{"id":"https://openalex.org/W2131117971","doi":"https://doi.org/10.1007/s11888-009-0029-2","title":"New therapeutics targeting colon cancer stem cells","display_name":"New therapeutics targeting colon cancer stem cells","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W2131117971","doi":"https://doi.org/10.1007/s11888-009-0029-2","mag":"2131117971","pmid":"https://pubmed.ncbi.nlm.nih.gov/20148131","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2818736"},"language":"en","primary_location":{"id":"doi:10.1007/s11888-009-0029-2","doi":"https://doi.org/10.1007/s11888-009-0029-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11888-009-0029-2","pdf_url":null,"source":{"id":"https://openalex.org/S69903676","display_name":"Current Colorectal Cancer Reports","issn_l":"1556-3790","issn":["1556-3790","1556-3804","2153-5833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Colorectal Cancer Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2818736","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112910871","display_name":"Arun Thenappan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arun Thenappan","raw_affiliation_strings":["Lombardi Comprehensive Cancer Center, Georgetown University, 3900 Reservoir Road, Northwest, Medical/Dental Building NW212, Washington, DC, 20007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center, Georgetown University, 3900 Reservoir Road, Northwest, Medical/Dental Building NW212, Washington, DC, 20007, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100770218","display_name":"Ying Li","orcid":"https://orcid.org/0000-0002-9316-2521","observed_orcids":["https://orcid.org/0000-0002-9316-2521","https://orcid.org/0000-0003-3149-8457","https://orcid.org/0009-0004-6166-2849"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Li","raw_affiliation_strings":["Lombardi Comprehensive Cancer Center, Georgetown University, 3900 Reservoir Road, Northwest, Medical/Dental Building NW212, Washington, DC, 20007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center, Georgetown University, 3900 Reservoir Road, Northwest, Medical/Dental Building NW212, Washington, DC, 20007, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034942083","display_name":"Kirti Shetty","orcid":"https://orcid.org/0000-0002-7725-6050","observed_orcids":["https://orcid.org/0000-0002-7725-6050"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirti Shetty","raw_affiliation_strings":["Lombardi Comprehensive Cancer Center, Georgetown University, 3900 Reservoir Road, Northwest, Medical/Dental Building NW212, Washington, DC, 20007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center, Georgetown University, 3900 Reservoir Road, Northwest, Medical/Dental Building NW212, Washington, DC, 20007, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073912546","display_name":"Lynt B. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynt Johnson","raw_affiliation_strings":["Lombardi Comprehensive Cancer Center, Georgetown University, 3900 Reservoir Road, Northwest, Medical/Dental Building NW212, Washington, DC, 20007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center, Georgetown University, 3900 Reservoir Road, Northwest, Medical/Dental Building NW212, Washington, DC, 20007, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034494074","display_name":"E. Premkumar Reddy","orcid":"https://orcid.org/0000-0002-0667-4191","observed_orcids":["https://orcid.org/0000-0002-0667-4191"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. P. Reddy","raw_affiliation_strings":["Lombardi Comprehensive Cancer Center, Georgetown University, 3900 Reservoir Road, Northwest, Medical/Dental Building NW212, Washington, DC, 20007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center, Georgetown University, 3900 Reservoir Road, Northwest, Medical/Dental Building NW212, Washington, DC, 20007, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091703176","display_name":"Lopa Mishra","orcid":"https://orcid.org/0000-0002-6850-0808","observed_orcids":["https://orcid.org/0000-0002-6850-0808"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lopa Mishra","raw_affiliation_strings":["Lombardi Comprehensive Cancer Center, Georgetown University, 3900 Reservoir Road, Northwest, Medical/Dental Building NW212, Washington, DC, 20007, USA","GEORGETOWN UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center, Georgetown University, 3900 Reservoir Road, Northwest, Medical/Dental Building NW212, Washington, DC, 20007, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"raw_affiliation_string":"GEORGETOWN UNIVERSITY","institution_ids":["https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091703176"],"corresponding_institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":null,"fwci":2.4487,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.89313633,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"5","issue":"4","first_page":"209","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.09030000120401382,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/therapeutic-targeting","display_name":"therapeutic