{"id":"https://openalex.org/W2129986286","doi":"https://doi.org/10.1126/science.1121143","title":"Structure of Human Urokinase Plasminogen Activator in Complex with Its Receptor","display_name":"Structure of Human Urokinase Plasminogen Activator in Complex with Its Receptor","publication_year":2006,"publication_date":"2006-02-02","ids":{"openalex":"https://openalex.org/W2129986286","doi":"https://doi.org/10.1126/science.1121143","mag":"2129986286","pmid":"https://pubmed.ncbi.nlm.nih.gov/16456079"},"language":"en","primary_location":{"id":"doi:10.1126/science.1121143","doi":"https://doi.org/10.1126/science.1121143","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1121143","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108452170","display_name":"Qing Huai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210119098","display_name":"Fujian Institute of Research on the Structure of Matter","ror":"https://ror.org/02j89k719","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"id":"https://openalex.org/I4391767757","display_name":"State Key Laboratory of Structural Chemistry","ror":"https://ror.org/023fpv336","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Qing Huai","raw_affiliation_strings":["Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"raw_affiliation_string":"Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065530824","display_name":"Andrew Paul Mazar","orcid":"https://orcid.org/0009-0000-3681-6704","observed_orcids":["https://orcid.org/0009-0000-3681-6704"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210119098","display_name":"Fujian Institute of Research on the Structure of Matter","ror":"https://ror.org/02j89k719","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"id":"https://openalex.org/I4391767757","display_name":"State Key Laboratory of Structural Chemistry","ror":"https://ror.org/023fpv336","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Andrew P. Mazar","raw_affiliation_strings":["Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"raw_affiliation_string":"Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alice Kuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210119098","display_name":"Fujian Institute of Research on the Structure of Matter","ror":"https://ror.org/02j89k719","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"id":"https://openalex.org/I4391767757","display_name":"State Key Laboratory of Structural Chemistry","ror":"https://ror.org/023fpv336","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Alice Kuo","raw_affiliation_strings":["Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"raw_affiliation_string":"Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070032076","display_name":"Graham C. Parry","orcid":"https://orcid.org/0000-0002-3009-4947","observed_orcids":["https://orcid.org/0000-0002-3009-4947"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210119098","display_name":"Fujian Institute of Research on the Structure of Matter","ror":"https://ror.org/02j89k719","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"id":"https://openalex.org/I4391767757","display_name":"State Key Laboratory of Structural Chemistry","ror":"https://ror.org/023fpv336","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Graham C. Parry","raw_affiliation_strings":["Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"raw_affiliation_string":"Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074305095","display_name":"David Elliot Shaw","orcid":"https://orcid.org/0000-0001-8265-5761","observed_orcids":["https://orcid.org/0000-0001-8265-5761"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210119098","display_name":"Fujian Institute of Research on the Structure of Matter","ror":"https://ror.org/02j89k719","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"id":"https://openalex.org/I4391767757","display_name":"State Key Laboratory of Structural Chemistry","ror":"https://ror.org/023fpv336","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"David E. Shaw","raw_affiliation_strings":["Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"raw_affiliation_string":"Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076651366","display_name":"Jennifer A. Callahan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210119098","display_name":"Fujian Institute of Research on the Structure of Matter","ror":"https://ror.org/02j89k719","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"id":"https://openalex.org/I4391767757","display_name":"State Key Laboratory of Structural Chemistry","ror":"https://ror.org/023fpv336","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jennifer Callahan","raw_affiliation_strings":["Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"raw_affiliation_string":"Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yongdong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210119098","display_name":"Fujian Institute of Research on the Structure of Matter","ror":"https://ror.org/02j89k719","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"id":"https://openalex.org/I4391767757","display_name":"State Key Laboratory of Structural Chemistry","ror":"https://ror.org/023fpv336","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yongdong Li","raw_affiliation_strings":["Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"raw_affiliation_string":"Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101723130","display_name":"Cai