{"id":"https://openalex.org/W2131936635","doi":"https://doi.org/10.1530/eje.0.1490521","title":"Insulin sensitivity and glucose tolerance improve in patients with acromegaly converted from depot octreotide to pegvisomant","display_name":"Insulin sensitivity and glucose tolerance improve in patients with acromegaly converted from depot octreotide to pegvisomant","publication_year":2003,"publication_date":"2003-12-01","ids":{"openalex":"https://openalex.org/W2131936635","doi":"https://doi.org/10.1530/eje.0.1490521","mag":"2131936635","pmid":"https://pubmed.ncbi.nlm.nih.gov/14640992"},"language":"en","primary_location":{"id":"doi:10.1530/eje.0.1490521","doi":"https://doi.org/10.1530/eje.0.1490521","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje.0.1490521","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113609062","display_name":"W M Drake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"WM Drake","raw_affiliation_strings":["Christie Hospital, Manchester, UK","Departments of Endocrinology, St Bartholomew's Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christie Hospital, Manchester, UK","institution_ids":["https://openalex.org/I4210131968"]},{"raw_affiliation_string":"Departments of Endocrinology, St Bartholomew's Hospital, London, UK","institution_ids":["https://openalex.org/I1307195382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065855984","display_name":"S Rowles","orcid":"https://orcid.org/0000-0002-3782-0745","observed_orcids":["https://orcid.org/0000-0002-3782-0745"]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"SV Rowles","raw_affiliation_strings":["Christie Hospital, Manchester, UK","Departments of Endocrinology, St Bartholomew's Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christie Hospital, Manchester, UK","institution_ids":["https://openalex.org/I4210131968"]},{"raw_affiliation_string":"Departments of Endocrinology, St Bartholomew's Hospital, London, UK","institution_ids":["https://openalex.org/I1307195382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100890260","display_name":"ME Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"ME Roberts","raw_affiliation_strings":["Christie Hospital, Manchester, UK","Departments of Endocrinology, St Bartholomew's Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christie Hospital, Manchester, UK","institution_ids":["https://openalex.org/I4210131968"]},{"raw_affiliation_string":"Departments of Endocrinology, St Bartholomew's Hospital, London, UK","institution_ids":["https://openalex.org/I1307195382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028688220","display_name":"FK Fode","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"FK Fode","raw_affiliation_strings":["Christie Hospital, Manchester, UK","Departments of Endocrinology, St Bartholomew's Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christie Hospital, Manchester, UK","institution_ids":["https://openalex.org/I4210131968"]},{"raw_affiliation_string":"Departments of Endocrinology, St Bartholomew's Hospital, London, UK","institution_ids":["https://openalex.org/I1307195382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111742453","display_name":"G. MICHAEL BESSER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"GM Besser","raw_affiliation_strings":["Christie Hospital, Manchester, UK","Departments of Endocrinology, St Bartholomew's Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christie Hospital, Manchester, UK","institution_ids":["https://openalex.org/I4210131968"]},{"raw_affiliation_string":"Departments of Endocrinology, St Bartholomew's Hospital, London, UK","institution_ids":["https://openalex.org/I1307195382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113690139","display_name":"JP Monson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"JP Monson","raw_affiliation_strings":["Christie Hospital, Manchester, UK","Departments of Endocrinology, St Bartholomew's Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christie Hospital, Manchester, UK","institution_ids":["https://openalex.org/I4210131968"]},{"raw_affiliation_string":"Departments of Endocrinology, St Bartholomew's Hospital, London, UK","institution_ids":["https://openalex.org/I1307195382"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086705461","display_name":"Peter James Trainer","orcid":"https://orcid.org/0000-0003-0146-3835","observed_orcids":["https://orcid.org/0000-0003-0146-3835"]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"PJ Trainer","raw_affiliation_strings":["Christie Hospital, Manchester, UK","Departments of Endocrinology, St Bartholomew's Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christie Hospital, Manchester, UK","institution_ids":["https://openalex.org/I4210131968"]},{"raw_affiliation_string":"Departments