{"id":"https://openalex.org/W2131474360","doi":"https://doi.org/10.1111/exd.12735","title":"Inhibition of hedgehog signalling attenuates UVB \u2010induced skin photoageing","display_name":"Inhibition of hedgehog signalling attenuates UVB \u2010induced skin photoageing","publication_year":2015,"publication_date":"2015-05-02","ids":{"openalex":"https://openalex.org/W2131474360","doi":"https://doi.org/10.1111/exd.12735","mag":"2131474360","pmid":"https://pubmed.ncbi.nlm.nih.gov/25939425"},"language":"en","primary_location":{"id":"doi:10.1111/exd.12735","doi":"https://doi.org/10.1111/exd.12735","is_oa":false,"landing_page_url":"https://doi.org/10.1111/exd.12735","pdf_url":null,"source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046356065","display_name":"Wanyeon Kim","orcid":"https://orcid.org/0000-0002-7611-5248","observed_orcids":["https://orcid.org/0000-0002-7611-5248"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Wanyeon Kim","raw_affiliation_strings":["Department of Biological Sciences, Pusan National University, Busan, South Korea","Nuclear Science Research Institute, Pusan National University, Busan, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Pusan National University, Busan, South Korea","institution_ids":["https://openalex.org/I4921948"]},{"raw_affiliation_string":"Nuclear Science Research Institute, Pusan National University, Busan, South Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087571931","display_name":"EunGi Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"EunGi Kim","raw_affiliation_strings":["Department of Integrated Biological Science, Pusan National University, Busan, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrated Biological Science, Pusan National University, Busan, South Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109177854","display_name":"Hee Jung Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee Jung Yang","raw_affiliation_strings":["Department of Biological Sciences, Pusan National University, Busan, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Pusan National University, Busan, South Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027141563","display_name":"TaeWoo Kwon","orcid":"https://orcid.org/0000-0002-7420-5661","observed_orcids":["https://orcid.org/0000-0002-7420-5661"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"TaeWoo Kwon","raw_affiliation_strings":["Department of Integrated Biological Science, Pusan National University, Busan, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrated Biological Science, Pusan National University, Busan, South Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057435123","display_name":"SeoYoung Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"SeoYoung Han","raw_affiliation_strings":["Department of Integrated Biological Science, Pusan National University, Busan, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrated Biological Science, Pusan National University, Busan, South Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100708051","display_name":"Sungmin Lee","orcid":"https://orcid.org/0009-0000-7172-7459","observed_orcids":["https://orcid.org/0009-0000-7172-7459"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sungmin Lee","raw_affiliation_strings":["Department of Integrated Biological Science, Pusan National University, Busan, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrated Biological Science, Pusan National University, Busan, South Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084084706","display_name":"HyeSook Youn","orcid":"https://orcid.org/0000-0003-0919-094X","observed_orcids":["https://orcid.org/0000-0003-0919-094X"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"HyeSook Youn","raw_affiliation_strings":["Department of Biological Sciences Pusan National University Busan South Korea","Nuclear Science Research Institute, Pusan National University, Busan, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences Pusan National University Busan South Korea","institution_ids":["https://openalex.org/I4921948"]},{"raw_affiliation_string":"Nuclear Science Research Institute, Pusan National University, Busan, South Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048224243","display_name":"Youngmi Jung","orcid":"https://orcid.org/0000-0003-2189-0658","observed_orcids":["https://orcid.org/0000-0003-2189-0658"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Youngmi Jung","raw_affiliation_strings":["Department of Biological Sciences, Pusan National University, Busan, South Korea","Department of Integrated Biological Science, Pusan National University, Busan, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Pusan National University, Busan, South Korea","institution_ids":["https://openalex.org/I4921948"]},{"raw_affiliation_string":"Department of Integrated Biological Science, Pusan National University, Busan, South Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071667418","display_name":"ChulHee Kang","orcid":"https://orcid.org/0000-0002-0693-7860","observed_orcids":["https://orcid.org/0000-0002-0693-7860"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ChulHee Kang","raw_affiliation_strings":["Department of Chemistry, Washington State University, Pullman, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Washington State University, Pullman, Washington, USA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005123608","display_name":"BuHyun Youn","orcid":"https://orcid.org/0000-0002-8010-519X","observed_orcids":["https://orcid.org/0000-0002-8010-519X"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"BuHyun Youn","raw_affiliation_strings":["Department of Biological Sciences, Pusan National University, Busan, South Korea","Department of Integrated Biological Science, Pusan National University, Busan, South Korea","Nuclear Science Research Institute, Pusan National University, Busan, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Pusan National University, Busan, South Korea","institution_ids":["https://openalex.org/I4921948"]},{"raw_affiliation_string":"Department of Integrated Biological Science, Pusan National University, Busan, South Korea","institution_ids":["https://openalex.org/I4921948"]},{"raw_affiliation_string":"Nuclear Science Research Institute, Pusan National University, Busan, South Korea","institution_ids":["https://openalex.org/I4921948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005123608"],"corresponding_institution_ids":["https://openalex.org/I4921948"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":4.4671,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.94488876,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"24","issue":"8","first_page":"611","last_page":"617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.10350000113248825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.9359999895095825},{"id":"https://openalex.org/keywords/uv-b-radiation","display_name":"UV-B