{"id":"https://openalex.org/W2131688872","doi":null,"title":"Effect of Olmesartan on serum cystatin C levels in the patients with essential hypertension.","display_name":"Effect of Olmesartan on serum cystatin C levels in the patients with essential hypertension.","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2131688872","mag":"2131688872","pmid":"https://pubmed.ncbi.nlm.nih.gov/22288300"},"language":"en","primary_location":{"id":"pmid:22288300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22288300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103266446","display_name":"Yener Ko\u00e7","orcid":"https://orcid.org/0000-0002-7939-9346","observed_orcids":["https://orcid.org/0000-0002-7939-9346"]},"institutions":[{"id":"https://openalex.org/I4210157622","display_name":"\u015ei\u015fli Etfal E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/05fmwts39","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210157622"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Y Koc","raw_affiliation_strings":["Department of Nephrology, Sisli Etfal Research and Educational Hospital, Istanbul, Turkey. dryenerkoc@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Sisli Etfal Research and Educational Hospital, Istanbul, Turkey. dryenerkoc@yahoo.com","institution_ids":["https://openalex.org/I4210157622"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081034433","display_name":"Emrah Erkan Maz\u0131","orcid":"https://orcid.org/0000-0003-4879-7584","observed_orcids":["https://orcid.org/0000-0003-4879-7584"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Mazi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015520433","display_name":"Tamer \u015eakac\u0131","orcid":"https://orcid.org/0000-0001-8083-2541","observed_orcids":["https://orcid.org/0000-0001-8083-2541"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Sakaci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027726050","display_name":"Taner Ba\u015ft\u00fcrk","orcid":"https://orcid.org/0000-0003-3371-1207","observed_orcids":["https://orcid.org/0000-0003-3371-1207"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Basturk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001050303","display_name":"Ayda Batuan Damar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Batuhan Damar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074898157","display_name":"Elbis Ahbap","orcid":"https://orcid.org/0000-0002-6179-2131","observed_orcids":["https://orcid.org/0000-0002-6179-2131"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Ahbap","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077849891","display_name":"Abd\u00fclkadir \u00dcnsal","orcid":"https://orcid.org/0000-0002-7989-4232","observed_orcids":["https://orcid.org/0000-0002-7989-4232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Unsal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055847200","display_name":"Fatih Borlu","orcid":"https://orcid.org/0000-0003-4248-3066","observed_orcids":["https://orcid.org/0000-0003-4248-3066"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Borlu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6441,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.75348837,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"15","issue":"12","first_page":"1389","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.03009999915957451,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/olmesartan","display_name":"olmesartan","score":1.0},{"id":"https://openalex.org/keywords/cystatin-c","display_name":"cystatin C","score":0.9890000224113464},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.9990000128746033},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6240000128746033},{"id":"https://openalex.org/keywords/hydrochlorothiazide","display_name":"hydrochlorothiazide","score":0.8429999947547913},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.5070000290870667},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.4749999940395355},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.8259999752044678},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.7400000095367432},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C2779766728","wikidata":"https://www.wikidata.org/wiki/Q421156","display_name":"Olmesartan","level":3,"score":0.9483965635299683},{"id":"https://openalex.org/C2779548226","wikidata":"https://www.wikidata.org/wiki/Q413243","display_name":"Cystatin