Yuan","orcid":"https://orcid.org/0000-0001-6122-0259","observed_orcids":["https://orcid.org/0000-0001-6122-0259"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210119098","display_name":"Fujian Institute of Research on the Structure of Matter","ror":"https://ror.org/02j89k719","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"id":"https://openalex.org/I4391767757","display_name":"State Key Laboratory of Structural Chemistry","ror":"https://ror.org/023fpv336","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Cai Yuan","raw_affiliation_strings":["Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"raw_affiliation_string":"Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102250336","display_name":"Chuanbing Bian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210119098","display_name":"Fujian Institute of Research on the Structure of Matter","ror":"https://ror.org/02j89k719","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"id":"https://openalex.org/I4391767757","display_name":"State Key Laboratory of Structural Chemistry","ror":"https://ror.org/023fpv336","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Chuanbing Bian","raw_affiliation_strings":["Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"raw_affiliation_string":"Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Liqing Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210119098","display_name":"Fujian Institute of Research on the Structure of Matter","ror":"https://ror.org/02j89k719","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"id":"https://openalex.org/I4391767757","display_name":"State Key Laboratory of Structural Chemistry","ror":"https://ror.org/023fpv336","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Liqing Chen","raw_affiliation_strings":["Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"raw_affiliation_string":"Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066321804","display_name":"Bruce Furie","orcid":"https://orcid.org/0000-0001-7610-1076","observed_orcids":["https://orcid.org/0000-0001-7610-1076"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210119098","display_name":"Fujian Institute of Research on the Structure of Matter","ror":"https://ror.org/02j89k719","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"id":"https://openalex.org/I4391767757","display_name":"State Key Laboratory of Structural Chemistry","ror":"https://ror.org/023fpv336","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Bruce Furie","raw_affiliation_strings":["Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"raw_affiliation_string":"Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110203685","display_name":"Barbara C. Furie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210119098","display_name":"Fujian Institute of Research on the Structure of Matter","ror":"https://ror.org/02j89k719","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"id":"https://openalex.org/I4391767757","display_name":"State Key Laboratory of Structural Chemistry","ror":"https://ror.org/023fpv336","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Barbara C. Furie","raw_affiliation_strings":["Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"raw_affiliation_string":"Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077478635","display_name":"Douglas B. Cines","orcid":"https://orcid.org/0000-0001-5986-504X","observed_orcids":["https://orcid.org/0000-0001-5986-504X"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210119098","display_name":"Fujian Institute of Research on the Structure of Matter","ror":"https://ror.org/02j89k719","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"id":"https://openalex.org/I4391767757","display_name":"State Key Laboratory of Structural Chemistry","ror":"https://ror.org/023fpv336","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Douglas B. Cines","raw_affiliation_strings":["Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"raw_affiliation_string":"Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025110808","display_name":"Mingdong Huang","orcid":"https://orcid.org/0000-0003-0085-9141","observed_orcids":["https://orcid.org/0000-0003-0085-9141"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210119098","display_name":"Fujian Institute of Research on the Structure of Matter","ror":"https://ror.org/02j89k719","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"id":"https://openalex.org/I4391767757","display_name":"State Key Laboratory of Structural Chemistry","ror":"https://ror.org/023fpv336","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I82495205","display_name":"University of Alabama in Huntsville","ror":"https://ror.org/02zsxwr40","country_code":"US","type":"education","lineage":["https://openalex.org/I82495205"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Mingdong Huang","raw_affiliation_strings":["Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attenuon, LLC, 11535 Sorrento Valley Road, Suite 401, San Diego, CA 92121, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]},{"raw_affiliation_string":"Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA","institution_ids":["https://openalex.org/I82495205"]},{"raw_affiliation_string":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4391767757"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5025110808"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I19820366","https://openalex.org/I4210119098","https://openalex.org/I4210143899","https://openalex.org/I4391767757","https://openalex.org/I79576946","https://openalex.org/I82495205"],"apc_list":null,"apc_paid":null,"fwci":8.7594,"has_fulltext":false,"cited_by_count":311,"citation_normalized_percentile":{"value":0.98386449,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"311","issue":"5761","first_page":"656","last_page":"659"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.06019999831914902,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.996999979019165},{"id":"https://openalex.org/keywords/urokinase-receptor","display_name":"urokinase