{"id":"https://openalex.org/W2131473533","doi":"https://doi.org/10.1152/ajpendo.00058.2004","title":"Integrated model of hepatic and peripheral glucose regulation for estimation of endogenous glucose production during the hot IVGTT","display_name":"Integrated model of hepatic and peripheral glucose regulation for estimation of endogenous glucose production during the hot IVGTT","publication_year":2005,"publication_date":"2005-01-05","ids":{"openalex":"https://openalex.org/W2131473533","doi":"https://doi.org/10.1152/ajpendo.00058.2004","mag":"2131473533","pmid":"https://pubmed.ncbi.nlm.nih.gov/15632105"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.00058.2004","doi":"https://doi.org/10.1152/ajpendo.00058.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00058.2004","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001723174","display_name":"Kevin M. Krudys","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin M. Krudys","raw_affiliation_strings":["Resource Facility for Population Kinetics, Department of Bioengineering, Box 352255, University of Washington, Seattle, WA 98195-2255, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Resource Facility for Population Kinetics, Department of Bioengineering, Box 352255, University of Washington, Seattle, WA 98195-2255, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076566919","display_name":"Michael Dodds","orcid":"https://orcid.org/0000-0002-0135-7840","observed_orcids":["https://orcid.org/0000-0002-0135-7840"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G. Dodds","raw_affiliation_strings":["","Resource Facility for Population Kinetics, Department of Bioengineering, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Resource Facility for Population Kinetics, Department of Bioengineering, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069986311","display_name":"Stephanie M. Nissen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie M. Nissen","raw_affiliation_strings":["","Resource Facility for Population Kinetics, Department of Bioengineering, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Resource Facility for Population Kinetics, Department of Bioengineering, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103510991","display_name":"Paolo Vicini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paolo Vicini","raw_affiliation_strings":["","Resource Facility for Population Kinetics, Department of Bioengineering, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Resource Facility for Population Kinetics, Department of Bioengineering, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":0.6662,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.725085,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"288","issue":"5","first_page":"E1038","last_page":"E1046"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.7304999828338623,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.7304999828338623,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.15160000324249268,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.051100000739097595,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endogenous-glucose-production","display_name":"endogenous glucose production","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glucose-kinetics","display_name":"glucose kinetics","score":0.40700000524520874},{"id":"https://openalex.org/keywords/minimal-models","display_name":"minimal models","score":0.5989999771118164},{"id":"https://openalex.org/keywords/glucose-effectiveness","display_name":"glucose effectiveness","score":0.6790000200271606},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/u-13c-glucose","display_name":"[U-13C]glucose","score":0.9760000109672546},{"id":"https://openalex.org/keywords/deconvolution","display_name":"deconvolution","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6771799325942993},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.6683908700942993},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6600484848022461},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6398894786834717},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5623795390129089},{"id":"https://openalex.org/C2780323453","wikidata":"https://www.wikidata.org/wiki/Q7113957","display_name":"Overshoot (microwave communication)","level":2,"score":0.5541566610336304},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.552104651927948},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5031535029411316},{"id":"https://openalex.org/C2778808658","wikidata":"https://www.wikidata.org/wiki/Q2975183","display_name":"Glucose clamp technique","level":5,"score":0.4877546429634094},{"id":"https://openalex.org/C3017594256","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin sensitivity","level":4,"score":0.29573777318000793},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.21463418006896973},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19792956113815308},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06859239935874939},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011865","descriptor_name":"Radioisotope Dilution Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpendo.00058.2004","doi":"https://doi.org/10.1152/ajpendo.00058.