["Biochemistry and Biophysics, University of North Carolina , Chapel Hill, NC 27599","*Biochemistry and Biophysics and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Biophysics, University of North Carolina , Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"*Biochemistry and Biophysics and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109101609","display_name":"Samantha E. Kerry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha E Kerry","raw_affiliation_strings":["Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","\u2020Microbiology and Immunology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"\u2020Microbiology and Immunology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078935078","display_name":"Douglas J. Loftus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Doug Loftus","raw_affiliation_strings":["\u00a7Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008183954","display_name":"Jeffrey A. Frelinger","orcid":"https://orcid.org/0000-0002-2503-6267","observed_orcids":["https://orcid.org/0000-0002-2503-6267"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A Frelinger","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, University of North Carolina , Chapel Hill, NC 27599","Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","\u2020Microbiology and Immunology, and","\u2021Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina , Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]},{"raw_affiliation_string":"Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"\u2020Microbiology and Immunology, and","institution_ids":[]},{"raw_affiliation_string":"\u2021Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; and","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036354240","display_name":"Ettore Appella","orcid":"https://orcid.org/0000-0003-0569-9722","observed_orcids":["https://orcid.org/0000-0003-0569-9722"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ettore Appella","raw_affiliation_strings":["\u00a7Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101699137","display_name":"Edward J. Collins","orcid":"https://orcid.org/0000-0002-3523-8532","observed_orcids":["https://orcid.org/0000-0002-3523-8532"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward J Collins","raw_affiliation_strings":["Biochemistry and Biophysics, University of North Carolina , Chapel Hill, NC 27599","Lineberger Comprehensive Cancer Center, University of North Carolina , Chapel Hill, NC 27599","Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","*Biochemistry and Biophysics and","\u2020Microbiology and Immunology, and","\u2021Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Biophysics, University of North Carolina , Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina , Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]},{"raw_affiliation_string":"Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"*Biochemistry and Biophysics and","institution_ids":[]},{"raw_affiliation_string":"\u2020Microbiology and Immunology, and","institution_ids":[]},{"raw_affiliation_string":"\u2021Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; and","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.4532,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.81315939,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"170","issue":"1","first_page":"373","last_page":"383"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-receptor","display_name":"T cell receptor","score":0.5870000123977661},{"id":"https://openalex.org/keywords/hla-a-0201","display_name":"HLA-A*0201","score":0.7049999833106995},{"id":"https://openalex.org/keywords/h-2db","display_name":"H-2Db","score":0.984000027179718},{"id":"https://openalex.org/keywords/cross-reactivity","display_name":"cross-reactivity","score":0.675000011920929},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.8100000023841858},{"id":"https://openalex.org/keywords/calcium-flux","display_name":"calcium flux","score":0.8659999966621399},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5789250731468201},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.5221439003944397},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4596867263317108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38570791482925415},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.35996025800704956},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35559502243995667},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34616759419441223},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2295588254928589},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.14789772033691406},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.06724676489830017}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015478","descriptor_name":"Antigens, Heterophile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016827","descriptor_name":"CD8 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016827","descriptor_name":"CD8 Antigens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020349","descriptor_name":"Surface Plasmon Resonance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064532","descriptor_name":"Histocompatibility Antigen