receptor","score":0.9789999723434448},{"id":"https://openalex.org/keywords/receptor-ligand-complex","display_name":"receptor-ligand complex","score":0.7799999713897705},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.875},{"id":"https://openalex.org/keywords/antibody-binding","display_name":"antibody binding","score":0.5199999809265137},{"id":"https://openalex.org/keywords/receptor-antagonists","display_name":"receptor antagonists","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.6190000176429749},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.906000018119812},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9629999995231628}],"concepts":[{"id":"https://openalex.org/C2776892390","wikidata":"https://www.wikidata.org/wiki/Q7119591","display_name":"Urokinase","level":2,"score":0.8894902467727661},{"id":"https://openalex.org/C56219504","wikidata":"https://www.wikidata.org/wiki/Q7900869","display_name":"Urokinase receptor","level":3,"score":0.8187065124511719},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6732795238494873},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5116501450538635},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.48689404129981995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4852592647075653},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.48420074582099915},{"id":"https://openalex.org/C164144092","wikidata":"https://www.wikidata.org/wiki/Q6587033","display_name":"Vitronectin","level":4,"score":0.44141173362731934},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4257015287876129},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3642142415046692},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32526957988739014},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2849188446998596},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17149001359939575},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13703656196594238},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.08764731884002686}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055293","descriptor_name":"Receptors, Urokinase Plasminogen Activator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.1121143","doi":"https://doi.org/10.1126/science.1121143","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1121143","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:16456079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16456079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7720605360","display_name":"Structural aspects of urokinase receptor in vascular biology","funder_award_id":"R01HL086584","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1275325292","https://openalex.org/W1470345216","https://openalex.org/W1548496378","https://openalex.org/W1974471520","https://openalex.org/W2002996779","https://openalex.org/W2005113904","https://openalex.org/W2010031911","https://openalex.org/W2010695917","https://openalex.org/W2011304249","https://openalex.org/W2012974717","https://openalex.org/W2066756817","https://openalex.org/W2088855481","https://openalex.org/W2092565468","https://openalex.org/W2095847870","https://openalex.org/W2131307163","https://openalex.org/W2143415621","https://openalex.org/W2150102277","https://openalex.org/W2162110019","https://openalex.org/W2167413291","https://openalex.org/W2329892194","https://openalex.org/W2416232996","https://openalex.org/W4300014906"],"related_works":["https://openalex.org/W4244091296","https://openalex.org/W2575804267","https://openalex.org/W2143415621","https://openalex.org/W2064283575","https://openalex.org/W2051823623","https://openalex.org/W2062403128","https://openalex.org/W1988059534","https://openalex.org/W2000989835","https://openalex.org/W2969051491","https://openalex.org/W2057938042"],"abstract_inverted_index":{"The":[0,52,72],"urokinase":[1,38,43,56,69,81],"plasminogen":[2],"activator":[3],"binds":[4],"to":[5],"its":[6,85],"cellular":[7],"receptor":[8,39,57,82,101],"with":[9,41,62,87],"high":[10],"affinity":[11],"and":[12,26,46,93],"initiates":[13],"signaling":[14],"cascades":[15],"that":[16,83],"are":[17],"implicated":[18],"in":[19],"pathological":[20],"processes":[21],"including":[22],"tumor":[23],"growth,":[24],"metastasis,":[25],"inflammation.":[27],"We":[28],"report":[29],"the":[30,37,42,50,68,77,80,97],"crystal":[31],"structure":[32,73],"at":[33],"1.9":[34],"angstroms":[35],"of":[36,55,79,91,99],"complexed":[40],"amino-terminal":[44],"fragment":[45,70],"an":[47],"antibody":[48],"against":[49],"receptor.":[51],"three":[53],"domains":[54],"form":[58],"a":[59,63,88,94],"concave":[60],"shape":[61],"central":[64],"cone-shaped":[65],"cavity":[66],"where":[67],"inserts.":[71],"provides":[74],"insight":[75],"into":[76],"flexibility":[78],"enables":[84],"interaction":[86],"wide":[89],"variety":[90],"ligands":[92],"basis":[95],"for":[96],"design":[98],"urokinase-urokinase":[100],"antagonists.":[102]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
