{"id":"https://openalex.org/W2131822571","doi":"https://doi.org/10.1001/jamasurg.2013.1372","title":"Postoperative Antibacterial Prophylaxis for the Prevention of Infectious Complications Associated With Tube Thoracostomy in Patients Undergoing Elective General Thoracic Surgery","display_name":"Postoperative Antibacterial Prophylaxis for the Prevention of Infectious Complications Associated With Tube Thoracostomy in Patients Undergoing Elective General Thoracic Surgery","publication_year":2013,"publication_date":"2013-01-16","ids":{"openalex":"https://openalex.org/W2131822571","doi":"https://doi.org/10.1001/jamasurg.2013.1372","mag":"2131822571","pmid":"https://pubmed.ncbi.nlm.nih.gov/23325435"},"language":"en","primary_location":{"id":"doi:10.1001/jamasurg.2013.1372","doi":"https://doi.org/10.1001/jamasurg.2013.1372","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jamasurg.2013.1372","pdf_url":null,"source":{"id":"https://openalex.org/S86924810","display_name":"JAMA Surgery","issn_l":"2168-6254","issn":["2168-6254","2168-6262"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050023282","display_name":"David Oxman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Oxman","raw_affiliation_strings":["Divisions of Infectious Diseases, Brigham and Women\u2019s Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Infectious Diseases, Brigham and Women\u2019s Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000363583","display_name":"Nicolas C. Issa","orcid":"https://orcid.org/0000-0002-6596-0518","observed_orcids":["https://orcid.org/0000-0002-6596-0518"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nicolas C. Issa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011325960","display_name":"Francisco M. Marty","orcid":"https://orcid.org/0000-0002-3708-8734","observed_orcids":["https://orcid.org/0000-0002-3708-8734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francisco M. Marty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Alka Patel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alka Patel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087397578","display_name":"Christia Panizales","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christia Z. Panizales","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022779149","display_name":"Nathaniel N. Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nathaniel N. Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033801057","display_name":"Jose Humberto Licona","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Humberto Licona","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003420070","display_name":"Shannon S. McKenna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shannon S. McKenna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028599693","display_name":"Gy\u00f6rgy Frendl","orcid":"https://orcid.org/0000-0001-8918-8553","observed_orcids":["https://orcid.org/0000-0001-8918-8553"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gyorgy Frendl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013315084","display_name":"Steven J. Mentzer","orcid":"https://orcid.org/0000-0003-1496-6044","observed_orcids":["https://orcid.org/0000-0003-1496-6044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven J. Mentzer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025278320","display_name":"Michael T. Jaklitsch","orcid":"https://orcid.org/0000-0003-4018-9955","observed_orcids":["https://orcid.org/0000-0003-4018-9955"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael T. Jaklitsch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102946061","display_name":"Raphael Bueno","orcid":"https://orcid.org/0000-0002-1258-8468","observed_orcids":["https://orcid.org/0000-0002-1258-8468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raphael Bueno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034925727","display_name":"Yolonda Lorig Colson","orcid":"https://orcid.org/0000-0002-8229-5636","observed_orcids":["https://orcid.org/0000-0002-8229-5636"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yolonda Colson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005764203","display_name":"Steven Swanson","orcid":"https://orcid.org/0000-0002-5896-1037","observed_orcids":["https://orcid.org/0000-0002-5896-1037"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott J. Swanson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109939587","display_name":"David J. Sugarbaker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David J. Sugarbaker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091029647","display_name":"Lindsey Robert Baden","orcid":"https://orcid.org/0009-0004-1752-1926","observed_orcids":["https://orcid.org/0009-0004-1752-1926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lindsey