{"id":"https://openalex.org/W2129951633","doi":"https://doi.org/10.1111/j.1365-2990.2009.01038.x","title":"Does Alzheimer's disease begin in the brainstem?","display_name":"Does Alzheimer's disease begin in the brainstem?","publication_year":2009,"publication_date":"2009-08-04","ids":{"openalex":"https://openalex.org/W2129951633","doi":"https://doi.org/10.1111/j.1365-2990.2009.01038.x","mag":"2129951633","pmid":"https://pubmed.ncbi.nlm.nih.gov/19682326","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2787819"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2990.2009.01038.x","doi":"https://doi.org/10.1111/j.1365-2990.2009.01038.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2990.2009.01038.x","pdf_url":null,"source":{"id":"https://openalex.org/S148217029","display_name":"Neuropathology and Applied Neurobiology","issn_l":"0305-1846","issn":["0305-1846","1365-2990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropathology and Applied Neurobiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2787819","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024150673","display_name":"Goran \u0160imi\u0107","orcid":"https://orcid.org/0000-0002-6339-9261","observed_orcids":["https://orcid.org/0000-0002-6339-9261","https://orcid.org/0009-0007-1954-1228"]},"institutions":[{"id":"https://openalex.org/I4405260292","display_name":"Hrvatski institut za istra\u017eivanje mozga","ror":"https://ror.org/03hhshb57","country_code":"HR","type":"facility","lineage":["https://openalex.org/I181343428","https://openalex.org/I4405260292"]}],"countries":["HR"],"is_corresponding":true,"raw_author_name":"G. Simic","raw_affiliation_strings":["Department of Neuroscience, Croatian Institute for Brain Research, Medical School Zagreb, Croatia. gsimic@hiim.hr","Department of Neuroscience, Croatian Institute for Brain Research, Medical School Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Croatian Institute for Brain Research, Medical School Zagreb, Croatia. gsimic@hiim.hr","institution_ids":["https://openalex.org/I4405260292"]},{"raw_affiliation_string":"Department of Neuroscience, Croatian Institute for Brain Research, Medical School Zagreb, Croatia","institution_ids":["https://openalex.org/I4405260292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074781603","display_name":"Gabrijela Stani\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086219","display_name":"Klini\u010dka bolnica \"Sveti Duh\"","ror":"https://ror.org/00t8kk495","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210086219"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"G. Stanic","raw_affiliation_strings":["Department of Pathology, General Hospital \u2018Sveti duh\u2019, Zagreb, Croatia, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, General Hospital \u2018Sveti duh\u2019, Zagreb, Croatia, and","institution_ids":["https://openalex.org/I4210086219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064667915","display_name":"Mihovil Mladinov","orcid":"https://orcid.org/0000-0002-4886-7119","observed_orcids":["https://orcid.org/0000-0002-4886-7119"]},"institutions":[{"id":"https://openalex.org/I4405260292","display_name":"Hrvatski institut za istra\u017eivanje mozga","ror":"https://ror.org/03hhshb57","country_code":"HR","type":"facility","lineage":["https://openalex.org/I181343428","https://openalex.org/I4405260292"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"M. Mladinov","raw_affiliation_strings":["Department of Neuroscience, Croatian Institute for Brain Research, Medical School Zagreb,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Croatian Institute for Brain Research, Medical School Zagreb,","institution_ids":["https://openalex.org/I4405260292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041122597","display_name":"Nata\u0161a Jovanov Milo\u0161evi\u0107","orcid":"https://orcid.org/0000-0001-7897-6212","observed_orcids":["https://orcid.org/0000-0001-7897-6212"]},"institutions":[{"id":"https://openalex.org/I4405260292","display_name":"Hrvatski institut za istra\u017eivanje mozga","ror":"https://ror.org/03hhshb57","country_code":"HR","type":"facility","lineage":["https://openalex.org/I181343428","https://openalex.org/I4405260292"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"N. Jovanov\u2010Milosevic","raw_affiliation_strings":["Department of Neuroscience, Croatian Institute for Brain Research, Medical School Zagreb,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Croatian Institute for Brain Research, Medical School Zagreb,","institution_ids":["https://openalex.org/I4405260292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016909550","display_name":"Ivica Kostovi\u0107","orcid":"https://orcid.org/0000-0002-4090-4114","observed_orcids":["https://orcid.org/0000-0002-4090-4114"]},"institutions":[{"id":"https://openalex.org/I4405260292","display_name":"Hrvatski institut za istra\u017eivanje