{"id":"https://openalex.org/W2131829136","doi":"https://doi.org/10.1093/gerona/glu114","title":"Genetic Regulation of Female Sexual Maturation and Longevity Through Circulating IGF1","display_name":"Genetic Regulation of Female Sexual Maturation and Longevity Through Circulating IGF1","publication_year":2014,"publication_date":"2014-07-28","ids":{"openalex":"https://openalex.org/W2131829136","doi":"https://doi.org/10.1093/gerona/glu114","mag":"2131829136","pmid":"https://pubmed.ncbi.nlm.nih.gov/25070661","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4481683"},"language":"en","primary_location":{"id":"doi:10.1093/gerona/glu114","doi":"https://doi.org/10.1093/gerona/glu114","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gerona/glu114","pdf_url":"https://academic.oup.com/biomedgerontology/article-pdf/70/7/817/16744467/glu114.pdf","source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/biomedgerontology/article-pdf/70/7/817/16744467/glu114.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058522873","display_name":"Rong Yuan","orcid":"https://orcid.org/0000-0001-9996-7331","observed_orcids":["https://orcid.org/0000-0001-9996-7331"]},"institutions":[{"id":"https://openalex.org/I196729704","display_name":"SIU Medicine","ror":"https://ror.org/0232r4451","country_code":"US","type":"education","lineage":["https://openalex.org/I196729704","https://openalex.org/I2801502357"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Yuan","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine. Geriatric Research Division, Internal Medicine, School of Medicine, Southern Illinois University, Springfield. ryuan@siumed.edu","Geriatric Research Division, Internal Medicine, School of Medicine, Southern Illinois University, Springfield","The Jackson Laboratory, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine. Geriatric Research Division, Internal Medicine, School of Medicine, Southern Illinois University, Springfield. ryuan@siumed.edu","institution_ids":["https://openalex.org/I196729704","https://openalex.org/I4210115256"]},{"raw_affiliation_string":"Geriatric Research Division, Internal Medicine, School of Medicine, Southern Illinois University, Springfield","institution_ids":["https://openalex.org/I196729704"]},{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030457099","display_name":"Daniel M. Gatti","orcid":"https://orcid.org/0000-0003-0667-9926","observed_orcids":["https://orcid.org/0000-0003-0667-9926"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel M. Gatti","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028337312","display_name":"Rebecca A. Krier-Burris","orcid":"https://orcid.org/0000-0001-9722-215X","observed_orcids":["https://orcid.org/0000-0001-9722-215X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Krier","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine. Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","The Jackson Laboratory, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine. Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4210115256"]},{"raw_affiliation_string":"Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043918968","display_name":"Ethan Malay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan Malay","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039729257","display_name":"David W Schultz","orcid":"https://orcid.org/0000-0001-6319-7574","observed_orcids":["https://orcid.org/0000-0001-6319-7574"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Schultz","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036956129","display_name":"Luanne L. Peters","orcid":"https://orcid.org/0000-0002-0784-0534","observed_orcids":["https://orcid.org/0000-0002-0784-0534"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luanne L. Peters","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012821611","display_name":"Gary A. Churchill","orcid":"https://orcid.org/0000-0001-9190-9284","observed_orcids":["https://orcid.org/0000-0001-9190-9284"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary A. Churchill","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064981080","display_name":"David E. Harrison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Harrison","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111487890","display_name":"Beverly J. Paigen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beverly Paigen","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4408,"currency":"USD","value_usd":4408},"apc_paid":null,"fwci":1.8754,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.86512356,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"70","issue":"7","first_page":"817","last_page":"826"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.6044999957084656,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.6044999957084656,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.29319998621940613,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.052299998700618744,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9959999918937683},{"id":"https://openalex.org/keywords/female-sexual-maturation","display_name":"female sexual