R. Baden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000363583"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2138,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.91441603,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"148","issue":"5","first_page":"440","last_page":"440"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11080","display_name":"Surgical site infection prevention","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11080","display_name":"Surgical site infection prevention","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11681","display_name":"Nosocomial Infections in ICU","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chest-tube-drainage","display_name":"chest tube drainage","score":0.8939999938011169},{"id":"https://openalex.org/keywords/elective-thoracic-surgery","display_name":"elective thoracic surgery","score":0.9010000228881836},{"id":"https://openalex.org/keywords/surgical-site-infection","display_name":"surgical site infection","score":0.9620000123977661},{"id":"https://openalex.org/keywords/postoperative-pneumonia","display_name":"postoperative pneumonia","score":0.9440000057220459},{"id":"https://openalex.org/keywords/empyema","display_name":"empyema","score":0.9909999966621399},{"id":"https://openalex.org/keywords/clostridium-difficile-colitis","display_name":"Clostridium difficile colitis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cefazolin","display_name":"cefazolin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/extended-antibiotic-prophylaxis","display_name":"extended antibiotic prophylaxis","score":0.5860000252723694},{"id":"https://openalex.org/keywords/postoperative-infection","display_name":"postoperative infection","score":0.6460000276565552},{"id":"https://openalex.org/keywords/preoperative-prophylaxis","display_name":"preoperative prophylaxis","score":0.578000009059906},{"id":"https://openalex.org/keywords/surgical-site-infection-prevention","display_name":"surgical site infection prevention","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9799963235855103},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6965175867080688},{"id":"https://openalex.org/C2776974961","wikidata":"https://www.wikidata.org/wiki/Q18394264","display_name":"Thoracostomy","level":3,"score":0.6526899337768555},{"id":"https://openalex.org/C2778353156","wikidata":"https://www.wikidata.org/wiki/Q415739","display_name":"Cefazolin","level":3,"score":0.6232418417930603},{"id":"https://openalex.org/C2778602436","wikidata":"https://www.wikidata.org/wiki/Q4774943","display_name":"Antibiotic prophylaxis","level":3,"score":0.5505384206771851},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5323059558868408},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.518844723701477},{"id":"https://openalex.org/C2776688490","wikidata":"https://www.wikidata.org/wiki/Q1069606","display_name":"Chemoprophylaxis","level":2,"score":0.48429030179977417},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.46657073497772217},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.39689815044403076},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.17482993006706238},{"id":"https://openalex.org/C2778329176","wikidata":"https://www.wikidata.org/wiki/Q203601","display_name":"Pneumothorax","level":2,"score":0.1698022484779358},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002437","descriptor_name":"Cefazolin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011182","descriptor_name":"Postoperative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013530","descriptor_name":"Surgical Wound Infection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013907","descriptor_name":"Thoracostomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015505","descriptor_name":"Chest Tubes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017558","descriptor_name":"Elective Surgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019072","descriptor_name":"Antibiotic Prophylaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1001/jamasurg.2013.1372","doi":"https://doi.org/10.1001/jamasurg.2013.1372","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jamasurg.2013.1372","pdf_url":null,"source":{"id":"https://openalex.org/S86924810","display_name":"JAMA