mozga","ror":"https://ror.org/03hhshb57","country_code":"HR","type":"facility","lineage":["https://openalex.org/I181343428","https://openalex.org/I4405260292"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"I. Kostovic","raw_affiliation_strings":["Department of Neuroscience, Croatian Institute for Brain Research, Medical School Zagreb,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Croatian Institute for Brain Research, Medical School Zagreb,","institution_ids":["https://openalex.org/I4405260292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110440505","display_name":"P. R. Hof","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. R. Hof","raw_affiliation_strings":["Department of Neuroscience, Mount Sinai School of Medicine, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mount Sinai School of Medicine, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024150673"],"corresponding_institution_ids":["https://openalex.org/I4405260292"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":3.6316,"has_fulltext":false,"cited_by_count":208,"citation_normalized_percentile":{"value":0.93842863,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"35","issue":"6","first_page":"532","last_page":"554"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.06019999831914902,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9769999980926514},{"id":"https://openalex.org/keywords/brainstem","display_name":"brainstem","score":0.8899999856948853},{"id":"https://openalex.org/keywords/dorsal-raphe-nucleus","display_name":"dorsal raphe nucleus","score":0.9660000205039978},{"id":"https://openalex.org/keywords/neurofibrillary-degeneration","display_name":"neurofibrillary degeneration","score":0.9049999713897705},{"id":"https://openalex.org/keywords/neuronal-cytoskeleton","display_name":"neuronal cytoskeleton","score":0.7910000085830688},{"id":"https://openalex.org/keywords/behavioral-and-psychological-symptoms-of-dementia","display_name":"behavioral and psychological symptoms of dementia","score":0.7570000290870667},{"id":"https://openalex.org/keywords/oxidative-damage","display_name":"oxidative damage","score":0.6489999890327454},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8870000243186951},{"id":"https://openalex.org/keywords/braak-staging","display_name":"Braak staging","score":0.8949999809265137},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.6704983115196228},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6514602899551392},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6123470067977905},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.5361034870147705},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5344933867454529},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4735542833805084},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.46822354197502136},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.43073326349258423},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3817787766456604},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30324435234069824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20935159921646118},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.10162419080734253},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011903","descriptor_name":"Raphe Nuclei","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011903","descriptor_name":"Raphe Nuclei","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015213","descriptor_name":"Neuroimmunomodulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/j.1365-2990.2009.01038.x","doi":"https://doi.org/10.1111/j.1365-2990.2009.01038.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2990.2009.01038.x","pdf_url":null,"source":{"id":"https://openalex.org/S148217029","display_name":"Neuropathology and Applied Neurobiology","issn_l":"0305-1846","issn":["0305-1846","1365-2990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropathology and Applied Neurobiology","raw_type":"journal-article"},{"id":"pmid:19682326","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19682326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropathology and applied neurobiology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1894990","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2787819","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2787819","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2787819/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuropathol Appl Neurobiol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.332.9901","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.332.9901","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dementia.hiim.hr/nan_1038.