{"id":"https://openalex.org/W2130072823","doi":"https://doi.org/10.1152/ajplung.00312.2002","title":"Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury","display_name":"Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W2130072823","doi":"https://doi.org/10.1152/ajplung.00312.2002","mag":"2130072823","pmid":"https://pubmed.ncbi.nlm.nih.gov/12730079"},"language":"en","primary_location":{"id":"doi:10.1152/ajplung.00312.2002","doi":"https://doi.org/10.1152/ajplung.00312.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00312.2002","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108190975","display_name":"Priya Prabhakaran","orcid":"https://orcid.org/0000-0003-4811-3322","observed_orcids":["https://orcid.org/0000-0003-4811-3322"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priya Prabhakaran","raw_affiliation_strings":["Department of Pediatrics, University of Alabama, Birmingham, Alabama 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Alabama, Birmingham, Alabama 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017253129","display_name":"Lorraine B. Ware","orcid":"https://orcid.org/0000-0002-9429-4702","observed_orcids":["https://orcid.org/0000-0002-9429-4702"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorraine B. Ware","raw_affiliation_strings":["","Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015924961","display_name":"Kimberly E. White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly E. White","raw_affiliation_strings":["","(University of Alabama)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"(University of Alabama)","institution_ids":["https://openalex.org/I17301866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041545465","display_name":"Michael T. Cross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael T. Cross","raw_affiliation_strings":["","(University of Alabama)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"(University of Alabama)","institution_ids":["https://openalex.org/I17301866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052576862","display_name":"Michael A. Matthay","orcid":"https://orcid.org/0000-0003-3039-8155","observed_orcids":["https://orcid.org/0000-0003-3039-8155"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Matthay","raw_affiliation_strings":["University of California at San Francisco,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at San Francisco,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055224390","display_name":"Mitchell A. Olman","orcid":"https://orcid.org/0000-0003-3262-3598","observed_orcids":["https://orcid.org/0000-0003-3262-3598"]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell A. Olman","raw_affiliation_strings":["University of Alabama","University of Alabama at Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama","institution_ids":["https://openalex.org/I17301866"]},{"raw_affiliation_string":"University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.6814,"has_fulltext":false,"cited_by_count":261,"citation_normalized_percentile":{"value":0.98012376,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"285","issue":"1","first_page":"L20","last_page":"L28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.7764000296592712,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.7764000296592712,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.06109999865293503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.058400001376867294,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.9860000014305115},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.765999972820282},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.7039999961853027},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.7039999961853027},{"id":"https://openalex.org/keywords/fibrin-turnover","display_name":"fibrin turnover","score":0.890999972820282},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.7940726280212402},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.779770016670227},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.6934715509414673},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.6482726335525513},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.6442539691925049},{"id":"https://openalex.org/C2776468924","wikidata":"https://www.wikidata.org/wiki/Q857667","display_name":"Pulmonary edema","level":3,"score":0.6038939356803894},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.55596524477005},{"id":"https://openalex.org/C2780675426","wikidata":"https://www.wikidata.org/wiki/Q410485","display_name":"Plasminogen activator inhibitor-1","level":3,"score":0.49541008472442627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4690105617046356},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.45893025398254395},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36754512786865234},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33123552799224854}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005338","descriptor_name":"Fibrin Fibrinogen Degradation Products","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005342","descriptor_name":"Fibrinolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006874","descriptor_name":"Hydrostatic Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D015633","descriptor_name":"Extravascular Lung Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajplung.00312.2002","doi":"https://doi.org/10.1152/ajplung.00312.