{"id":"https://openalex.org/W2131736664","doi":"https://doi.org/10.1128/mcb.21.7.2581-2593.2001","title":"Two Immunologically Distinct Human DNA Polymerase \u03b1-Primase Subpopulations Are Involved in Cellular DNA Replication","display_name":"Two Immunologically Distinct Human DNA Polymerase \u03b1-Primase Subpopulations Are Involved in Cellular DNA Replication","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W2131736664","doi":"https://doi.org/10.1128/mcb.21.7.2581-2593.2001","mag":"2131736664","pmid":"https://pubmed.ncbi.nlm.nih.gov/11259605","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/86889"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.21.7.2581-2593.2001","doi":"https://doi.org/10.1128/mcb.21.7.2581-2593.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.21.7.2581-2593.2001","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC86889","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006952671","display_name":"Silke Dehde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137251492","display_name":"Leibniz Institute of Virology (LIV)","ror":"https://ror.org/02r2q1d96","country_code":"DE","type":"facility","lineage":["https://openalex.org/I137251492","https://openalex.org/I315704651"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Silke Dehde","raw_affiliation_strings":["Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg","Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg","institution_ids":["https://openalex.org/I137251492","https://openalex.org/I159176309"]},{"raw_affiliation_string":"Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg","institution_ids":["https://openalex.org/I137251492","https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070107354","display_name":"Gabor Rohaly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137251492","display_name":"Leibniz Institute of Virology (LIV)","ror":"https://ror.org/02r2q1d96","country_code":"DE","type":"facility","lineage":["https://openalex.org/I137251492","https://openalex.org/I315704651"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gabor Rohaly","raw_affiliation_strings":["Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg","Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg","institution_ids":["https://openalex.org/I137251492","https://openalex.org/I159176309"]},{"raw_affiliation_string":"Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg","institution_ids":["https://openalex.org/I137251492","https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074679735","display_name":"Oliver Schub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125523173","display_name":"Institute of Molecular Biotechnology","ror":"https://ror.org/01zqrxf85","country_code":"AT","type":"facility","lineage":["https://openalex.org/I125523173","https://openalex.org/I138211613"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Oliver Schub","raw_affiliation_strings":["Institut f\u00fcr Molekulare Biotechnologie, Abteilung Biochemie","Institut f\u00fcr Molekulare Biotechnologie, Abteilung Biochemie, D-07745 Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Molekulare Biotechnologie, Abteilung Biochemie","institution_ids":["https://openalex.org/I125523173"]},{"raw_affiliation_string":"Institut f\u00fcr Molekulare Biotechnologie, Abteilung Biochemie, D-07745 Jena, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090427264","display_name":"Heinz\u2010Peter Nasheuer","orcid":"https://orcid.org/0000-0002-9218-9079","observed_orcids":["https://orcid.org/0000-0002-9218-9079"]},"institutions":[{"id":"https://openalex.org/I125523173","display_name":"Institute of Molecular Biotechnology","ror":"https://ror.org/01zqrxf85","country_code":"AT","type":"facility","lineage":["https://openalex.org/I125523173","https://openalex.org/I138211613"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Heinz-Peter Nasheuer","raw_affiliation_strings":["Institut f\u00fcr Molekulare Biotechnologie, Abteilung Biochemie","Institut f\u00fcr Molekulare Biotechnologie, Abteilung Biochemie, D-07745 Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Molekulare Biotechnologie, Abteilung Biochemie","institution_ids":["https://openalex.org/I125523173"]},{"raw_affiliation_string":"Institut f\u00fcr Molekulare Biotechnologie, Abteilung Biochemie, D-07745 Jena, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036602695","display_name":"Wolfgang Bohn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137251492","display_name":"Leibniz Institute of Virology (LIV)","ror":"https://ror.org/02r2q1d96","country_code":"DE","type":"facility","lineage":["https://openalex.org/I137251492","https://openalex.org/I315704651"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Bohn","raw_affiliation_strings":["Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg","Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg","institution_ids":["https://openalex.org/I137251492","https://openalex.org/I159176309"]},{"raw_affiliation_string":"Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg","institution_ids":["https://openalex.org/I137251492","https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065079296","display_name":"Jan Chemnitz","orcid":"https://orcid.org/0009-0001-7259-4974","observed_orcids":["https://orcid.org/0009-0001-7259-4974"]},"institutions":[{"id":"https://openalex.org/I137251492","display_name":"Leibniz Institute of Virology (LIV)","ror":"https://ror.org/02r2q1d96","country_code":"DE","type":"facility","lineage":["https://openalex.org/I137251492","https://openalex.org/I315704651"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Chemnitz","raw_affiliation_strings":["Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg","Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg","institution_ids":["https://openalex.org/I137251492","https://openalex.org/I159176309"]},{"raw_affiliation_string":"Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg","institution_ids":["https://openalex.org/I137251492","https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091514112","display_name":"Wolfgang Deppert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137251492","display_name":"Leibniz Institute of Virology (LIV)","ror":"https://ror.org/02r2q1d96","country_code":"DE","type":"facility","lineage":["https://openalex.org/I137251492","https://openalex.org/I315704651"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Deppert","raw_affiliation_strings":["Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg","Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg","institution_ids":["https://openalex.org/I137251492","https://openalex.org/I159176309"]},{"raw_affiliation_string":"Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg","institution_ids":["https://openalex.org/I137251492","https://openalex.org/I159176309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113945300","display_name":"Irena Dornreiter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137251492","display_name":"Leibniz Institute of Virology (LIV)","ror":"https://ror.org/02r2q1d96","country_code":"DE","type":"facility","lineage":["https://openalex.org/I137251492","https://openalex.org/I315704651"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Irena Dornreiter","raw_affiliation_strings":["Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg","Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg","institution_ids":["https://openalex.org/I137251492","https://openalex.org/I159176309"]},{"raw_affiliation_string":"Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg","institution_ids":["https://openalex.org/I137251492","https://openalex.org/I159176309"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4428,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.80383237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"21","issue":"7","first_page":"2581","last_page":"2593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7827000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7827000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.08529999852180481,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.056299999356269836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-polymerase-alpha-primase","display_name":"DNA polymerase alpha-primase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hypophosphorylation","display_name":"hypophosphorylation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/protein-phosphatase-2a","display_name":"protein phosphatase 2A","score":0.6850000023841858},{"id":"https://openalex.org/keywords/cyclin-e-cdk2","display_name":"cyclin E/CDK2","score":0.9259999990463257},{"id":"https://openalex.org/keywords/large-t-antigen","display_name":"large T antigen","score":0.7670000195503235},{"id":"https://openalex.org/keywords/dna-replication-initiation","display_name":"DNA replication initiation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/mcm2","display_name":"MCM2","score":0.8759999871253967},{"id":"https://openalex.org/keywords/replication-fork","display_name":"replication fork","score":0.4059999883174896},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.5820000171661377},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.6019999980926514},{"id":"https://openalex.org/keywords/simian-virus-40","display_name":"simian virus 40","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8528306484222412},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.6479859352111816},{"id":"https://openalex.org/C151158763","wikidata":"https://www.wikidata.org/wiki/Q1626856","display_name":"Origin recognition complex","level":5,"score":0.6359140276908875},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6111358404159546},{"id":"https://openalex.org/C194830204","wikidata":"https://www.wikidata.org/wiki/Q106940703","display_name":"Primase","level":5,"score":0.5948376655578613},{"id":"https://openalex.org/C98086919","wikidata":"https://www.wikidata.org/wiki/Q118019","display_name":"Eukaryotic DNA replication","level":4,"score":0.5703614950180054},{"id":"https://openalex.org/C35195891","wikidata":"https://www.wikidata.org/wiki/Q2289513","display_name":"S phase","level":5,"score":0.549502968788147},{"id":"https://openalex.org/C104690221","wikidata":"https://www.wikidata.org/wiki/Q5165872","display_name":"Control of chromosome duplication","level":4,"score":0.5392744541168213},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.5237707495689392},{"id":"https://openalex.org/C188036394","wikidata":"https://www.wikidata.org/wiki/Q14902224","display_name":"Replication factor C","level":5,"score":0.5128543376922607},{"id":"https://openalex.org/C76535049","wikidata":"https://www.wikidata.org/wiki/Q3487941","display_name":"DNA polymerase delta","level":5,"score":0.49421146512031555},{"id":"https://openalex.org/C88354546","wikidata":"https://www.wikidata.org/wiki/Q3502973","display_name":"DNA polymerase II","level":5,"score":0.46384814381599426},{"id":"https://openalex.org/C113271649","wikidata":"https://www.wikidata.org/wiki/Q2565234","display_name":"Replication