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1894990","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2787819","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3550458066","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P50AG005138","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8494904870","display_name":"Clinical and Biological Studies of Early AD","funder_award_id":"P01AG002219","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":171,"referenced_works":["https://openalex.org/W84489083","https://openalex.org/W164490541","https://openalex.org/W810764090","https://openalex.org/W1250594259","https://openalex.org/W1481130297","https://openalex.org/W1487997090","https://openalex.org/W1500435375","https://openalex.org/W1509571186","https://openalex.org/W1552978522","https://openalex.org/W1553552908","https://openalex.org/W1556008598","https://openalex.org/W1600934558","https://openalex.org/W1765690683","https://openalex.org/W1820073353","https://openalex.org/W1846929122","https://openalex.org/W1847168837","https://openalex.org/W1967082239","https://openalex.org/W1968155895","https://openalex.org/W1971817501","https://openalex.org/W1976452134","https://openalex.org/W1976602187","https://openalex.org/W1978668412","https://openalex.org/W1981471614","https://openalex.org/W1982064952","https://openalex.org/W1982643751","https://openalex.org/W1985696068","https://openalex.org/W1985747467","https://openalex.org/W1985802666","https://openalex.org/W1986900475","https://openalex.org/W1986909933","https://openalex.org/W1987793916","https://openalex.org/W1991886821","https://openalex.org/W1992720458","https://openalex.org/W1994693522","https://openalex.org/W1995261175","https://openalex.org/W1997417397","https://openalex.org/W1997764398","https://openalex.org/W1999184697","https://openalex.org/W2000054651","https://openalex.org/W2000658130","https://openalex.org/W2001704669","https://openalex.org/W2005503435","https://openalex.org/W2006962925","https://openalex.org/W2007522537","https://openalex.org/W2013884279","https://openalex.org/W2014670147","https://openalex.org/W2015728316","https://openalex.org/W2015860144","https://openalex.org/W2017431783","https://openalex.org/W2019628288","https://openalex.org/W2020497815","https://openalex.org/W2020951799","https://openalex.org/W2023055592","https://openalex.org/W2023586735","https://openalex.org/W2023831571","https://openalex.org/W2025869353","https://openalex.org/W2026353898","https://openalex.org/W2026589693","https://openalex.org/W2028436804","https://openalex.org/W2029462234","https://openalex.org/W2031309116","https://openalex.org/W2031654442","https://openalex.org/W2031686950","https://openalex.org/W2032576201","https://openalex.org/W2035282018","https://openalex.org/W2035339855","https://openalex.org/W2035462700","https://openalex.org/W2037851765","https://openalex.org/W2039402963","https://openalex.org/W2039765555","https://openalex.org/W2039900537","https://openalex.org/W2045509178","https://openalex.org/W2046424371","https://openalex.org/W2050454006","https://openalex.org/W2050591554","https://openalex.org/W2050665230","https://openalex.org/W2051033492","https://openalex.org/W2051218719","https://openalex.org/W2052742260","https://openalex.org/W2053051596","https://openalex.org/W2053104990","https://openalex.org/W2053116497","https://openalex.org/W2054384828","https://openalex.org/W2057013121","https://openalex.org/W2057888342","https://openalex.org/W2059501379","https://openalex.org/W2063366627","https://openalex.org/W2065137341","https://openalex.org/W2066977853","https://openalex.org/W2068376950","https://openalex.org/W2070137740","https://openalex.org/W2071397750","https://openalex.org/W2073009405","https://openalex.org/W2075061360","https://openalex.org/W2075342209","https://openalex.org/W2075632954","https://openalex.org/W2075638616","https://openalex.org/W2076608120","https://openalex.org/W2076932399","https://openalex.org/W2077481531","https://openalex.org/W2077731832","https://openalex.org/W2080583793","https://openalex.org/W2081836725","https://openalex.org/W2084453905","https://openalex.org/W2084957666","https://openalex.org/W2086729582","https://openalex.org/W2087540782","https://openalex.org/W2088923332","https://openalex.org/W2092665983","https://openalex.org/W2092789470","https://openalex.org/W2098213300","https://openalex.org/W2098427054","https://openalex.org/W2099264124","https://openalex.org/W2100198693","https://openalex.org/W2102701929","https://openalex.org/W2103976905","https://openalex.org/W2105704879","https://openalex.org/W2109727228","https://openalex.org/W2109845730","https://openalex.org/W2111399612","https://openalex.org/W2111417422","https://openalex.org/W2114022129","https://openalex.org/W2115790527","https://openalex.org/W2116784956","https://openalex.org/W2122306148","https://openalex.org/W2123403836","https://openalex.org/W2125436534","https://openalex.org/W2125851351","https://openalex.org/W2126124658","https://openalex.org/W2126587429","https://openalex.org/W2126927216","https://