{"id":"https://openalex.org/W2129911161","doi":"https://doi.org/10.2337/db13-0903","title":"Lipopolysaccharides-Mediated Increase in Glucose-Stimulated Insulin Secretion: Involvement of the GLP-1 Pathway","display_name":"Lipopolysaccharides-Mediated Increase in Glucose-Stimulated Insulin Secretion: Involvement of the GLP-1 Pathway","publication_year":2013,"publication_date":"2013-11-02","ids":{"openalex":"https://openalex.org/W2129911161","doi":"https://doi.org/10.2337/db13-0903","mag":"2129911161","pmid":"https://pubmed.ncbi.nlm.nih.gov/24186868"},"language":"en","primary_location":{"id":"doi:10.2337/db13-0903","doi":"https://doi.org/10.2337/db13-0903","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db13-0903","pdf_url":"https://diabetes.diabetesjournals.org/content/diabetes/63/2/471.full.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://diabetes.diabetesjournals.org/content/diabetes/63/2/471.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109229745","display_name":"Anh Thoai Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177064439","display_name":"Universit\u00e9 de Bourgogne","ror":"https://ror.org/03k1bsr36","country_code":"FR","type":"education","lineage":["https://openalex.org/I177064439","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4210139033","display_name":"Centre de recherche Translationnelle en M\u00e9decine mol\u00e9culaire","ror":"https://ror.org/04d70nb60","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I2746051580","https://openalex.org/I4210117091","https://openalex.org/I4210135996","https://openalex.org/I4210139033","https://openalex.org/I4399657933","https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anh Thoai Nguyen","raw_affiliation_strings":["INSERM UMR866-LabEx LipSTIC, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Bourgogne, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR866-LabEx LipSTIC, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Bourgogne, Dijon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I177064439","https://openalex.org/I4210139033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077944210","display_name":"St\u00e9phane Mandard","orcid":"https://orcid.org/0000-0002-7298-821X","observed_orcids":["https://orcid.org/0000-0002-7298-821X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177064439","display_name":"Universit\u00e9 de Bourgogne","ror":"https://ror.org/03k1bsr36","country_code":"FR","type":"education","lineage":["https://openalex.org/I177064439","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4210139033","display_name":"Centre de recherche Translationnelle en M\u00e9decine mol\u00e9culaire","ror":"https://ror.org/04d70nb60","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I2746051580","https://openalex.org/I4210117091","https://openalex.org/I4210135996","https://openalex.org/I4210139033","https://openalex.org/I4399657933","https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phane Mandard","raw_affiliation_strings":["INSERM UMR866-LabEx LipSTIC, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Bourgogne, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR866-LabEx LipSTIC, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Bourgogne, Dijon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I177064439","https://openalex.org/I4210139033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037519865","display_name":"C\u00e9dric Dray","orcid":"https://orcid.org/0000-0002-4712-791X","observed_orcids":["https://orcid.org/0000-0002-4712-791X"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210147779","display_name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/04d73z393","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210147779","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9dric Dray","raw_affiliation_strings":["INSERM Unit\u00e9 1048, Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Toulouse, France Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit\u00e9 1048, Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Toulouse, France Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210147779","https://openalex.org/I4405258862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067529530","display_name":"Val\u00e9rie Deckert","orcid":"https://orcid.org/0000-0001-5728-1710","observed_orcids":["https://orcid.org/0000-0001-5728-1710"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177064439","display_name":"Universit\u00e9 de Bourgogne","ror":"https://ror.org/03k1bsr36","country_code":"FR","type":"education","lineage":["https://openalex.org/I177064439","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4210139033","display_name":"Centre de recherche Translationnelle en M\u00e9decine mol\u00e9culaire","ror":"https://ror.org/04d70nb60","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I2746051580","https://openalex.org/I4210117091","https://openalex.org/I4210135996","https://openalex.org/I4210139033","https://openalex.org/I4399657933","https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Val\u00e9rie