{"id":"https://openalex.org/W2129997607","doi":"https://doi.org/10.1345/aph.1a053","title":"Ziprasidone: The Fifth Atypical Antipsychotic","display_name":"Ziprasidone: The Fifth Atypical Antipsychotic","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W2129997607","doi":"https://doi.org/10.1345/aph.1a053","mag":"2129997607","pmid":"https://pubmed.ncbi.nlm.nih.gov/11978164"},"language":"en","primary_location":{"id":"doi:10.1345/aph.1a053","doi":"https://doi.org/10.1345/aph.1a053","is_oa":false,"landing_page_url":"https://doi.org/10.1345/aph.1a053","pdf_url":null,"source":{"id":"https://openalex.org/S113426163","display_name":"Annals of Pharmacotherapy","issn_l":"0012-6578","issn":["0012-6578","1060-0280","1542-6270"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086462893","display_name":"Charles F. Caley","orcid":"https://orcid.org/0000-0002-6047-1053","observed_orcids":["https://orcid.org/0000-0002-6047-1053"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles F Caley","raw_affiliation_strings":["Charles F Caley PharmD BCPP, Assistant Clinical Professor of Pharmacy, School of Pharmacy, University of Connecticut, Storrs, CT; Clinical Psychopharmacology Consultant, The Institute of Living, Burlingame Center for Psychiatric Research and Education, Hartford, CT","Clinical Psychopharmacology Consultant, The Institute of Living, Burlingame Center for Psychiatric Research and Education, Hartford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles F Caley PharmD BCPP, Assistant Clinical Professor of Pharmacy, School of Pharmacy, University of Connecticut, Storrs, CT; Clinical Psychopharmacology Consultant, The Institute of Living, Burlingame Center for Psychiatric Research and Education, Hartford, CT","institution_ids":["https://openalex.org/I140172145"]},{"raw_affiliation_string":"Clinical Psychopharmacology Consultant, The Institute of Living, Burlingame Center for Psychiatric Research and Education, Hartford, CT","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044386628","display_name":"Chandra Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1323778983","display_name":"Yale New Haven Hospital","ror":"https://ror.org/05tszed37","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1323778983","https://openalex.org/I4210117499"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandra K Cooper","raw_affiliation_strings":["Chandra K Cooper PharmD, Clinical Pharmacy Specialist, Psychiatry, Yale\u2014New Haven Psychiatric Hospital, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chandra K Cooper PharmD, Clinical Pharmacy Specialist, Psychiatry, Yale\u2014New Haven Psychiatric Hospital, New Haven, CT","institution_ids":["https://openalex.org/I1323778983","https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5086462893"],"corresponding_institution_ids":["https://openalex.org/I140172145"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":5.8362,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.96393835,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"36","issue":"5","first_page":"839","last_page":"851"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ziprasidone","display_name":"ziprasidone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.9980000257492065},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9649999737739563},{"id":"https://openalex.org/keywords/schizoaffective-disorder","display_name":"schizoaffective