H-2D","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.170.1.373","doi":"https://doi.org/10.4049/jimmunol.170.1.373","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.170.1.373","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:12496422","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12496422","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G130156950","display_name":null,"funder_award_id":"007273","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G5723008927","display_name":"Role of the MHC Class I in CD8 T Cell Activation","funder_award_id":"R01GM067143","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1481172479","https://openalex.org/W1484208379","https://openalex.org/W1496291074","https://openalex.org/W1519533633","https://openalex.org/W1520695040","https://openalex.org/W1533591329","https://openalex.org/W1546500015","https://openalex.org/W1548757996","https://openalex.org/W1562441478","https://openalex.org/W1570398970","https://openalex.org/W1586305848","https://openalex.org/W1593034497","https://openalex.org/W1609618324","https://openalex.org/W1654974774","https://openalex.org/W1667815498","https://openalex.org/W1855822212","https://openalex.org/W1922950570","https://openalex.org/W1963569988","https://openalex.org/W1966038880","https://openalex.org/W1967234833","https://openalex.org/W1968385313","https://openalex.org/W1968463439","https://openalex.org/W1970252429","https://openalex.org/W1983960385","https://openalex.org/W1991693947","https://openalex.org/W1992699522","https://openalex.org/W1995138538","https://openalex.org/W1995925083","https://openalex.org/W1996017127","https://openalex.org/W1997795463","https://openalex.org/W2009781034","https://openalex.org/W2011110777","https://openalex.org/W2015292653","https://openalex.org/W2015681299","https://openalex.org/W2024441858","https://openalex.org/W2025229322","https://openalex.org/W2031482359","https://openalex.org/W2044219128","https://openalex.org/W2044311894","https://openalex.org/W2047351190","https://openalex.org/W2048725216","https://openalex.org/W2052869090","https://openalex.org/W2053369043","https://openalex.org/W2055271950","https://openalex.org/W2060137087","https://openalex.org/W2060165194","https://openalex.org/W2060264122","https://openalex.org/W2061785082","https://openalex.org/W2067069532","https://openalex.org/W2078125157","https://openalex.org/W2078494443","https://openalex.org/W2099814898","https://openalex.org/W2102903171","https://openalex.org/W2106160458","https://openalex.org/W2112997727","https://openalex.org/W2119879881","https://openalex.org/W2120766171","https://openalex.org/W2121503187","https://openalex.org/W2127353647","https://openalex.org/W2129134079","https://openalex.org/W2140844094","https://openalex.org/W2148426299","https://openalex.org/W2150345297","https://openalex.org/W2166313015","https://openalex.org/W2412887707","https://openalex.org/W2762980752"],"related_works":["https://openalex.org/W161325165","https://openalex.org/W2042973385","https://openalex.org/W2078125157","https://openalex.org/W7098875964","https://openalex.org/W1984493616","https://openalex.org/W2132776501","https://openalex.org/W2165051352","https://openalex.org/W2065430316","https://openalex.org/W1532828658","https://openalex.org/W1964115378"],"abstract_inverted_index":{"The":[0],"TCR":[1,46,85],"from":[2],"a":[3,76],"xenoreactive":[4],"murine":[5,13,82,88],"cytotoxic":[6],"T":[7,35,91,129],"lymphocyte":[8],"clone,":[9],"AHIII":[10,44,83,127],"12.2,":[11],"recognizes":[12],"H-2D(b)":[14],"complexed":[15,25],"with":[16,26,103,108,115,131],"peptide":[17],"p1058":[18],"(FAPGFFPYL)":[19],"as":[20,22,53,106],"well":[21],"human":[23,27,73,104],"HLA-A2.1":[24],"self-peptide":[28],"p1049":[29],"(ALWGFFPVL).":[30],"To":[31],"understand":[32],"more":[33],"about":[34],"cell":[36,92],"biology":[37],"and":[38,56,66,94,137,143],"cross-reactivity,":[39],"the":[40,43,57,81,119,155],"ectodomains":[41],"of":[42,99,121,126,157,173],"12.2":[45,84,128],"have":[47],"been":[48],"produced":[49],"in":[50,118],"E.":[51],"coli":[52],"inclusion":[54],"bodies":[55],"protein":[58],"folded":[59],"to":[60,154],"its":[61],"native":[62],"conformation.":[63],"Flow":[64],"cytometric":[65],"surface":[67],"plasmon":[68],"resonance":[69,145],"analyses":[70],"indicate":[71,165],"that":[72,111,166],"p1049/A2":[74,105,133],"has":[75],"significantly":[77],"greater":[78],"affinity":[79,177],"for":[80,171],"than":[86],"does":[87],"p1058/D(b).":[89],"Yet,":[90],"binding":[93],"cytolytic":[95],"activity":[96],"are":[97],"independent":[98],"CD8":[100,113,123,151,174],"when":[101],"stimulated":[102],"demonstrated":[107],"anti-CD8":[109],"Abs":[110],"block":[112],"association":[114],"MHC.":[116],"Even":[117],"absence":[120],"direct":[122],"binding,":[124],"stimulation":[125],"cells":[130],"\"CD8-independent\"":[132],"produces":[134],"p56(lck)":[135],"activation":[136],"calcium":[138],"flux.":[139],"Confocal":[140],"fluorescence":[141,144],"microscopy":[142],"energy":[146],"transfer":[147],"flow":[148],"cytometry":[149],"demonstrate":[150],"is":[152],"recruited":[153],"site":[156],"TCR:peptide":[158,178],"MHC":[159,179],"binding.":[160],"Taken":[161],"together,":[162],"these":[163],"results":[164],"there":[167],"exists":[168],"another":[169],"mechanism":[170],"recruitment":[172],"during":[175],"high":[176],"engagement.":[180]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}