of Endocrinology, St Bartholomew's Hospital, London, UK","institution_ids":["https://openalex.org/I1307195382"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113609062"],"corresponding_institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I4210131968"],"apc_list":{"value":3798,"currency":"EUR","value_usd":4292},"apc_paid":null,"fwci":4.932,"has_fulltext":false,"cited_by_count":128,"citation_normalized_percentile":{"value":0.95993357,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"149","issue":"6","first_page":"521","last_page":"527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acromegaly","display_name":"acromegaly","score":0.9959999918937683},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.8420000076293945},{"id":"https://openalex.org/keywords/pegvisomant","display_name":"pegvisomant","score":0.8569999933242798},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8659999966621399},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.6629999876022339},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.7099999785423279},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.5640000104904175},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.4819999933242798},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.5299999713897705},{"id":"https://openalex.org/keywords/somatostatin-analogs","display_name":"somatostatin analogues","score":0.6549999713897705},{"id":"https://openalex.org/keywords/growth-hormone-excess","display_name":"growth hormone excess","score":0.49900001287460327},{"id":"https://openalex.org/keywords/insulin-tolerance-test","display_name":"insulin tolerance test","score":0.5860000252723694},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.8759999871253967},{"id":"https://openalex.org/keywords/treatment-switching","display_name":"treatment switching","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C2777433750","wikidata":"https://www.wikidata.org/wiki/Q189580","display_name":"Acromegaly","level":4,"score":0.939602255821228},{"id":"https://openalex.org/C2778886798","wikidata":"https://www.wikidata.org/wiki/Q409697","display_name":"Pegvisomant","level":5,"score":0.8972111344337463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8666330575942993},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8237146735191345},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7794638276100159},{"id":"https://openalex.org/C2781025020","wikidata":"https://www.wikidata.org/wiki/Q419935","display_name":"Octreotide","level":3,"score":0.709668755531311},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5803290605545044},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.49998927116394043},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.48242148756980896},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.2101755440235138},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.14224424958229065},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.10067301988601685}],"mesh":[{"descriptor_ui":"D000172","descriptor_name":"Acromegaly","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000172","descriptor_name":"Acromegaly","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011986","descriptor_name":"Receptors, Somatotropin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011986","descriptor_name":"Receptors, Somatotropin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015282","descriptor_name":"Octreotide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015282","descriptor_name":"Octreotide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020249","descriptor_name":"Hormone Replacement Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1530/eje.0.1490521","doi":"https://doi.org/10.1530/eje.0.1490521","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje.0.1490521","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:14640992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14640992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of endocrinology","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.558.991","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.558.991","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.eje-online.org/content/149/6/521.