disorder","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.800000011920929},{"id":"https://openalex.org/keywords/5-ht1a-receptor-agonism","display_name":"5-HT1A receptor agonism","score":0.9100000262260437},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.597000002861023},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.824999988079071},{"id":"https://openalex.org/keywords/extrapyramidal-symptoms","display_name":"extrapyramidal symptoms","score":0.9610000252723694},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.5519999861717224},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.8479999899864197},{"id":"https://openalex.org/keywords/refractory-schizophrenia","display_name":"refractory schizophrenia","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C2777270317","wikidata":"https://www.wikidata.org/wiki/Q205517","display_name":"Ziprasidone","level":4,"score":0.9813926219940186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.588646650314331},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5709717869758606},{"id":"https://openalex.org/C2776921671","wikidata":"https://www.wikidata.org/wiki/Q758295","display_name":"Atypical antipsychotic","level":4,"score":0.44365620613098145},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.42695263028144836},{"id":"https://openalex.org/C2780092697","wikidata":"https://www.wikidata.org/wiki/Q7455053","display_name":"Serotonin reuptake inhibitor","level":4,"score":0.4239288866519928},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.27390486001968384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26084578037261963},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.24912029504776},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.18746599555015564},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07451358437538147}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001480","descriptor_name":"Basal Ganglia Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006261","descriptor_name":"Headache","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008133","descriptor_name":"Long QT Syndrome","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1345/aph.1a053","doi":"https://doi.org/10.1345/aph.1a053","is_oa":false,"landing_page_url":"https://doi.org/10.1345/aph.1a053","pdf_url":null,"source":{"id":"https://openalex.org/S113426163","display_name":"Annals of Pharmacotherapy","issn_l":"0012-6578","issn":["0012-6578","1060-0280","1542-6270"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Pharmacotherapy","raw_type":"journal-article"},{"id":"doi:10.1345/1542-6270(2002)036<0839:ztfaa>2.0.co;2","doi":"https://doi.org/10.1345/1542-6270(2002)036<0839:ztfaa>2.0.co;2","is_oa":false,"landing_page_url":"https://doi.org/10.1345/1542-6270(2002)036<0839:ztfaa>2.0.co;2","pdf_url":null,"source":{"id":"https://openalex.org/S113426163","display_name":"Annals of Pharmacotherapy","issn_l":"0012-6578","issn":["0012-6578","1060-0280","1542-6270"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Annals of Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:11978164","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11978164","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Annals of