{"id":"https://openalex.org/W2131115331","doi":"https://doi.org/10.1038/mt.2008.93","title":"In Vivo Biosafety Model to Assess the Risk of Adverse Events From Retroviral and Lentiviral Vectors","display_name":"In Vivo Biosafety Model to Assess the Risk of Adverse Events From Retroviral and Lentiviral Vectors","publication_year":2008,"publication_date":"2008-05-06","ids":{"openalex":"https://openalex.org/W2131115331","doi":"https://doi.org/10.1038/mt.2008.93","mag":"2131115331","pmid":"https://pubmed.ncbi.nlm.nih.gov/18461052","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3013368"},"language":"en","primary_location":{"id":"doi:10.1038/mt.2008.93","doi":"https://doi.org/10.1038/mt.2008.93","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mt.2008.93","pdf_url":"http://www.cell.com/article/S1525001616324728/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S1525001616324728/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109974195","display_name":"Gerhard Bauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerhard Bauer","raw_affiliation_strings":["Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California 95817, USA","Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California 95817, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113503690","display_name":"Mo A. Dao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mo A Dao","raw_affiliation_strings":["Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077959007","display_name":"Scott S. Case","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott S Case","raw_affiliation_strings":["Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082143103","display_name":"Todd E. Meyerrose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Meyerrose","raw_affiliation_strings":["Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063955435","display_name":"Louisa Wirthlin","orcid":"https://orcid.org/0009-0003-4927-1602","observed_orcids":["https://orcid.org/0009-0003-4927-1602"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louisa Wirthlin","raw_affiliation_strings":["Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103049750","display_name":"Ping Zhou","orcid":"https://orcid.org/0000-0002-6644-788X","observed_orcids":["https://orcid.org/0000-0002-6644-788X"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping Zhou","raw_affiliation_strings":["Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036506606","display_name":"Xiuli Wang","orcid":"https://orcid.org/0000-0001-5964-4327","observed_orcids":["https://orcid.org/0000-0001-5964-4327"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiuli Wang","raw_affiliation_strings":["Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059904874","display_name":"Phillip E. Herrbrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip Herrbrich","raw_affiliation_strings":["Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046597190","display_name":"Jesusa M.G. Arevalo","orcid":"https://orcid.org/0000-0001-9659-7881","observed_orcids":["https://orcid.org/0000-0001-9659-7881"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesusa Arevalo","raw_affiliation_strings":["Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015611970","display_name":"Susie Csik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susie Csik","raw_affiliation_strings":["Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111426650","display_name":"Dianne C. Skelton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dianne C Skelton","raw_affiliation_strings":["Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109873199","display_name":"Jon E. Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon Walker","raw_affiliation_strings":["Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033377588","display_name":"Karen A. Pepper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Pepper","raw_affiliation_strings":["Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050971129","display_name":"Donald B. Kohn","orcid":"https://orcid.org/0000-0003-1840-6087","observed_orcids":["https://orcid.org/0000-0003-1840-6087"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald B Kohn","raw_affiliation_strings":["Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085630765","display_name":"Jan A. Nolta","orcid":"https://orcid.org/0000-0003-4576-8542","observed_orcids":["https://orcid.org/0000-0003-4576-8542"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jan A Nolta","raw_affiliation_strings":["Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California, USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085630765"],"corresponding_institution_ids":["https://openalex.org/I1336910626","https://openalex.org/I84218800"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":4.5711,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.95595179,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":"7","first_page":"1308","last_page":"1315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosafety","display_name":"biosafety","score":0.5389999747276306},{"id":"https://openalex.org/keywords/retroviral-vectors","display_name":"retroviral vectors","score":0.8820000290870667},{"id":"https://openalex.org/keywords/lentiviral-vectors","display_name":"lentiviral vectors","score":1.0},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.6620000004768372},{"id":"https://openalex.org/keywords/replication-competent-retrovirus","display_name":"replication-competent retrovirus","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.8109999895095825},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":1.0},{"id":"https://openalex.org/keywords/insertional-mutagenesis","display_name":"insertional mutagenesis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.7480000257492065},{"id":"https://openalex.org/keywords/hiv-p24","display_name":"HIV p24","score":0.8579999804496765},{"id":"https://openalex.org/keywords/immunodeficient-mice","display_name":"immunodeficient mice","score":0.8500000238418579},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.7736673951148987},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.6985030174255371},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6119564175605774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5750998854637146},{"id":"https://openalex.org/C2778431562","wikidata":"https://www.wikidata.org/wiki/Q189308","display_name":"Retrovirus","level":3,"score":0.5662789940834045},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.5570484399795532},{"id":"https://openalex.org/C52384281","wikidata":"https://www.wikidata.org/wiki/Q864713","display_name":"Biosafety","level":2,"score":0.5340321063995361},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5179028511047363},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5117080211639404},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46056681871414185},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4509744346141815},{"id":"https://openalex.org/C107635520","wikidata":"https://www.wikidata.org/wiki/Q1967554","display_name":"Insertional