protein A","level":5,"score":0.45875951647758484},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35720986127853394},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2960735559463501},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1883767545223236},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.14501044154167175},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0798187255859375},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.07599332928657532},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.06543493270874023},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019915","descriptor_name":"DNA Primase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019915","descriptor_name":"DNA Primase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/mcb.21.7.2581-2593.2001","doi":"https://doi.org/10.1128/mcb.21.7.2581-2593.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.21.7.2581-2593.2001","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:183990","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC86889","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:86889","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/86889","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:11259605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11259605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:183990","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC86889","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320316264","display_name":"Freistaat Th\u00fcringen","ror":"https://ror.org/05x6abf22"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320321721","display_name":"Bundesministerium f\u00fcr Gesundheit","ror":"https://ror.org/05vp4ka74"},{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W345743902","https://openalex.org/W1480336359","https://openalex.org/W1503567487","https://openalex.org/W1526067074","https://openalex.org/W1590134197","https://openalex.org/W1594700207","https://openalex.org/W1600772876","https://openalex.org/W1605174965","https://openalex.org/W1605712430","https://openalex.org/W1642473590","https://openalex.org/W1848751398","https://openalex.org/W1850062430","https://openalex.org/W1874646775","https://openalex.org/W1892570697","https://openalex.org/W1962559236","https://openalex.org/W1974394081","https://openalex.org/W2028527119","https://openalex.org/W2034434494","https://openalex.org/W2034490685","https://openalex.org/W2041903626","https://openalex.org/W2055348937","https://openalex.org/W2056590571","https://openalex.org/W2060418366","https://openalex.org/W2069352564","https://openalex.org/W2080835326","https://openalex.org/W2085898164","https://openalex.org/W2093268779","https://openalex.org/W2103646786","https://openalex.org/W2106130068","https://openalex.org/W2115733615","https://openalex.org/W2116808406","https://openalex.org/W2120758008","https://openalex.org/W2120947776","https://openalex.org/W2122225488","https://openalex.org/W2129781454","https://openalex.org/W2166621888","https://openalex.org/W2169154093","https://openalex.org/W2170085122","https://openalex.org/W2188023518","https://openalex.org/W2275430962","https://openalex.org/W2323496633","https://openalex.org/W4206302388","https://openalex.org/W4388384783","https://openalex.org/W4388384803"],"related_works":["https://openalex.org/W1492423656","https://openalex.org/W2323496633","https://openalex.org/W4385311804","https://openalex.org/W2047429509","https://openalex.org/W1962559236","https://openalex.org/W2006076220","https://openalex.org/W2092598571","https://openalex.org/W1981696977","https://openalex.org/W7095611829","https://openalex.org/W2166621888"],"abstract_inverted_index":{"Metabolic":[0],"labeling":[1],"of":[2,8,59,81,89,151],"primate":[3],"cells":[4],"revealed":[5],"the":[6,28,44,66,69,111,132,141,145,148,152],"existence":[7],"phosphorylated":[9,45,106,142],"and":[10,38,56,63,78,140],"hypophosphorylated":[11,29,90,123,133],"DNA":[12,82,136],"polymerase":[13],"alpha-primase":[14],"(Pol-Prim)":[15],"populations":[16],"that":[17,27,121,131],"are":[18],"distinguishable":[19],"by":[20,61],"monoclonal":[21],"antibodies.":[22],"Cell":[23],"cycle":[24],"studies":[25],"showed":[26],"form":[30,143],"was":[31,47],"found":[32],"in":[33,41,54,94],"a":[34,50],"complex":[35],"with":[36,49,68,92,110,116,126],"PP2A":[37,62],"cyclin":[39,51],"E-Cdk2":[40],"G1,":[42],"whereas":[43],"enzyme":[46,134],"associated":[48,125],"A":[52],"kinase":[53],"S":[55,95],"G2.":[57],"Modification":[58],"Pol-Prim":[60,91,124],"Cdks":[64],"regulated":[65],"interaction":[67],"simian":[70],"virus":[71],"40":[72],"origin-binding":[73],"protein":[74],"large":[75],"T":[76],"antigen":[77],"thus":[79],"initiation":[80],"replication.":[83],"Confocal":[84],"microscopy":[85],"demonstrated":[86],"nuclear":[87],"colocalization":[88],"MCM2":[93],"phase":[96],"nuclei,":[97],"but":[98,114],"its":[99],"presence":[100],"preceded":[101],"5-bromo-2'-deoxyuridine":[102],"(BrdU)":[103],"incorporation.":[104],"The":[105,128],"replicase":[107],"exclusively":[108],"colocalized":[109],"BrdU":[112],"signal,":[113],"not":[115],"MCM2.":[117,127],"Immunoprecipitation":[118],"experiments":[119],"proved":[120],"only":[122],"data":[129],"indicate":[130],"initiates":[135],"replication":[137,153],"at":[138],"origins,":[139],"synthesizes":[144],"primers":[146],"for":[147],"lagging":[149],"strand":[150],"fork.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}