pharmacotherapy","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W13210705","https://openalex.org/W122505910","https://openalex.org/W1569270003","https://openalex.org/W1607161974","https://openalex.org/W1659296215","https://openalex.org/W1965809313","https://openalex.org/W1972522199","https://openalex.org/W1979700184","https://openalex.org/W1985517071","https://openalex.org/W1987632018","https://openalex.org/W1988730265","https://openalex.org/W1989974319","https://openalex.org/W1994013773","https://openalex.org/W1999327683","https://openalex.org/W2003553071","https://openalex.org/W2007865301","https://openalex.org/W2018764313","https://openalex.org/W2019648896","https://openalex.org/W2019879674","https://openalex.org/W2033616909","https://openalex.org/W2038721188","https://openalex.org/W2040538157","https://openalex.org/W2044780752","https://openalex.org/W2061276728","https://openalex.org/W2069028183","https://openalex.org/W2070290419","https://openalex.org/W2071615167","https://openalex.org/W2074305421","https://openalex.org/W2077206280","https://openalex.org/W2111105929","https://openalex.org/W2113425464","https://openalex.org/W2162222189","https://openalex.org/W2414908506","https://openalex.org/W4246433026","https://openalex.org/W4322388555"],"related_works":["https://openalex.org/W2371170659","https://openalex.org/W2357252764","https://openalex.org/W1994924067","https://openalex.org/W3111327234","https://openalex.org/W1410213541","https://openalex.org/W3006332013","https://openalex.org/W2469370134","https://openalex.org/W2468270220","https://openalex.org/W4243346757","https://openalex.org/W2064750161"],"abstract_inverted_index":{"AbstractOBJECTIVE:To":[0],"review":[1],"the":[2,34,53,57,70,128,133,230,241,345,363],"pharmacology,":[3],"pharmacokinetics,":[4],"clinical":[5,258],"efficacy,":[6],"and":[7,50,59,80,103,114,148,156,189,271,293,300,312,319,358,370],"adverse":[8],"effects":[9,315,388],"of":[10,27,39,52,56,73,90,132,154,171,176,204,213,232,243,248,306,332,366],"ziprasidone":[11,32,74,164,177,214,237,307,375,413,440,482,593,608,654,683,762,787,891,931,994,1020,1055,1076,1124,1152,1253,1274],"as":[12,33,143,149,165,238,379],"a":[13,21,87,121,144,150,167,349,356,380,455,631,682,710,868,1021],"treatment":[14,242,382],"for":[15,45,77,97,240,362,374,383],"schizophrenia.DATA":[16],"SOURCES:Information":[17],"was":[18],"selected":[19,84,110],"from":[20,48,106,261],"MEDLINE":[22,430,907],"search":[23,35],"(July":[24],"2000\u2013October":[25],"2001)":[26],"English-language":[28],"medical":[29,46],"literature":[30],"using":[31],"term.":[36],"Manual":[37],"searches":[38],"pertinent":[40,71],"journal":[41],"article":[42],"references,":[43],"request":[44],"information":[47,68],"Pfizer,":[49],"access":[51],"Web":[54],"site":[55],"Food":[58],"Drug":[60],"Administration":[61],"were":[62,75,83,95,109],"also":[63,227],"performed.STUDY":[64],"SELECTION:All":[65],"available":[66,134],"published":[67],"regarding":[69],"characteristics":[72,305],"considered":[76,207],"selection.DATA":[78],"EXTRACTION:Pharmacology":[79],"pharmacokinetic":[81],"studies":[82,235],"to":[85,208,229,263,277,326,347,394],"provide":[86],"comprehensive":[88],"description":[89],"these":[91,205,257],"characteristics.":[92],"Clinical":[93,234],"investigations":[94,108],"evaluated":[96],"design,":[98],"sample":[99],"size,":[100],"diagnosis,":[101],"duration,":[102],"outcome.":[104],"Data":[105],"all":[107],"by":[111,116,215,344],"1":[112],"author":[113],"reviewed":[115],"both":[117],"authors.DATA":[118],"SYNTHESIS:Ziprasidone":[