{"id":"https://openalex.org/W2130833499","doi":"https://doi.org/10.1161/hypertensionaha.110.163972","title":"Endothelin-Converting Enzyme/Neutral Endopeptidase Inhibitor SLV338 Prevents Hypertensive Cardiac Remodeling in a Blood Pressure\u2013Independent Manner","display_name":"Endothelin-Converting Enzyme/Neutral Endopeptidase Inhibitor SLV338 Prevents Hypertensive Cardiac Remodeling in a Blood Pressure\u2013Independent Manner","publication_year":2011,"publication_date":"2011-02-22","ids":{"openalex":"https://openalex.org/W2130833499","doi":"https://doi.org/10.1161/hypertensionaha.110.163972","mag":"2130833499","pmid":"https://pubmed.ncbi.nlm.nih.gov/21339476"},"language":"en","primary_location":{"id":"doi:10.1161/hypertensionaha.110.163972","doi":"https://doi.org/10.1161/hypertensionaha.110.163972","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.110.163972","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007484586","display_name":"Philipp Kalk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4210094013","display_name":"Porsolt (France)","ror":"https://ror.org/00ra8jw08","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210094013"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Philipp Kalk","raw_affiliation_strings":["From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France","institution_ids":["https://openalex.org/I4210094013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090379669","display_name":"Yuliya Sharkovska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4210094013","display_name":"Porsolt (France)","ror":"https://ror.org/00ra8jw08","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210094013"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Yuliya Sharkovska","raw_affiliation_strings":["From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France","institution_ids":["https://openalex.org/I4210094013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010304788","display_name":"Elena V. Kashina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4210094013","display_name":"Porsolt (France)","ror":"https://ror.org/00ra8jw08","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210094013"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Elena Kashina","raw_affiliation_strings":["From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France","institution_ids":["https://openalex.org/I4210094013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017332628","display_name":"Karoline von Websky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4210094013","display_name":"Porsolt (France)","ror":"https://ror.org/00ra8jw08","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210094013"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Karoline von Websky","raw_affiliation_strings":["From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France","institution_ids":["https://openalex.org/I4210094013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082183114","display_name":"Katharina Relle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4210094013","display_name":"Porsolt (France)","ror":"https://ror.org/00ra8jw08","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210094013"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Katharina Relle","raw_affiliation_strings":["From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France","institution_ids":["https://openalex.org/I4210094013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059070828","display_name":"Thiemo Pfab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4210094013","display_name":"Porsolt (France)","ror":"https://ror.org/00ra8jw08","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210094013"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Thiemo Pfab","raw_affiliation_strings":["From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France","institution_ids":["https://openalex.org/I4210094013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026754112","display_name":"Markus Alter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4210094013","display_name":"Porsolt (France)","ror":"https://ror.org/00ra8jw08","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210094013"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Markus Alter","raw_affiliation_strings":["From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France","institution_ids":["https://openalex.org/I4210094013"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Philippe Guillaume","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4210094013","display_name":"Porsolt (France)","ror":"https://ror.org/00ra8jw08","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210094013"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Philippe Guillaume","raw_affiliation_strings":["From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France","institution_ids":["https://openalex.org/I4210094013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050709034","display_name":"Daniel Provost","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4210094013","display_name":"Porsolt (France)","ror":"https://ror.org/00ra8jw08","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210094013"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Daniel Provost","raw_affiliation_strings":["From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France","institution_ids":["https://openalex.org/I4210094013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101424397","display_name":"Katrin Hoffmann","orcid":"https://orcid.org/0000-0002-0872-9264","observed_orcids":["https://orcid.org/0000-0002-0872-9264"]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4210094013","display_name":"Porsolt (France)","ror":"https://ror.org/00ra8jw08","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210094013"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Katrin Hoffmann","raw_affiliation_strings":["From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France","institution_ids":["https://openalex.org/I4210094013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051629956","display_name":"Yvan