maturation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.7160000205039978},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.7540000081062317},{"id":"https://openalex.org/keywords/quantitative-trait-loci","display_name":"quantitative trait loci","score":0.8339999914169312},{"id":"https://openalex.org/keywords/chromosome-2","display_name":"chromosome 2","score":0.8370000123977661},{"id":"https://openalex.org/keywords/f2-intercross","display_name":"F2 intercross","score":0.5849999785423279},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.4059999883174896},{"id":"https://openalex.org/keywords/genetic-mapping","display_name":"gene mapping","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2778849439","wikidata":"https://www.wikidata.org/wiki/Q6397985","display_name":"Kexin","level":5,"score":0.7753522396087646},{"id":"https://openalex.org/C2778824825","wikidata":"https://www.wikidata.org/wiki/Q7250439","display_name":"Proprotein convertase","level":5,"score":0.6982207298278809},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6826294660568237},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.6233027577400208},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6054680347442627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5678855776786804},{"id":"https://openalex.org/C192536144","wikidata":"https://www.wikidata.org/wiki/Q609370","display_name":"Sexual maturity","level":2,"score":0.5510955452919006},{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.4331231117248535},{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.41478079557418823},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29317617416381836},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1913679838180542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14997181296348572},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.0},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.0},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008126","descriptor_name":"Lod Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012741","descriptor_name":"Sexual Maturation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012741","descriptor_name":"Sexual Maturation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045706","descriptor_name":"Proprotein Convertase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/gerona/glu114","doi":"https://doi.org/10.1093/gerona/glu114","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gerona/glu114","pdf_url":"https://academic.oup.com/biomedgerontology/article-pdf/70/7/817/16744467/glu114.pdf","source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4481683","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4481683","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gerontol A Biol Sci Med Sci","raw_type":"Text"},{"id":"pmid:25070661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25070661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journals of gerontology. Series A, Biological sciences and medical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:stfb2015-1107","doi":null,"is_oa":false,"landing_page_url":"http://biomedgerontology.oxfordjournals.org/content/70/7/817.long","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2015","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/gerona/glu114","doi":"https://doi.org/10.1093/gerona/glu114","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gerona/glu114","pdf_url":"https://academic.oup.com/biomedgerontology/article-pdf/70/7/817/16744467/glu114.pdf","source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1207641460","display_name":"Depressing Nrip1 Reduces IGF1 Signaling Improves Metabolism and Extends Longevity","funder_award_id":"K01AG046432","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1986919273","display_name":"Genetic Regulation of Circulating IGF1","funder_award_id":"R21AG034349","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2048828936","display_name":null,"funder_award_id":"AG025007","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2272491022","display_name":"Diet Restriction (DR) Regulates Stem Cell Aging","funder_award_id":"R01AG025007","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G264413161","display_name":null,"funder_award_id":"AG046432","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2645922251","display_name":"Identify genetic mechanisms that regulate female sexual maturation","funder_award_id":"R03AG046605","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2887941546","display_name":"From QTL to Gene for HDL Cholesterol","funder_award_id":"R37HL077796","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3078109728","display_name":null,"funder_award_id":"AG034349","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G46104105","display_name":null,"funder_award_id":"AG-038070","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7683118187","display_name":"Genetic Definition of Mechanisms by which Rapamycin Retards Mammalian Aging","funder_award_id":"R01AG038560","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G878603290","display_name":null,"funder_award_id":"AG046605","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000888880","display_name":"Interventions That Retard Mammalian Aging","funder_award_id":"U01AG022308","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000893965","display_name":"Nathan Shock Center for Excellence in Basic Biology of Aging","funder_award_id":"P30AG038070","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000917281","display_name":"Cancer Center Support (CORE) Grant","funder_award_id":"P30CA034196","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2131829136.pdf","grobid_xml":"https://content.openalex.org/works/W2131829136.