119],"is":[120,181,185,192,355],"benzisothiazolyl":[122,1001],"piperazine\u2014type":[123],"atypical":[124,135,360],"antipsychotic":[125,361],"that":[126],"shares":[127],"serotonin2A/dopamine2":[129],"(5-HT2A/D2)":[130],"profile":[131],"antipsychotics.":[136],"Ziprasidone":[137,322,563],"has":[138,323],"demonstrated":[139],"in":[140,256,290,397,567,1029],"vitro":[141,568,1030],"activity":[142],"5-HT1A":[145,573,1028],"receptor":[146,572],"agonist":[147],"very":[151],"weak":[152],"inhibitor":[153,170],"serotonin":[155],"norepinephrine":[157],"reuptake.":[158,173],"These":[159],"data":[160,369,373],"do":[161],"not":[162],"support":[163,236,376],"being":[166],"clinically":[168],"meaningful":[169],"serotonin/norepinephrine":[172],"Oral":[174],"bioavailability":[175],"taken":[178],"with":[179,222,245,297,399],"food":[180],"approximately":[182,186,333],"60%,":[183,617,1083],"half-life":[184],"6\u20137":[187,626],"hours,":[188],"protein":[190],"binding":[191],"extensive":[193],"at":[194],">99%.":[195],"Twelve":[196],"metabolites":[197],"have":[198,274,337,348],"been":[199,275,324,339],"identified,":[200],"yet":[201],"only":[202,220,267,338],"4":[203,643,1113],"are":[206],"be":[209,283],"primary":[210],"metabolites.":[211],"Metabolism":[212],"aldehyde":[216],"oxidase":[217],"produces":[218],"its":[219,377,386],"metabolite":[221],"potential":[223,387],"pharmacologic":[224],"activity;":[225],"CYP3A4":[226],"contributes":[228],"metabolism":[231],"ziprasidone.":[233,506,677],"efficacious":[239,359],"patients":[244,341,398,1157,1262,1326],"acute":[246,364],"exacerbations":[247],"schizophrenia":[249],"or":[250],"schizoaffective":[251,298],"disorder.":[252,302],"Daily":[253],"doses":[254,268,1184],"permitted":[255],"trials":[259],"ranged":[260],"40":[262,709,1177],"160":[264,272,711,1179,1188],"mg,":[265,712,1180],"but":[266],"between":[269],"120":[270,1186],"mg/d":[273,719],"superior":[276,722],"placebo.":[278,724,1197],"Future":[279],"research":[280],"efforts":[281],"should":[282],"directed":[284],"toward":[285],"refractory":[286],"schizophrenia,":[287,291],"cognitive":[288],"impairment":[289],"affective":[292],"anxiety":[294],"symptoms":[295,318],"associated":[296],"disorder,":[299],"bipolar":[301],"Adverse":[303],"effect":[304],"commonly":[308],"include":[309,316],"headache,":[310],"nausea,":[311,767],"somnolence;":[313],"infrequent":[314],"extrapyramidal":[317],"weight":[320],"gain.":[321],"reported":[325,343],"cause":[327],"an":[328],"average":[329],"QTc":[330,351,793,811,1257],"prolongation":[331],"20":[334,796,1259],"msec;":[335,797],"there":[336],"2":[340,801,992,1261],"(0.06%)":[342,803,1263],"manufacturer":[346],"measured":[350],"interval":[352],">500":[353,815],"msec.CONCLUSIONS:Ziprasidone":[354],"safe":[357],"management":[365],"schizophrenia.":[367],"Efficacy":[368],"most":[371],"safety":[372],"use":[378],"first-line":[381],"schizophrenia;":[384],"however,":[385],"on":[389],"ventricular":[390,865],"repolarization":[391],"relegate":[392],"it":[393],"second-line":[395],"status":[396],"comorbid":[400],"cardiovascular":[401],"risks.":[402],"ResumenOBJETIVO:Revisar":[403],"la":[404,417,432,461,464,472,519,550,580,600,618,656,734,737,829,836,855,863,879,881,890,896,904,930,939,942,971,1038,1041,1045,1054,1062,1065,1069,1075,1084,1123,1151,1207,1215,1228,1306,1329],"farmacolog\u00eda,":[405],"farmacocin\u00e9tica,":[406],"eficacia":[407,834],"cl\u