C","level":3,"score":0.8164122104644775},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.8139537572860718},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7040186524391174},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7007982134819031},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6908037662506104},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5251107811927795},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5120349526405334},{"id":"https://openalex.org/C2780361556","wikidata":"https://www.wikidata.org/wiki/Q423930","display_name":"Hydrochlorothiazide","level":3,"score":0.4526713192462921},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.4257190227508545},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3599178194999695}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006852","descriptor_name":"Hydrochlorothiazide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006852","descriptor_name":"Hydrochlorothiazide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D055316","descriptor_name":"Cystatin C","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D055316","descriptor_name":"Cystatin C","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:22288300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22288300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Comparative Study"},{"id":"mag:2131688872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22288300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1966266726","https://openalex.org/W2015143075","https://openalex.org/W2023219175","https://openalex.org/W2033797593","https://openalex.org/W2048243265","https://openalex.org/W2059342423","https://openalex.org/W2072075701","https://openalex.org/W2078547453","https://openalex.org/W2086380315","https://openalex.org/W2092509173","https://openalex.org/W2104736981","https://openalex.org/W2110716234","https://openalex.org/W2146222853","https://openalex.org/W2171409035","https://openalex.org/W2171503067","https://openalex.org/W2434389956"],"related_works":["https://openalex.org/W2078547453","https://openalex.org/W2094533715","https://openalex.org/W2086380315","https://openalex.org/W2062786288","https://openalex.org/W2375929165","https://openalex.org/W2363143119","https://openalex.org/W2335594123","https://openalex.org/W2373334748","https://openalex.org/W2364995299","https://openalex.org/W2385400413"],"abstract_inverted_index":{"AIM:":[0],"We":[1],"aimed":[2],"to":[3,45,73,229,236,243,255],"investigate":[4],"whether":[5],"Olmesartan":[6,69,240],"had":[7],"an":[8],"effect":[9],"on":[10],"cystatin":[11,85,130,162,218,247],"C":[12,131,163,219,223,248],"levels":[13,135,180,200],"in":[14,51,122,145,188,197,260,270],"hypertensive":[15,263],"patients,":[16],"and":[17,84,90,100,108,132,167,174,177,184,214,217,264],"evaluate":[18],"its":[19],"correlation":[20,102,208],"with":[21,33,106,262],"blood":[22,271],"pressure":[23],"(BP).":[24],"MATERIALS":[25],"AND":[26],"METHODS:":[27],"Seventy-two":[28],"patients":[29,32,99,261],"essential":[30],"hypertension":[31],"a":[34,225,244],"known":[35],"for,":[36],"at":[37,91,148],"most,":[38],"the":[39,46,92,95,101,120,159,210,257],"last":[40],"3":[41,147,154],"years":[42],"were":[43,49,87,115,205],"enrolled":[44],"study.":[47],"Patients":[48],"divided":[50],"three":[52],"groups":[53,121],"(group":[54],"1;":[55],"receives":[56,62,68],"20":[57],"mg/day":[58,64],"olmesartan;":[59,65],"group":[60,66,146],"2,":[61],"40":[63],"3,":[67],"plus":[70],"hydrochlorothiazide),":[71],"according":[72],"their":[74],"BP":[75,107,134,141,179,216],"measurements.":[76],"Blood":[77],"samples":[78],"(serum":[79],"urea,":[80,128],"creatinine,":[81,129],"sodium,":[82],"potassium":[83],"C)":[86],"collected":[88],"initially":[89],"end":[93],"of":[94,103,124,156,212,231,246,268],"study":[96],"from":[97],"all":[98,189],"these":[104],"parameters":[105],"drug":[109],"use":[110],"was":[111,142,193],"investigated.":[112],"RESULTS:":[113],"There":[114,204],"no":[116,194],"significantly":[117,143],"difference":[118,196],"between":[119,209],"terms":[123],"age,":[125],"gender,":[126],"serum":[127,161,198,237],"diastolic":[133,178,215],"(p":[136,150,201],">":[137,202],"0.05);":[138],"while,":[139],"systolic":[140,170,213],"higher":[144],"baseline":[149],"=":[151],"0.001).":[152],"After":[153],"months":[155],"olmesartan":[157,251],"treatment,":[158],"mean":[160],"(p:":[164,171,181],"0.001,":[165,172,182],"0.023":[166],"0.018":[168],"respectively),":[169],"0.001":[173,175,183,185],"respectively)":[176,186],"decreased":[187],"groups.":[190],"However,":[191],"there":[192],"significant":[195],"creatinine":[199,238],"0.05).":[203],"not":[206],"found":[207],"changes":[211],"levels.":[220],"CONCLUSIONS:":[221],"Cystatin":[222],"is":[224,266],"more":[226],"sensitive":[227],"marker":[228],"detect":[230],"early":[232],"kidney":[233],"dysfunction":[234],"compared":[235],"level.":[239,249],"treatment":[241],"led":[242],"decrease":[245],"Therefore,":[250],"can":[252],"be":[253],"used":[254],"prevent":[256],"renal":[258],"damage":[259],"it":[265],"independent":[267],"drop":[269],"pressure.":[272]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}