{"id":"https://openalex.org/W2131154089","doi":"https://doi.org/10.1128/jb.173.22.7269-7274.1991","title":"The primary role of comA in establishment of the competent state in Bacillus subtilis is to activate expression of srfA","display_name":"The primary role of comA in establishment of the competent state in Bacillus subtilis is to activate expression of srfA","publication_year":1991,"publication_date":"1991-11-01","ids":{"openalex":"https://openalex.org/W2131154089","doi":"https://doi.org/10.1128/jb.173.22.7269-7274.1991","mag":"2131154089","pmid":"https://pubmed.ncbi.nlm.nih.gov/1938921","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/209234"},"language":"en","primary_location":{"id":"doi:10.1128/jb.173.22.7269-7274.1991","doi":"https://doi.org/10.1128/jb.173.22.7269-7274.1991","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.173.22.7269-7274.1991","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC209234/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037549166","display_name":"MICHIKO M. NAKANO","orcid":"https://orcid.org/0000-0002-0635-8535","observed_orcids":["https://orcid.org/0000-0002-0635-8535"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M M Nakano","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, Shreveport 71130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, Shreveport 71130","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062069964","display_name":"Peter Zuber","orcid":"https://orcid.org/0000-0003-1757-7837","observed_orcids":["https://orcid.org/0000-0003-1757-7837"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Zuber","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, Shreveport 71130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, Shreveport 71130","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.941,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.91441594,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"173","issue":"22","first_page":"7269","last_page":"7274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/genetic-competence","display_name":"genetic competence","score":0.8899999856948853},{"id":"https://openalex.org/keywords/coma","display_name":"coma","score":0.9449999928474426},{"id":"https://openalex.org/keywords/comp","display_name":"COMP","score":0.7770000100135803},{"id":"https://openalex.org/keywords/competence-regulon","display_name":"competence regulon","score":0.8679999709129333},{"id":"https://openalex.org/keywords/surfactin","display_name":"surfactin","score":0.8109999895095825},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7260000109672546},{"id":"https://openalex.org/keywords/spo0a","display_name":"Spo0A","score":0.5109999775886536},{"id":"https://openalex.org/keywords/nutritional-regulation","display_name":"nutritional regulation","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.7656080722808838},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7508654594421387},{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.7132673859596252},{"id":"https://openalex.org/C170344550","wikidata":"https://www.wikidata.org/wiki/Q311359","display_name":"lac operon","level":4,"score":0.6931580305099487},{"id":"https://openalex.org/C62361671","wikidata":"https://www.wikidata.org/wiki/Q1754612","display_name":"Regulon","level":4,"score":0.49539101123809814},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49300023913383484},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4684465229511261},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4585019052028656},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4449467658996582},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.4280615448951721},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4276418089866638},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3849785327911377},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.36114975810050964},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.13807892799377441}],"mesh":[{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002876","descriptor_name":"Chromosomes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014169","descriptor_name":"Transformation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/jb.173.22.7269-7274.1991","doi":"https://doi.org/10.1128/jb.173.22.7269-7274.1991","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.173.22.7269-7274.1991","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmid:1938921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1938921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:209234","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC209234/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.631.6340","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.631.6340","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jb.asm.org/content/173/22/7269.