00ednica,":[408],"y":[409,441,458,468,494,523,536,574,584,628,745,753,768,774,777,822,835],"efectos":[410,758,771,860],"adversos":[411,759,772],"de":[412,416,424,431,442,445,448,463,466,481,492,495,502,505,514,518,527,549,558,579,582,585,599,602,607,615,621,624,644,653,658,676,689,694,746,761,765,794,828,833,838,841,848,852,889,895,948,953,967,976,999,1037,1040,1044,1061,1064,1068,1074,1082,1087,1095,1102,1104,1114,1122,1150,1162,1165,1176,1185,1206,1219,1222,1227,1250,1269,1271,1288,1303,1305,1315,1328],"como":[414,569,575,648,684,770,781,846],"tratamiento":[415,688,853],"esquizofrenia.FUENTES":[418],"DE":[419,470,488,898,935],"INFORMACI\u00d3N:La":[420],"informaci\u00f3n":[421,454,473],"fue":[422,483],"seleccionada":[423],"una":[425,499,665,789,847],"b\u00fasqueda":[426],"en":[427,435,512,703,728,740,779,792,862,872,911,1077,1300,1321],"el":[428,438,555,591,629,687,750,754,806,825],"sistema":[429],"literatura":[433],"m\u00e9dica":[434],"ingl\u00e9s":[436],"utilizando":[437],"t\u00e9rmino":[439,513],"b\u00fasquedas":[443],"manuales":[444],"las":[446,478,503,529,715,849],"bibliograf\u00edas":[447],"algunos":[449],"art\u00edculos.":[450],"Adem\u00e1s,":[451],"se":[452,459,610,1192],"solicit\u00f3":[453],"Pfizer":[456],"Incorporated":[457],"acces\u00f3":[460],"red":[462],"Administraci\u00f3n":[465],"Drogas":[467],"Alimentos.SELECCI\u00d3N":[469],"ART\u00cdCULOS:Toda":[471],"publicada":[474],"disponible":[475],"relacionada":[476],"con":[477,612,664,691,749,808,874],"caracter\u00edsticas":[479,504],"pertinentes":[480,928],"considerada":[484],"para":[485,497,686,824,854],"ser":[486,731],"seleccionada.OBTENCI\u00d3N":[487],"DATOS:Fueron":[489],"seleccionados":[490],"estudios":[491,679,705],"farmacolog\u00eda":[493],"farmacocin\u00e9tica":[496],"proveer":[498],"descripci\u00f3n":[500],"extensa":[501],"Las":[507,699],"investigaciones":[508,530],"cl\u00ednicas":[509],"fueron":[510,531],"evaluadas":[511],"su":[515,661,844],"dise\u00f1o,":[516],"tama\u00f1o":[517],"muestra,":[520],"diagn\u00f3stico,":[521],"duraci\u00f3n,":[522],"resultado.":[524],"Los":[525,678,725,757,831],"datos":[526,588,832,840],"todas":[528],"seleccionadas":[532],"por":[533,538,655,805],"un":[534,542,595,809,818,869,984,996,1010,1057,1130,1248,1267,1276],"autor":[535],"revisados":[537],"ambos":[539],"autores.S\u00cdNTESIS:Ziprasidone":[540],"es":[541,614,623,633,817],"antipsic\u00f3tico":[543,819],"at\u00edpico":[544,820],"que":[545,592,786,812,1053,1226],"pertenece":[546],"al":[547,674,723],"tipo":[548],"benzisotiazolil":[551],"piperazinas.":[552],"Este":[553],"comparte":[554],"perfil":[556],"5-HT2A/D2":[557],"los":[559,742,839],"antipsic\u00f3ticos":[560],"at\u00edpicos":[561],"disponibles.":[562],"ha":[564,784],"demostrado":[565],"actividad":[566,666],"agonista":[570],"del":[571],"inhibidor":[576,596],"bien":[577],"d\u00e9bil":[578],"recaptaci\u00f3n":[581,601],"serotonina":[583],"norepinefrina.":[586],"Estos":[587],"no":[589],"apoyan":[590,681,843],"sea":[594],"cl\u00ednicamente":[597],"significativo":[598],"serotonina/norepinefrina.":[603],"La":[604,1019,1071,1168,1252],"biodisponibilidad":[605],"oral":[606],"si":[609],"toma":[611],"comidas":[613],"aproximadamente":[616,625,795],"vida":[619],"media":[620],"eliminaci\u00f3n":[622],"horas,":[627],"enlace":[630],"prote\u00ednas":[632],"extenso":[634],"(>99%).":[635],"Se":[636,783],"han":[637,720,799],"identificado":[638],"12":