radiation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/evodiamine","display_name":"evodiamine","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hedgehog-pathway-inhibitors","display_name":"Hedgehog pathway inhibitors","score":0.7440000176429749},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9520000219345093},{"id":"https://openalex.org/keywords/premature-senescence","display_name":"premature senescence","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7429999709129333},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9800000190734863}],"concepts":[{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.6608694791793823},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5122711062431335},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5086156129837036},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4630458652973175},{"id":"https://openalex.org/C2777605378","wikidata":"https://www.wikidata.org/wiki/Q3271319","display_name":"Cyclopamine","level":4,"score":0.4243418574333191},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4190105199813843},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4159424304962158},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4126725494861603},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.41199129819869995},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39616239070892334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3778049647808075},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30826956033706665},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18699824810028076},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/exd.12735","doi":"https://doi.org/10.1111/exd.12735","is_oa":false,"landing_page_url":"https://doi.org/10.1111/exd.12735","pdf_url":null,"source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},{"id":"pmid:25939425","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25939425","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental dermatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321284","display_name":"Pusan National University","ror":"https://ror.org/01an57a31"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1676048097","https://openalex.org/W1893591129","https://openalex.org/W1909028724","https://openalex.org/W1965431780","https://openalex.org/W1969050050","https://openalex.org/W1975156735","https://openalex.org/W1994553956","https://openalex.org/W1994952359","https://openalex.org/W1996275969","https://openalex.org/W1996375656","https://openalex.org/W2006261269","https://openalex.org/W2008628163","https://openalex.org/W2014064761","https://openalex.org/W2016478164","https://openalex.org/W2023515195","https://openalex.org/W2033203283","https://openalex.org/W2034058906","https://openalex.org/W2036133465","https://openalex.org/W2036434773","https://openalex.org/W2041129913","https://openalex.org/W2041163647","https://openalex.org/W2042167274","https://openalex.org/W2045912291","https://openalex.org/W2046465935","https://openalex.org/W2049217551","https://openalex.org/W2049561692","https://openalex.org/W2049581949","https://openalex.org/W2051754408","https://openalex.org/W2054657634","https://openalex.org/W2057989198","https://openalex.org/W2059456940","https://openalex.org/W2066582786","https://openalex.org/W2078146177","https://openalex.org/W2086152184","https://openalex.org/W2088342479","https://openalex.org/W2093215619","https://openalex.org/W2094569187","https://openalex.org/W2099525640","https://openalex.org/W2099885838","https://openalex.org/W2107394975","https://openalex.org/W2108235396","https://openalex.org/W2113070730","https://openalex.org/W2115400932","https://openalex.org/W2124317241","https://openalex.org/W2129924682","https://openalex.org/W2140715357","https://openalex.org/W2146735463","https://openalex.org/W2147822820","https://openalex.org/W2161192247","https://openalex.org/W2162238879","https://openalex.org/W2916793719"],"related_works":["https://openalex.org/W2915924151","https://openalex.org/W7211903826","https://openalex.org/W2924699894","https://openalex.org/W4408966130","https://openalex.org/W3128422565","https://openalex.org/W2027285722","https://openalex.org/W4378348802","https://openalex.org/W2987071249","https://openalex.org/W3121733383","https://openalex.org/W2016478164"],"abstract_inverted_index":{"The":[0],"hedgehog":[1],"(Hh)":[2],"signalling":[3,59,90,158,169],"pathway":[4],"regulates":[5],"normal":[6],"development":[7],"and":[8,21,97,113,116,124,130,134],"cell":[9],"proliferation":[10],"in":[11,42,60,82,127,132,135,146],"metazoan":[12],"organisms,":[13],"but":[14],"its":[15,34,40,175],"aberrant":[16],"activation":[17,105],"can":[18],"promote":[19],"tumorigenesis":[20],"progression":[22],"of":[23,26,46,57,69,94,120,167],"a":[24,44,75,138,147,180],"variety":[25],"aggressive":[27],"human":[28],"cancers":[29],"including":[30],"skin":[31,48,149],"cancer.":[32],"Despite":[33],"importance,":[35],"little":[36],"is":[37,159],"known":[38],"about":[39],"role":[41],"photoageing,":[43,163,173],"type":[45],"UV-induced":[47],"lesions.":[49],"In":[50],"this":[51,184],"study,":[52],"we":[53],"investigated":[54],"the":[55,61,67,92],"involvement":[56],"Hh":[58,89,95,104,140,157,168],"photoageing":[62,81,131,144],"process":[63],"as":[64,66,74,179],"well":[65],"use":[68,178],"an":[70],"Hh-regulating":[71],"alkaloid":[72],"compound":[73],"novel":[76],"therapeutic":[77,181],"drug":[78],"to":[79],"regulate":[80],"keratinocytes.":[83],"We":[84],"found":[85],"that":[86,156],"UVB":[87],"induced":[88],"by":[91],"expression":[93],"ligands":[96],"Hh-mediated":[98],"transcription":[99],"factors,":[100],"respectively.":[101],"Moreover,":[102],"UVB-induced":[103,162],"relied":[106],"on":[107],"mitogen-activated":[108],"protein":[109],"kinase":[110],"(p38,":[111],"ERK":[112],"JNK)":[114],"activity":[115],"inflammatory":[117],"responses":[118],"(upregulation":[119],"COX-2,":[121],"IL-1\u03b2,":[122],"IL-6":[123],"TNF-\u03b1),":[125],"resulting":[126],"premature":[128],"senescence":[129],"vitro":[133],"vivo.":[136],"Notably,":[137],"selected":[139],"inhibitor,":[141],"evodiamine,":[142],"mediated":[143],"blockade":[145],"mouse":[148],"model.":[150],"Taken":[151],"together,":[152],"our":[153],"findings":[154],"demonstrated":[155],"associated":[160],"with":[161],"while":[164],"pharmacological":[165],"inhibition":[166],"significantly":[170],"reduced":[171],"experimental":[172],"indicating":[174],"potential":[176],"for":[177,183],"target":[182],"disease.":[185]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