Deckert","raw_affiliation_strings":["INSERM UMR866-LabEx LipSTIC, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Bourgogne, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR866-LabEx LipSTIC, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Bourgogne, Dijon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I177064439","https://openalex.org/I4210139033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088946409","display_name":"Philippe Valet","orcid":"https://orcid.org/0000-0001-6520-7393","observed_orcids":["https://orcid.org/0000-0001-6520-7393"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210147779","display_name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/04d73z393","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210147779","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Valet","raw_affiliation_strings":["INSERM Unit\u00e9 1048, Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Toulouse, France Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit\u00e9 1048, Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Toulouse, France Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210147779","https://openalex.org/I4405258862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033529457","display_name":"Philippe Besnard","orcid":"https://orcid.org/0000-0002-3702-5709","observed_orcids":["https://orcid.org/0000-0002-3702-5709"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177064439","display_name":"Universit\u00e9 de Bourgogne","ror":"https://ror.org/03k1bsr36","country_code":"FR","type":"education","lineage":["https://openalex.org/I177064439","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4210139033","display_name":"Centre de recherche Translationnelle en M\u00e9decine mol\u00e9culaire","ror":"https://ror.org/04d70nb60","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I2746051580","https://openalex.org/I4210117091","https://openalex.org/I4210135996","https://openalex.org/I4210139033","https://openalex.org/I4399657933","https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Besnard","raw_affiliation_strings":["INSERM UMR866-LabEx LipSTIC, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Bourgogne, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR866-LabEx LipSTIC, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Bourgogne, Dijon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I177064439","https://openalex.org/I4210139033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057472647","display_name":"Daniel J. Drucker","orcid":"https://orcid.org/0000-0001-6688-8127","observed_orcids":["https://orcid.org/0000-0001-6688-8127"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Daniel J. Drucker","raw_affiliation_strings":["Department of Medicine, Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I185261750","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069249242","display_name":"Laurent Lagrost","orcid":"https://orcid.org/0000-0002-8878-6081","observed_orcids":["https://orcid.org/0000-0002-8878-6081"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177064439","display_name":"Universit\u00e9 de Bourgogne","ror":"https://ror.org/03k1bsr36","country_code":"FR","type":"education","lineage":["https://openalex.org/I177064439","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4210116240","display_name":"CHU Dijon Bourgogne","ror":"https://ror.org/0377z4z10","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210116240"]},{"id":"https://openalex.org/I4210139033","display_name":"Centre de recherche Translationnelle en M\u00e9decine mol\u00e9culaire","ror":"https://ror.org/04d70nb60","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I2746051580","https://openalex.org/I4210117091","https://openalex.org/I4210135996","https://openalex.org/I4210139033","https://openalex.org/I4399657933","https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Lagrost","raw_affiliation_strings":["Centre Hospitalier Universitaire Dijon, H\u00f4pital du Bocage, Dijon, France","INSERM UMR866-LabEx LipSTIC, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Bourgogne, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire Dijon, H\u00f4pital du Bocage, Dijon, France","institution_ids":["https://openalex.org/I4210116240"]},{"raw_affiliation_string":"INSERM UMR866-LabEx LipSTIC, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Bourgogne, Dijon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I177064439","https://openalex.org/I4210139033"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106477714","display_name":"Jacques Grober","orcid":"https://orcid.org/0000-0003-0503-4819","observed_orcids":["https://orcid.org/0000-0003-0503-4819"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177064439","display_name":"Universit\u00e9 