{"id":"https://openalex.org/W2131106803","doi":"https://doi.org/10.1128/mcb.17.1.326","title":"Volatility of Internal Eliminated Segments in Germ Line Genes of Hypotrichous Ciliates","display_name":"Volatility of Internal Eliminated Segments in Germ Line Genes of Hypotrichous Ciliates","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2131106803","doi":"https://doi.org/10.1128/mcb.17.1.326","mag":"2131106803","pmid":"https://pubmed.ncbi.nlm.nih.gov/8972213","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/231757"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.17.1.326","doi":"https://doi.org/10.1128/mcb.17.1.326","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.17.1.326","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC231757","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049480617","display_name":"Michelle L. DuBois","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle L. DuBois","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111750361","display_name":"David M. Prescott","orcid":"https://orcid.org/0000-0002-9798-9526","observed_orcids":["https://orcid.org/0000-0002-9798-9526"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David M. Prescott","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347","institution_ids":["https://openalex.org/I188538660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111750361"],"corresponding_institution_ids":["https://openalex.org/I188538660"],"apc_list":null,"apc_paid":null,"fwci":3.3535,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.91980865,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"17","issue":"1","first_page":"326","last_page":"337"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.7710000276565552,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.7710000276565552,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11879","display_name":"Protist diversity and phylogeny","score":0.19339999556541443,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/germline-genes","display_name":"germline genes","score":0.6679999828338623},{"id":"https://openalex.org/keywords/hypotrichous-ciliates","display_name":"hypotrichous ciliates","score":0.902999997138977},{"id":"https://openalex.org/keywords/macronuclear-development","display_name":"macronuclear development","score":0.6740000247955322},{"id":"https://openalex.org/keywords/intron-conservation","display_name":"intron conservation","score":0.5410000085830688},{"id":"https://openalex.org/keywords/at-rich-sequences","display_name":"AT-rich sequences","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9334185123443604},{"id":"https://openalex.org/C56683836","wikidata":"https://www.wikidata.org/wiki/Q1886511","display_name":"Macronucleus","level":3,"score":0.9151128530502319},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7338199019432068},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5931228399276733},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.5750910043716431}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005854","descriptor_name":"Germ Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016810","descriptor_name":"Hypotrichida","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016813","descriptor_name":"Oxytricha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017125","descriptor_name":"Genes, Protozoan","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048631","descriptor_name":"Micronucleus, Germline","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/mcb.17.1.326","doi":"https://doi.org/10.1128/mcb.17.1.326","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.17.1.326","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:228596","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC231757","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:231757","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/231757","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:8972213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8972213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:228596","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC231757","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337397","display_name":"Division of Molecular and Cellular Biosciences","ror":"https://ror.org/002jdaq33"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W165389991","https://openalex.org/W1597112157","https://openalex.org/W1912524364","https://openalex.org/W1965124661","https://openalex.org/W1966035178","https://openalex.org/W1972814863","https://openalex.org/W1974194748","https://openalex.org/W1981525356","https://openalex.org/W1984779456","https://openalex.org/W1986472179","https://openalex.org/W1992842240","https://openalex.org/W1999819702","https://openalex.org/W2003668302","https://openalex.org/W2004106262","https://openalex.org/W2010975156","https://openalex.org/W2019410656","https://openalex.org/W2022959766","https://openalex.org/W2025283176","https://openalex.org/W2033003155","https://openalex.org/W2047043554","https://openalex.org/W2048478689","https://openalex.org/W2048483518","https://openalex.org/W2052506668","https://openalex.org/W2063414758","https://openalex.org/W2079214991","https://openalex.org/W2079751194","https://openalex.org/W2080087756","https://openalex.org/W2088089212","https://openalex.org/W2094095429","https://openalex.org/W2096893503","https://openalex.org/W2107538318","https://openalex.org/W2138270253","https://openalex.org/W2314225431","https://openalex.org/W4238471362"],"related_works":["https://openalex.org/W2107538318","https://openalex.org/W2017521503","https://openalex.org/W2029625516","https://openalex.org/W1980653279","https://openalex.org/W2079621163","https://openalex.org/W2088089212","https://openalex.org/W2075788500","https://openalex.org/W2049172654","https://openalex.org/W2021827074","https://openalex.org/W2087442891"],"abstract_inverted_index":{"Germ":[0],"line":[1,244],"micronuclear":[2,37,83,120],"genes":[3,14,162,213],"in":[4,36,69,81,96,143,158,182,205,210,217,241],"ciliated":[5],"protozoa":[6],"contain":[7,15],"two":[8],"types":[9],"of":[10,64,67,88,105,114,118,136,190,223],"interrupting":[11],"sequences.":[12],"Some":[13],"introns,":[16],"but":[17],"internal":[18],"eliminated":[19],"segments":[20,30,34],"(IESs)":[21],"are":[22,27,41,93,216,229,234],"much":[23],"more":[24],"prevalent.":[25],"IESs":[26,40,56,68,80,117,138,157,228],"AT-rich":[28],"DNA":[29],"that":[31,233],"separate":[32],"macronucleus-destined":[33],"(MDSs)":[35],"genes.":[38],"All":[39],"excised":[42],"and":[43,116,134,142,154,208,238],"destroyed":[44],"when":[45],"a":[46,50,177,191],"micronucleus":[47],"develops":[48],"into":[49],"macronucleus":[51],"after":[52],"each":[53],"cell":[54],"mating.":[55],"have":[57,167],"no":[58],"discernible":[59],"function.":[60],"Therefore,":[61,227],"an":[62,151],"investigation":[63],"the":[65,82,86,89,103,111,119,130,137,146,159,164,183,211,221,224,242],"behavior":[66],"evolution":[70,104],"has":[71,124],"been":[72,125],"undertaken":[73],"to":[74,172,220],"assess":[75],"their":[76],"possible":[77],"significance.":[78],"The":[79,203],"gene":[84,123,149],"encoding":[85],"beta-subunit":[87],"telomere-binding":[90],"protein":[91],"(beta-TP)":[92],"not":[94,198],"conserved":[95,126],"number,":[97],"position,":[98],"sequence,":[99],"or":[100],"length":[101],"during":[102,127],"four":[106],"oxytrichid":[107],"ciliates.":[108],"In":[109],"contrast,":[110],"scrambled":[112],"pattern":[113],"MDSs":[115],"actin":[121,147,160],"I":[122,148,161],"evolution;":[128],"however,":[129],"precise":[131],"positions,":[132],"sequences,":[133],"lengths":[135],"differ":[139],"among":[140,163,195,214],"species,":[141],"some":[144],"organisms":[145,166],"contains":[150],"additional":[152],"IES":[153,201,206],"MDS.":[155],"Corresponding":[156],"different":[165],"shifted":[168],"positions":[169],"by":[170,176],"1":[171],"14":[173],"bp,":[174],"presumably":[175],"mutation-shifting":[178],"mechanism,":[179],"creating":[180],"differences":[181],"repeat":[184,193],"sequences":[185],"flanking":[186],"IESs.":[187],"Thus,":[188],"conservation":[189],"particular":[192],"sequence":[194],"species":[196],"is":[197],"required":[199],"for":[200],"excision.":[202],"changes":[204],"number":[207],"position":[209],"beta-TP":[212],"ciliates":[215],"sharp":[218],"contrast":[219],"stability":[222],"intron":[225],"position.":[226],"volatile,":[230],"hypermutable":[231],"elements":[232],"inserted,":[235],"removed,":[236],"shifted,":[237],"modified":[239],"continuously":[240],"germ":[243],"through":[245],"evolutionary":[246],"time.":[247]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
