{"id":"https://openalex.org/W2131024302","doi":"https://doi.org/10.1378/chest.07-0945","title":"Up-Regulation of Thrombin Activity Induced by Vascular Endothelial Growth Factor in Asthmatic Airways","display_name":"Up-Regulation of Thrombin Activity Induced by Vascular Endothelial Growth Factor in Asthmatic Airways","publication_year":2007,"publication_date":"2007-10-01","ids":{"openalex":"https://openalex.org/W2131024302","doi":"https://doi.org/10.1378/chest.07-0945","mag":"2131024302","pmid":"https://pubmed.ncbi.nlm.nih.gov/17934112"},"language":"en","primary_location":{"id":"doi:10.1378/chest.07-0945","doi":"https://doi.org/10.1378/chest.07-0945","is_oa":false,"landing_page_url":"https://doi.org/10.1378/chest.07-0945","pdf_url":null,"source":{"id":"https://openalex.org/S76900504","display_name":"CHEST Journal","issn_l":"0012-3692","issn":["0012-3692","1931-3543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111883822","display_name":"Hiroshi Kanazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kanazawa","raw_affiliation_strings":["Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abenoku, Osaka, 545-8585, Japan. kanazawa-h@med.osaka-cu.ac.jp","Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abenoku, Osaka, 545-8585, Japan. kanazawa-h@med.osaka-cu.ac.jp","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101636615","display_name":"Takahiro Yoshikawa","orcid":"https://orcid.org/0000-0002-8175-5880","observed_orcids":["https://orcid.org/0000-0002-8175-5880"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Yoshikawa","raw_affiliation_strings":["Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan","institution_ids":["https://openalex.org/I317356780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I317356780"],"apc_list":{"value":4160,"currency":"USD","value_usd":4160},"apc_paid":null,"fwci":1.8887,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.86620145,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"132","issue":"4","first_page":"1169","last_page":"1174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombin-activity","display_name":"thrombin activity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.8830000162124634},{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-c","display_name":"protein C","score":0.7089999914169312},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.9750000238418579},{"id":"https://openalex.org/keywords/induced-sputum","display_name":"induced sputum","score":0.9120000004768372},{"id":"https://openalex.org/keywords/subepithelial-fibrosis","display_name":"subepithelial fibrosis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.878000020980835},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8318084478378296},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.7470681667327881},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.6372495293617249},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.6071141958236694},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6042130589485168},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5523666143417358},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.5480071902275085},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4587988257408142},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.4580293297767639},{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.4406633973121643},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.4338802695274353},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.3888043165206909},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3239809572696686},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2134007215499878},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.14932942390441895},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.13299742341041565},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07386821508407593},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.06220412254333496},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011486","descriptor_name":"Protein C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013183","descriptor_name":"Sputum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1378/chest.07-0945","doi":"https://doi.org/10.1378/chest.07-0945","is_oa":false,"landing_page_url":"https://doi.org/10.1378/chest.07-0945","pdf_url":null,"source":{"id":"https://openalex.org/S76900504","display_name":"CHEST Journal","issn_l":"0012-3692","issn":["0012-3692","1931-3543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"journal-article"},{"id":"pmid:17934112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17934112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W122369139","https://openalex.org/W1783580437","https://openalex.org/W1861812628","https://openalex.org/W1932972513","https://openalex.org/W1934670864","https://openalex.org/W1977056120","https://openalex.org/W1978923969","https://openalex.org/W1980358070","https://openalex.org/W1980626129","https://openalex.org/W1988277233","https://openalex.org/W1995511753","https://openalex.org/W1998424851","https://openalex.org/W2003598961","https://openalex.org/W2012008911","https://openalex.org/W2023902338","https://openalex.org/W2030790832","https://openalex.org/W2052812481","https://openalex.org/W2053568297","https://openalex.org/W2058504265","https://openalex.org/W2067485348","https://openalex.org/W2074001528","https://openalex.org/W2078626679","https://openalex.org/W2084506573","https://openalex.org/W2088301689","https://openalex.org/W2091118947","https://openalex.org/W2092902440","https://openalex.org/W2121464855","https://openalex.org/W2127203245","https://openalex.org/W2138312725","https://openalex.org/W2138519685","https://openalex.org/W2146463187","https://openalex.org/W2160053403","https://openalex.org/W2160926771","https://openalex.org/W2162565890","https://openalex.org/W2165179802","https://openalex.org/W2262202248","https://openalex.org/W2272893616","https://openalex.org/W2418876388","https://openalex.org/W4211171942","https://openalex.org/W4236639597","https://openalex.org/W6645455455","https://openalex.org/W6672755188"],"related_works":["https://openalex.org/W1995511753","https://openalex.org/W7098916201","https://openalex.org/W1861812628","https://openalex.org/W2042288131","https://openalex.org/W1988277233","https://openalex.org/W2311704360","https://openalex.org/W2026030771","https://openalex.org/W2091118947","https://openalex.org/W2079670549","https://openalex.org/W2553696115"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}