{"id":"https://openalex.org/W2130057537","doi":"https://doi.org/10.1002/ptr.1369","title":"Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells: differential effects between methanolic extract and hypericin","display_name":"Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells: differential effects between methanolic extract and hypericin","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2130057537","doi":"https://doi.org/10.1002/ptr.1369","mag":"2130057537","pmid":"https://pubmed.ncbi.nlm.nih.gov/14750204"},"language":"en","primary_location":{"id":"doi:10.1002/ptr.1369","doi":"https://doi.org/10.1002/ptr.1369","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.1369","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068424408","display_name":"Gianna Roscetti","orcid":"https://orcid.org/0000-0002-4566-2660","observed_orcids":["https://orcid.org/0000-0002-4566-2660"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gianna Roscetti","raw_affiliation_strings":["Department of Neuroscience, School of Medicine, University of Rome Rome, Italy. Gianna.Gianna@uniroma2.it","Chair of Human Physiology, Department of Neuroscience, School of Medicine, University of Rome Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, School of Medicine, University of Rome Rome, Italy. Gianna.Gianna@uniroma2.it","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Chair of Human Physiology, Department of Neuroscience, School of Medicine, University of Rome Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086719612","display_name":"Ornella Franzese","orcid":"https://orcid.org/0000-0002-6396-4603","observed_orcids":["https://orcid.org/0000-0002-6396-4603"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ornella Franzese","raw_affiliation_strings":["Chair of Pharmacology, Department of Neuroscience, School of Medicine, University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Pharmacology, Department of Neuroscience, School of Medicine, University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088361218","display_name":"Alessandro Comandini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Comandini","raw_affiliation_strings":["Chair of Pharmacology, Department of Neuroscience, School of Medicine, University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Pharmacology, Department of Neuroscience, School of Medicine, University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108354000","display_name":"Enzo Bonmassar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enzo Bonmassar","raw_affiliation_strings":["Chair of Pharmacology, Department of Neuroscience, School of Medicine, University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Pharmacology, Department of Neuroscience, School of Medicine, University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068424408"],"corresponding_institution_ids":["https://openalex.org/I116067653","https://openalex.org/I861853513"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":5.3625,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.9530606,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"1","first_page":"66","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypericum-perforatum","display_name":"Hypericum perforatum","score":1.0},{"id":"https://openalex.org/keywords/hypericin","display_name":"hypericin","score":0.972000002861023},{"id":"https://openalex.org/keywords/methanol-extract","display_name":"methanol extract","score":0.8019999861717224},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/erythroleukemia","display_name":"erythroleukemia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.8820000290870667},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.5649999976158142},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2778432610","wikidata":"https://www.wikidata.org/wiki/Q425409","display_name":"Hypericin","level":2,"score":0.9736155271530151},{"id":"https://openalex.org/C2776651039","wikidata":"https://www.wikidata.org/wiki/Q158289","display_name":"Hypericum perforatum","level":2,"score":0.8643946647644043},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.6506051421165466},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5684534907341003},{"id":"https://openalex.org/C2778215561","wikidata":"https://www.wikidata.org/wiki/Q156935","display_name":"Hypericum","level":2,"score":0.4710659384727478},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4558791220188141},{"id":"https://openalex.org/C93226319","wikidata":"https://www.wikidata.org/wiki/Q193137","display_name":"Differential (mechanical device)","level":2,"score":0.4401729106903076},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3674003779888153},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.365243524312973},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3428570628166199},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.31274133920669556},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3022705912590027},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18463468551635742},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15700265765190125},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0675828754901886},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000873","descriptor_name":"Anthracenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010569","descriptor_name":"Perylene","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010569","descriptor_name":"Perylene","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010569","descriptor_name":"Perylene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010569","descriptor_name":"Perylene","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020902","descriptor_name":"Hypericum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/ptr.1369","doi":"https://doi.org/10.1002/ptr.1369","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.1369","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},{"id":"pmid:14750204","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14750204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy research : PTR","raw_type":"Journal Article"},{"id":"pmh:oai:art.torvergata.it:2108/58690","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/58690","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W19962429","https://openalex.org/W159741139","https://openalex.org/W1487531210","https://openalex.org/W1523826811","https://openalex.org/W1856643335","https://openalex.org/W1879250105","https://openalex.org/W1926202956","https://openalex.org/W1944310027","https://openalex.org/W1970331131","https://openalex.org/W1971787629","https://openalex.org/W1978871608","https://openalex.org/W1983991264","https://openalex.org/W1984515770","https://openalex.org/W1987305615","https://openalex.org/W2000216883","https://openalex.org/W2018817270","https://openalex.org/W2019500797","https://openalex.org/W2034867106","https://openalex.org/W2041552459","https://openalex.org/W2054632770","https://openalex.org/W2056056123","https://openalex.org/W2072937220","https://openalex.org/W2086749245","https://openalex.org/W2093843660","https://openalex.org/W2110413467","https://openalex.org/W2131878763","https://openalex.org/W2163371594","https://openalex.org/W2170101247","https://openalex.org/W2410380161"],"related_works":["https://openalex.org/W2804811328","https://openalex.org/W2072828534","https://openalex.org/W2404089574","https://openalex.org/W2513743962","https://openalex.org/W3141876367","https://openalex.org/W2005920345","https://openalex.org/W2254172639","https://openalex.org/W2185936110","https://openalex.org/W3138768187","https://openalex.org/W2588969490"],"abstract_inverted_index":{"The":[0,54],"influence":[1],"of":[2,6,11,21,38,107,123],"a":[3,22,79,101,154],"methanolic":[4],"extract":[5,99,144],"Hypericum":[7,97,124],"perforatum":[8,125],"L.":[9,126],"and":[10,51,68,86,104,110,130],"purified":[12,75],"hypericin":[13,36,76],"has":[14,77],"been":[15],"comparatively":[16],"tested":[17],"on":[18,56,83],"the":[19,42,96,120,133,142],"growth":[20,58,85,149],"human":[23],"erythroleukemic":[24],"cell":[25,57,63,84,92,108,113,148],"line":[26],"(K562).":[27],"After":[28],"1":[29],"h":[30,50],"exposure":[31],"to":[32],"increasing":[33],"concentrations":[34],"(as":[35],"content)":[37],"both":[39],"agents":[40],"in":[41,89,127,141,153],"dark,":[43],"leukemic":[44],"cells":[45],"were":[46,59],"grown":[47],"for":[48],"24":[49],"48":[52],"h.":[53],"effects":[55],"determined":[60],"by":[61],"viable":[62],"count,":[64],"flow":[65],"cytometry":[66],"analysis":[67],"fluorescence":[69],"microscopy.":[70],"Our":[71],"data":[72],"show":[73],"that":[74,135],"only":[78],"weak":[80],"inhibitory":[81],"effect":[82,88],"no":[87],"inducing":[90],"apoptotic":[91,112],"death.":[93,114],"In":[94],"contrast,":[95],"flower":[98],"shows":[100],"significant":[102],"concentration-dependent":[103],"long-lasting":[105],"inhibition":[106],"growth,":[109],"induces":[111],"This":[115],"work":[116],"con":[117],"fi":[118],"rms":[119],"interesting":[121],"role":[122],"cancer":[128],"therapy":[129],"strongly":[131],"supports":[132],"hypothesis":[134],"agents,":[136],"other":[137],"than":[138],"hypericin,":[139],"present":[140],"total":[143],"can":[145],"impair":[146],"tumor":[147],"acting":[150],"separately":[151],"or":[152],"combined":[155],"manner.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