[639],"metabolitos,":[640],"aunque":[641],"solamente":[642,714,798],"estos":[645,704],"son":[646,1143],"considerados":[647],"metabolitos":[649],"principales.":[650],"El":[651,669],"metabolismo":[652,675],"oxidasa":[657],"aldehido":[659],"produce":[660],"\u00fanico":[662],"metabolito":[663],"farmacol\u00f3gica":[667],"potencial.":[668],"citocromo":[670],"P3A4":[671],"tambi\u00e9n":[672],"contribuye":[673],"cl\u00ednicos":[680,706],"eficaz":[685,823],"pacientes":[690,802,873],"exacerbaciones":[692],"agudas":[693],"esquizofrenia":[695,735,856],"o":[696],"trastornos":[697],"esquizoafectivos.":[698],"dosis":[700,716],"diarias":[701],"permitidas":[702],"fluctuaron":[707],"entre":[708,717],"pero":[713],"120\u2013160":[718],"sido":[721],"esfuerzos":[726],"futuros":[727],"investigaci\u00f3n":[729],"deben":[730],"dirigidos":[732],"hacia":[733],"refractaria,":[736],"disfunci\u00f3n":[738],"cognoscitiva":[739],"esquizofrenia,":[741],"s\u00edntomas":[743,775],"afectivos,":[744],"ansiedad":[747],"asociados":[748],"trastorno":[751,755],"esquizoafectivo":[752],"bipolar.":[756],"caracter\u00edsticos":[760],"incluyen":[763],"dolor":[764],"cabeza,":[766],"somnolencia":[769],"comunes;":[773],"extrapiramidales":[776],"ganancia":[778],"peso":[780],"infrecuentes.":[782],"informado":[785],"causa":[788],"prolongaci\u00f3n":[790],"promedio":[791],"habido":[800],"informados":[804],"manufacturero":[807],"intervalo":[810],"haya":[813],"medido":[814],"msec.CONCLUSIONES:Ziprasidone":[816],"seguro":[821],"manejo":[826],"agudo":[827],"esquizofrenia.":[830],"mayor\u00eda":[837],"seguridad":[842],"uso":[845],"primeras":[850],"opciones":[851],"sin":[857],"embargo,":[858],"sus":[859],"potenciales":[861],"repolarizaci\u00f3n":[864],"lo":[866],"relegan":[867],"estatus":[870],"secundario":[871],"riesgos":[875],"cardiovasculares":[876],"com\u00f3rbidos.":[877],"R\u00e9sum\u00e9OBJECTIF:Revoir":[878],"pharmacologie,":[880],"pharmacocin\u00e9tique,":[882],"l'efficacit\u00e9":[883,1149],"clinique,":[884],"et":[885,914,941,973,1031,1043,1067,1092,1221,1241,1247,1280,1293],"les":[886,922,926,951,974,991,1006,1014,1183,1234,1309,1325],"effets":[887,1232,1310],"ind\u00e9sirables":[888,1233,1311],"pour":[892,1013,1153,1282],"le":[893,915,965,969,1093,1135,1154,1204,1283,1313,1319],"traitement":[894,1155,1205,1284,1304],"schizophr\u00e9nie.REVUE":[897],"LITT\u00c9RATURE:L'information":[899],"provient":[900],"d'une":[901],"recherche":[902],"dans":[903,1171],"banque":[905],"informatis\u00e9e":[906],"des":[908,986,1026,1117,1156,1159,1210,1217,1244],"articles":[909],"publi\u00e9s":[910],"langue":[912],"anglaise":[913],"terme":[916],"recherch\u00e9":[917],"\u00e9tait":[918],"ziprasidone.S\u00c9LECTION":[919],"DES":[920],"\u00c9TUDES:Toutes":[921],"\u00e9tudes":[923,937,1146],"publi\u00e9es":[924],"concernant":[925],"donn\u00e9es":[927,979,1048,1291],"sur":[929,938,1203,1312],"ont":[932,944,959,980,1108,1264],"\u00e9t\u00e9":[933,945,960,981,1109],"retenues.S\u00c9LECTION":[934],"L'INFORMATION:Les":[936],"pharmacologie":[940],"pharmacocin\u00e9tique":[943],"analys\u00e9es":[946],"afin":[947],"d\u00e9crire":[949],"ad\u00e9quatement":[950],"caract\u00e9ristiques":[952,1236],"ce":[954],"m\u00e9dicament.":[955],"Les":[956,978,1145,1231,1290],"essais":[957,1173],"cliniques":[958,1147,1174],"\u00e9valu\u00e9s":[961],"selon":[962],"leur":[963],"devis,":[964],"nombre":[966],"sujets,":[968],"diagnostic,