mutagenesis","level":4,"score":0.4220835268497467},{"id":"https://openalex.org/C2779562191","wikidata":"https://www.wikidata.org/wiki/Q673848","display_name":"Murine leukemia virus","level":3,"score":0.4191626012325287},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4152563512325287},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37523263692855835},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17409464716911316},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1718747615814209},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.10956323146820068},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.09394115209579468},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0879252552986145},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008979","descriptor_name":"Moloney murine leukemia virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/mt.2008.93","doi":"https://doi.org/10.1038/mt.2008.93","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mt.2008.93","pdf_url":"http://www.cell.com/article/S1525001616324728/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},{"id":"pmid:18461052","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18461052","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy : the journal of the American Society of Gene Therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3013368","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3013368","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Ther","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/mt.2008.93","doi":"https://doi.org/10.1038/mt.2008.93","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mt.2008.93","pdf_url":"http://www.cell.com/article/S1525001616324728/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1331030567","display_name":"Functional dissection of human adipose and bone marrow-derived MSC phenotypes","funder_award_id":"R01HL073256","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G516734054","display_name":"Ex Vivo Stem Cell Manipulation and Human Hematopoiesis","funder_award_id":"R01DK053041","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5251259329","display_name":"HSC DIFFERENTIATION","funder_award_id":"P50HL054850","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8860800669","display_name":"Immunodeficient mouse model of stem cell plasticity","funder_award_id":"R01DK061848","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2131115331.pdf"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1482247814","https://openalex.org/W1511818607","https://openalex.org/W1780248548","https://openalex.org/W1965406709","https://openalex.org/W1965953554","https://openalex.org/W1975497198","https://openalex.org/W1976479369","https://openalex.org/W1980439517","https://openalex.org/W1980886652","https://openalex.org/W1981481637","https://openalex.org/W2004565189","https://openalex.org/W2005848913","https://openalex.org/W2008991566","https://openalex.org/W2017925058","https://openalex.org/W2027321452","https://openalex.org/W2030805338","https://openalex.org/W2052150955","https://openalex.org/W2058895038","https://openalex.org/W2059066863","https://openalex.org/W2068102253","https://openalex.org/W2077013971","https://openalex.org/W2097606337","https://openalex.org/W2099557749","https://openalex.org/W2102146319","https://openalex.org/W2104549243","https://openalex.org/W2129475443","https://openalex.org/W2132859839","https://openalex.org/W2136139751","https://openalex.org/W2150110701","https://openalex.org/W2151137440","https://openalex.org/W2286095548","https://openalex.org/W2322025889","https://openalex.org/W2323613689","https://openalex.org/W2338577546","https://openalex.org/W2398771789","https://openalex.org/W2410584964","https://openalex.org/W2418036621","https://openalex.org/W2491966893","https://openalex.org/W4232073409","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2555098864","https://openalex.org/W2078105998","https://openalex.org/W2417541186","https://openalex.org/W4212959576","https://openalex.org/W1982786506","https://openalex.org/W2028478786","https://openalex.org/W2029161351","https://openalex.org/W2063857001","https://openalex.org/W2618078148","https://openalex.org/W2293164235"],"abstract_inverted_index":{"Serious":[0],"adverse":[1,40,170],"events":[2,41,171],"in":[3,42,44,128,187,191,213],"some":[4],"human":[5,123,181],"gene":[6,22,215],"therapy":[7,216],"clinical":[8,214],"trials":[9],"have":[10],"raised":[11],"safety":[12],"concerns":[13],"when":[14,204],"retroviral":[15,205],"or":[16,125,206],"lentiviral":[17,160,207],"vectors":[18,68,208],"are":[19,79,209],"used":[20],"for":[21,28,92,165,211],"transfer.":[23],"We":[24],"evaluated":[25],"the":[26,35,88,129,134,177,201],"potential":[27],"generating":[29],"replication-competent":[30],"retrovirus":[31],"(RCR)":[32],"and":[33,50,54,87,105,162,174],"assessed":[34],"risk":[36],"of":[37,39,74,99,110,118,176,200],"occurrence":[38],"an":[43,198],"vivo":[45,192],"system.":[46],"Human":[47],"hematopoietic":[48],"stem":[49,56],"progenitor":[51],"cells":[52,57,83],"(HSCs)":[53],"mesenchymal":[55],"(MSCs)":[58],"transduced":[59,158],"with":[60,96,159],"two":[61],"different":[62],"Moloney":[63],"murine":[64],"leukemia":[65],"virus":[66,183],"(MoMuLV)-based":[67],"were":[69,90,101,136,163,172],"cotransplanted":[70],"into":[71],"a":[72,108],"total":[73],"481":[75],"immune-deficient":[76],"mice":[77,155,178],"(that":[78],"unable":[80],"to":[81,107,122,196],"reject":[82],"that":[84],"become":[85],"transformed),":[86],"animals":[89,135],"monitored":[91],"18":[93,130],"months.":[94,167],"Animals":[95],"any":[97],"signs":[98],"illness":[100],"immediately":[102],"killed,":[103],"autopsied,":[104],"subjected":[106],"range":[109],"biosafety":[111],"studies.":[112],"There":[113],"was":[114,148],"no":[115,149],"detectable":[116,150,180],"evidence":[117],"insertional":[119],"mutagenesis":[120],"leading":[121],"leukemias":[124],"solid":[126],"tumors":[127],"months":[131],"during":[132],"which":[133],"studied.":[137],"In":[138],"117":[139],"serum":[140],"samples":[141],"analyzed":[142],"by":[143],"vector":[144],"rescue":[145],"assay":[146],"there":[147],"RCR.":[151],"An":[152],"additional":[153],"149":[154],"received":[156],"HSCs":[157],"vectors,":[161],"followed":[164],"2-6":[166],"No":[168],"vector-associated":[169],"observed,":[173],"none":[175],"had":[179],"immunodeficiency":[182],"(HIV)":[184],"p24":[185],"antigen":[186],"their":[188],"sera.":[189],"Our":[190],"system,":[193],"therefore,":[194],"helps":[195],"provide":[197],"assessment":[199],"risks":[202],"involved":[203],"considered":[210],"use":[212],"applications.":[217]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