targeting","score":0.47200000286102295},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":1.0},{"id":"https://openalex.org/keywords/lgr5","display_name":"Lgr5","score":0.9940000176429749},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8069999814033508},{"id":"https://openalex.org/keywords/apc","display_name":"APC","score":0.38999998569488525},{"id":"https://openalex.org/keywords/smad4","display_name":"SMAD4","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.4779999852180481},{"id":"https://openalex.org/keywords/stem-cell-self-renewal","display_name":"stem cell self-renewal","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8333467245101929},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6833798289299011},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5369401574134827},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5182361602783203},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4640547037124634},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4221014380455017},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34703126549720764},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31713229417800903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09093022346496582},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1007/s11888-009-0029-2","doi":"https://doi.org/10.1007/s11888-009-0029-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11888-009-0029-2","pdf_url":null,"source":{"id":"https://openalex.org/S69903676","display_name":"Current Colorectal Cancer Reports","issn_l":"1556-3790","issn":["1556-3790","1556-3804","2153-5833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Colorectal Cancer Reports","raw_type":"journal-article"},{"id":"pmid:20148131","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20148131","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current colorectal cancer reports","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1948937","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2818736","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2818736","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2818736","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Colorectal Cancer Rep","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1948937","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2818736","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4866649638","display_name":" Gastrointestinal Cell Proliferation and Cell Cycle","funder_award_id":"R01CA106614","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8590142907","display_name":"Metastatic Potential of Colorectal Carcinoma","funder_award_id":"R01CA042857","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8751832488","display_name":"CELLULAR AND MOLECULAR MECHANISMS OF GASTROINTESTINAL CANCERS","funder_award_id":"P01CA130821","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1593560164","https://openalex.org/W1633357948","https://openalex.org/W1846418786","https://openalex.org/W1912879943","https://openalex.org/W1965256905","https://openalex.org/W1975244118","https://openalex.org/W1979141490","https://openalex.org/W1979421565","https://openalex.org/W1982603620","https://openalex.org/W1983961550","https://openalex.org/W1985760249","https://openalex.org/W1992470401","https://openalex.org/W1992782005","https://openalex.org/W2001258296","https://openalex.org/W2002404925","https://openalex.org/W2008384246","https://openalex.org/W2009629707","https://openalex.org/W2009857926","https://openalex.org/W2009886857","https://openalex.org/W2017632960","https://openalex.org/W2019264784","https://openalex.org/W2021370278","https://openalex.org/W2023351030","https://openalex.org/W2023427658","https://openalex.org/W2023649138","https://openalex.org/W2026644829","https://openalex.org/W2029231546","https://openalex.org/W2041491387","https://openalex.org/W2042082068","https://openalex.org/W2046881486","https://openalex.org/W2051055358","https://openalex.org/W2051357113","https://openalex.org/W2055781284","https://openalex.org/W2059972525","https://openalex.org/W2065367851","https://openalex.org/W2067526109","https://openalex.org/W2067836992","https://openalex.org/W2073873870","https://openalex.org/W2081447858","https://openalex.org/W2082257942","https://openalex.org/W2085581448","https://openalex.org/W2091723114","https://openalex.org/W2093531978","https://openalex.org/W2100701799","https://openalex.org/W2108973415","https://openalex.org/W2110504545","https://openalex.org/W2121877441","https://openalex.org/W2122934448","https://openalex.org/W2125639774","https://openalex.org/W2127341411","https://openalex.org/W2128564789","https://openalex.org/W2129644533","https://openalex.org/W2153382986","https://openalex.org/W2154568166","https://openalex.org/W2155507705","https://openalex.org/W2156365913","https://openalex.org/W2158403848","https://openalex.org/W2171262765","https://openalex.org/W2171996338"],"related_works":["https://openalex.org/W3213222623","https://openalex.org/W2810565746","https://openalex.org/W2909511724","https://openalex.org/W1983796869","https://openalex.org/W2766225128","https://openalex.org/W2083235235","https://openalex.org/W2810175029","https://openalex.org/W2134083283","https://openalex.org/W2318404004","https://openalex.org/W2108224617"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}