Fischer","orcid":"https://orcid.org/0009-0006-8632-3469","observed_orcids":["https://orcid.org/0009-0006-8632-3469"]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4210094013","display_name":"Porsolt (France)","ror":"https://ror.org/00ra8jw08","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210094013"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Yvan Fischer","raw_affiliation_strings":["From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France","institution_ids":["https://openalex.org/I4210094013"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022687335","display_name":"Berthold Hocher","orcid":"https://orcid.org/0000-0001-8143-0579","observed_orcids":["https://orcid.org/0000-0001-8143-0579"]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4210094013","display_name":"Porsolt (France)","ror":"https://ror.org/00ra8jw08","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210094013"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Berthold Hocher","raw_affiliation_strings":["From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Nephrology (P.K., T.P., M.A.), Charit\u00e9, Campus Benjamin Franklin, Berlin, Germany; Center for Cardiovascular Research/Institute of Pharmacology (P.K., Y.S., E.K., K.v.W., K.R., T.P., M.A., B.H.), Charit\u00e9, Campus Mitte, Berlin, Germany; Institute for Nutritional Science (Y.S., K.v.W., K.R., B.H.), University of Potsdam, Potsdam, Germany; Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France; Abbott Products GmbH (K.H., Y.F.), Hannover, Germany; and","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Abbott Products GmbH (K.H., Y.F.), Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Porsolt and Partners Pharmacology (P.G., D.P.), Le Genest-Saint-Isle, France","institution_ids":["https://openalex.org/I4210094013"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7304,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.95421691,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"57","issue":"4","first_page":"755","last_page":"763"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.3407999873161316,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.3407999873161316,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.2565999925136566,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.2206999957561493,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-converting-enzyme-inhibition","display_name":"endothelin-converting enzyme inhibition","score":0.8989999890327454},{"id":"https://openalex.org/keywords/neutral-endopeptidase-inhibition","display_name":"neutral endopeptidase inhibition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renovascular-hypertension","display_name":"renovascular hypertension","score":0.9850000143051147},{"id":"https://openalex.org/keywords/2-kidney-1-clip-model","display_name":"two-kidney one-clip model","score":0.9129999876022339},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.9229999780654907},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8870000243186951},{"id":"https://openalex.org/keywords/natriuretic-peptides","display_name":"natriuretic peptides","score":0.8180000185966492},{"id":"https://openalex.org/keywords/endothelin","display_name":"endothelin","score":0.6470000147819519},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.8777787089347839},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7335763573646545},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7063022255897522},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6373914480209351},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5712810754776001},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.5603020191192627},{"id":"https://openalex.org/C104826730","wikidata":"https://www.wikidata.org/wiki/Q414232","display_name":"Neprilysin","level":3,"score":0.5458765625953674},{"id":"https://openalex.org/C3018763269","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Myocardial fibrosis","level":3,"score":0.5085595846176147},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4905702471733093},{"id":"https://openalex.org/C2777420927","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Cardiac fibrosis","level":3,"score":0.48629364371299744},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.4827967882156372},{"id":"https://openalex.org/C2781243531","wikidata":"https://www.wikidata.org/wiki/Q3296793","display_name":"Renovascular hypertension","level":3,"score":0.4812716841697693},{"id":"https://openalex.org/C2779611605","wikidata":"https://www.wikidata.org/wiki/Q288280","display_name":"ACE inhibitor","level":4,"score":0.46334442496299744},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.4284828007221222},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.35956770181655884},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13428324460983276},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0901404619216919},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072396","descriptor_name":"Endothelin-Converting Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072396","descriptor_name":"Endothelin-Converting Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072396","descriptor_name":"Endothelin-Converting Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006978","descriptor_name":"Hypertension, Renovascular","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006978","descriptor_name":"Hypertension, Renovascular","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006978","descriptor_name":"Hypertension, Renovascular","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006978","descriptor_name":"Hypertension, Renovascular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006978","descriptor_name":"Hypertension, Renovascular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006978","descriptor_name":"Hypertension, Renovascular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006978","descriptor_name":"Hypertension, Renovascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006978","descriptor_name":"Hypertension, Renovascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006978","descriptor_name":"Hypertension, Renovascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006978","descriptor_name":"Hypertension, Renovascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006978","descriptor_name":"Hypertension, Renovascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006978","descriptor_name":"Hypertension, Renovascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015260","descriptor_name":"Neprilysin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015260","descriptor_name":"Neprilysin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015260","descriptor_name":"Neprilysin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/hypertensionaha.110.163972","doi":"https://doi.org/10.1161/hypertensionaha.110.163972","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.110.163972","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},{"id":"pmid:21339476","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21339476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension (Dallas, Tex. : 1979)","raw_type":"Journal Article"},{"id":"pmh:oai:kobv.de-opus4-uni-potsdam:36939","doi":null,"is_oa":false,"landing_page_url":"https://publishup.uni-potsdam.de/frontdoor/index/index/docId/36939","pdf_url":null,"source":{"id":"https://openalex.org/S4306400594","display_name":"publish.UP (University of Potsdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176453806","host_organization_name":"University of Potsdam","host_organization_lineage":["https://openalex.org/I176453806"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8799999952316284}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W137536100","https://openalex.org/W846607674","https://openalex.org/W1533862150","https://openalex.org/W1992666213","https://openalex.org/W1998137947","https://openalex.org/W2031012006","https://openalex.org/W2037191838","https://openalex.org/W2043346058","https://openalex.org/W2056851052","https://openalex.org/W2057386289","https://openalex.org/W2057508448","https://openalex.org/W2065254627","https://openalex.org/W2072591618","https://openalex.org/W2072628367","https://openalex.org/W2075100686","https://openalex.org/W2076293103","https://openalex.org/W2078016545","https://openalex.org/W2094988613","https://openalex.org/W2118643525","https://openalex.org/W2130196477","https://openalex.org/W2132602077","https://openalex.org/W2136145230","https://openalex.org/W2140909944","https://openalex.org/W2144360877","https://openalex.org/W2144935053","https://openalex.org/W2166338527","https://openalex.org/W2167004336","https://openalex.org/W2322134991","https://openalex.org/W2325687453","https://openalex.org/W2428411855","https://openalex.org/W4229755335"],"related_works":["https://openalex.org/W2074067577","https://openalex.org/W4200248193","https://openalex.org/W2353687379","https://openalex.org/W3170395972","https://openalex.org/W2343473696","https://openalex.org/W4386945927","https://openalex.org/W4362469413","https://openalex.org/W3087046692","https://openalex.org/W2367160260","https://openalex.org/W3056688886"],"abstract_inverted_index":{"Hypertensive":[0],"heart":[1],"disease":[2],"is":[3,11,132,240],"a":[4,12,54,133,227,232],"major":[5],"contributor":[6],"to":[7,72,219],"cardiovascular":[8],"mortality.":[9],"Endothelin":[10],"potent":[13],"vasoconstrictive":[14],"and":[15,36,88,93,142,178,205],"profibrotic":[16],"mediator":[17],"produced":[18],"by":[19,28,153],"the":[20,29,146,220],"endothelin-converting":[21],"enzyme":[22],"(ECE),":[23],"whereas":[24,157,201],"natriuretic":[25],"peptides,":[26],"degraded":[27],"neutral":[30],"endopeptidase":[31],"(NEP),":[32],"have":[33],"diuretic,":[34],"vasodilatory,":[35],"antifibrotic":[37],"properties.":[38],"Thus,":[39],"combined":[40],"ECE/NEP":[41,56,135,213],"inhibition":[42],"may":[43],"halt":[44],"hypertensive":[45],"cardiac":[46,59,171,182,217,248],"remodeling.":[47],"This":[48,238],"study":[49,117],"examined":[50],"effects":[51],"of":[52,127,160,181,235,247],"SLV338,":[53],"novel":[55],"inhibitor,":[57,136],"on":[58],"protection":[60],"in":[61,140,143,195,226,231],"experimental":[62],"renovascular":[63,236],"hypertension":[64],"(2-kidney,":[65],"1-clip":[66],"[2K1C]).":[67],"Male":[68],"rats":[69,198],"were":[70,120],"allocated":[71],"5":[73],"groups:":[74],"sham-operated":[75],"rats,":[76],"untreated":[77,196],"animals":[78,82,95],"with":[79,84,97,203],"2K1C,":[80],"2K1C":[81,94,147,197],"treated":[83,96],"oral":[85,98],"SLV338":[86,128,131,161,166,204,215],"(30":[87],"100":[89],"mg/kg":[90,101],"per":[91,102],"day),":[92],"losartan":[99,149,206],"(20":[100],"day).":[103],"Treatment":[104],"duration":[105],"was":[106,111,192],"12":[107],"weeks.":[108,115],"Blood":[109],"pressure":[110,152],"assessed":[112],"every":[113],"4":[114],"At":[116],"end,":[118],"hearts":[119],"taken":[121],"for":[122],"histology/computer-aided":[123],"histomorphometry/immunohistochemistry.":[124],"Pharmacological":[125],"properties":[126],"are":[129],"described.":[130],"dual":[134,212],"as":[137,184,223],"demonstrated":[138],"both":[139,158],"vitro":[141],"vivo.":[144],"In":[145],"study,":[148],"lowered":[150],"blood":[151,228],"\u226446":[154],"mm":[155],"Hg,":[156],"dosages":[159],"had":[162],"no":[163],"effect.":[164,209],"However,":[165],"(both":[167],"dosages)":[168],"completely":[169],"normalized":[170],"interstitial":[172],"fibrosis,":[173,175],"perivascular":[174],"myocyte":[176],"diameter,":[177],"media:lumen":[179],"ratio":[180],"arteries,":[183],"did":[185],"losartan.":[186],"Cardiac":[187],"transforming":[188,249],"growth":[189,250],"factor-\u03b21":[190,251],"expression":[191],"significantly":[193],"enhanced":[194],"versus":[199],"controls,":[200],"treatment":[202],"prevented":[207],"this":[208],"Taken":[210],"together,":[211],"inhibitor":[214],"prevents":[216],"remodeling":[218],"same":[221],"extent":[222],"losartan,":[224],"but":[225],"pressure-independent":[229],"manner,":[230],"rat":[233],"model":[234],"hypertension.":[237],"effect":[239],"at":[241],"least":[242],"partially":[243],"mediated":[244],"via":[245],"suppression":[246],"expression.":[252]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