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1965105130","https://openalex.org/W1965386842","https://openalex.org/W1980214906","https://openalex.org/W1984510069","https://openalex.org/W2009323605","https://openalex.org/W2010772266","https://openalex.org/W2012898950","https://openalex.org/W2017091398","https://openalex.org/W2031639107","https://openalex.org/W2036600263","https://openalex.org/W2042546360","https://openalex.org/W2043275746","https://openalex.org/W2050515584","https://openalex.org/W2060583741","https://openalex.org/W2072866212","https://openalex.org/W2079869308","https://openalex.org/W2085671408","https://openalex.org/W2086985095","https://openalex.org/W2088031764","https://openalex.org/W2089110549","https://openalex.org/W2093971360","https://openalex.org/W2099948919","https://openalex.org/W2111216596","https://openalex.org/W2114972202","https://openalex.org/W2134166265","https://openalex.org/W2141897214","https://openalex.org/W2147795491","https://openalex.org/W2151287536","https://openalex.org/W2156302750","https://openalex.org/W2158162115","https://openalex.org/W2160234571","https://openalex.org/W2161027467","https://openalex.org/W2164303686","https://openalex.org/W2169401893","https://openalex.org/W2319820122","https://openalex.org/W2336144997"],"related_works":["https://openalex.org/W2291405372","https://openalex.org/W7098987437","https://openalex.org/W2045942594","https://openalex.org/W2047894687","https://openalex.org/W1983950740","https://openalex.org/W2621907360","https://openalex.org/W2107244929","https://openalex.org/W2289241168","https://openalex.org/W2004483751","https://openalex.org/W2161555684"],"abstract_inverted_index":{"AIM":[0],"AND":[1],"METHOD:":[2],"Insulin":[3],"resistance":[4],"leading,":[5],"in":[6,35,39,189,283,304,315,334],"some":[7],"cases,":[8],"to":[9,17,32,89,178,212,232,310],"glucose":[10,120,171,198,209,301],"intolerance":[11],"is":[12],"an":[13,331],"important":[14,332],"contributory":[15],"factor":[16,333],"the":[18,214,248,251,335],"cardiovascular":[19],"morbidity":[20],"and":[21,84,121,124,150,184,300,318],"mortality":[22],"associated":[23],"with":[24,45,57,91,148,151,273,342],"acromegaly.":[25,343],"The":[26],"aim":[27],"of":[28,42,61,78,104,203,250,337],"this":[29],"study":[30,252],"was":[31,111,134,185,245,296],"document":[33],"changes":[34],"insulin":[36,122,128],"sensitivity":[37],"(IS)":[38],"a":[40,58,76,102,126,313],"group":[41],"seven":[43,191],"patients":[44,305,341],"acromegaly":[46],"(three":[47],"male,":[48],"four":[49,69,194],"female,":[50],"mean+/-s.d.":[51,168],"age":[52],"59+/-13":[53],"Years)":[54],"treated":[55],"initially":[56],"stable":[59],"dose":[60,66,94],"depot":[62],"octreotide":[63],"(OT;":[64],"median":[65,77,103],"30":[67],"mg":[68,96],"times":[70],"weekly,":[71],"range":[72,98,216],"10-30":[73],"mg)":[74,100],"for":[75,101,340],"18":[79],"Months":[80,106],"(range":[81,107],"16-19":[82],"Months)":[83],"who":[85],"were":[86,153],"then":[87],"transferred":[88],"treatment":[90],"pegvisomant":[92,152,165,182,188,238,271],"(median":[93],"15":[95],"daily,":[97],"10-20":[99],"8":[105],"7-9":[108],"Months).":[109],"IS":[110,221,241,299],"assessed":[112,135],"by":[113,125,136],"homeostatic":[114],"model":[115],"assessment":[116],"(HOMA)":[117],"using":[118],"fasting":[119,169,196,208],"concentrations":[123,145,323],"short":[127],"tolerance":[129,302],"test":[130],"(sITT).":[131],"Body":[132],"composition":[133,317],"dual":[137],"energy":[138],"X-ray":[139],"absorptiometry.":[140],"RESULTS:":[141],"Mean+/-s.d.":[142,219,240,261],"serum":[143,321],"IGF-I":[144,322],"during":[146],"therapy":[147,309,339],"OT":[149,160,177,211,231,255,274,308],"not":[154],"statistically":[155,280],"different":[156],"(283+/-119":[157],"ng/ml":[158,163],"on":[159,164,176,181,187,210,217,230,237,254,258,270],"vs":[161,256,276],"191+/-39":[162],"(P=0.4)).":[166],"However,":[167],"plasma":[170,197],"fell":[172,199],"from":[173,200,225,307],"6.2+/-1.0":[174],"mmol/l":[175,180],"5.2+/-0.6":[179],"(P=0.017)":[183],"lower":[186],"all":[190],"patients.":[192],"In":[193],"patients,":[195],"values":[201],"diagnostic":[202],"diabetes":[204],"mellitus":[205],"or":[206,290],"impaired":[207],"within":[213],"normal":[215],"pegvisomant.":[218],"peripheral":[220],"(by":[222,242],"sITT)":[223],"increased":[224],"139+/-39":[226],"micromol/l":[227,234],"per":[228,235],"min":[229,236],"169+/-59":[233],"(P=0.037).":[239],"HOMA":[243],"%S)":[244],"unchanged":[246],"over":[247],"course":[249],"(149.1+/-43.7%":[253],"139.9+/-76.6%":[257],"pegvisomant,":[259,311],"P=0.28).":[260],"pancreatic":[262],"beta-cell":[263],"secretory":[264],"function":[265],"(HOMA":[266],"%B)":[267],"improved":[268,303],"significantly":[269],"compared":[272],"(49.4+/-19.2%":[275],"82.4+/-43.5%,":[277],"P=0.01).":[278],"No":[279],"significant":[281],"change":[282,314],"total":[284],"fat":[285,288],"(P=0.3),":[286],"%":[287],"(P=0.28)":[289],"circulating":[291],"non-esterified":[292],"fatty":[293],"acids":[294],"(P=0.35)":[295],"observed.":[297],"CONCLUSIONS:":[298],"converted":[306],"without":[312],"body":[316],"even":[319],"when":[320],"remained":[324],"equally":[325],"well":[326],"controlled.":[327],"This":[328],"may":[329],"be":[330],"choice":[336],"medical":[338]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}