":[970],"dur\u00e9e,":[972],"mesures":[975],"r\u00e9sultats.":[977],"s\u00e9lectionn\u00e9es":[982],"par":[983,990,1125,1190],"seul":[985,1131],"auteurs":[987],"mais":[988,1111,1181],"revues":[989],"auteurs.R\u00c9SUM\u00c9:La":[993],"est":[995,1080,1099,1275],"antipsychotique":[997,1277],"atypique":[998,1278],"type":[1000],"pip\u00e9razine":[1002],"qui":[1003],"poss\u00e8de":[1004],"comme":[1005],"autres":[1007],"agents":[1008],"atypiques":[1009],"ratio":[1011],"d'affinit\u00e9":[1012],"r\u00e9cepteurs":[1015,1027],"5-HT2/D2":[1016],"plus":[1017,1103,1235,1242,1270],"marqu\u00e9.":[1018],"montr\u00e9":[1022],"une":[1023,1032],"activit\u00e9":[1024,1035],"agoniste":[1025],"tr\u00e9s":[1033],"faible":[1034],"inhibitrice":[1036],"recapture":[1039,1063],"s\u00e9rotonine":[1042,1066],"nor\u00e9pin\u00e9phrine.":[1046,1070],"Ces":[1047],"ne":[1049],"supporte":[1050],"pas":[1051],"l'assertion":[1052],"soit":[1056,1101],"inhibiteur":[1058],"cliniquement":[1059],"significatif":[1060],"biodisponibilit\u00e9":[1072],"orale":[1073],"pr\u00e9sence":[1078],"d'aliments":[1079],"approximativement":[1081],"demi-vie":[1085],"d'\u00e9limination":[1086],"6":[1088],"\u00e0":[1089,1142,1178,1187,1214],"7":[1090],"heures,":[1091],"taux":[1094],"liaison":[1096],"aux":[1097],"prot\u00e9ines":[1098],"important,":[1100],"99%.":[1105],"Douze":[1106],"m\u00e9tabolites":[1107,1118],"identifi\u00e9s":[1110],"seulement":[1112,1182],"ceux-ci":[1115],"sont":[1116,1193,1237],"primaires.":[1119],"Le":[1120],"m\u00e9tabolisme":[1121],"l'enzyme":[1126],"ald\u00e9hyde":[1127],"oxydase":[1128],"produit":[1129],"m\u00e9tabolit\u00e9":[1132],"potentiellement":[1133],"actif;":[1134],"cytochrome":[1136],"CYP":[1137],"3A4":[1138],"contribue":[1139],"lui":[1140],"aussi":[1141],"m\u00e9tabolisme.":[1144],"supportent":[1148],"pr\u00e9sentant":[1158,1327],"\u00e9pisodes":[1160],"aigus":[1161],"schizophr\u00e9nie":[1163,1208],"ou":[1164],"maladie":[1166,1229],"schizoaffective.":[1167],"posologie":[1169],"quotidienne":[1170],"ces":[1172],"variait":[1175],"mg":[1189],"jour":[1191],"av\u00e9r\u00e9es":[1194],"sup\u00e9rieures":[1195],"au":[1196],"D'autres":[1198],"recherches":[1199],"devraient":[1200],"\u00eatre":[1201,1298],"dirig\u00e9es":[1202],"r\u00e9fractaire,":[1209],"troubles":[1211,1218],"cognitifs":[1212],"li\u00e9s":[1213],"schizophr\u00e9nie,":[1216],"l'humeur,":[1220],"l'anxi\u00e9t\u00e9":[1223],"associ\u00e9s":[1224],"ainsi":[1225],"bipolaire.":[1230],"c\u00e9phal\u00e9es,":[1238],"naus\u00e9es,":[1239],"somnolence,":[1240],"rarement,":[1243],"manifestations":[1245],"extrapyramidales":[1246],"gain":[1249],"poids.":[1251],"peut":[1254,1297],"allonger":[1255],"l'intervalle":[1256],"d'environ":[1258],"millisecondes;":[1260],"cependant":[1265,1308],"pr\u00e9sent\u00e9":[1266],"allongement":[1268],"500":[1272],"millisecondes.CONCLUSIONS:La":[1273],"s\u00e9curitaire":[1279],"efficace":[1281],"d'un":[1285],"\u00e9pisode":[1286],"aigu":[1287],"schizophr\u00e9nie.":[1289],"d'efficacit\u00e9":[1292],"d'innocuit\u00e9":[1294],"confirme":[1295],"qu'il":[1296],"utilis\u00e9":[1299],"premi\u00e8re":[1301],"intention":[1302,1323],"schizophr\u00e9nie;":[1307],"temps":[1314],"repolarisation":[1316],"du":[1317],"ventricule":[1318],"rel\u00e8gue":[1320],"deuxi\u00e8me":[1322],"chez":[1324],"co-morbidit\u00e9":[1330],"cardiovasculaire.":[1331]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