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00312.2002","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},{"id":"pmid:12730079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12730079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Lung cellular and molecular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3429402575","display_name":null,"funder_award_id":"HL-51856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8055508284","display_name":"Lung Fluid Balance and Mesenchymal Stem Cells","funder_award_id":"R01HL051854","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8363032888","display_name":"Alveolar Epithelium in Acute Lung Injury","funder_award_id":"K08HL070521","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8429517854","display_name":"Mechanisms of u-PAR-Mediated Lung Fibroblast Motility","funder_award_id":"R01HL058655","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W102892713","https://openalex.org/W1516214401","https://openalex.org/W1574225807","https://openalex.org/W1745661527","https://openalex.org/W1794971901","https://openalex.org/W1796081530","https://openalex.org/W1814751417","https://openalex.org/W1844637553","https://openalex.org/W1908907230","https://openalex.org/W1931526140","https://openalex.org/W1978960863","https://openalex.org/W1984901243","https://openalex.org/W1988996360","https://openalex.org/W1992644897","https://openalex.org/W1996401536","https://openalex.org/W1996620001","https://openalex.org/W1997645326","https://openalex.org/W2003593894","https://openalex.org/W2015053020","https://openalex.org/W2015667478","https://openalex.org/W2022800656","https://openalex.org/W2023686656","https://openalex.org/W2034332958","https://openalex.org/W2037268333","https://openalex.org/W2042868166","https://openalex.org/W2044478331","https://openalex.org/W2048031208","https://openalex.org/W2049617601","https://openalex.org/W2059075122","https://openalex.org/W2084866134","https://openalex.org/W2093852073","https://openalex.org/W2098407049","https://openalex.org/W2117860495","https://openalex.org/W2128349740","https://openalex.org/W2130104463","https://openalex.org/W2133310011","https://openalex.org/W2136761840","https://openalex.org/W2138153375","https://openalex.org/W2144304154","https://openalex.org/W2146919918","https://openalex.org/W2148024031","https://openalex.org/W2161328469","https://openalex.org/W2175638767","https://openalex.org/W2183958885","https://openalex.org/W2322121630","https://openalex.org/W2407742355","https://openalex.org/W2408215270","https://openalex.org/W2414289726","https://openalex.org/W2418828419","https://openalex.org/W2597070792","https://openalex.org/W4294658238"],"related_works":["https://openalex.org/W2098823578","https://openalex.org/W2060569054","https://openalex.org/W2042759857","https://openalex.org/W2087735673","https://openalex.org/W2162598971","https://openalex.org/W4392017306","https://openalex.org/W2374792499","https://openalex.org/W2351253668","https://openalex.org/W2066057720","https://openalex.org/W925700904"],"abstract_inverted_index":{"The":[0,164],"alveolar":[1,128],"fibrinolytic":[2,14,183],"system":[3],"is":[4,173],"altered":[5],"in":[6,24,41,59,67,110,115,134,150,170],"acute":[7],"lung":[8],"injury":[9],"(ALI).":[10],"Levels":[11],"of":[12,107,122,144,176],"the":[13,88,126],"protease":[15],"inhibitor,":[16],"plasminogen":[17],"activator":[18],"inhibitor-1":[19],"(PAI-1),":[20],"are":[21],"too":[22],"low":[23],"bronchoalveolar":[25],"lavage":[26],"to":[27,36],"address":[28],"its":[29],"prognostic":[30],"significance.":[31],"This":[32],"study":[33],"was":[34],"performed":[35],"assess":[37],"whether":[38],"PAI-1":[39,56,76,94,116,123,148],"antigen":[40,57,95],"undiluted":[42],"pulmonary":[43],"edema":[44,63,74,92,151],"fluid":[45,64,75,93,152],"levels":[46,58,121,130,149],"can":[47],"identify":[48,155],"patients":[49,111,138],"with":[50,70,80,82,99,112,120,157],"ALI":[51,68,81,137,158,172],"and":[52,62,73,85,91,104,153,181],"predict":[53],"their":[54],"outcome.":[55],"both":[60,135],"plasma":[61,90,154],"were":[65,97,118,131],"higher":[66,101,141],"compared":[69],"hydrostatic":[71],"edema,":[72],"values":[77,96],"identified":[78],"those":[79,156],"high":[83,89],"sensitivity":[84],"specificity.":[86],"Both":[87],"associated":[98],"a":[100,140,161,174,177],"mortality":[102],"rate":[103],"fewer":[105],"days":[106],"unassisted":[108],"ventilation":[109],"ALI.":[113],"Differences":[114],"activity":[117],"concordant":[119],"antigen.":[124],"Although":[125],"fibrin-derived":[127],"D-dimer":[129],"strikingly":[132],"similar":[133],"groups,":[136],"had":[139],"relative":[142],"proportion":[143],"D-monomer.":[145],"In":[146],"conclusion,":[147],"that":[159,167],"have":[160],"poor":[162],"prognosis.":[163],"data":[165],"indicate":[166],"fibrin":[168],"turnover":[169],"early":[171],"consequence":[175],"rapid":[178],"fibrinogen":[179],"influx":[180],"fractional":[182],"inhibition.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}