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00058.2004","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmid:15632105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15632105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Endocrinology and metabolism","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3659820382","display_name":"Cross-Disciplinary Dental Science Research Training","funder_award_id":"T32DE007023","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G4207640449","display_name":"Resource Facility for Population Kinetics","funder_award_id":"P41EB001975","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W82332366","https://openalex.org/W106180575","https://openalex.org/W1789692956","https://openalex.org/W1827964533","https://openalex.org/W1844367202","https://openalex.org/W1967653333","https://openalex.org/W1971781956","https://openalex.org/W1972088904","https://openalex.org/W1972992272","https://openalex.org/W1981737637","https://openalex.org/W1991491264","https://openalex.org/W1999449727","https://openalex.org/W2001875222","https://openalex.org/W2028006779","https://openalex.org/W2037211078","https://openalex.org/W2058361630","https://openalex.org/W2058834317","https://openalex.org/W2060591324","https://openalex.org/W2063628000","https://openalex.org/W2064503593","https://openalex.org/W2084643101","https://openalex.org/W2086279639","https://openalex.org/W2099442609","https://openalex.org/W2100588873","https://openalex.org/W2100795674","https://openalex.org/W2116159103","https://openalex.org/W2119886572","https://openalex.org/W2125624587","https://openalex.org/W2126288890","https://openalex.org/W2127605988","https://openalex.org/W2130171861","https://openalex.org/W2130377792","https://openalex.org/W2133137653","https://openalex.org/W2145333208","https://openalex.org/W2148139015","https://openalex.org/W2153716175","https://openalex.org/W2155059543","https://openalex.org/W2163261947","https://openalex.org/W2164061949","https://openalex.org/W2172957830","https://openalex.org/W2185677714","https://openalex.org/W2218995813","https://openalex.org/W2300639120","https://openalex.org/W2344994915","https://openalex.org/W2936189053"],"related_works":["https://openalex.org/W2344994915","https://openalex.org/W2300639120","https://openalex.org/W2104163763","https://openalex.org/W1982657656","https://openalex.org/W2001875222","https://openalex.org/W2154949364","https://openalex.org/W1771429046","https://openalex.org/W7098257051","https://openalex.org/W2097471965","https://openalex.org/W294521188"],"abstract_inverted_index":{"We":[0,30],"have":[1],"developed":[2],"a":[3,12,22,34,78,85,143,181,191,229,240],"new":[4,97,144,223],"model":[5,98,112,164,225],"to":[6,20,88,151,197,233],"describe":[7],"endogenous":[8,26,91,100],"glucose":[9,16,27,92,101,116],"kinetics":[10,102],"during":[11],"labeled":[13],"(hot)":[14],"intravenous":[15],"tolerance":[17],"test":[18],"(IVGTT)":[19],"derive":[21],"time":[23,171],"profile":[24],"of":[25,115,149,155,169,173,188,243],"production":[28],"(EGP).":[29],"reanalyzed":[31],"data":[32],"from":[33],"previously":[35],"published":[36],"study":[37],"(P.":[38],"Vicini,":[39],"J.":[40,41],"Zachwieja,":[42],"K.":[43],"E.":[44],"Yarasheski,":[45],"D.":[46],"M.":[47],"Bier,":[48],"A.":[49],"Caumo,":[50],"and":[51,142,190,212],"C.":[52],"Cobelli.":[53],"Am":[54],"J":[55],"Physiol":[56],"Endocrinol":[57],"Metab":[58],"276:":[59],"E285-E294,":[60],"1999),":[61],"in":[62,72,84],"which":[63],"insulin-modified":[64],"[6,6-2H2]glucose-labeled":[65],"IVGTTs":[66],"(0.33":[67],"g/kg":[68],"glucose)":[69],"were":[70],"performed":[71],"10":[73],"normal":[74],"subjects.":[75],"In":[76],"addition,":[77],"second":[79],"tracer":[80],"([U-13C]glucose)":[81],"was":[82,103],"infused":[83],"variable":[86],"rate":[87],"clamp":[89,216],"the":[90,106,147,152,170,213,222],"tracer-to-tracee":[93],"ratio":[94],"(TTR).":[95],"Our":[96,201],"describing":[99,146],"incorporated":[104],"into":[105],"two-compartment":[107],"hot":[108],"minimal-model":[109],"structure.":[110],"The":[111,163],"gave":[113],"estimates":[114,202],"effectiveness":[117],"[1.54":[118],"+/-":[119,130,160],"0.31":[120],"(SE)":[121],"ml":[122],"x":[123,125,134,136,138,140],"kg(-1)":[124,135],"min(-1)],":[126],"insulin":[127,156],"sensitivity":[128,148],"(37.74":[129],"5.23":[131],"10(4)":[132],"dl":[133],"min(-1)":[137],"microU(-1)":[139],"ml),":[141],"parameter":[145],"EGP":[150,174,195],"inhibitory":[153,183],"effect":[154,184],"(IC50":[157],"=":[158],"0.0195":[159],"0.0046":[161],"min(-1)).":[162],"additionally":[165],"provided":[166],"an":[167],"estimate":[168],"course":[172],"showing":[175],"almost":[176],"immediate":[177],"inhibition,":[178],"followed":[179],"by":[180,186],"secondary":[182],"caused":[185],"infusion":[187],"insulin,":[189],"large":[192],"overshoot":[193],"as":[194,228],"returns":[196],"its":[198],"basal":[199],"value.":[200],"show":[203],"very":[204],"good":[205],"agreement":[206],"with":[207],"those":[208],"obtained":[209],"via":[210],"deconvolution":[211],"model-independent":[214],"TTR":[215],"technique.":[217],"These":[218],"results":[219],"suggest":[220],"that":[221],"integrated":[224],"can":[226],"serve":[227],"simple":[230],"one-step":[231],"approach":[232],"obtain":[234],"metabolic":[235],"indexes":[236],"while":[237],"also":[238],"providing":[239],"parametric":[241],"description":[242],"EGP.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