openalex.org/W2127229268","https://openalex.org/W2128307173","https://openalex.org/W2129792115","https://openalex.org/W2131819352","https://openalex.org/W2132948185","https://openalex.org/W2133703021","https://openalex.org/W2136995208","https://openalex.org/W2137554996","https://openalex.org/W2140542463","https://openalex.org/W2145533532","https://openalex.org/W2146400336","https://openalex.org/W2146729934","https://openalex.org/W2148570557","https://openalex.org/W2150392025","https://openalex.org/W2150999725","https://openalex.org/W2151391567","https://openalex.org/W2154584808","https://openalex.org/W2156220037","https://openalex.org/W2158592797","https://openalex.org/W2158926311","https://openalex.org/W2159789463","https://openalex.org/W2159838014","https://openalex.org/W2159994020","https://openalex.org/W2160456898","https://openalex.org/W2162563187","https://openalex.org/W2165679544","https://openalex.org/W2165722945","https://openalex.org/W2167720733","https://openalex.org/W2170537094","https://openalex.org/W2170630216","https://openalex.org/W2171405125","https://openalex.org/W2223656268","https://openalex.org/W2363633697","https://openalex.org/W2411352353","https://openalex.org/W2470862058","https://openalex.org/W2504116834","https://openalex.org/W2725718031","https://openalex.org/W2911236093","https://openalex.org/W4285719527","https://openalex.org/W4317564112"],"related_works":["https://openalex.org/W7099243186","https://openalex.org/W2432513713","https://openalex.org/W2532750654","https://openalex.org/W1976452134","https://openalex.org/W4401580050","https://openalex.org/W2519899359","https://openalex.org/W2050591554","https://openalex.org/W2039900537","https://openalex.org/W3139461084","https://openalex.org/W2039765555"],"abstract_inverted_index":{"Although":[0,190],"substantial":[1],"evidence":[2],"indicates":[3],"that":[4,122,202,246],"the":[5,11,18,26,34,42,114,120,123,150,161,167,191,208,215,218,237],"progression":[6,187],"of":[7,10,20,31,58,69,81,104,113,119,132,152,157,169,175,185,194,211,236,250],"pathological":[8],"changes":[9],"neuronal":[12,43],"cytoskeleton":[13],"is":[14,217,231],"crucial":[15],"in":[16,22,86,166,243],"determining":[17],"severity":[19],"dementia":[21,82],"Alzheimer's":[23],"disease":[24],"(AD),":[25],"exact":[27],"causes":[28],"and":[29,41,71,78,90,95,110,125,129,154,178],"evolution":[30],"these":[32,105,173],"changes,":[33],"initial":[35],"site":[36],"at":[37],"which":[38],"they":[39],"begin,":[40],"susceptibility":[44,177],"levels":[45],"for":[46,56,222],"their":[47,142],"development":[48],"are":[49,60],"poorly":[50],"understood.":[51],"The":[52,101],"current":[53],"clinical":[54],"criteria":[55,138],"diagnosis":[57],"AD":[59,186],"focused":[61],"mostly":[62],"on":[63,172],"cognitive":[64],"deficits":[65],"produced":[66],"by":[67],"dysfunction":[68],"hippocampal":[70],"high-order":[72],"neocortical":[73],"areas,":[74],"whereas":[75],"noncognitive,":[76],"behavioural":[77],"psychological":[79],"symptoms":[80,106],"such":[83,226],"as":[84,214,234],"disturbances":[85],"mood,":[87],"emotion,":[88],"appetite,":[89],"wake-sleep":[91],"cycle,":[92],"confusion,":[93],"agitation":[94],"depression":[96],"have":[97],"been":[98],"less":[99],"considered.":[100],"early":[102,155],"occurrence":[103],"suggests":[107],"brainstem":[108],"involvement,":[109],"more":[111],"specifically":[112],"serotonergic":[115],"nuclei.":[116],"In":[117],"spite":[118],"fact":[121],"Braak":[124,126],"staging":[127],"system":[128],"National":[130],"Institutes":[131],"Aging":[133],"-":[134],"Reagan":[135],"Institute":[136],"(NIA-RI)":[137],"do":[139],"not":[140],"include":[141],"evaluation,":[143],"several":[144],"recent":[145],"reports":[146],"drew":[147],"attention":[148],"to":[149],"possibility":[151],"selective":[153],"involvement":[156],"raphe":[158,163],"nuclei,":[159],"particularly":[160],"dorsal":[162],"nucleus":[164],"(DRN),":[165],"pathogenesis":[168],"AD.":[170,224],"Based":[171],"findings":[174],"differential":[176],"anatomical":[179],"connectivity,":[180],"a":[181,227,240],"novel":[182],"pathogenetic":[183],"scheme":[184],"was":[188],"proposed.":[189],"precise":[192],"mechanisms":[193],"neurofibrillary":[195],"degeneration":[196],"still":[197],"await":[198],"elucidation,":[199],"we":[200],"speculated":[201],"cumulative":[203],"oxidative":[204],"damage":[205],"may":[206],"be":[207],"main":[209,219],"cause":[210],"DRN":[212],"alterations,":[213],"age":[216],"risk":[220],"factor":[221],"sporadic":[223],"Within":[225],"framework,":[228],"beta-amyloid":[229],"production":[230],"considered":[232],"only":[233],"one":[235,242],"factors":[238],"(although":[239],"significant":[241],"familial":[244],"cases)":[245],"promotes":[247],"molecular":[248],"series":[249],"events":[251],"underlying":[252],"AD-related":[253],"neuropathological":[254],"changes.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}