Surgery","issn_l":"2168-6254","issn":["2168-6254","2168-6262"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Surgery","raw_type":"journal-article"},{"id":"pmid:23325435","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23325435","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W189066495","https://openalex.org/W1970576960","https://openalex.org/W1971457529","https://openalex.org/W1971576516","https://openalex.org/W1977799841","https://openalex.org/W1977897824","https://openalex.org/W1984228354","https://openalex.org/W1993607004","https://openalex.org/W1999337545","https://openalex.org/W2000083261","https://openalex.org/W2001980337","https://openalex.org/W2002789571","https://openalex.org/W2006517986","https://openalex.org/W2009890227","https://openalex.org/W2016357762","https://openalex.org/W2044059011","https://openalex.org/W2052416209","https://openalex.org/W2071679629","https://openalex.org/W2073060575","https://openalex.org/W2083966677","https://openalex.org/W2090059197","https://openalex.org/W2097674110","https://openalex.org/W2105539696","https://openalex.org/W2113444295","https://openalex.org/W2131148629","https://openalex.org/W2132482965","https://openalex.org/W2153996209","https://openalex.org/W2159709005","https://openalex.org/W2168843978","https://openalex.org/W2400411045","https://openalex.org/W2405669360","https://openalex.org/W2411668898","https://openalex.org/W2417867976","https://openalex.org/W4406790886"],"related_works":["https://openalex.org/W1992467512","https://openalex.org/W102779181","https://openalex.org/W2285257495","https://openalex.org/W1999951158","https://openalex.org/W2350650213","https://openalex.org/W2013516574","https://openalex.org/W2021973075","https://openalex.org/W2626483091","https://openalex.org/W2052456381","https://openalex.org/W2385042715"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2],"whether":[3],"extended":[4,103],"postoperative":[5,144,276],"antibacterial":[6,72,104,277],"prophylaxis":[7,26,73,105,278,299],"for":[8,114,279],"patients":[9,54,88,152,172,180,203,211,233,241,269,280],"undergoing":[10,55,281],"elective":[11,56,282],"thoracic":[12,57,283],"surgery":[13,58,284],"with":[14,24,74,297],"tube":[15,60,286],"thoracostomy":[16,61,120,287],"reduces":[17],"the":[18,81,156,162,168,175,183,206,214,236,244,263,291],"risk":[19],"of":[20,51,133,150,293],"infectious":[21,294],"complications":[22,295],"compared":[23,296],"preoperative":[25,71,298],"only.":[27,300],"DESIGN:":[28],"Prospective,":[29],"randomized,":[30],"double-blind,":[31],"placebo-controlled":[32],"trial.":[33],"SETTING:":[34],"Brigham":[35],"and":[36,65,139,165,178,209,239],"Women's":[37],"Hospital,":[38],"an":[39],"800-bed":[40],"tertiary":[41],"care":[42],"teaching":[43],"hospital":[44],"in":[45,155,161,167,174,182,205,213,235,243,262],"Boston,":[46],"Massachusetts.":[47],"PARTICIPANTS:":[48],"A":[49,148],"total":[50,149],"251":[52],"adult":[53],"requiring":[59,285],"between":[62],"April":[63,66],"2008":[64],"2011.":[67],"INTERVENTIONS:":[68],"Patients":[69],"received":[70],"cefazolin":[75],"sodium":[76],"(or":[77],"other":[78],"drug":[79],"if":[80],"patient":[82,261],"was":[83],"allergic":[84],"to":[85,101,197,227,255],"cefazolin).":[86],"Postoperatively,":[87],"were":[89,122,153],"randomly":[90],"assigned":[91],"(at":[92],"a":[93,97,187],"1:1":[94],"ratio)":[95],"using":[96],"computer-generated":[98],"randomization":[99],"sequence":[100],"receive":[102],"(n":[106,111],"=":[107,112,200,230,258],"125)":[108],"or":[109,117],"placebo":[110,169,184,215,245],"126)":[113],"48":[115],"hours":[116],"until":[118],"all":[119],"tubes":[121],"removed,":[123],"whichever":[124],"came":[125],"first.":[126],"MAIN":[127],"OUTCOME":[128],"MEASURES:":[129],"The":[130],"combined":[131],"occurrence":[132],"surgical":[134,218],"site":[135,219],"infection,":[136],"empyema,":[137],"pneumonia,":[138],"Clostridium":[140],"difficile":[141,272],"colitis":[142],"by":[143],"day":[145],"28.":[146],"RESULTS:":[147],"245":[151],"included":[154],"modified":[157],"intention-to-treat":[158],"analysis":[159],"(121":[160],"intervention":[163,176,207,237,264],"group":[164,177,185,208,216,238,246,265],"124":[166],"group).":[170],"Thirteen":[171],"(10.7%)":[173],"8":[179],"(6.5%)":[181],"had":[186],"primary":[188],"end":[189],"point":[190],"(risk":[191,221,249],"difference,":[192,222,250],"-4.3%":[193],"[95%":[194,224,252],"CI,":[195,225,253],"-11.3%":[196],"2.7%];":[198],"P":[199,229,257],".26).":[201],"Six":[202],"(5.0%)":[204],"5":[210],"(4.0%)":[212],"developed":[217,247,266],"infections":[220],"-0.93%":[223],"-6.1%":[226],"4.3%];":[228],".77).":[231],"Seven":[232],"(5.8%)":[234],"3":[240],"(2.4%)":[242],"pneumonia":[248],"-3.4%":[251],"-8.3%":[254],"1.6%];":[256],".21).":[259],"One":[260],"empyema.":[267],"No":[268],"experienced":[270],"C":[271],"colitis.":[273],"CONCLUSIONS:":[274],"Extended":[275],"did":[288],"not":[289],"reduce":[290],"number":[292],"TRIAL":[301],"REGISTRATION:":[302],"clinicaltrials.gov":[303],"Identifier:":[304],"NCT00818766.":[305]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}