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:209234","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC209234/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2990460474","display_name":null,"funder_award_id":"GM39476","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W280994533","https://openalex.org/W1499467171","https://openalex.org/W1530669588","https://openalex.org/W1534697008","https://openalex.org/W1575886045","https://openalex.org/W1582834972","https://openalex.org/W1672676644","https://openalex.org/W1719124555","https://openalex.org/W1761143397","https://openalex.org/W1819938056","https://openalex.org/W1835434814","https://openalex.org/W1850656556","https://openalex.org/W1866166444","https://openalex.org/W1901538719","https://openalex.org/W1916437228","https://openalex.org/W1926048579","https://openalex.org/W1935566882","https://openalex.org/W1946539893","https://openalex.org/W1956487875","https://openalex.org/W1962830614","https://openalex.org/W1968668907","https://openalex.org/W1977031942","https://openalex.org/W1995543860","https://openalex.org/W2006495190","https://openalex.org/W2020657021","https://openalex.org/W2028790693","https://openalex.org/W2034805458","https://openalex.org/W2035400583","https://openalex.org/W2039401254","https://openalex.org/W2039853230","https://openalex.org/W2071773887","https://openalex.org/W2073894003","https://openalex.org/W2095955490","https://openalex.org/W2102938999","https://openalex.org/W2128830783","https://openalex.org/W2145489514","https://openalex.org/W2150447081","https://openalex.org/W2158763887","https://openalex.org/W2436474853"],"related_works":["https://openalex.org/W1935566882","https://openalex.org/W7098750883","https://openalex.org/W2147780194","https://openalex.org/W7096547444","https://openalex.org/W2098510587","https://openalex.org/W1575886045","https://openalex.org/W2122170001","https://openalex.org/W1565434305","https://openalex.org/W7095456907","https://openalex.org/W7127573402"],"abstract_inverted_index":{"The":[0,71],"establishment":[1],"of":[2,11,23,36,62,74,80,89,95,100,108,117,134,154,160,173,178,191,218,224,228,234,243],"genetic":[3],"competence":[4,13,68,96,225,246],"in":[5,17,60,92,123,126,165,170,196,220,236],"Bacillus":[6],"subtilis":[7],"requires":[8,76],"the":[9,12,18,37,63,77,87,93,98,101,109,115,118,131,152,161,171,204,216,221,232,237],"genes":[10,91],"regulon":[14],"which":[15],"function":[16],"binding,":[19],"processing,":[20],"and":[21,46,83,114,157,175,180,188,194,240],"transport":[22],"DNA.":[24],"Their":[25],"expression":[26,73,99,116,133,146,217],"is":[27,53,213],"governed":[28],"by":[29,186],"multiple":[30],"regulatory":[31,222],"pathways":[32,64],"that":[33,65,144,203],"are":[34],"composed":[35],"comA,":[38,82,156,193],"comP,":[39,81,155,192],"sin,":[40],"abrB,":[41],"spo0H,":[42],"spo0K,":[43],"spo0A,":[44],"degU,":[45],"srfA":[47,52,75,102,145,219,235],"gene":[48,69,78],"products.":[49],"Among":[50],"these,":[51],"thought":[54],"to":[55],"occupy":[56],"an":[57],"intermediate":[58],"position":[59],"one":[61],"controls":[66],"late":[67,245],"expression.":[70],"full":[72],"products":[79,153],"spo0K.":[84,158],"To":[85],"determine":[86],"role":[88],"these":[90],"regulation":[94,242],"development,":[97],"operon":[103,139],"was":[104,121,142,147,168,176,184,189],"placed":[105],"under":[106],"control":[107],"isopropyl-beta-D-thiogalactopyranoside":[110],"(IPTG)-inducible":[111],"promoter":[112],"Pspac":[113],"Pspac-srfA":[119,135,229],"construct":[120],"examined":[122,231],"mutants":[124],"blocked":[125],"early":[127],"competence.":[128],"By":[129],"monitoring":[130],"IPTG-induced":[132],"with":[136],"a":[137,244],"srfA-lacZ":[138],"fusion,":[140],"it":[141],"observed":[143],"no":[148],"longer":[149],"dependent":[150],"on":[151],"Production":[159],"lipopeptide":[162],"antibiotic":[163],"surfactin":[164],"Pspac-srfA-bearing":[166],"cells":[167,197],"induced":[169,185],"presence":[172],"IPTG":[174,187],"independent":[177,190],"ComP":[179],"ComA.":[181],"Competence":[182],"development":[183],"spo0K":[195],"carrying":[198],"Pspac-srfA.":[199],"These":[200],"results":[201],"suggest":[202],"ComP-ComA":[205],"signal":[206],"transduction":[207],"pathway":[208],"as":[209,211],"well":[210],"Spo0K":[212],"required":[214],"for":[215],"cascade":[223],"development.":[226],"Studies":[227],"also":[230],"involvement":[233],"growth":[238],"stage-specific":[239],"nutritional":[241],"gene.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