de Bourgogne","ror":"https://ror.org/03k1bsr36","country_code":"FR","type":"education","lineage":["https://openalex.org/I177064439","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4210139033","display_name":"Centre de recherche Translationnelle en M\u00e9decine mol\u00e9culaire","ror":"https://ror.org/04d70nb60","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I2746051580","https://openalex.org/I4210117091","https://openalex.org/I4210135996","https://openalex.org/I4210139033","https://openalex.org/I4399657933","https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jacques Grober","raw_affiliation_strings":["INSERM UMR866-LabEx LipSTIC, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Bourgogne, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR866-LabEx LipSTIC, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Bourgogne, Dijon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I177064439","https://openalex.org/I4210139033"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.9071,"has_fulltext":true,"cited_by_count":166,"citation_normalized_percentile":{"value":0.97017348,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"63","issue":"2","first_page":"471","last_page":"482"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.05700000002980232,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11623","display_name":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9819999933242798},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.8690000176429749},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.9829999804496765},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.9089999794960022},{"id":"https://openalex.org/keywords/glp-1-receptor","display_name":"GLP-1 receptor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.9589999914169312},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.6489999890327454},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.843999981880188},{"id":"https://openalex.org/keywords/phospholipid-transfer-protein","display_name":"phospholipid transfer protein","score":0.8889999985694885},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.5090000033378601},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.8044379949569702},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7692053318023682},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7500122785568237},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.6702511310577393},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5311607122421265},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5133263468742371},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.4367194175720215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4319569170475006},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4259960353374481},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2924770712852478},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.2427276372909546}],"mesh":[{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049294","descriptor_name":"Phospholipid Transfer Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049294","descriptor_name":"Phospholipid Transfer Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.2337/db13-0903","doi":"https://doi.org/10.2337/db13-0903","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db13-0903","pdf_url":"https://diabetes.diabetesjournals.org/content/diabetes/63/2/471.full.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:24186868","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24186868","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:inserm-00880061v1","doi":null,"is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-00880061","pdf_url":"https://inserm.hal.science/inserm-00880061/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes, 2014, 63 (2), pp.471-82. ⟨10.2337/db13-0903⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1026.7374","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1026.7374","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://diabetes.diabetesjournals.org/content/diabetes/63/2/471.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.2337/db13-0903","doi":"https://doi.org/10.2337/db13-0903","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db13-0903","pdf_url":"https://diabetes.diabetesjournals.org/content/diabetes/63/2/471.full.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7228256837","display_name":"Lipoprot\u00e9ines et sant\u00e9 : pr\u00e9vention et traitement des maladies inflammatoires non vasculaires et du cancer","funder_award_id":"ANR-11-LABX-0021","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129911161.pdf","grobid_xml":"https://content.openalex.org/works/W2129911161.