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1548504211","https://openalex.org/W1662191918","https://openalex.org/W1685382538","https://openalex.org/W1791864903","https://openalex.org/W1887169756","https://openalex.org/W1940527306","https://openalex.org/W1948927501","https://openalex.org/W1981761798","https://openalex.org/W1984497969","https://openalex.org/W1986686489","https://openalex.org/W1987478369","https://openalex.org/W1988246627","https://openalex.org/W1992118324","https://openalex.org/W1994273828","https://openalex.org/W2015706586","https://openalex.org/W2016517460","https://openalex.org/W2020372413","https://openalex.org/W2024573448","https://openalex.org/W2038671576","https://openalex.org/W2051136241","https://openalex.org/W2051839343","https://openalex.org/W2062837346","https://openalex.org/W2063048263","https://openalex.org/W2069333577","https://openalex.org/W2076585242","https://openalex.org/W2077067158","https://openalex.org/W2077553349","https://openalex.org/W2078882097","https://openalex.org/W2082947145","https://openalex.org/W2092419417","https://openalex.org/W2100412071","https://openalex.org/W2100864852","https://openalex.org/W2112692827","https://openalex.org/W2116053845","https://openalex.org/W2118729796","https://openalex.org/W2119302231","https://openalex.org/W2125860227","https://openalex.org/W2128977956","https://openalex.org/W2129529285","https://openalex.org/W2134454718","https://openalex.org/W2140997600","https://openalex.org/W2146074741","https://openalex.org/W2149945426","https://openalex.org/W2151464048","https://openalex.org/W2151488747","https://openalex.org/W2155225646","https://openalex.org/W2164235861","https://openalex.org/W2165681440","https://openalex.org/W2170245737","https://openalex.org/W2170363318","https://openalex.org/W2315739973","https://openalex.org/W4236757670"],"related_works":["https://openalex.org/W7100716183","https://openalex.org/W2077067158","https://openalex.org/W2594941765","https://openalex.org/W1995729841","https://openalex.org/W2607028609","https://openalex.org/W1887169756","https://openalex.org/W1685382538","https://openalex.org/W3121447888","https://openalex.org/W2039726057","https://openalex.org/W2024696822"],"abstract_inverted_index":{"We":[0,49,64,178],"previously":[1],"reported":[2],"that":[3,146,195,212],"insulin-like":[4],"growth":[5],"factor":[6],"1":[7],"(IGF1)":[8],"was":[9],"involved":[10,217],"in":[11,134,172,188,209,218],"coregulating":[12],"female":[13,46,169],"sexual":[14,170],"maturation":[15,171],"and":[16,32,41,43,57,75,93,118,128,151,191,206],"longevity.":[17],"To":[18],"understand":[19],"the":[20,26,51,58,123,135,180,219],"underlying":[21],"genetic":[22],"mechanisms,":[23],"based":[24],"on":[25],"strain":[27],"survey":[28],"assays":[29],"of":[30,53,61,91,125,138,182,197,221],"development":[31],"aging":[33],"traits,":[34],"we":[35],"crossed":[36],"two":[37],"mouse":[38],"strains,":[39],"KK/HIJ":[40],"PL/J,":[42],"produced":[44],"307":[45],"F2":[47],"mice.":[48],"observed":[50],"age":[52],"vaginal":[54],"patency":[55],"(AVP)":[56],"life":[59,119,129,152],"span":[60,130],"these":[62],"females.":[63],"also":[65,214],"measured":[66],"circulating":[67],"IGF1":[68,78,87,190,205],"level":[69,79],"at":[70,80,89],"7,":[71],"16,":[72],"24,":[73],"52,":[74],"76":[76,94],"weeks.":[77],"7":[81],"weeks":[82,95],"significantly":[83,203],"correlated":[84,97],"with":[85,98,168],"AVP.":[86],"levels":[88],"ages":[90],"52":[92],"negatively":[96],"longevity":[99],"(p":[100],"\u2264":[101],".05).":[102],"A":[103],"gene":[104],"mapping":[105],"study":[106],"found":[107,164],"22,":[108],"4":[109],",and":[110],"3":[111],"quantitative":[112,131],"trait":[113,132],"loci":[114,133],"for":[115],"IGF1,":[116,126,149],"AVP,":[117,127,150],"span,":[120],"respectively.":[121],"Importantly,":[122],"colocalization":[124],"distal":[136],"region":[137],"chromosome":[139],"2":[140,161,187,202],"suggests":[141],"this":[142,155],"locus":[143],"carries":[144],"gene(s)":[145],"could":[147],"regulate":[148],"span.":[153],"In":[154],"region,":[156],"proprotein":[157,183,198],"convertase":[158,184,199],"subtilisin/kexin":[159,185,200],"type":[160,186,201],"has":[162],"been":[163],"to":[165],"be":[166,216],"associated":[167],"a":[173],"human":[174],"genome-wide":[175],"association":[176],"study.":[177],"verified":[179],"roles":[181],"regulating":[189],"AVP":[192,208],"by":[193],"showing":[194],"depletion":[196],"reduced":[204],"delayed":[207],"mice,":[210],"suggesting":[211],"it":[213],"might":[215],"regulation":[220],"aging.":[222]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}