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1535477022","https://openalex.org/W1551851929","https://openalex.org/W1708450707","https://openalex.org/W1868745190","https://openalex.org/W1944260161","https://openalex.org/W1965454146","https://openalex.org/W1979670900","https://openalex.org/W1982178858","https://openalex.org/W1987205815","https://openalex.org/W1998721468","https://openalex.org/W2002225831","https://openalex.org/W2009649501","https://openalex.org/W2016723022","https://openalex.org/W2018066581","https://openalex.org/W2023084005","https://openalex.org/W2023478520","https://openalex.org/W2035634246","https://openalex.org/W2036173588","https://openalex.org/W2038263945","https://openalex.org/W2042176582","https://openalex.org/W2047732676","https://openalex.org/W2048491170","https://openalex.org/W2049600217","https://openalex.org/W2052332602","https://openalex.org/W2056548679","https://openalex.org/W2059043020","https://openalex.org/W2060454917","https://openalex.org/W2069573358","https://openalex.org/W2075401410","https://openalex.org/W2080128749","https://openalex.org/W2081666098","https://openalex.org/W2096728414","https://openalex.org/W2098226285","https://openalex.org/W2102995040","https://openalex.org/W2104084845","https://openalex.org/W2124852816","https://openalex.org/W2131536322","https://openalex.org/W2134285290","https://openalex.org/W2135967557","https://openalex.org/W2139819899","https://openalex.org/W2143014102","https://openalex.org/W2149163359","https://openalex.org/W2150882383","https://openalex.org/W2159001939","https://openalex.org/W2159420204","https://openalex.org/W2161074858","https://openalex.org/W2166870744","https://openalex.org/W2169780324","https://openalex.org/W2171831692","https://openalex.org/W2268917154","https://openalex.org/W2273288188","https://openalex.org/W2275318210","https://openalex.org/W2398135414","https://openalex.org/W2398312545","https://openalex.org/W2398957006","https://openalex.org/W2400435137","https://openalex.org/W2400447682","https://openalex.org/W2409141832","https://openalex.org/W2409864371","https://openalex.org/W2411980500","https://openalex.org/W2416307853","https://openalex.org/W2433731585","https://openalex.org/W2441031695","https://openalex.org/W2460558925"],"related_works":["https://openalex.org/W7099663280","https://openalex.org/W2945018190","https://openalex.org/W7037367709","https://openalex.org/W2043876934","https://openalex.org/W3117330240","https://openalex.org/W7143901287","https://openalex.org/W2479726526","https://openalex.org/W2619491520","https://openalex.org/W7147655339","https://openalex.org/W7099949260"],"abstract_inverted_index":{"Lipopolysaccharides":[0],"(LPS)":[1],"of":[2,6,32,43,52,59,74,78,93,106,144,155,161,198],"the":[3,44,50,112,132,157,177,183,196],"cell":[4],"wall":[5],"gram-negative":[7],"bacteria":[8],"trigger":[9],"inflammation,":[10],"which":[11],"is":[12,21,29],"associated":[13,100,201],"with":[14,101,137,202],"marked":[15],"changes":[16,185],"in":[17,37,65,83,168,181,186],"glucose":[18,84,121,126,147,187],"metabolism.":[19,188],"Hyperglycemia":[20],"frequently":[22],"observed":[23],"during":[24],"bacterial":[25],"infection":[26],"and":[27,67,86,123,128,170,193],"it":[28],"a":[30,33,75,153],"marker":[31],"poor":[34],"clinical":[35],"outcome":[36],"critically":[38],"ill":[39],"patients.":[40],"The":[41,71,142],"aim":[42],"current":[45],"study":[46],"was":[47,98],"to":[48,119],"investigate":[49],"effect":[51],"an":[53,81],"acute":[54,72],"injection":[55,73],"or":[56,159],"continuous":[57],"infusion":[58,92],"LPS":[60,79,94,107,138,145],"on":[61,146],"experimentally":[62],"induced":[63],"hyperglycemia":[64],"wild-type":[66,169],"genetically":[68],"engineered":[69],"mice.":[70],"single":[76],"dose":[77],"produced":[80],"increase":[82],"disposal":[85,122],"glucose-stimulated":[87],"insulin":[88],"secretion":[89,192],"(GSIS).":[90],"Continuous":[91],"through":[95],"mini-osmotic":[96],"pumps":[97],"also":[99],"increased":[102,120],"GSIS.":[103,124],"Finally,":[104],"manipulation":[105],"detoxification":[108],"by":[109],"knocking":[110],"out":[111],"plasma":[113],"phospholipid":[114],"transfer":[115],"protein":[116],"(PLTP)":[117],"led":[118],"Overall,":[125],"tolerance":[127],"GSIS":[129],"tests":[130],"supported":[131],"hypothesis":[133],"that":[134],"mice":[135,174],"treated":[136],"develop":[139],"glucose-induced":[140],"hyperinsulinemia.":[141],"effects":[143],"metabolism":[148],"were":[149],"significantly":[150],"altered":[151],"as":[152],"result":[154],"either":[156],"accumulation":[158],"antagonism":[160],"glucagon-like":[162],"peptide":[163],"1":[164],"(GLP-1).":[165],"Complementary":[166],"studies":[167],"GLP-1":[171,178,191],"receptor":[172],"knockout":[173],"further":[175],"implicated":[176],"receptor-dependent":[179],"pathway":[180],"mediating":[182],"LPS-mediated":[184],"Hence,":[189],"enhanced":[190],"action":[194],"underlies":[195],"development":[197],"glucose-mediated":[199],"hyperinsulinemia":[200],"endotoxemia.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}